Menée en Norvège par questionnaire auprès de 130 053 participantes âgées de 34 à 70 ans, cette étude prospective évalue la part des cancers du sein attribuable au tabagisme (4 293 cas entre 1991 et 2007)

The fraction of breast cancer attributable to smoking: The Norwegian women and cancer study 1991-2012

Gram, Inger T. ; Little, Melissa A. ; Lund, Eiliv ; Braaten, Tonje

Background: Results from several recent cohort studies on smoking and breast cancer incidence and mortality suggest that the burden of smoking on society is underestimated. We estimated the fraction of breast cancer attributable to smoking in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study. Methods: We followed 130 053 women, aged 34–70 years, who completed a baseline questionnaire between 1991 and 2007, through linkages to national registries through [...]

A partir des données de la cohorte européenne EPIC, cette étude compare l'association entre une adiposité abdominale ou une adiposité générale et le risque de cancer de l'intestin grêle (durée moyenne de suivi : 13,9 ans ; 131 cas)

Comparison of abdominal adiposity and overall obesity in relation to risk of small intestinal cancer in a European Prospective Cohort

Lu, Yunxia ; Cross, Amanda J. ; Murphy, Neil ; Freisling, Heinz ; Travis, Ruth C. ; Ferrari, Pietro ; Katzke, Verena A. ; Kaaks, Rudolf ; Olsson, Åsa ; Johansson, Ingegerd ; Renström, Frida ; Panico, Salvatore ; Pala, Valeria ; Palli, Domenico ; Tumino, Rosario ; Peeters, Petra H. ; Siersema, Peter D. ; Bueno-de-Mesquita, H. B. ; Trichopoulou, Antonia ; Klinaki, Eleni ; Tsironis, Christos ; Agudo, Antonio ; Navarro, Carmen ; Sánchez, María-José ; Barricarte, Aurelio ; Boutron-Ruault, Marie-Christine ; Fagherazzi, Guy ; Racine, Antoine ; Weiderpass, Elisabete ; Gunter, Marc J. ; Riboli, Elio

Background : The etiology of small intestinal cancer (SIC) is largely unknown, and there are very few epidemiological studies published to date. No studies have investigated abdominal adiposity in relation to SIC. Methods : We investigated overall obesity and abdominal adiposity in relation to SIC in the European Prospective Investigation into Cancer and Nutrition (EPIC), a large prospective cohort of approximately half a million men and women from ten European countries. Overall obesity and [...]

A partir de données de sept cohortes européennes et d'une cohorte américaine incluant 329 576 participants, cette étude évalue l'association entre la durée d'un surpoids tout au long de la vie, ainsi que son niveau, et le risque de divers types de cancers après l'âge de 50 ans

Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States

Arnold, Melina ; Freisling, Heinz ; Stolzenberg-Solomon, Rachael ; Kee, Frank ; O’Doherty, Mark George ; Ordóñez-Mena, José Manuel ; Wilsgaard, Tom ; May, Anne Maria ; Bueno-de-Mesquita, Hendrik Bas ; Tjønneland, Anne ; Orfanos, Philippos ; Trichopoulou, Antonia ; Boffetta, Paolo ; Bray, Freddie ; Jenab, Mazda ; Soerjomataram, Isabelle

Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n = 329,576). Trajectories of body mass [...]

Menée en Inde auprès de 350 patients atteints d'un cancer de la cavité buccale et de 371 témoins, cette étude évalue l'association entre des maladies parodontales et le risque de cancer, sur la période 2008-2012

Periodontal diseases and risk of oral cancer in Southern India: Results from the HeNCe Life study

Laprise, Claudie ; Shahul, Hameed Puthiyannal ; Madathil, Sreenath Arekunnath ; Thekkepurakkal, Akhil Soman ; Castonguay, Geneviève ; Varghese, Ipe ; Shiraz, Shameena ; Allison, Paul ; Schlecht, Nicolas F. ; Rousseau, Marie-Claude ; Franco, Eduardo L. ; Nicolau, Belinda

Some studies suggest that periodontal diseases increase the risk of oral cancer, but contradictory results also exist. Inadequate control of confounders, including life course exposures, may have influenced prior findings. We estimate the extent to which high levels of periodontal diseases, measured by gingival inflammation and recession, are associated with oral cancer risk using a comprehensive subset of potential confounders and applying a stringent adjustment approach. In a hospital-based [...]

Menée aux Etats-Unis, cette étude analyse le risque de divers cancers chez des parents au premier et second degré d'individus porteurs de mutations des gènes BRCA1 et BRCA2 (9 032 proches de 784 porteurs)

Cancer Incidence in First- and Second-Degree Relatives of BRCA1 and BRCA2 Mutation Carriers

Streff, Haley ; Profato, Jessica ; Ye, Yuanqing ; Nebgen, Denise ; Peterson, Susan K. ; Singletary, Claire ; Arun, Banu K. ; Litton, Jennifer K.

Background. Mutations in the BRCA1 and BRCA2 genes are associated with increased risk of breast, ovarian, and several other cancers. The purpose of the present study was to evaluate the incidence of cancer in first- and second-degree relatives of BRCA mutation carriers compared with the general population. Materials and Methods. A total of 1,086 pedigrees of BRCA mutation carriers was obtained from a prospectively maintained, internal review board-approved study of persons referred for clinical [...]

Menée aux Etats-Unis à partir de données portant sur 2 710 patientes âgées de 20 à 69 ans, cette étude évalue les disparités ethniques dans l'association entre des facteurs reproductifs et le risque de cancer du sein par sous-type (luminal, triple négatif, HER2+)

Reproductive factors and risk of luminal, HER2-overexpressing and triple negative breast cancer among multiethnic women

Chen, Lu ; Li, Christopher I. ; Tang, Mei-Tzu C. ; Porter, Peggy ; Hill, Deirdre A. ; Wiggins, Charles L. ; Cook, Linda S.

Background:Reproductive factors are among the most well-established risk factors for breast cancer. However, their associations with different breast cancer subtypes defined by joint estrogen receptor (ER)/progesterone receptor (PR)/HER2 status remain unclear. Methods:We assessed relationships between reproductive factors and risks of luminal A (ER+/HER2-), luminal B (ER+/HER2+), triple negative (TN, ER-/PR-/HER2-), and HER2-overexpressing (H2E, ER-/HER2+) breast cancers in a population-based [...]