Menée à l'aide de données portant sur 90 504 Japonais (durée moyenne de suivi : 15 ans), cette étude analyse l'association entre la consommation de poisson, de crustacés ou d'acides gras oméga-3 et le risque de cancer gastrique (2 701 cas) en fonction du sexe et de la présence d'une infection par Helicobacter pylori

Association between fish and shellfish consumption, n-3 polyunsaturated fatty acids, and gastric cancer risk: the Japan Public Health Center-based Prospective Study

Hirabayashi, Mayo ; Wilunda, Calistus ; Murai, Utako ; Yamaji, Taiki ; Iwasaki, Motoki ; Inoue, Manami ; Tsugane, Shoichiro ; Sawada, Norie ; for the, Jphc Study Group

Purpose: Fish and shellfish consumption is suggested to be a cancer-protective factor. However, studies investigating this association for gastric cancer, especially considering Helicobacter pylori (H. pylori) and atrophic gastritis (AG), are limited. We investigated gastric cancer risk associated with fish, shellfish, and n-3 polyunsaturated fatty acids (n-3 PUFAs) consumption among Japanese adults. Methods: 90,504 subjects enrolled in the Japan Public Health Center-based Prospective Study [...]

A partir d'une revue systématique de la littérature (33 méta-analyses), cette étude évalue l'association entre des facteurs alimentaires et le risque de carcinome épidermoïde ou d'adénocarcinome de l'oesophage

Role of diet in the risks of esophageal adenocarcinoma and squamous cell carcinoma: an updated umbrella review

Zhang, Xiaorui ; Zheng, Xite ; Gao, Ran ; Wang, Yijie ; Wei, Tong ; Zang, Zhaoping ; Zhu, Lingyan ; Li, Quanmei ; Zhang, Yijun ; Liu, Fen

Purpose: This updated umbrella review aimed to evaluate the evidence regarding the associations between dietary factors and the risks of esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). Methods: The PubMed, Embase, Cochrane Library, and Web of Science databases were searched to identify relevant studies. The quality of the included meta-analyses was evaluated using A MeaSurement Tool to Assess systematic Reviews 2 (AMSTAR 2). For each association, the number of [...]

Menée en Norvège auprès de 1,3 million de femmes âgées d'au moins 45 ans (durée médiane de suivi : 12,7 ans), cette étude analyse l'association entre l'utilisation d'un traitement hormonal substitutif et le risque de cancer du sein (33 654 cas)

Menopausal hormone therapy and breast cancer risk: a population-based cohort study of 1.3 million women in Norway

Støer, Nathalie C. ; Vangen, Siri ; Singh, Deependra ; Fortner, Renée T. ; Hofvind, Solveig ; Ursin, Giske ; Botteri, Edoardo

Background: It is important to monitor the association between menopausal hormone therapy (HT) use and breast cancer (BC) risk with contemporary estimates, and specifically focus on HT types and new drugs. Methods: We estimated hazard ratios (HR) of BC risk according to HT type, administration route and individual drugs, overall and stratified by body mass index (BMI), molecular subtype and detection mode, with non-HT use as reference. Results: We included 1,275,783 women, 45+ years, followed [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2024 (31 méta-analyses), cette étude évalue l'association entre une infection par le papillomavirus humain et le risque de cancer par localisation

Human papillomavirus infection and the risk of cancer at specific sites other than anogenital tract and oropharyngeal region: an umbrella review

Cao, Fan ; Li, Yi-Zi ; Zhang, De-Yu ; Wang, Xiao-Ying ; Chen, Wen-Xiao ; Liu, Fang-Hua ; Men, Yi-Xuan ; Gao, Song ; Lin, Chun-Qing ; Zou, Hua-Chun ; Gong, Ting-Ting ; Wu, Qi-Jun

Background: Despite numerous studies having evaluated the associations between human papillomavirus (HPV) infection and risk of specific cancers other than anogenital tract and oropharyngeal, the findings are inconsistent and the quality of evidence has not been systematically quantified. We aimed to summarise the existing evidence as well as to evaluate the strength and credibility of these associations. Methods: We conducted an umbrella review of systematic reviews and meta-analyses of [...]

Menée à partir de données de "The Sister Study" portant sur 50 884 femmes ayant une soeur atteinte d'un cancer du sein, cette étude analyse l'association entre l'utilisation de produits de soins intimes et le risque de cancer du sein, de l'ovaire et de l'utérus

Intimate Care Products and Incidence of Hormone-Related Cancers: A Quantitative Bias Analysis

Katie M. O'Brien ; Nicolas Wentzensen ; Kemi Ogunsina ; Clarice R. Weinberg ; Aimee A. D'Aloisio ; Jessie K. Edwards ; Dale P. Sandler

PURPOSE: Intimate care products may contain substances associated with increased risk of hormone-related cancers. The relationship between genital talc use and ovarian cancer, in particular, has been well studied, but concerns about recall bias and exposure misclassification have precluded conclusions. We examined the association between intimate care products and female hormone–related cancers, accounting for potential biases, using data from a US-based cohort study. METHODS: The Sister Study [...]

Menée à partir de données coréennes portant sur près de 2,5 millions de femmes âgées d'au moins 40 ans (durée moyenne de suivi : 8,3 ans), cette étude analyse l'association entre le statut glycémique (prédiabète ou diabète de type 2) et le risque de cancer gastrique (16 504 cas) en fonction du statut ménopausique

Association between glycemic status and the risk of gastric cancer in pre/peri-and postmenopausal women: A nationwide cohort study

Han, Kyung Hee ; Choi, Yoon Jin ; Il Kim, Tae ; Park, Noh Hyun ; Han, Kyung-Do ; Lee, Dong Ho

Purpose: This study aimed to assess the correlation between glycemic status (prediabetes and type 2 diabetes mellitus) and the risk of gastric cancer according to menopausal status. Methods: A total of 982,559 pre/peri-menopausal and 1445,419 postmenopausal women aged ≥ 40, who underwent the Korean national health screening in 2009, were included and followed up until 2018. Hazard ratio (HR) and 95% confidence interval (CI) were calculated for development of gastric cancers according to [...]

Menée à partir de données des registres américains des cancers portant sur 133 324 femmes âgées ayant survécu à un cancer du sein (âge : 66-84 ans ; durée médiane de suivi : 4,3 ans), cette étude analyse l'association entre un diabète et le risque de second cancer (10 452 cas)

Association between diabetes and subsequent malignancy risk among older breast cancer survivors

Hardell, Kaitlyn N Lewis ; Schonfeld, Sara J ; Ramin, Cody ; Vo, Jacqueline B ; Morton, Lindsay M

Type II diabetes is associated with cancer risk in the general population but has not been well-studied as a risk factor for subsequent malignancies among cancer survivors. We investigated the association between diabetes and subsequent cancer risk among older (66-84 years), one-year breast cancer survivors within the linked Surveillance Epidemiology and End Results (SEER)-Medicare database using Cox regression analyses to quantify hazard ratios (HR) and corresponding 95% confidence intervals [...]

Menée à l'aide de données de la "UK Biobank" portant sur 43 542 adultes (âge : 38-73 ans ; durée médiane de suivi : 5,8 ans), cette étude analyse l'association entre le nombre absolu d'éosinophiles et le risque de cancer par localisation (22 747 cas)

Associations between eosinophils and cancer risk in the UK Biobank

Wang, Jeanny H. ; Rabkin, Charles S. ; Engels, Eric A. ; Song, Minkyo

Eosinophils exhibit anti-tumor cytotoxic responses in the tumor microenvironment and may contribute to tumor immunosurveillance. To assess the relationship between circulating eosinophils and cancer risk, we analyzed data from 443,542 adults aged 38–73 in the UK Biobank, who were initially cancer-free, had over a year of follow-up, and baseline white blood cell count measurements. Using multivariable Cox regression, we estimated hazard ratios (aHR) and 95% confidence intervals (95%CI) for each [...]

Menée à partir de données de la "UK Biobank" portant sur 426 524 personnes, cette étude analyse l'association entre les taux de lipides sériques et le risque de cancer du poumon en fonction d'un score de risque polygénique

Serum lipid levels, genetic risk, and lung cancer incidence: A large prospective cohort study

Wang, Jing ; Wang, Qi ; Shi, Ziwei ; Yan, Xiaolong ; Lei, Zhiqun ; Zhu, Wenmin

Background: Previous studies usually focused on the separate association of metabolism or genetic factors with lung cancer risk and have largely ignored their combined effect. We aimed to examine the associations between serum lipid levels, genetic risk, and lung cancer risk. Methods: 426,524 participants of the UK Biobank were included. The Cox proportional hazards models and restricted cubic splines were performed to assess the association between serum lipid and lung cancer risk. Polygenic [...]

Menée à partir de données portant sur 205 489 professionnels de santé américains, cette étude identifie des facteurs associés au risque de cancer colorectal agressif (899 cas)

Identifying modifiable risk factors to prevent aggressive colorectal cancer

Wang, Peilu ; Song, Mingyang ; Eliassen, A. Heather ; Wang, Molin ; Chan, Andrew T. ; Meyerhardt, Jeffrey A. ; Tabung, Fred K. ; Zhang, Xuehong ; Ugai, Tomotaka ; Ogino, Shuji ; Giovannucci, Edward L.

It remains unclear if pre-diagnostic factors influence the developmental pathways of colorectal cancer (CRC) that could enhance tumor aggressiveness. This study used prospective data from 205,489 cancer-free US health professionals to investigate the associations of 31 known or putative risk factors with the risk of aggressive CRC. Tumor aggressiveness was characterized by three endpoints: aggressive CRC (cancer that causes death within 5 years of diagnosis), fatal CRC, and tumor stage at [...]

Menée à l'aide de données internationales portant sur 6 085 patients ayant survécu à un cancer colorectal (durée médiane de suivi : 12 ans), cette étude identifie les caractéristiques pathologiques de la tumeur associées au risque de développer un cancer colorectal métachrone (138 cas)

Associations between pathological features and risk of metachronous colorectal cancer

Zhang, Ye ; Win, Aung Ko ; Makalic, Enes ; Buchanan, Daniel D. ; Pai, Rish K. ; Phipps, Amanda I. ; Rosty, Christophe ; Boussioutas, Alex ; Karahalios, Amalia ; Jenkins, Mark A.

Survivors of colorectal cancer (CRC) are at risk of developing another primary colorectal cancer - metachronous CRC. Understanding which pathological features of the first tumour are associated with risk of metachronous CRC might help tailor existing surveillance guidelines. Population-based CRC cases were recruited from the United States, Canada and Australia between 1997 and 2012 and followed prospectively until 2022 by the Colon Cancer Family Registry. Metachronous CRC was defined as a new [...]

Menée à partir de données d'études d'association pangénomiques portant sur 22 104 témoins et 18 034 patientes atteintes d'un cancer du sein et d'origine africaine, cette étude identifie 12 loci de susceptibilité à la maladie

Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction

Jia, Guochong ; Ping, Jie ; Guo, Xingyi ; Yang, Yaohua ; Tao, Ran ; Li, Bingshan ; Ambs, Stefan ; Barnard, Mollie E. ; Chen, Yu ; Garcia-Closas, Montserrat ; Gu, Jian ; Hu, Jennifer J. ; Huo, Dezheng ; John, Esther M. ; Li, Christopher I. ; Li, James L. ; Nathanson, Katherine L. ; Nemesure, Barbara ; Olopade, Olufunmilayo I. ; Pal, Tuya ; Press, Michael F. ; Sanderson, Maureen ; Sandler, Dale P. ; Shu, Xiao-Ou ; Troester, Melissa A. ; Yao, Song ; Adejumo, Prisca O. ; Ahearn, Thomas ; Brewster, Abenaa M. ; Hennis, Anselm J. M. ; Makumbi, Timothy ; Ndom, Paul ; O’Brien, Katie M. ; Olshan, Andrew F. ; Oluwasanu, Mojisola M. ; Reid, Sonya ; Butler, Eboneé N. ; Huang, Maosheng ; Ntekim, Atara ; Qian, Huijun ; Zhang, Haoyu ; Ambrosone, Christine B. ; Cai, Qiuyin ; Long, Jirong ; Palmer, Julie R. ; Haiman, Christopher A. ; Zheng, Wei

We performed genome-wide association studies of breast cancer including 18,034 cases and 22,104 controls of African ancestry. Genetic variants at 12 loci were associated with breast cancer risk (P < 5 × 10−8), including associations of a low-frequency missense variant rs61751053 in ARHGEF38 with overall breast cancer (odds ratio (OR) = 1.48) and a common variant rs76664032 at chromosome 2q14.2 with triple-negative breast cancer (TNBC) (OR = 1.30). Approximately 15.4% of cases with TNBC carried [...]

Menée à l'aide de données de la "Finnish Maternity Cohort" portant sur 1 185 témoins et 605 patientes atteintes d'un cancer papillaire de la thyroïde diagnostiqué jusqu'à 11 ans après une grossesse (âge : 18-44 ans), cette étude analyse l'association entre les niveaux de stéroïdes sexuels et d'hormones thyroïdiennes en début de grossesse et le risque de développer la maladie

Early-pregnancy sex steroid and thyroid function hormones, thyroid autoimmunity, and maternal papillary thyroid cancer incidence in the Finnish Maternity Cohort

Kitahara, Cari M. ; Surcel, Helja-Marja ; Falk, Roni ; Pfeiffer, Ruth M. ; Männistö, Tuija ; Gissler, Mika ; Trabert, Britton

Thyroid cancer more commonly affects women than men and is the third most frequently diagnosed cancer among women of reproductive age. We conducted a nested case–control study within the Finnish Maternity Cohort to evaluate pre-diagnostic sex steroid and thyroid function markers in relation to subsequent maternal papillary thyroid cancer. Cases (n = 605) were women ages 18–44 years, who provided an early-pregnancy (<20 weeks gestation) blood sample and were diagnosed with papillary thyroid [...]