Menée sur une cohorte canadienne de 89 835 femmes âgées de 40 à 59 ans (durée moyenne de suivi : 22,1 ans), cette étude évalue l'association entre différents paramètres du tabagisme (nombre de cigarettes consommées par jour, durée du tabagisme, ...) et le risque de cancer du sein (6 549 cas)

Active cigarette smoking and risk of breast cancer

Catsburg, Chelsea ; Miller, Anthony B. ; Rohan, Thomas E.

Although epidemiological evidence on the role of active cigarette smoking in breast cancer risk has been inconsistent, recent literature supports a modest association between smoking and breast cancer. This association is particularly observed in women who smoke for a long duration, or who smoke for a long time prior to their first pregnancy. Here, we provide updated results on cigarette smoking and breast cancer risk in the Canadian National Breast Screening Study (NBSS). The NBSS is a large [...]

Cet article passe en revue les travaux sur l'association entre des composés phytochimiques et le risque de cancer

Toxic phytochemicals and their potential risks for human cancer

Bode, Ann M. ; Dong, Zigang

Consuming plants for their presumed health benefits has occurred since early civilizations. Phytochemicals are found in various plants that are frequently included in the human diet and are generally thought to be safe for consumption because they are produced naturally. However, this is not always the case and in fact many natural compounds found in several commonly consumed plants are potential carcinogens or tumor promoters and should be avoided.

Menée au Japon auprès de 393 participantes, cette étude évalue l'association entre une ingestion d'acrylamides d'origine alimentaire, le niveau plasmatique d'hormones sexuelles et de prolactine, et le risque de cancer du sein avant la ménopause

Associations of acrylamide intake with circulating levels of sex hormones and prolactin in premenopausal Japanese women

Nagata, Chisato ; Konishi, Kie ; Tamura, Takashi ; Wada, Keiko ; Tsuji, Michiko ; Hayashi, Makoto ; Takeda, Noriyuki ; Yasuda, Keigo

Background: It has been hypothesized that alteration of hormone systems is involved in the carcinogenesis of acrylamide. The aim of the present study was to examine the cross-sectional associations between dietary acrylamide intake and sex hormone levels in premenopausal Japanese women. Methods: Study subjects were 393 women who had regular menstrual cycles less than 40 days long. Acrylamide intake was assessed with a food-frequency questionnaire and was based on acrylamide concentration [...]

Menée en France auprès de 1 069 cas et 925 témoins puis répliquée sur 1 085 cas et 801 témoins en Espagne et enfin sur 1 808 cas et 1 894 témoins en Allemagne, cette étude évalue l'association entre des polymorphismes à simple nucléotide des gènes WNT3 et VPS41 et le risque de mélanome

Genes involved in the WNT and vesicular trafficking pathways are associated with melanoma predisposition

Ibarrola-Villava, Maider ; Kumar, Rajiv ; Nagore, Eduardo ; Benfodda, Meriem ; Guedj, Mickaël ; Gazal, Steven ; Hu, Hui-Han ; Guan, Jian ; Rachkonda, P. Sivaramakishna ; Descamps, Vincent ; Basset-Seguin, Nicole ; Bensussan, Armand ; Bagot, Martine ; Saiag, Philippe ; Schadendorf, Dirk ; Martin-Gonzalez, Manuel ; Mayor, Matias ; Grandchamp, Bernard ; Ribas, Gloria ; Nadem, Soufir

Multifactorial predisposition to melanoma includes genes involved in pigmentation, immunity and DNA repair. Nonetheless, missing heritability in melanoma is still important. We studied the role of 335 candidate SNPs in melanoma susceptibility by using a dedicated chip and investigating 110 genes involved in different pathways. A discovery set was comprised of 1069 melanoma patients and 925 controls from France. Data were replicated using validation phases II (1085 cases and 801 controls from [...]

Menée aux Etats-Unis à partir de données d'études cas-témoins en population incluant 2 023 femmes d'origine hispanique et 2 384 femmes blanches, cette étude évalue les disparités ethniques dans l'association entre l'adiposité, l'indice de masse corporelle et le risque de cancer du sein, en fonction du statut du récepteur hormonal, avant la ménopause

Overall and abdominal adiposity and premenopausal breast cancer risk among Hispanic women: The Breast Cancer Health Disparities Study

John, Esther M. ; Sangaramoorthy, Meera ; Hines, Lisa M ; Stern, Mariana C. ; Baumgartner, Kathy B ; Giuliano, Anna R. ; Wolff, Roger K. ; Slattery, Martha L.

Background: Few studies in Hispanic women have examined the relation between adult body size and risk of premenopausal breast cancer (BC) defined by hormone receptor status. Methods: The Breast Cancer Health Disparities Study pooled interview and anthropometric data from two large U.S. population-based case-control studies. We examined associations of overall and abdominal adiposity with risk of estrogen receptor and progesterone receptor positive (ER+PR+) and negative (ER-PR-) breast cancer in [...]

Menée aux Etats-Unis à partir de données d'études cas-témoins en population incluant 2 023 femmes d'origine hispanique et 2 384 femmes blanches, cette étude évalue les disparités ethniques dans l'association entre l'évolution de la corpulence à l'âge adulte et le risque de cancer du sein après la ménopause

Body size throughout adult life influences postmenopausal breast cancer risk among Hispanic women: The Breast Cancer Health Disparities Study

John, Esther M. ; Sangaramoorthy, Meera ; Hines, Lisa M ; Stern, Mariana C. ; Baumgartner, Kathy B. ; Giuliano, Anna R. ; Wolff, Roger K. ; Slattery, Martha L.

Background: Few studies have assessed the association of body size with postmenopausal breast cancer (BC) risk in Hispanic women. Findings are inconsistent and appear to contradict those reported for non-Hispanic White (NHW) women. Methods: We pooled interview and anthropometric data for 2,023 Hispanic and 2,384 NHW women from two U.S. population-based case-control studies. Using logistic regression analysis, we examined associations of overall and abdominal adiposity with risk of [...]

Menée à partir des données de 11 études incluant au total 8 290 patients atteints d'un cancer colorectal et 9 115 témoins, cette étude évalue l'effet d'un polymorphisme génétique associé à l'activité de la N-acétyltransférase 2 sur la relation entre la consommation de viande rouge et le risque de cancer colorectal

Red meat intake, NAT2, and risk of colorectal cancer: A pooled analysis of 11 studies

Ananthakrishnan, Ashwin N ; Du, Mengmeng ; Berndt, Sonja I. ; Brenner, Hermann ; Caan, Bette J. ; Casey, Graham ; Chang-Claude, Jenny ; Duggan, David ; Fuchs, Charles S. ; Gallinger, steven ; Giovannucci, Edward L. ; Harrison, Tabitha A. ; Hayes, Richard B. ; Hoffmeister, Michael ; Hopper, John L. ; Hou, Lifang ; Hsu, Li ; Jenkins, Mark A. ; Kraft, Peter ; Ma, Jing ; Nan, Hongmei ; Newcomb, Polly A. ; Ogino, Shuji ; Potter, John D. ; Seminara, Daniela ; Slattery, Martha L. ; Thornquist, Mark ; White, Emily ; Wu, Kana ; Peters, Ulrike ; Chan, Andrew T.

Background : Red meat intake has been associated with risk of colorectal cancer (CRC), potentially mediated through heterocyclic amines. The metabolic efficiency of N-acetyltransferase 2 (NAT2) required for the metabolic activation of such amines is influenced by genetic variation. The interaction between red meat intake, NAT2 genotype, and CRC has been inconsistently reported. Methods : We used pooled individual-level data from the Colon Cancer Family Registry (CCFR) and the Genetics and [...]