Mené sur 53 patients atteints d'un cancer de stade avancé et suivis à domicile, cet essai randomisé évalue l'impact, sur leur douleur et sur leurs symptômes d'anxiété et de dépression, d'une intervention de réalité virtuelle

Virtual Reality for advanced cancer patients assisted at home: A randomized controlled interventional study

Giannelli, Andrea ; Moscato, Serena ; Ostan, Rita ; Pannuti, Raffaella ; Chiari, Lorenzo ; Biasco, Guido ; Varani, Silvia

Objective: Virtual Reality (VR) has been demonstrated to be an effective option for integrating psychological interventions in different therapeutic settings. This randomized controlled interventional study aims to assess the effects of VR, compared to tablet controlled intervention, on anxiety, depression, pain, and short-term psychophysical symptoms in advanced cancer patients assisted at home. Methods: Participants were provided with a VR headset or a tablet (TAB) for 4 days. On the first [...]

A partir d'une revue systématique de la littérature publiée depuis 2000 (141 articles), cette étude analyse l'adhésion des patients aux recommandations concernant l'utilisation de traitements prophylactiques des nausées et vomissements induits par la chimiothérapie

Outcomes of chemotherapy-induced nausea and vomiting guideline adherence in pediatric and adult patients: a systematic review

Renaux Torres, Marie Charlotte ; Robinson, Paula D. ; Sung, Lillian ; Dupuis, L. Lee ; Bate, Jessica ; Behm, Shirley ; Bouttefroy, Séverine ; Digout, Carol ; Kebudi, Rejin ; Kimball, Gwendolyn ; Orsey, Andrea D. ; Phillips, Bob ; Poiree, Marilyne ; Tissing, Wim ; Thompson, Joel C. ; Thouvenin-Doulet, Sandrine ; van de Wetering, Marianne ; on behalf of the international Pediatric Oncology supportive care Guideline, Network

Purpose: This study describes chemotherapy-induced nausea and vomiting (CINV) control rates in pediatric and adult patients who did or did not receive guideline-consistent CINV prophylaxis. Methods: We conducted a systematic literature review of studies published in 2000 or later that evaluated CINV control in patients receiving guideline-consistent vs. guideline-inconsistent CINV prophylaxis and reported at least one CINV-related patient outcome. Studies were excluded if the guideline [...]

Menée auprès de 12 patients atteints d'un cancer du pancréas et recevant une chimiothérapie, cette étude analyse l'impact, sur leur qualité de vie, de l'ajout d'une nutrition parentérale aux "meilleurs soins de support" nutritionnels

Effects of parenteral nutrition + best supportive nutritional care vs. best supportive nutritional care alone on quality of life in patients with pancreatic cancer—a secondary analysis of PANUSCO

Emanuel, Aline ; Rosenberger, Friederike ; Krampitz, Julia ; Decker-Baumann, Christiane ; Märten, Angela ; Jäger, Dirk ; Rötzer, Ingeborg

Purpose: Parenteral nutrition (PN) can be an effective treatment to improve the nutritional status of patients with pancreatic cancer, but the effects of PN on quality of life (QoL) are still understudied. Therefore, we aimed at investigating whether the best supportive nutritional care (BSNC) in combination with PN at home compared to BSNC alone changed QoL in patients with advanced pancreatic cancer undergoing chemotherapy over a period of 7 weeks. Methods: n = 12 patients in the PANUSCO [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2023 (56 études, 3 904 patientes), cette méta-analyse évalue l'impact des interventions à base d'exercices physiques sur la qualité de vie des patientes atteintes d'un cancer du sein

Effects of exercise interventions on quality of life in patients with breast cancer: A systematic review and network meta-analysis

Han, Bing ; Zhang, Peizhen ; Zhao, Haojie ; Zhang, Xiaojie ; Gao, Hongyue ; Dong, Jiating ; Zeng, Liqing ; Pi, Peng ; Pei, Jiayi

Objective: To compare and rank the effectiveness of four primary categories of exercise modalities (aerobic, resistance, mind-body, and combined exercise [CE]) in improving the Quality of life (QoL) of women with breast cancer in a network meta-analysis (NMA). Methods: Articles published in English and indexed in the PubMed (MEDLINE), EBSCO, Web of Science, SPORTDiscus, The Cochrane Library, Google Scholar, PsycINFO, EMBASE, and CINAHL Plus databases were identified from inception to 12 October [...]

Menée à partir de données portant sur 158 patientes atteintes d'un cancer du sein HR+ et incluses dans des essais cliniques, cette étude analyse l'intérêt de l'acupuncture pour soulager les bouffées de chaleur liées à un traitement endocrinien

Acupuncture for hot flashes in hormone receptor-positive breast cancer: A pooled analysis of individual patient data from parallel randomized trials

Lu, Weidong ; Giobbie-Hurder, Anita ; Tanasijevic, Anna ; Kassis, Sylvia Baedorf ; Park, Sung Hwan ; Jeong, Young Ju ; Shin, Im Hee ; Yao, Chang ; Jung, Hyun Jung ; Zhu, Zhiyuan ; Bao, Chao ; Bao, Ting ; Yang, EunMee ; Bierer, Barbara E. ; Ligibel, Jennifer A.

Background: Hot flashes are a common side effect of endocrine therapy (ET) that contribute to poor quality of life and decreased treatment adherence. Methods: Patients with breast cancer wo were receiving ET and experiencing hot flashes were enrolled through three parallel, randomized trials conducted in the United States, China, and South Korea. Participants were randomized to either immediate acupuncture (IA) or delayed acupuncture control (DAC). IA participants received 20 acupuncture [...]

Menée à partir de données de registres britanniques portant sur 182 589 patientes atteintes d'un cancer diagnostiqué entre 1998 et 2019 (17 localisations), cette étude analyse l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause et la mortalité spécifique

Hormone replacement therapy and cancer mortality in women with 17 site-specific cancers: a cohort study using linked medical records

Cardwell, Chris R. ; Ranger, Tom A. ; Labeit, Alexander M. ; Coupland, Carol A. C. ; Hicks, Blanaid ; Hughes, Carmel ; McMenamin, Úna ; Mei, Xue W. ; Murchie, Peter ; Hippisley-Cox, Julia

Background: There is limited evidence on the safety of Hormone Replacement Therapy (HRT) in women with cancer. Therefore, we systematically examined HRT use and cancer-specific mortality in women with 17 site-specific cancers. Methods: Women newly diagnosed with 17 site-specific cancers from 1998 to 2019, were identified from general practitioner (GP) records, hospital diagnoses or cancer registries in Scotland, Wales and England. Breast cancer patients were excluded because HRT is [...]

Menée à partir de données du registre texan des cancers portant sur 29 730 enfants atteints d'un cancer diagnostiqué entre 1995 et 2017 (âge inférieur ou égal à 19 ans), cette étude analyse l'association entre la proximité résidentielle de puits de pétrole ou de gaz et la survie

Residential proximity to oil and gas developments and childhood cancer survival

Hoang, Thanh T. ; Rathod, Rutu A. ; Rosales, Omar ; Castellanos, Maria I. ; Schraw, Jeremy M. ; Burgess, Elyse ; Peckham-Gregory, Erin C. ; Oluyomi, Abiodun O. ; Scheurer, Michael E. ; Hughes, Amy E. ; Lupo, Philip J.

Background: Environmental toxicants may impact survival in children with cancer, but the literature investigating these associations remains limited. Because oil and gas developments emit several hazardous air pollutants, the authors evaluated the relationship between residential proximity to oil or gas development and survival across 21 different pediatric cancers. Methods: The Texas Cancer Registry had 29,730 children (≤19 years old) diagnosed with a primary cancer between 1995 to 2017. [...]

Menée à partir de données portant sur 375 patients atteints d'un cancer de stade avancé, cette étude rétrospective analyse l'effet, sur la survie sans progression et la survie globale, d'une utilisation concomitante d'analgésiques opioïdes et d'un traitement par inhibiteurs de point de contrôle immunitaire

Impact of opioid analgesics on survival in cancer patients receiving immune checkpoint inhibitors

Kavgaci, Gozde ; Guven, Deniz Can ; Kaygusuz, Yunus ; Karaca, Ece ; Dizdar, Ömer ; Kılıçkap, Saadettin ; Aksoy, Sercan ; Erman, Mustafa ; Yalcin, Suayib

Purpose: This study aimed to assess the effects of concurrent opioid analgesic (OA) use with immune checkpoint inhibitors (ICIs) on progression-free survival (PFS) and overall survival (OS). Methods: In this observational retrospective study, we included advanced cancer patients who received ICIs at Hacettepe University Hospital’s Department of Medical Oncology between June 2018 and January 2023. Results: Our study included 375 recurrent or metastatic cancer patients treated with ICIs in the [...]

Menée à l'aide de données portant sur 5 923 patients atteints d'un cancer du pancréas, du duodénum, des voies biliaires ou de la papille duodénale traité par chirurgie, cette étude analyse l'évolution, sur la période 1964-2016, du rapport bénéfice-risque après une pancréatoduodénectomie

Dramatic improvements in outcome following pancreatoduodenectomy for pancreatic and periampullary cancers

Xu, Hui ; Bretthauer, Michael ; Fang, Fang ; Ye, Weimin ; Yin, Li ; Adami, Hans-Olov

Background: Pancreatoduodenectomy is the only cure for cancers of the pancreas and the periampullary region but has considerable operative complications and uncertain prognosis. Our goal was to analyse temporal improvements and provide contemporary population-based benchmarks for outcomes following pancreatoduodenectomy. Methods: We empanelled a cohort comprising all patients in Sweden with pancreatic or periampullary cancer treated with pancreatoduodenectomy from 1964 to 2016 and achieved [...]

Menée aux Etats-Unis à partir de données portant sur 758 patients pédiatriques atteints d'un ostéosarcome non métastatique (âge : 5-21 ans), cette étude de cohorte rétrospective analyse l'association entre la pauvreté et la survie en fonction de l'origine ethnique

Poverty, race, ethnicity, and survival in pediatric nonmetastatic osteosarcoma: a Children’s Oncology Group report

Ilcisin, Lenka ; Han, Ruxu ; Krailo, Mark ; Shulman, David S ; Weil, Brent R ; Weldon, Christopher B ; Umaretiya, Puja ; Aziz-Bose, Rahela ; Greenzang, Katie A ; Gorlick, Richard ; Reed, Damon R ; Randall, R Lor ; Nadel, Helen ; Binitie, Odion ; Dubois, Steven G ; Janeway, Katherine A ; Bona, Kira

Background: Children living in poverty and those of marginalized race or ethnicity experience inferior disease outcomes across many cancers. Whether survival disparities exist in osteosarcoma is poorly defined. We investigated the association between race, ethnicity, and proxied poverty exposures and event-free and overall survival for children with nonmetastatic osteosarcoma receiving care on a cooperative group trial. Methods: We conducted a retrospective cohort study of US patients with [...]

A partir d'une revue de la littérature publiée jusqu'en janvier 2024 (13 études qualitatives), cette étude décrit les expériences des employeurs lors de la reprise du travail de patients ayant survécu à un cancer

The experiences and perceptions of employers on cancer survivors returning to work: a meta-synthesis of qualitative studies

Kuai, BenXin ; Huang, Yanjun ; Su, Xiaoqin ; Shi, Yue ; Feng, Guojia ; Hu, Lanyue ; Guo, YuJie

Purpose: Employers play an important role in the return-to-work (RTW) of cancer survivors (CSs), and recently a substantial number of qualitative studies from the employers’ perspective have emerged. This meta-synthesis aims to systematically review these qualitative studies regarding employers’ experiences with CSs’ RTW. Methods: Five electronic databases were searched from inception to January 2024 to identify the studies. Three researchers conducted quality assessment of included. [...]

Menée au Danemark à partir de données portant sur 4 353 patientes atteintes d'un cancer du sein ER+ diagnostiqué avant la ménopause, cette étude de cohorte analyse l'association entre des facteurs sociaux (statut marital, niveau socioéconomique, emploi, revenus, etc.) et l'adhésion à un traitement endocrinien adjuvant

Social Characteristics and Adherence to Adjuvant Endocrine Therapy in Premenopausal Women With Breast Cancer

Julie A. Schmidt ; Kirsten M. Woolpert ; Cathrine F. Hjorth ; Dóra K. Farkas ; Bent Ejlertsen ; Deirdre Cronin-Fenton

Purpose: Social characteristics, including cohabitation/marital status and socioeconomic position (SEP)—education level, employment status, and income—influence breast cancer prognosis. We investigated the impact of these social characteristics on adherence to adjuvant endocrine therapy (AET) from treatment initiation to 5 years after diagnosis. Methods: We assembled a nationwide, population-based cohort of premenopausal women diagnosed in Denmark with stage I-III, estrogen receptor–positive [...]

A partir d'une revue systématique de la littérature publiée entre 2002 et 2022 (17 articles), cette étude analyse l'intérêt et la sécurité d'un cathéter central à insertion périphérique et d'un cathéter périphérique long de type "Midline" chez les patients atteints d'un cancer et recevant des soins palliatifs

Use of peripherally inserted central venous catheters and midline catheters for palliative care in patients with cancer: a systematic review

Gravdahl, Eva ; Haugen, Dagny Faksvåg ; Fredheim, Olav Magnus

Background: Peripherally inserted central catheters (PICCs) and midline catheters (MCs) may offer convenient intravenous access, but evidence to support their place in palliative care is limited. This review aimed to assess catheter indications, utilization, complications, dwell time, and patient experiences in cancer patients receiving palliative care. Methods: A systematic search for studies on catheter utilization for supportive or symptom treatment was conducted in Medline, Embase, CINAHL, [...]

Menée à partir de données portant sur 20 patients atteints d'un myélome multiple récemment diagnostiqué (âge médian : 65 ans), cette étude de cohorte prospective évalue l'intérêt de soins palliatifs dispensés précocement pour améliorer leur qualité de vie

Effects of early palliative care integration on patients with newly diagnosed multiple myeloma

Samala, Renato V. ; Nurse, Daniel P. ; Chen, Xiaoying ; Wei, Wei ; Crook, Jasmine J. ; Fada, Sherry D. ; Valent, Jason

Purpose: While numerous studies underscore the benefits of early palliative care (EPC) for patients with solid tumors, its effects on patients with multiple myeloma (MM) are not as widely known. This study aims to determine the effects of EPC integration on patients with newly diagnosed symptomatic MM and the feasibility of this approach. Methods: This prospective cohort study enrolled patients within eight weeks of diagnosis. Participants met with a palliative care team monthly for 12 months. [...]

Cet article passe en revue les données concernant le rôle de l'activité physique dans la lutte contre le cancer

The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities

Yang, Lin ; Courneya, Kerry S. ; Friedenreich, Christine M.

Background: We proposed the Physical Activity and Cancer Control (PACC) framework in 2007 to help organise, focus, and stimulate research on physical activity in eight cancer control categories: prevention, detection, treatment preparation/coping, treatment coping/effectiveness, recovery/rehabilitation, disease prevention/health promotion, palliation, and survival. Methods: This perspective paper provides a high-level overview of the scientific advances in physical activity research across [...]