Menée par questionnaire auprès de 55 témoins et 90 patients ayant survécu à un cancer pédiatrique, cette étude identifie des facteurs prédictifs de fatigue

Sleep quality and physical fitness as modifiable contributors of fatigue in childhood cancer survivors

Vanrusselt, Deveny ; Sleurs, Charlotte ; Van Ermengem, Nel ; Torrekens, Astrid ; Lemiere, Jurgen ; Verschueren, Sabine ; Uyttebroeck, Anne

Purpose: Advances in cancer treatment have increased childhood cancer patient’s survival rates. However, many childhood cancer survivors (CCS) face long-term effects such as fatigue. This study assessed fatigue in CCS and healthy controls (HCs), its contributors, and associated outcomes. Methods: This cross-sectional study included 90 CCS and 55 age and sex-matched HCs. Fatigue was measured using the Pediatric Quality of Life Multidimensional Fatigue Scale, and modifiable contributors included [...]

Menée à partir de données néerlandaises portant sur 1 496 patients atteints d'un adénocarcinome pancréatique diagnostiqué sur la période 2015-2020 (45 % de femmes), cette étude analyse la qualité de vie liée à la santé en fonction des traitements en cours

Longitudinal health-related quality of life in patients with pancreatic cancer stratified by treatment: a nationwide cohort study

Gehrels, Anne M. ; Vissers, Pauline A. J. ; Sprangers, Mirjam A. G. ; Fijnheer, Nienke M. ; Pijnappel, Esther N. ; van der Geest, Lydia G. ; Cirkel, Geert A. ; de Vos-Geelen, Judith ; Homs, Marjolein Y. V. ; Creemers, Geert-Jan ; Stommel, Martijn W. J. ; Daamen, Lois A. ; Besselink, Marc G. ; Wilmink, Johanna W. ; van Laarhoven, Hanneke W. M.

Background: Pancreatic adenocarcinoma (PAC) has a poor prognosis and substantially impairs health-related quality of life (HRQoL). Large studies on longitudinal HRQoL in patients with PAC, taking patient treatment into account, are lacking. This study aimed to investigate HRQoL over time in patients with PAC undergoing various treatments. Methods: This nationwide cohort study included patients diagnosed with PAC between 2015 and 2020. Data were collected from the Dutch Pancreatic Cancer Project [...]

Cette étude compare l'intérêt d'une photobiomodulation et du bétanéchol pour réduire les effets indésirables de la radiothérapie chez les patients atteints d'un cancer de la tête et du cou

Effects of photobiomodulation and bethanechol chloride treatment on salivary composition and flow rate in head and neck cancer patients undergoing radiotherapy: longitudinal interventional experimental clinical study

Schepanski, Natália ; da Silva Liebl, Bruna Melo ; Mendes, Reila Taina ; Costa, Floriatan Santos ; Amaral, Clarice D. B. ; Machado, Raquel C. ; Nogueira, Ana Rita A. ; Sassi, Laurindo Moacir ; de Araujo, Melissa Rodrigues

Objective: To evaluate the efficacy of photobiomodulation therapy (PBMT) and bethanechol chloride (BC) on the quantity and quality of saliva in patients undergoing radiotherapy (RT) for head and neck cancer. Methods: Saliva samples were collected from patients before and after RT, who were treated with PBMT or BC. Clinical parameters, including salivary flow rate (SFR), pH, xerostomia, and concentrations of macro and microelements in saliva, were assessed. Data were compared and analyzed using [...]

Menée à partir de données hospitalières portant sur 1 425 témoins et 1 425 patients traités par inhibiteurs de point de contrôle immunitaire, cette étude analyse le risque d'événement cardiovasculaire et thromboembolique associé au traitement

Cardiovascular and thromboembolic outcomes with immune checkpoint inhibitors in gastroesophageal cancer: a propensity score-matched cohort study

Bahar, Furkan ; Ibis, Betul ; Cakir Colak, Sena ; Banga, Akshat ; Song, Junmin ; Chang, Yu-Cheng ; Chi, Kuan-Yu ; Chang, Yu ; Chiang, Cho-Hung ; Chiang, Cho-Han

Background: Immune checkpoint inhibitors (ICIs) have been associated with an increased risk of cardiovascular and thromboembolic events. However, the incidence of cardiovascular and thromboembolic events associated with ICIs in gastroesophageal cancers is unknown. Methods: We performed a propensity score-matched cohort study using the TriNetX Analytics Network database, which comprises de-identified data from over 130 participating healthcare institutions. Patients who received ICI and [...]

Menée à partir des données d'une enquête réalisée sur la période 2019-2021, cette étude analyse l'association entre un traitement pour des troubles de la santé mentale (dépression ou anxiété) et la participation au dépistage du cancer du sein, du côlon-rectum ou du col de l'utérus

Association of mental health treatment receipt with cancer screening among US adults with a history of anxiety or depression

Baeker Bispo, Jordan ; Jemal, Ahmedin ; Islami, Farhad

Background: Low participation in cancer screening contributes to a disproportionate burden of cancer morbidity and mortality among adults with mental health (MH) disorders like depression and anxiety. It is unknown whether MH treatment affects screening participation in this population. Methods: Using the 2019 and 2021 National Health Interview Survey, data from screening-eligible respondents with a history of depression or anxiety were analyzed. Dependent variables include up-to-date screening [...]

Menée auprès de 19 481 patients atteints d'un cancer traité par chirurgie, cette étude analyse l'adhésion à un outil électronique d'évaluation des symptômes postopératoires, de la gravité des symptômes et des réadmissions en soins intensifs en fonction du statut tabagique

Impact of smoking status on engagement in remote symptom monitoring after oncologic surgery: Implications for symptom management and readmission rates

Cracchiolo, Jennifer R. ; Li, Yuelin ; Lui, Michelle L. ; Carlsson, Sigrid V. ; Matulewicz, Richard S. ; Ostroff, Jamie S.

Background: Remote symptom monitoring (RSM) is an evidence-based strategy shown to mitigate postoperative morbidity; however, platform engagement is required to benefit from RSM. Patients who report current smoking are at high risk for postoperative complications, but it is unknown whether smoking status influences engagement with RSM, symptom severity, or unanticipated acute care visits. Methods: This observational case–control study was conducted in patients undergoing ambulatory oncologic [...]

Cette étude analyse, pour la période 2017-2023, les subventions pour la recherche des "National Institutes of Health (NIH)" concernant les patients ayant survécu à un cancer rare

Rare cancer survivorship research funding at the National Institutes of Health (NIH), 2017 to 2023

Gallicchio, Lisa ; Mollica, Michelle ; Tesauro, Gina ; Doose, Michelle ; Guida, Jennifer L. ; Maher, Molly E. ; Tonorezos, Emily

Purpose: Rare cancers are defined as those for which there are less than 15 cases per 100,000 in the population annually. While much progress in detection and treatment has been made over the past decade for many rare cancers, less progress has been made in understanding survivorship needs. The objective of this study was to characterize the National Institutes of Health (NIH) cancer survivorship grant portfolio focused on rare cancers and to identify gaps specific to this area of science. [...]

Menée à l'aide de données d'enquêtes coréennes portant sur 6 732 témoins et 2 245 patients ayant survécu à un cancer, cette étude analyse l'association entre une exposition à la pollution atmosphérique (PM10, PM2.5, SO2, NO2 et CO) et le risque d'ostéoporose en fonction du sexe

Association of long-term exposure to ambient air pollution with osteoporosis among cancer survivors: Results from the Korea National Health and nutrition examination survey

Hwang, Juyeon ; Kim, Kyounghyeon ; Ahn, Seohyun ; Lee, Da-eun ; Lee, Seung Won ; Kim, Hyun-Jin ; Kim, Kyeezu

Introduction: Recent studies suggest that ambient air pollution may contribute to osteoporosis; however, research focusing on populations with greater susceptibility is lacking. This study seeks to explore the association between air pollution and osteoporosis focusing on cancer survivors. Materials and methods: We analyzed data from 8977 individuals (2245 cancer survivors, 6732 cancer-free population) obtained from the Korea National Health and Nutrition Examination Survey (KNHANES) during [...]

Menée en Suède et au Danemark à partir de données des registres nationaux des cancers portant sur 20 665 enfants atteints d'un cancer, cette étude évalue l'effet d'une cardiopathie congénitale sur la mortalité 5 ans après le diagnostic de cancer

Mortality after cancer diagnosis among children with congenital heart disease in Denmark and Sweden

Kampitsi, Christina-Evmorfia ; Kenborg, Line ; Mogensen, Hanna ; Broberg, Olof ; Glimelius, Ingrid ; Erdmann, Friederike ; Falck Winther, Jeanette ; Feychting, Maria ; Tettamanti, Giorgio

Recent decades have witnessed tangible improvements in childhood cancer survival. However, the prognosis for children with congenital heart disease (CHD), the most prevalent birth defect, remains unclear. Due to improved survival of CHD and childhood cancer, evaluating outcomes within this intersection is important for clinical practice. We aimed to assess mortality post-cancer diagnosis among children with CHD.We conducted a study on the population of Denmark and Sweden, born 1970–2014, with a [...]

Menée aux Etats-Unis à l'aide de données 2016-2020 de la base "National Center for Health Statistics" portant sur 3 143 comtés américains, cette étude analyse l'association entre le statut socioéconomique local et la mortalité prématurée due au cancer (entre 25 et 64 ans)

County socioeconomic status and premature mortality from cancer in the United States

Thomas, Aleah L. ; Kulchar, Rachel J. ; Stephens, Erica S. ; Mason, Lee ; Jackson, Sarah S. ; Harris, Alexandra R. ; Ewing, Aldenise P. ; Shiels, Meredith S. ; Pichardo, Catherine M. ; McGee-Avila, Jennifer K. ; Lawrence, Wayne R.

Introduction: There are consistent data demonstrating socioeconomic status (SES) is associated with cancer survivorship among older adults, but research on the relationship between area-level SES and risk of premature mortality from cancer remains not well understood. This study investigated the association between county-level SES and premature mortality from cancer. Methods: Demographic characteristics and causes of death were ascertained from the national death certificate data for years [...]

Menée à partir de données 2014-2017 des registres américains des cancers portant sur 3 902 patients atteints d'un carcinome épidermoïde de la langue, cette étude identifie des facteurs de risque de métastases osseuses synchrones et analyse leur effet sur la survie

Long-term survival and risk factors of synchronous bone metastasis in oral tongue squamous cell carcinoma patients

Li, Yujiao ; Hu, Chaosu

The objective of this study was to analyze the risk factors for synchronous bone metastases in patients with oral tongue squamous cell carcinomas (OTSCC). OTSCC patients were extracted from the Surveillance, Epidemiology and End Results database between 2014 and 2017. We examined the association between risk factors and synchronous bone metastases using Chi-squared tests. Predictors of survival rates were assessed using univariate and multivariate analyses. A total of 3902 patients were [...]

Menée à partir de données de la base "Global Burden of Diseases Injuries, and Risk Factors Study (GBD) 2021", cette étude analyse le nombre de décès par cancer colorectal attribuable au tabagisme et les années de vie corrigées de l'incapacité au niveau régional, national et mondial

The global, regional, and national burden of colorectal cancer attributable to smoking from 1990 to 2021: a population-based study

Wang, Shuai ; Zhang, Tao ; Li, Dongming ; Cao, Xueyuan

Colorectal cancer (CRC) is the third leading cause of cancer-related deaths worldwide, with smoking being a significant risk factor. Understanding the temporal and spatial patterns of the CRC burden attributable to smoking is crucial for global public health strategies. Data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 were used to calculate the number of deaths, disability-adjusted life years (DALYs), age-standardized mortality rate (ASMR) per 100 000 [...]

Menée à partir des résultats de 2 essais randomisés multicentriques de phase II incluant au total 628 patients atteints d'un cancer du rectum localement avancé (durées médianes de suivi : 3,6 et 5,1 ans), cette étude analyse la survie sans maladie en fonction de la stratégie thérapeutique (surveillance active ou exérèse totale du mésorectum)

Survival Among Patients Treated with Total Mesorectal Excision or Selective Watch-and-Wait After Total Neoadjuvant Therapy: A Pooled Analysis of the CAO/ARO/AIO-12 and OPRA Randomized Phase II Trials

Williams, H. ; Fokas, E. ; Diefenhardt, M. ; Lee, C. ; Verheij, F. S. ; Omer, D. M. ; Lin, S. T. ; Dunne, R. F. ; Marcet, J. ; Cataldo, P. ; Polite, B. ; Piso, P. ; Polat, B. ; Dapper, H. ; Ghadimi, M. ; Hofheinz, R. D. ; Qin, L. X. ; Saltz, L. B. ; Wu, A. J. ; Gollub, M. J. ; Smith, J. J. ; Weiser, M. R. ; Rödel, C. ; Garcia-Aguilar, J.

Background: Prospective data comparing watch-and-wait (WW) to mandatory total mesorectal excision (TME) in patients with locally advanced rectal cancer (LARC) remains limited, as randomized control trials assessing these two treatment approaches are considered impractical. This pooled analysis of the CAO/ARO/AIO-12 and OPRA trials analyzes survival outcomes among LARC patients managed with either a selective WW or mandatory TME strategy following total neoadjuvant therapy (TNT). Patients and [...]

Menée à partir de données de la base "Global Burden of Disease 2019", cette étude estime, dans les pays du Moyen-Orient et d'Afrique du Nord, la part des décès par cancer du sein attribuable au diabète, au tabagisme et au tabagisme passif

Burden and mortality of breast cancer attributed to diabetes and smoking in women: a secondary analysis based on Global Burden of Disease 2019 in North Africa and the Middle East

Shadmani, Fatemeh Khosravi ; Abedi Gheshlaghi, Leili ; Jafari-Khounigh, Ali ; Rezakhani, Leila ; Khazaei, Mozafar

Background: Breast cancer (BC) is the second most common cancer in the world. This study aimed to investigate the burden of BC due to some risk factors in the Middle East and North Africa (MENA) countries from 1990 to 2019. Methods: This study is a secondary analysis based on the Global Burden of Disease 2019 data. In this study, we used data for disability-adjusted life years (DALYs) and mortality of BC in MENA countries. Also, we presented data for DALYs and mortality attributed to diabetes, [...]

Menée à partir de données danoises portant sur 838 patients atteints d'un mélanome et présentant des métastases cérébrales, cette étude analyse la survie en fonction des traitements reçus

Survival Improvements in Patients with Melanoma Brain Metastases and Leptomeningeal Disease in the Modern Era: Insights from a Nationwide Study (2015-2022)

Pedersen, Sidsel ; Johansen, Emma Lund ; Højholt, Karen Louise ; Pedersen, Marie Wett ; Mogensen, Anne Mark ; Petersen, Søren Kjær ; Haslund, Charlotte Aaquist ; Donia, Marco ; Schmidt, Henrik ; Bastholt, Lars ; Friis, Rasmus ; Svane, Inge Marie ; Ellebaek, Eva

Introduction: Advances in modern therapies have improved outcomes for patients with melanoma brain metastases (MBM), though prognosis remains poor. The optimal treatment strategy for patients who do not meet clinical trial inclusion criteria is unclear. Methods: This study included all MBM patients diagnosed in Denmark between 2015 and 2022, identified through the Danish Metastatic Melanoma Database (DAMMED) and local surgical and radiotherapy records. Data were collected from electronic [...]

Menée à l'aide de données des registres américains des cancers portant sur 39 000 patientes atteintes d'un cancer du col de l'utérus diagnostiqué sur la période 2006-2020, cette étude analyse la survie globale en fonction de l'origine ethnique, de facteurs sociodémographiques et de catégories d'âge (21-64 ans ou 65 ans et plus)

Sociodemographic inequities in overall survival among younger and older women with cervical cancer

Holt, Hunter K. ; Calip, Gregory S. ; Peterson, Caryn E. ; David, Shannon MacLaughlan ; Geller, Stacie ; Guadamuz, Jenny S.

Purpose: Older Black women and women living in areas of low socioeconomic status (SES) diagnosed with cervical cancer (CC) have worse overall survival (OS). The objective was to investigate associations between OS and race/ethnicity and sociodemographic factors in younger (21–64 years) and older women (≥ 65 years) diagnosed with CC using Surveillance, Epidemiology, and End Results Program data. Methods: This retrospective, population-based cohort study included 39,000 women ≥ 21 years diagnosed [...]

Menée au Brésil à l'aide de données 1988-2020 de 30 registres nationaux, cette étude analyse les tendances de l'incidence des cancers oropharyngés

Oropharyngeal cancer incidence and trends in Brazil

Arboleda, Lady Paola Aristizabal ; de Souza, Dyego LB ; Mendonça e Silva, Diego Rodrigues. ; Curado, Maria Paula.

Background: Oropharyngeal cancer (OPC) incidence is rising globally, predominantly in high-income countries due to human papillomavirus (HPV) infection. However, further data on OPC incidence in Brazil is needed. The aim of this study was to estimate the incidence, trends, and predictions of OPC in Brazilian population-based cancer registries (PBCRs) by period, sex, and topography. Methods: Data on OPC were collected from PBCRs (1988–2020). Age-standardized rates were calculated from 2000 [...]

Menée par questionnaires dans 126 pays, cette étude met à jour les données de l'"European Society for Medical Oncology (ESMO)" concernant la disponibilité des médicaments anticancéreux à l’échelle mondiale et le reste à charge du patient en fonction du niveau de développement économique du pays

ESMO Global Consortium Study on the availability, out-of-pocket costs, and accessibility of cancer medicines: 2023 update

Cherny, N. I. ; Trapani, D. ; Galotti, M. ; Saar, M. ; Bricalli, G. ; Roitberg, F. ; Gyawali, B. ; Curigliano, G. ; Blay, J. Y. ; Meier, K. ; Latino, N. J. ; de Vries, E. G. E.

Background: The availability and affordability of safe, effective cancer therapies are core requirements for effective cancer control. Global disparities exist in access, however, yielding unequal cancer outcomes. The goal of this study was to provide updated data regarding the formulary availability, out-of-pocket costs, and accessibility of cancer medicines in countries across the full spectrum of economic development areas. Methods: This study was conducted through an online survey based on [...]

Menée à partir de données américaines portant sur des patients ayant reçu un diagnostic de cancer avancé du côlon-rectum, du poumon, de la prostate ou du sein sur la période 2010-2013, cette étude analyse le recours aux soins palliatifs ambulatoires avant le décès ainsi que l'intensité des soins de fin de vie

Outpatient palliative care and end-of-life care intensity: Linking Massachusetts cancer registry with All-Payer claims

Keating, Nancy L ; Weissman, Joel S ; Wright, Alexi A ; Wolf, Robert ; Gershman, Susan ; Knowlton, Richard ; Ayanian, John Z

Early palliative care is associated with better outcomes for patients with advanced-stage cancers. Using a novel data linkage, we assessed outpatient palliative care use before death and its association with end-of-life care intensity and variation across eight provider networks.We linked Massachusetts Cancer Registry and the All-Payer Claims Database for individuals with commercial insurance, Medicaid or Medicare Advantage diagnosed with colorectal, lung, prostate, and breast cancers from 2010 [...]