Cette étude américaine présente les résultats de travaux menés par l'"Institute of Medicine" sur les besoins médicaux et psychosociaux spécifiques des adolescents et jeunes adultes atteints de cancer

Identifying and Addressing the Needs of Adolescents and Young Adults With Cancer: Summary of an Institute of Medicine Workshop

Nass, Sharyl J. ; Beaupin, Lynda K. ; Demark-Wahnefried, Wendy ; Fasciano, Karen ; Ganz, Patricia A. ; Hayes-Lattin, Brandon ; Hudson, Melissa M. ; Nevidjon, Brenda ; Oeffinger, Kevin C. ; Rechis, Ruth ; Richardson, Lisa C. ; Seibel, Nita L. ; Smith, Ashley W.

Cancer is the leading disease-related cause of death in adolescents and young adults (AYAs). This population faces many short- and long-term health and psychosocial consequences of cancer diagnosis and treatment, but many programs for cancer treatment, survivorship care, and psychosocial support do not focus on the specific needs of AYA cancer patients. Recognizing this health care disparity, the National Cancer Policy Forum of the Institute of Medicine convened a public workshop to examine the [...]

Cette étude américaine analyse l'efficacité des parcours personnalisés après un cancer pour prendre en charge les besoins spécifiques des patients atteints d'un cancer de stade avancé ou métastatique

Is there a role for survivorship care plans in advanced cancer?

Mayer, D. K. ; Green, M. ; Check, D. K. ; Gerstel, A. ; Chen, R. C. ; Asher, G. ; Wheeler, S. B. ; Hanson, L. C. ; Rosenstein, D. L.

Purpose : The Institute of Medicine (2006) has recommended that cancer survivors completing treatment receive a survivorship care plan (SCP). The survivorship needs in advanced cancer have been overlooked and understudied. The potential role of SCPs for survivors with advanced or metastatic cancer is unknown and was explored in this study. Methods : We conducted two focus groups of survivors with advanced or metastatic cancer. Participants reviewed a sample JourneyForward™ SCP modified for [...]

Menée aux Etats-Unis auprès de survivants à 2, 5 et 10 ans d'un cancer et âgés de 24 à 97 ans (1 514 répondants), cette étude analyse leurs besoins en soins de nature psychosociale ou physique

Current unmet needs of cancer survivors: Analysis of open-ended responses to the American Cancer Society Study of Cancer Survivors II

Burg, Mary Ann ; Adorno, Gail ; Lopez, Ellen D. S. ; Loerzel, Victoria ; Stein, Kevin ; Wallace, Cara ; Sharma, Dinghy Kristine B.

BACKGROUND Cancer survivors may continue to experience psychosocial and physical needs related to their cancer experience for many years after treatment. The specification of these needs across cancer types and by survivor characteristics may lead to better prevention approaches and clinical responses. Mixed methods were used to examine responses to an open-ended question about current unmet needs from a survey of 2-, 5-, and 10-year cancer survivors. METHODS Qualitative techniques were used to [...]

Menée aux Etats-Unis par questionnaire auprès de 570 oncologues et 546 spécialistes de la lutte contre la douleur et de la médecine palliative, cette étude analyse leurs connaissances et leurs pratiques relatives à la prise en charge de la douleur liée au cancer

How Well Do Medical Oncologists Manage Chronic Cancer Pain?: A National Survey

Breuer, Brenda ; Chang, Victor T. ; von Roenn, Jamie H. ; von Gunten, Charles ; Neugut, Alfred I. ; Kaplan, Ronald ; Wallenstein, Sylvan ; Portenoy, Russell K.

Background. Cancer pain is usually managed by oncologists, occasionally with input from specialists in hospice and palliative medicine (PLM) or pain medicine (PMD). We evaluated the knowledge of cancer pain management in these three specialty groups. Methods. Eight vignettes depicting challenging scenarios of patients with poorly controlled pain were developed; each had five or six treatment choices. Respondents indicated choices likely to be safe and efficacious as “true” and choices likely to [...]

Menée au Danemark par entretiens auprès de 19 participants, cette étude qualitative longitudinale analyse la faisabilité et l'efficacité d'une intervention à base d'exercices physiques destinée aux patients atteints d'un cancer du poumon non à petites cellules après leur traitement chirurgical

Exercise intervention for patients diagnosed with operable non-small cell lung cancer: a qualitative longitudinal feasibility study

Missel, Malene ; Pedersen, JesperHolst ; Hendriksen, Carsten ; Tewes, Marianne ; Adamsen, Lis

Purpose : The purpose was to explore operable lung cancer patient experiences with an exercise intervention from a longitudinal perspective according to patient motivation and patient perceived benefits and barriers of exercise. Methods : Nineteen patients enrolled in an exercise intervention 2 weeks post-surgery participated in qualitative interviews at three time points. A criteria sampling strategy was applied. Ricoeur’s phenomenological hermeneutical philosophy inspired the analysis. [...]

Menée aux Etats-Unis par enquête auprès de 1 396 survivants d'un cancer du poumon, cette étude analyse l'évolution de leur qualité de vie

Health-related quality of life in lung cancer survivors: Latent class and latent transition analysis

Kenzik, Kelly M. ; Martin, Michelle Y. ; Fouad, Mona N. ; Pisu, Maria

BACKGROUND Health-related quality of life (HRQOL) heterogeneity among cancer survivors may mask subgroups (classes) with different limitations and long-term outcomes. The authors determined the HRQOL classes that exist among lung cancer survivors, examined transitions among those classes over time, and compared survival outcomes of patients according to the classes present in the initial phase of care. METHODS Lung cancer survivors in the Cancer Care Outcomes Research and Surveillance [...]

Menée en Corée auprès de 60 survivantes d'un cancer du sein, cette étude évalue l'association entre les niveaux sériques de la fibronectine 1 et de l'apolipoprotéine E et le risque de lymphœdème

Serum fibronectin 1 and ApoE levels increase with risk of lymphedema in Korean breast cancer survivors

Yim, SeungYun ; Ryu, Eunjung ; Lim, Jae-Young ; Yang, EunJoo ; Lee, Seung-Min

Purpose : Lymphedema is an irreversible disorder often seen as a postoperative side effect in breast cancer survivors. We aimed to identify serum factors that are associated with lymphedema risk in breast cancer survivors. Methods : This study recruited 60 volunteer breast cancer survivors. Participants were classified into either a CTRL group who underwent sentinel lymph node biopsy (SLNB), a RISK group who underwent axillary lymph node dissection (ALND) with removal of fewer than five lymph [...]

Menée aux Etats-Unis auprès de 452 cas et 375 témoins, cette étude transversale analyse les disparités ethniques dans les comportements de santé chez des survivants d'un cancer de l'enfance

Health behaviors of minority childhood cancer survivors

Stolley, Melinda R. ; Sharp, Lisa K. ; Tangney, Christy C. ; Schiffer, Linda A. ; Arroyo, Claudia ; Kim, Yoonsang ; Campbell, Richard T. ; Schmidt, Mary Lou ; Breen, Kathleen ; Kinahan, Karen E. ; Dilley, Kim J. ; Henderson, Tara O. ; Korenblit, Allen D. ; Seligman, Katya

BACKGROUND Available data have suggested that childhood cancer survivors (CCSs) are comparable to the general population with regard to many lifestyle parameters. However, to the authors' knowledge, little is known regarding minority CCSs. This cross-sectional study describes and compares the body mass index and health behaviors of African American, Hispanic, and white survivors with each other and with noncancer controls. METHODS Participants included 452 adult CCSs (150 African American, 152 [...]

Menée en France, cette étude ré-évalue l'association entre des critères sociéconomiques et le risque de cancer en prenant en compte les biais induits par la mobilité géographique résidentielle des individus

Correction of misclassification bias induced by the residential mobility in studies examining the link between socioeconomic environment and cancer incidence

Bryere, Josephine ; Pornet, Carole ; Dejardin, Olivier ; Launay, Ludivine ; Guittet, Lydia ; Launoy, Guy

Background : Many international ecological studies that examine the link between social environment and cancer incidence use a deprivation index based on the subjects’ address at the time of diagnosis to evaluate socioeconomic status. Thus, social past details are ignored, which leads to misclassification bias in the estimations. The objectives of this study were to include the latency delay in such estimations and to observe the effects. Methods : We adapted a previous methodology to correct [...]

Menée aux Etats-Unis auprès de 88 patients pédiatriques atteints d'un adénome de la glande corticosurrénale, cette étude analyse la prévalence de mutations du gène TP53 et leurs effets sur les fonctions physiques des patients et les complications associées

Prevalence and Functional Consequence of TP53 Mutations in Pediatric Adrenocortical Carcinoma: A Children's Oncology Group Study

Wasserman, Jonathan D. ; Novokmet, Ana ; Eichler-Jonsson, Claudia ; Ribeiro, Raul C. ; Rodriguez-Galindo, Carlos ; Zambetti, Gerard P. ; Malkin, David

Purpose : Adrenocortical carcinoma (ACC) is a rare pediatric malignancy. It occurs in excess among individuals with the Li-Fraumeni syndrome, which results primarily from germline mutations in the TP53 gene. Prior series exploring frequencies of germline TP53 mutation among children with ACC have been small, geographically limited, or subject to referral bias. The functional consequence of mutations has not been related to phenotype. We provide a genotype-phenotype analysis of TP53 mutations in [...]

Menée aux Etats-Unis à partir des données de neuf études, cette méta-analyse évalue l'indice de masse corporelle chez des patients adolescents et jeunes adultes ayant survécu à une leucémie lymphoblastique aiguë pédiatrique

A meta-analysis of body mass index of adolescent and adult survivors of pediatric acute lymphoblastic leukemia

Nam, GinaE ; Kaul, Sapna ; Wu, Yelena P. ; Nelson, RichardE ; Wright, Jennifer ; Fluchel, MarkN ; Hacking, ClaireC ; Kirchhoff, AnneC

Purpose : We conducted a meta-analysis of existing studies to examine body mass index (BMI) of adolescent and adult survivors of pediatric acute lymphoblastic leukemia (ALL) compared to individuals without cancer. Methods : Studies were identified and reviewed using specific inclusion criteria. The effect size was odds ratio (OR) of the prevalence of overweight/obese BMI (≥25 kg/m2) in ALL survivors versus comparison groups. Study data were coded and validated. Fixed-effects (FE) and [...]

A partir des données des registres américains des cancers portant sur 44 879 survivants d'un lymphome hodgkinien, cette étude évalue le risque d'un second cancer primitif de la tête et du cou

Second primary head and neck cancer after Hodgkin lymphoma: A population-based study of 44,879 survivors of Hodgkin lymphoma

Chowdhry, Amit K. ; McHugh, Colin ; Fung, Chunkit ; Dhakal, Sughosh ; Constine, Louis S. ; Milano, Michael T.

BACKGROUND Survivors of Hodgkin lymphoma (HL) are at an increased risk of developing second malignancies. To the authors' knowledge, the risks of head and neck cancer (HNC) after HL and subsequent survival have not been thoroughly investigated. METHODS From the US population-based Surveillance, Epidemiology, and End Results (SEER) database for 1973 through 2011, survivors of HL who developed HNC as a second cancer were analyzed. Patients with a first primary HNC were used as a comparison group. [...]

Menée aux Etats-Unis auprès de 20 600 patients atteints d'un lymphome hodgkinien de stade précoce, cette étude analyse les facteurs associés au choix du traitement, chimiothérapie seule ou thérapie combinée, et évalue la survie

Treatment Selection and Outcomes in Early-Stage Classical Hodgkin Lymphoma: Analysis of the National Cancer Data Base

Olszewski, Adam J. ; Shrestha, Rajesh ; Castillo, Jorge J.

Purpose : The choice between combined-modality therapy (CMT) and chemotherapy alone for early-stage Hodgkin lymphoma (HL) remains controversial. Our objective was to define factors affecting treatment selection and resulting survival outcomes in the United States. Patients and Methods : We identified 20,600 patients treated with CMT or chemotherapy between 2003 and 2011 from the National Cancer Data Base. Factors affecting treatment selection were studied in a mixed-effects logistic model. [...]

A partir des données 2012 de la base GLOBOCAN, cette étude évalue l'intérêt du rapport mortalité/incidence pour analyser les disparités internationales dans le dépistage du cancer colorectal, dans les traitements et dans la mortalité spécifique

The colorectal cancer mortality-to-incidence ratio as an indicator of global cancer screening and care

Sunkara, Vasu ; Hebert, James R.

BACKGROUND Disparities in cancer screening, incidence, treatment, and survival are worsening globally. The mortality-to-incidence ratio (MIR) has been used previously to evaluate such disparities. METHODS The MIR for colorectal cancer is calculated for all Organisation for Economic Cooperation and Development (OECD) countries using the 2012 GLOBOCAN incidence and mortality statistics. Health system rankings were obtained from the World Health Organization. Two linear regression models were fit [...]

Menée aux Pays-Bas auprès de 30 patients atteints d'un cancer pédiatrique, cette étude analyse l'efficacité d'un programme d'interventions de nature psychosociale destinée aux patients pédiatriques et à leurs parents

Applicability and evaluation of a psychosocial intervention program for childhood cancer patients

van Dijk-Lokkart, ElisabethM ; Braam, KatjaI ; Kaspers, GertjanJ L. ; van Dulmen-den Broeder, Eline ; Takken, Tim ; Grootenhuis, MarthaA ; Streng, IsabelleC ; Bierings, Marc ; Merks, JohannesH ; van den Heuvel-Eibrink, MarryM ; Veening, MargreetA ; Huisman, Jaap

Purpose : The purpose of this study is to explore the applicability of a psychosocial intervention in childhood cancer patients. Methods :This individualized structured psychosocial program to enhance social-emotional functioning and coping with disease-related effects includes six sessions for children and two sessions for parents. This program was part of a combined intervention with physical exercise. Questionnaires are used to evaluate completion of the psychosocial intervention, coping and [...]

Menée auprès de 164 participantes, cette étude britannique analyse les facteurs associés à une détresse psychologique chez des femmes après une colposcopie

Correlates of psychological distress immediately following colposcopy

Kola-Palmer, Susanna ; Walsh, Jane C.

Objective : Women are at risk for prolonged psychological distress following attendance at colposcopy for cervical abnormalities, with potentially negative consequences. Little is presently known about the correlates of post-colposcopy distress. The present study aimed to extend knowledge of correlates of post-colposcopy anxiety and negative affect, and identify women at risk for elevated psychological distress. Methods : Psychosocial data (demographic variables, anxiety, negative affect, and [...]

Menée en Belgique à partir de données portant sur 10 660 patients atteints d'un cancer de l'estomac ou de l'œsophage diagnostiqué entre 2004 et 2008, cette étude analyse l'efficacité et la pertinence de différents indicateurs permettant de mesurer la qualité des soins

Quality indicators for oesophageal and gastric cancer: a population-based study in Belgium, 2004–2008

Stordeur, S. ; Vlayen, J. ; Vrijens, F. ; Camberlin, C. ; De Gendt, C. ; Van Eycken, E. ; Lerut, T.

This study aimed at developing and measuring quality indicators for oesophageal cancer (OC) and gastric cancer (GC) and to support quality improvement for practitioners. Quality indicators were identified from a systematic literature search including clinical guidelines. The selection process involved experts evaluating relevance, reliability, interpretability and actionability of each indicator. Three national databases were linked: the cancer registry, the population registry and the claims [...]

Menée en Autriche auprès de 60 patients atteints de cancer, cette étude prospective observationnelle analyse les facteurs associés à la prise en charge puis à la sortie et au retour à domicile de patients admis dans des unités de soins palliatifs

Coming and going: predicting the discharge of cancer patients admitted to a palliative care unit: easier than thought?

Masel, EvaK ; Huber, Patrick ; Schur, Sophie ; Kierner, KatharinaA ; Nemecek, Romina ; Watzke, HerbertH

Purpose : Discharging a patient admitted to an inpatient palliative care unit (PCU) is a major challenge. A predictor of the feasibility of home discharge at the time of admission would be very useful. We tried to identify such predictors in a prospective observational study. Methods : Sixty patients with advanced cancer admitted to a PCU were enrolled. Sociodemographic data were recorded and a panel of laboratory tests performed. The Karnofsky performance status scale (KPS) and the palliative [...]

Menée aux Pays-Bas auprès de 38 patientes et 31 témoins, cette étude analyse la faisabilité et le rapport coût-efficacité de consultations médicales de groupe (4 à 8 patientes) dans le cadre d'un suivi de patientes atteintes d'un cancer du sein et soignées à l'extérieur de l'hôpital

Group medical consultations in the follow-up of breast cancer: a randomized feasibility study

Visser, Annemiek ; van Laarhoven, HannekeW M. ; Govaert, PaulienH M. ; Schlooz, MargretheS ; Jansen, Lisette ; van Dalen, Thijs ; Prins, JudithB

Purpose : Group medical consultations (GMCs) provide individual medical visits conducted within a group of four to eight peer patients. This study evaluated the feasibility and efficacy of GMCs in the follow-up of breast cancer. Methods : In this randomized controlled trial, 38 patients participated in a single GMC (intervention group), while the control group (n = 31) received individual outpatient visits. Feasibility is measured in terms of acceptability, demand, practicability and costs, [...]