Menée à partir de données de 3 bases européennes portant au total sur 45 431 femmes non ménopausées et 173 476 ménopausées, cette étude analyse l'association entre des dérèglements hormonaux liés à une consommation d'alcool et le risque de cancer du sein

Alcohol intake and endogenous sex hormones in women: Meta-analysis of cohort studies and Mendelian randomization

Tin Tin, Sandar ; Smith-Byrne, Karl ; Ferrari, Pietro ; Rinaldi, Sabina ; McCullough, Marjorie L. ; Teras, Lauren R. ; Manjer, Jonas ; Giles, Graham ; Le Marchand, Loic ; Haiman, Christopher A. ; Wilkens, Lynne R. ; Chen, Yu ; Hankinson, Sue ; Tworoger, Shelley ; Eliassen, A. Heather ; Willett, Walter C. ; Ziegler, Regina G. ; Fuhrman, Barbara J. ; Sieri, Sabina ; Agnoli, Claudia ; Cauley, Jane ; Menon, Usha ; Fourkala, Evangelia Ourania ; Rohan, Thomas E. ; Kaaks, Rudolf ; Reeves, Gillian K. ; Key, Timothy J.

Background: The mechanisms underlying alcohol-induced breast carcinogenesis are not fully understood but may involve hormonal changes. Methods: Cross-sectional associations were investigated between self-reported alcohol intake and serum or plasma concentrations of estradiol, estrone, progesterone (in premenopausal women only), testosterone, androstenedione, dehydroepiandrosterone sulfate, and sex hormone binding globulin (SHBG) in 45 431 premenopausal and 173 476 postmenopausal women. [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données européennes portant sur 483 181 témoins et 2 497 patientes atteintes d'un cancer de l'ovaire ou du col utérin, cette étude analyse l'association entre une utilisation de médicaments hypolipidémiants et le risque de développer ces maladies

Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study

Li, Jinshuai ; Yang, Zixian ; Wang, Tao ; Li, Mengqi ; Wu, Xiangjian ; Fu, Xiaoyan ; Yang, Chunfeng ; Li, Yangpu ; Wang, Ximing ; Lan, Zhiming ; Li, Minfang ; Chen, Sheng

Background: The causal impact of lipid-lowering drugs on ovarian cancer (OC) and cervical cancer (CC) has received considerable attention, but its causal relationship is still a subject of debate. Hence, the objective of this study is to evaluate the impact of lipid-lowering medications on the occurrence risk of OC and CC through Mendelian randomization (MR) analysis of drug targets. Methods: This investigation concentrated on the primary targets of lipid-lowering medications, specifically, [...]

Menée à partir de données de registres suédois portant sur 11 905 personnes, cette étude analyse l'association entre tatouage et risque de lymphome par sous-type

Tattoos as a risk factor for malignant lymphoma: a population-based case–control study

Nielsen, Christel ; Jerkeman, Mats ; Jöud, Anna Saxne

Background: The popularity of tattoos has increased dramatically over the last few decades. Tattoo ink often contains carcinogenic chemicals, e.g., primary aromatic amines, polycyclic aromatic hydrocarbons, and metals. The tattooing process invokes an immunologic response that causes translocation of tattoo ink from the injection site. Deposition of tattoo pigment in lymph nodes has been confirmed but the long-term health effects remain unexplored. We used Swedish National Authority Registers [...]

Menée à l'aide de données de registres Suédois portant sur 6 400 témoins et 1 283 patients atteints d'un gliome diagnostiqué sur la période 2009-2013, cette étude analyse l'association entre une utilisation d'antidépresseurs et le risque de développer la maladie par grade tumoral

Antidepressant drugs and risk of developing glioma: a national registry-based case control study and a meta-analysis

Malmberg, Charlotte ; Hellquist, Barbro Numan ; Sadanandan, Sajna Anand ; Sandström, Maria ; Wu, Wendy Yi-Ying ; Björkblom, Benny ; Melin, Beatrice ; Sjöberg, Rickard L

The aim of the present study was to investigate if use of antidepressants is related to the risk of developing lower (WHO grade 2-3) and higher grade (WHO grade 4) glioma. A registry-based case-control study was performed using 1283 glioma cases and 6400 age-, sex- and geographically matched controls, diagnosed in Sweden 2009-2013. Conditional logistic regression was used to analyze whether Selective Serotonin Reuptake Inhibitors (SSRIs) or non-SSRIs were associated with the risk of developing [...]

Menée auprès de 4 270 témoins et 3 584 patients atteints d'un cancer (durée médiane de suivi : 15,8 ans), cette étude analyse l'association entre les taux plasmatiques d'albumine, de bilirubine et d'acide urique et le risque de développer la maladie

Plasma Albumin, Bilirubin, and Uric Acid and the Subsequent Risk of Cancer: A Case-Cohort Study in the Japan Public Health Center-based Prospective Study

Ihira, Hikaru ; Nakano, Shiori ; Yamaji, Taiki ; Katagiri, Ryoko ; Sawada, Norie ; Inoue, Manami ; Tsugane, Shoichiro ; Iwasaki, Motoki

Several epidemiological studies have investigated the circulating levels of albumin, bilirubin, and uric acid (UA) in relation to cancer risk; however, they have provided equivocal evidence. In this prospective case-cohort study, we aimed to explore the association of plasma albumin, bilirubin, and UA levels with cancer incidence. We measured the plasma levels of albumin, bilirubin, and UA and investigated their association with cancer incidence in 3,584 cases and 4,270 randomly selected [...]