A partir d'une revue de la littérature, cette étude analyse l'effet de l'activité physique sur le microbiome intestinal des patients atteints d'un cancer pendant et après les traitements

Exercise and the gut microbiome: implications for supportive care in cancer

Hart, Nicolas H. ; Wallen, Matthew P. ; Farley, Morgan J. ; Haywood, Darren ; Boytar, Alexander N. ; Secombe, Kate ; Joseph, Ria ; Chan, Raymond J. ; Kenkhuis, Marlou-Floor ; Buffart, Laurien M. ; Skinner, Tina L. ; Wardill, Hannah R.

Purpose: Growing recognition of the gut microbiome as an influential modulator of cancer treatment efficacy and toxicity has led to the emergence of clinical interventions targeting the microbiome to enhance cancer and health outcomes. The highly modifiable nature of microbiota to endogenous, exogenous, and environmental inputs enables interventions to promote resilience of the gut microbiome that have rapid effects on host health, or response to cancer treatment. While diet, probiotics, and [...]

Menée aux Pays-Bas à partir de données portant sur 565 témoins et 6 693 patients ayant survécu à un cancer, cette étude analyse leur qualité de vie en fonction de leur niveau socio-économique

Socioeconomic differences in health-related quality of life among cancer survivors and comparison with a cancer-free population: a PROFILES study

Levinsen, Anne Katrine Graudal ; van de Poll-Franse, Lonneke ; Ezendam, Nicole ; Aarts, Mieke J. ; Kjaer, Trille Kristina ; Dalton, Susanne Oksbjerg ; Oerlemans, Simone

Purpose: This study investigates the association between socioeconomic position (SEP) and health-related quality of life (HRQoL) in a cross-sectional cohort among cancer survivors and compares with cancer-free people. Methods: Survivors of colorectal, hematological, gynecological, prostate, thyroid cancer, and melanoma diagnosed 2000–2014 were identified in the PROFILES registry, and an age- and sex-matched cancer-free population were identified in the CentER panel. HRQoL, education, and [...]

Menée aux Etats-Unis à partir de données portant sur 15 936 hommes et 7 026 femmes ayant survécu à un cancer, cette étude de cohorte évalue l'association entre une supplémentation en multivitamines et la mortalité

Multivitamin use and all-cause and cause-specific mortality in cancer survivors

Park, Yikyung ; Farhat, Zeinab ; Liao, Linda M. ; Inoue-Choi, Maki ; Loftfield, Erikka

Background: Despite no sufficient evidence on benefits and harms of multivitamin use, cancer survivors use multivitamins as a self-care strategy to improve or maintain health. We examined if multivitamin use was associated with mortality in cancer survivors. Methods: 15,936 male and 7026 female cancer survivors in the NIH-AARP Diet and Health Study were included in the analysis. Types and frequency of multivitamin use at on average 4.6 years after cancer diagnosis were assessed. [...]

Menée au Danemark à partir de données portant sur 119 patients ayant survécu à un cancer (âge moyen : 51 ans), cette étude de cohorte rétrospective analyse les changements dans leur situation professionnelle depuis le diagnostic de la maladie

Employment status among cancer survivors in a Late Effects Clinic in Denmark

Skovgaards, Annette Sicko ; Mattsson, Thea Otto ; Tolstrup, Lærke Kjær

Purpose: This study aims to investigate changes in employment status among disease-free working-age cancer survivors (CSs) with late effects from diagnosis to their first meeting in the Late Effects Clinic (LEC) and investigate associated patient-reported outcomes of reduced employment status. Methods: Retrospective analysis of a cohort of CSs followed in a LEC at a single institution from January, 2022, to March, 2023. Working-age CSs with no current evidence of active cancer were included in [...]

Menée à partir de données portant sur 234 patients présentant des mutations constitutionnelles du gène BRCA1 ou BRCA2 et atteints d'un carcinome canalaire du pancréas, cette étude évalue la survie des patients en fonction du gène muté (BRCA1 ou BRCA2)

Analysis of BRCA1- and BRCA2-Related Pancreatic Cancer and Survival

Boursi, Ben ; Wileyto, E. Paul ; Mamtani, Ronac ; Domchek, Susan M. ; Golan, Talia ; Hood, Ryan ; Reiss, Kim A.

Introduction : Patients with pancreatic cancer (PDAC) and pathogenic variants (PVs) in BRCA1 or BRCA2 have historically been grouped together.1,2 However, preclinical and clinical data in other BRCA-related tumors suggests that the biological implications of BRCA1 and BRCA2 PVs may be different.3-5 To explore this further, we compared outcomes of patients with BRCA1 vs BRCA2-related PDAC using 2 large data sets. Methods : The institutional review board at the University of Pennsylvania deemed [...]

Menée à partir de données des registres américains des cancers et de la base Medicare portant sur 1 438 patients ayant survécu à un cancer de la prostate, cette étude analyse, en fonction de l'origine ethnique, leurs expériences en matière de soins et de traitements définitifs reçus

Association of race/ethnicity and patient care experiences with receipt of definitive treatment among prostate cancer survivors: a SEER-CAHPS study

Pandit, Ambrish A. ; Halpern, Michael T. ; Gressler, Laura E. ; Kamel, Mohamed ; Payakachat, Nalin ; Li, Chenghui

Purpose: This study aimed to evaluate the association of race/ethnicity, patient care experiences (PCEs), and receipt of definitive treatment and treatment modality among older adults in the United States (US) with localized prostate cancer (PCa). Methods: Using Surveillance, Epidemiology and End Results dataset linked to Medicare Consumer Assessment of Healthcare Providers and Systems (SEER-CAHPS) for 2007–2015, we identified men aged ≥ 65 years who completed a CAHPS survey within one year [...]

Menée à partir de données portant sur 3 876 patientes atteintes d'un cancer invasif du sein (âge : 20-69 ans), cette étude de cohorte prospective analyse l'association entre une consommation d'alcool, une pratique tabagique et le risque de récidive de la maladie ou de décès par sous-type moléculaire

Alcohol, smoking, and risks of breast cancer recurrence and mortality among women with luminal, triple-negative, and HER2-overexpressing breast cancer

Loroña, Nicole C. ; Othus, Megan ; Malone, Kathleen E. ; Linden, Hannah M. ; Tang, Mei-Tzu C. ; Li, Christopher I.

Background: This study evaluates the relationship between smoking, alcohol, and breast cancer outcomes according to molecular subtype. Methods: This population-based prospective cohort consisted of 3,876 women aged 20-69 diagnosed with a first primary invasive breast cancer from 2004 through 2015 in the Seattle–Puget Sound region. Breast cancer was categorized into three subtypes based on estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) [...]

Menée à partir de données portant sur 305 patients atteints d'un carcinome du rhinopharynx, cette étude transversale identifie les facteurs associés au risque de malnutrition

Risk factors for malnutrition in patients with nasopharyngeal carcinoma

Wang, Pengpeng ; Soh, Kim Lam ; Ying, Yanping ; Liao, Jinlian ; Huang, Xueling ; Zhao, Huihan ; Pan, Xiao ; Deng, Lan ; Yu, Xiaoxia

Background: Malnutrition is a common complication in patients with nasopharyngeal carcinoma (NPC). However, there are few studies on risk factors for malnutrition in NPC patients. Our aims were to identify the risk factors for malnutrition in NPC patients. Methods: NPC patients were recruited in this cross-sectional study, and they were divided into well-nourished and malnourished groups according to the Global Leadership Initiative on Malnutrition (GLIM). Potential risk factors were initially [...]

Menée auprès de 100 patients ayant survécu à un cancer pédiatrique (âge moyen : 15,8 ans) et auprès de 186 parents, cette étude analyse la prévalence d'un stress lié à la maladie puis évalue l'association entre ce stress, leurs perceptions des risques pour la santé (pronostic, risque d'une qualité de vie moindre) et la qualité de vie

Cancer-related stress in childhood cancer survivorship: Prevalence and associations with perceptions of health risks and quality of life

Himelhoch, Alexandra C. ; Olsavsky, Anna L. ; Darow, Eva L. ; Lipak, Keagan G. ; Kenney, Ansley E. ; Fisher, Rachel S. ; Prussien, Kemar V. ; Vannatta, Kathryn A. ; Compas, Bruce E. ; Gerhardt, Cynthia A.

Objective: Limited research has characterized cancer-related stress (CRS) among families of childhood cancer survivors. We examined the prevalence of CRS among survivors and caregivers, as well as its association with health risk perceptions (i.e., prognosis, risk for diminished quality of life) and views of survivor quality of life (QoL). Methods: At five years post-diagnosis or relapse, survivors (n = 100; Mage = 15.84 years; 89% White), mothers (n = 127), and fathers (n = 59) reported their [...]

Menée à partir des données 2000-2019 des registres américains des cancers portant sur 6 754 704 patients, cette étude analyse l'association entre le pronostic de la maladie et le risque de suicide

Prognosis and risk of suicide after cancer diagnosis

Kinslow, Connor J. ; Kumar, Prashanth ; Olfson, Mark ; Wall, Melanie M. ; Petridis, Petros D. ; Horowitz, David P. ; Wang, Tony J. C. ; Kachnic, Lisa A. ; Cheng, Simon K. ; Prigerson, Holly G. ; Yu, James B. ; Neugut, Alfred I.

Introduction: Suicide rates are elevated after cancer diagnosis. Existential distress caused by awareness of one’s impending death is well-described in patients with cancer. The authors hypothesized that suicide risk is associated with cancer prognosis, and the impact of prognosis on suicide risk is greatest for populations with higher baseline suicide risk. Methods: The authors identified patients (≥16 years old) with newly diagnosed cancers from 2000 to 2019 in the Surveillance, Epidemiology, [...]