A partir des données de la cohorte européenne "European Pharmacogenetic Opioid Study" portant sur 2 294 patients atteints de cancer, cette étude analyse les facteurs cliniques et génétiques associés à des douleurs osseuses induites par la maladie ou à d'autres types de douleurs ainsi que la réponse au traitement par opioïdes

Clinical and Genetic Factors Related to Cancer-Induced Bone Pain and Bone Pain Relief

Scarpi, Emanuela ; Calistri, Daniele ; Klepstad, Pål ; Kaasa, Stein ; Skorpen, Frank ; Habberstad, Ragnhild ; Nanni, Oriana ; Amadori, Dino ; Maltoni, Marco

Objective : The study objective was to evaluate whether there are clinical or genetic differences between patients with cancer-induced bone pain (CIBP) and patients with non-CIBP, and, in the CIBP group, in those with good versus poor opioid response. Materials and Methods : A total of 2,294 adult patients with cancer who were receiving opioids for moderate or severe pain were included in the European Pharmacogenetic Opioid Study. Pain intensity and pain relief were measured using the Brief [...]

Menée en Corée auprès de 129 patientes atteintes d'un cancer gynécologique, cette étude transversale analyse les facteurs démographiques, cliniques et psychologiques associés au risque de malnutrition

Depression and appetite: predictors of malnutrition in gynecologic cancer

Nho, Ju-Hee ; Kim, SungReul ; Kwon, YongSoon

Purpose : The reported prevalence of malnutrition and related factors in gynecologic cancer varies. We aimed to describe nutritional status and to identify demographic, clinical, psychological, and nutritional factors contributing to malnutrition in gynecologic cancer patients. Methods : We used a descriptive cross-sectional design. A total of 129 subjects were enrolled. Subjects agreed to undergo a face-to-face interview, including measurement of body mass index (BMI) and administration of [...]

Mené aux Etats-Unis auprès de 200 survivantes d'un cancer du sein de stade 0-IIIA, cet essai randomisé évalue l'association entre la pratique du yoga et leurs difficultés cognitives auto-déclarées

Yoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial

Derry, Heather M. ; Jaremka, Lisa M. ; Bennett, Jeanette M. ; Peng, Juan ; Andridge, Rebecca ; Shapiro, Charles ; Malarkey, William B. ; Emery, Charles F. ; Layman, Rachel ; Mrozek, Ewa ; Glaser, Ronald ; Kiecolt-Glaser, Janice K.

Objectives : Cancer survivors often report cognitive problems. Furthermore, decreases in physical activity typically occur over the course of cancer treatment. Although physical activity benefits cognitive function in noncancer populations, evidence linking physical activity to cognitive function in cancer survivors is limited. In our recent randomized controlled trial, breast cancer survivors who received a yoga intervention had lower fatigue and inflammation following the trial compared with [...]

A partir d'une revue systématique de la littérature (15 études), cette méta-analyse évalue les effets des traitements d'une néoplasie cervicale intraépithéliale sur la fertilité et le déroulement de la grossesse

Fertility and early pregnancy outcomes after treatment for cervical intraepithelial neoplasia: systematic review and meta-analysis

Maria Kyrgiou ; Anita Mitra ; Marc Arbyn ; Sofia Melina Stasinou ; Pierre Martin-Hirsch

Objective : To determine the impact of cervical excision for cervical intraepithelial neoplasia on fertility and early pregnancy outcomes. Design : Systematic review and meta-analysis of cohort studies. Data sources : Medline and Embase. Eligibility criteria : Studies assessing fertility and early pregnancy outcomes in women with a history of treatment for cervical intraepithelial neoplasia versus untreated women. We classified the included studies according to treatment type and fertility or [...]

Menée aux Pays-Bas auprès de 626 survivants à 5 ans d'un cancer pédiatrique, cette étude de cohorte analyse l'association entre une radiothérapie et/ou un traitement par anthracyclines et le risque d'anomalies valvulaires subséquentes

Valvular Abnormalities Detected by Echocardiography in 5-Year Survivors of Childhood Cancer: A Long-Term Follow-Up Study

van der Pal, Helena J. ; van Dijk, Irma W. ; Geskus, Ronald B. ; Kok, Wouter E. ; Koolen, Marianne ; Sieswerda, Elske ; Oldenburger, Foppe ; Koning, Caro C. ; van Leeuwen, Flora E. ; Caron, Huib N. ; Kremer, Leontien C. ; van Dalen, Elvira C.

Purpose : To determine the prevalence of valvular abnormalities after radiation therapy involving the heart region and/or treatment with anthracyclines and to identify associated risk factors in a large cohort of 5-year childhood cancer survivors (CCS). Methods and Materials : The study cohort consisted of all 626 eligible 5-year CCS diagnosed with childhood cancer in the Emma Children's Hospital/Academic Medical Center between 1966 and 1996 and treated with radiation therapy involving the [...]

Menée par enquête auprès de 69 086 patients atteints de cancer, cette étude anglaise analyse les disparités dans leurs expériences relatives à la qualité des soins, en fonction de la localisation du cancer et de caractéristiques socio-démographiques

Inequalities in reported cancer patient experience by socio-demographic characteristic and cancer site: evidence from respondents to the English Cancer Patient Experience Survey

Saunders, C. L. ; Abel, G. A. ; Lyratzopoulos, G.

Patient experience is a critical dimension of cancer care quality. Understanding variation in experience among patients with different cancers and characteristics is an important first step for designing targeted improvement interventions. We analysed data from the 2011/2012 English Cancer Patient Experience Survey (n = 69 086) using logistic regression to explore inequalities in care experience across 64 survey questions. We additionally calculated a summary measure of variation in patient [...]

Menée en Californie auprès de 193 survivants d'un cancer pédiatrique, cette étude analyse les facteurs associés à la continuation des soins de suivi, en fonction de leur origine (hispanique ou non)

Cancer-related follow-up care among hispanic and non-Hispanic childhood cancer survivors: The project forward study

Milam, Joel E. ; Meeske, Kathleen ; Slaughter, Rhona I. ; Sherman-Bien, Sandra ; Ritt-Olson, Anamara ; Kuperberg, Aura ; Freyer, David R. ; Hamilton, Ann S.

BACKGROUND Follow-up care is critical for childhood cancer survivors (CCS), who are at high risk for comorbidities and late effects of cancer treatments. Understanding the factors associated with maintaining follow-up care is needed, especially for Hispanic CCS, who have been under-represented in previous studies. METHODS Risk factors and protective factors for receiving cancer-related follow-up care were examined among 193 Los Angeles County CCS diagnosed between 2000 and 2007 (54% Hispanic; [...]

Menée en France à partir de données portant sur 81 enfants âgés de moins de 18 ans et atteints de leucémie myéloïde chronique, cette étude de cohorte analyse l'association entre un traitement de première ligne par imatinib et la croissance staturale

Growth deceleration in children treated with imatinib for chronic myeloid leukaemia

Millot, Frédéric ; Guilhot, Joëlle ; Baruchel, André ; Petit, Arnaud ; Leblanc, Thierry ; Bertrand, Yves ; Mazingue, Françoise ; Lutz, Patrick ; Vérité, Cecile ; Berthou, Christian ; Galambrun, Claire ; Sirvent, Nicolas ; Yacouben, Karima ; Chastagner, Pascal ; Gandemer, Virginie ; Reguerre, Yves ; Couillault, Gérard ; Khalifeh, Tackwa ; Rialland, Fanny

Purpose The aim is to study statural growth in a large cohort of children with chronic myeloid leukaemia (CML) treated with front-line imatinib. Methods Retrospective data from 81 children less than 18 years of age with CML identified in the French pediatric registry were analysed. Height was expressed as standard deviation score (SDS). Results A gradual decrease in height SDS was observed over time since starting imatinib. The height SDS was significantly lower 12 months and 24 months after [...]

Menée sur 1 153 patientes atteintes d'un cancer invasif du sein traité par doxorubicine entre 1998 et 2006 (durée moyenne de suivi : 7,6 ans), cette étude identifie les facteurs prédictifs associés au risque de survenue, sur le long terme, d'une insuffisance cardiaque

Predictors of late-onset heart failure in breast cancer patients treated with doxorubicin

Qin, Angel ; Thompson, CherylL ; Silverman, Paula

Purpose : Anthracyclines are an integral component of breast cancer chemotherapy. They exert many cardiotoxic effects, including heart failure. The onset of anthracycline-induced heart failure (AIHF) can occur years after completion of chemotherapy and incurs significant morbidity and mortality. Few studies have attempted to characterize risk factors for its development. Our purpose was to determine the incidence of early and late AIHF in breast cancer survivors and to identify factors that [...]

Menée aux Pays-Bas auprès de 1 340 patients atteints de cancer, cette étude transversale analyse les disparités, selon le statut marital et l'âge des patients, dans la prévalence de symptômes de détresse et dans leurs intentions de recourir à des spécialistes en soins de support

Distress, problems and referral wish of cancer patients: differences according to relationship status and life phase

Tuinman, Marrit A. ; Van Nuenen, F. M. ; Hagedoorn, M. ; Hoekstra-Weebers, J. E. H. M.

Objective : The aim of this study is to examine differences in distress, problems and referral wish in cancer patients according to relationship status and life phase. Methods : A cross-sectional group of 1340 patients (response = 51%) completed socio-demographic and illness-related questions, and the Dutch version of the Distress Thermometer and Problem List that also assesses desire for additional care (yes, maybe and no). Relationship status was categorized into six groups (married, [...]

A partir d'une revue systématique de la littérature (20 études), cette étude fait le point sur les interventions téléphoniques de nature psychosociale destinées aux patients atteints de cancer et aux survivants d'un cancer

Psychosocial telephone interventions for patients with cancer and survivors: a systematic review

Okuyama, Sonia ; Jones, Whitney ; Ricklefs, Christine ; Tran, Zung Vu

Objective Over one third of patients with cancer experience elevated psychosocial distress. As screening for distress becomes more common, the number of patients referred for psychosocial care will increase. Psychosocial telephone interventions are recommended as a convenient and exportable alternative to in-person interventions addressing psychosocial distress. This study reviews the efficacy of randomized controlled trials (RCTs) of psychosocial telephone interventions for patients with [...]

Menée en Malaisie par entretiens auprès de 467 patients atteints de cancer, cette étude longitudinale évalue l'association entre des symptômes de dépression et d'anxiété et la survie des patients

Effects of depression and anxiety on mortality in a mixed cancer group: a longitudinal approach using standardised diagnostic interviews

Chan, Caryn Mei Hsien ; Wan Ahmad, Wan Azman ; Md Yusof, Mastura ; Ho, Gwo-Fuang ; Krupat, Edward

Background : Distress and psychiatric morbidity in cancer patients are associated with poorer outcomes including mortality. In this study, we examined the prevalence of psychiatric morbidity and its association with cancer survival over time. Methods : Participants were 467 consecutive adult cancer patients attending oncology follow-ups at a single academic medical centre. Assessment consisted of the Hospital Anxiety and Depression Scale and Structured Clinical Interview for Diagnostic and [...]

Menée en Corée auprès de 373 cas et 746 témoins, cette étude analyse les facteurs associés au risque de suicide dans la première année suivant le diagnostic chez des patients atteints de cancer

Suicide in cancer patients within the first year of diagnosis

Ahn, Myung Hee ; Park, Subin ; Lee, Hochang Benjamin ; Ramsey, Christine M. ; Na, Riji ; Kim, Seon Ok ; Kim, Jeong Eun ; Yoon, Shinkyo ; Hong, Jin Pyo

Background : A diagnosis of cancer is associated with an increased suicide risk, and this risk is the highest within the first year of diagnosis. The aim of the present study was to determine risk factors of suicide occurring within the first year of cancer diagnosis (early suicide). Methods : The sampling pool consisted of 164,497 patients with cancer admitted to a general hospital in Seoul, South Korea, from 1996 to 2009. We conducted a 1:2 matched case-control study by matching 373 patients [...]

Menée aux Etats-Unis par questionnaires auprès de 141 survivants d'un cancer du poumon non à petites cellules un à six ans après le traitement, cette étude analyse l'association entre leur croissance post-traumatique, le moment de l'arrêt du tabac (avant ou après le diagnostic), le sentiment d'être stigmatisé à cause de leur tabagisme antérieur, et leur détresse psychologique

The role of posttraumatic growth and timing of quitting smoking as moderators of the relationship between stigma and psychological distress among lung cancer survivors who are former smokers

Shen, Megan Johnson ; Coups, Elliot J. ; Li, Yuelin ; Holland, Jimmie C. ; Hamann, Heidi A. ; Ostroff, Jamie S.

Objective : Patients diagnosed with lung cancer report high levels of stigma and psychological distress. This study examined posttraumatic growth among lung cancer survivors as a potential buffer against this relationship between stigma and psychological distress and examined how these relationships differed by the timing of quitting smoking (pre versus post-diagnosis). Methods : Stages IA and IB non-small-cell lung cancer survivors (N = 141) who were former smokers, 1–6 years post-treatment, [...]

A partir des données des registres danois des cancers portant sur 44 494 patientes atteintes d'un cancer du sein, cette étude de cohorte évalue le risque de dépression et l'utilisation de médicaments anti-dépresseurs, sur la période 1998-2001

Increased Risk for Depression After Breast Cancer: A Nationwide Population-Based Cohort Study of Associated Factors in Denmark, 1998-2011

Suppli, Nis P. ; Johansen, Christoffer ; Christensen, Jane ; Kessing, Lars V. ; Kroman, Niels ; Dalton, Susanne O.

Purpose : To investigate the risk for first depression, assessed as incident hospital contacts for depression and incident use of antidepressants, among women with breast cancer. Patients and Methods : Danish national registries were used to identify 1,997,669 women with no diagnosis of cancer or a major psychiatric disorder. This cohort was followed from 1998 to 2011 for a diagnosis of breast cancer and for the two outcomes, hospital contact for depression and redeemed prescriptions for [...]

Menée en Australie par questionnaire auprès de 106 patientes atteintes d'un cancer gynécologique, cette étude analyse leurs expériences et leur satisfaction après avoir bénéficié d'un programme de prise en charge accélérée pour une intervention chirurgicale

Patients' satisfaction with fast-track surgery in gynaecological oncology

Philp, S. ; Carter, J. ; Pather, S. ; Barnett, C. ; D'Abrew, N. ; White, K.

This study investigates the experience and satisfaction with care of fast-tracked gynaecological patients. The Sydney Gynaecological Oncology Group, New South Wales, Australia, has previously shown the benefits of a fast-track surgery programme for gynaecology patients with both complex benign gynaecological pathology and gynaecological malignancy. The question of whether these benefits translate into a positive experience for fast-tracked patients, in the context of their hospital stay and [...]

Menée aux Etats-Unis auprès de 4 326 survivants de cancer et de 57 109 participants non malades, cette étude évalue l'association entre des symptômes de détresse psychologique sévère, une utilisation de soins de santé et les coûts médicaux

Association between serious psychological distress and health care use and expenditures by cancer history

Han, Xuesong ; Lin, Chun Chieh ; Li, Chunyu ; de Moor, Janet S. ; Rodriguez, Juan L. ; Kent, Erin E. ; Forsythe, Laura P.

BACKGROUND Serious psychological distress (SPD) is associated with adverse health outcomes such as poor quality of life and shorter survival in cancer survivors, but to the authors' knowledge, the relationship between SPD and health care use and medical expenditures is not clear. METHODS A total of 4326 cancer survivors and 57,109 noncancer participants were identified from the 2008 through 2010 Medical Expenditure Panel Survey, a nationwide population-based survey, and their psychological [...]

Cette étude analyse, à partir du cas du trastuzumab, les facteurs associés aux délais entre l'autorisation européenne de mise sur le marché et l'approbation du remboursement du médicament au niveau national

An exploratory analysis of the factors leading to delays in cancer drug reimbursement in the European Union: The trastuzumab case

Ades, Felipe ; Senterre, Chistelle ; Zardavas, Dimitrios ; de Azambuja, Evandro ; Popescu, Razvan ; Parent, Florence ; Piccart, Martine

Background : The European Union (EU) has adopted a common procedure for granting marketing authorisation for cancer drugs. Nevertheless, pricing and reimbursement decisions are a competency of EU national governments, and their policies are diverse. We aimed to evaluate the time for trastuzumab reimbursement approval and its association to health expenditure, to health policy performance, to the availability of cost-effectiveness studies and to breast cancer outcome. Methods : Breast cancer [...]

Menée au Royaume-Uni par entretiens auprès de partenaires de vie et de parents de patients atteints de cancer, cette étude transversale analyse leurs besoins en information sur la maladie

‘You can't say, “what about me?” I'm not the one with cancer’: information and support needs of relatives

Foster, Claire ; Myall, Michelle ; Scott, Isobel ; Sayers, Mary ; Brindle, Lucy ; Cotterell, Phil ; Addington-Hall, Julia ; Hopkinson, Jane ; Payne, Sheila ; Robinson, Judith

Objective The aims of this study were to explore relatives' experiences of talking about cancer within the family and to identify their information and support needs. Method A cross-sectional in-depth interview study with relatives and partners (n = 22) of cancer patients recruited through community settings was conducted. A thematic approach was used for analysis. Results Information sharing and communication within families operated within a context of cancer-related uncertainty. Discussion [...]

Menée à Taïwan à partir de données portant sur 32 800 patients décédés, cette étude analyse des indicateurs d'aggressivité des soins prodigués pendant le dernier mois de vie en fonction du statut socioéconomique des patients

Low Socioeconomic Status Is Associated With More Aggressive End-of-Life Care for Working-Age Terminal Cancer Patients

Chang, Chun-Ming ; Wu, Chin-Chia ; Yin, Wen-Yao ; Juang, Shiun-Yang ; Yu, Chia-Hui ; Lee, Ching-Chih

Background. The relationship between low socioeconomic status (SES) and aggressiveness of end-of-life (EOL) care in cancer patients of working age (older than 18 years and younger than 65 years) is not clear. We assessed the association between aggressiveness of EOL care and differences in SES among working-age terminal cancer patients from Taiwan between 2009 and 2011. Methods. A total of 32,800 cancer deaths were identified from the Taiwan National Health Insurance Research Database. The [...]

Menée en Italie, cette étude fait le point sur l'association entre une infection par le virus de l'hépatite C et le risque de lymphome, ainsi que ses méthodes de diagnostic et de prise en charge

Hepatitis C virus and lymphoma

Paydas, Semra

Hepatitis C virus (HCV) is a hepatotrophic and lymphotrophic virus and is a global health problem. Cirrhosis and hepatocellular cancer are the most common complications of HCV. Association between HCV and B cell non-Hodgkin lymphomas (B-NHL) has been shown in epidemiological studies in the last 20 years. High prevalence of HCV infection among patients with NHL has been reported in the early 1990s by Ferri in Italy and this association has been confirmed in later studies. Geographically, HCV [...]

Menée au Danemark à partir des données de registres médicaux et portant sur 21 246 patients atteints d'un cancer colorectal diagnostiqué entre 2001 et 2011, cette étude analyse l'efficacité d'un algorithme pour prédire le risque de récidive

A validated algorithm to ascertain colorectal cancer recurrence using registry resources in Denmark

Lash, Timothy L. ; Riis, Anders H. ; Ostenfeld, Eva B. ; Erichsen, Rune ; Vyberg, Mogens ; Thorlacius-Ussing, Ole

Colorectal cancer recurrences are difficult to ascertain accurately and efficiently. We developed and validated an algorithm to identify recurrences that uses Danish medical registries. The algorithm uses metastasis and chemotherapy codes in the Danish National Patient Registry and codes indicating cancer recurrence in the Danish Pathology Registry. We applied the algorithm to a cohort (n = 21,246) of colorectal cancer patients diagnosed 2001–2011 and followed through 2012. In a cohort [...]

Menée en France, cette étude fait le point sur la prise en charge, les traitements et les soins de support des patients âgés atteints de gliome

Management of Elderly Patients With Gliomas

Gállego Pérez-Larraya, Jaime ; Delattre, Jean-Yves

The current progressive aging of the population is resulting in a continuous increase in the incidence of gliomas in elderly people, especially the most frequent subtype, glioblastoma (GBM). This sociohealth shift, known as the “silver tsunami,” has prompted the neuro-oncology community to investigate the role of specific antitumor treatments, such as surgery, radiotherapy, chemotherapy, and other targeted therapies, for these traditionally undertreated patients. Advanced age, a widely [...]