Menée à partir de données portant sur 1 233 177 femmes ménopausées (âge moyen : 56 ans ; durée moyenne de suivi : 17 ans), cette étude prospective analyse l'association entre une consommation d'alcool et le risque de cancer en fonction d'une pratique tabagique, de l'indice de masse corporelle et d'une utilisation d'un traitement hormonal substitutif de la ménopause

Alcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy

Floud, Sarah ; Hermon, Carol ; Simpson, Rachel F. ; Reeves, Gillian K.

Background: Alcohol consumption has been associated with increased risks of certain site-specific cancers and decreased risks of some other cancers. There is, however, little reliable evidence as to whether the alcohol-associated risks for specific cancers are modified by smoking, body mass index (BMI) and menopausal hormone therapy (MHT) use. Methods: In the prospective UK Million Women Study, 1,233,177 postmenopausal women without prior cancer, mean age 56 (SD 5) years, reported their alcohol [...]

Menée au Japon par questionnaire auprès de 84 063 personnes (durée de suivi : 1 272 298 personnes-années ; âge : 45-74 ans), cette étude analyse l'association entre la consommation de poisson, d'acides gras oméga 3 et le risque de carcinome à cellules rénales (262 cas)

Dietary fish and n-3 polyunsaturated fatty acid consumption, and renal cell carcinoma risk in Japan: The Japan Public Health Center-based Prospective Study

Takahashi, Michiko ; Sobue, Tomotaka ; Zha, Ling ; Kitamura, Tetsuhisa ; Iwasaki, Motoki ; Inoue, Manami ; Yamaji, Taiki ; Tsugane, Shoichiro ; Sawada, Norie

Background: Previous epidemiological studies found inconsistent associations between fish consumption and renal cell carcinoma (RCC). Although the consumption of n-3 polyunsaturated fatty acids (n-3 PUFA) was reported to protect against the development of some types of cancer, little is known regarding its association with RCC. Methods: We investigated the association between fish and n-3 PUFA consumption and RCC risk using the Japan Public Health Center-based Prospective Study. We examined [...]

Menée à partir de données de 2 cohortes suédoises portant sur 58 672 personnes (durée moyenne de suivi : 16,8 ans), cette étude analyse l'association entre une exposition aux trihalométhanes contenus dans l'eau potable et le risque de cancer colorectal (1 913 cas) en fonction du sexe

Disinfection by-products in drinking water and risk of colorectal cancer: a population-based cohort study

Helte, Emilie ; Säve-Söderbergh, Melle ; Larsson, Susanna C ; Martling, Anna ; Akesson, Agneta

Colorectal cancer is the third most common malignancy worldwide, and it is strongly linked to lifestyle and environmental risk factors. While several drinking water disinfection by-products are confirmed rodent carcinogens, there is still inconclusive evidence for human carcinogenicity, including colorectal cancer.We assessed the association of long-term exposure to Trihalomethanes (THMs, the most prevalent disinfection by-products in chlorinated drinking water) with incidence of colorectal [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de 2 études d'association à l'échelle du génome entier, cette étude analyse l'association entre une utilisation d'antidépresseurs ou d'inhibiteurs sélectifs de la recapture de la sérotonine et le risque de cancer du sein

The relationship between antidepressants and breast cancer: evidence from Mendelian randomization

Niu, Dong ; Li, Chenchen ; Yan, Xiaoyu ; Qu, Haoran ; Zheng, Yuling

Background: The use of antidepressants has increased over the years, but the relationship between antidepressant use and the risk of breast cancer is not uniform because of confounding factors. We aimed to assess the effect of antidepressants on breast cancer risk using a two-sample Mendelian randomization (MR) approach.stet Methods: Secondary data analysis was performed on pooled data from genome-wide association studies based on single-nucleotide polymorphisms that were highly correlated with [...]

Menée à partir de données de registres danois portant sur 160 484 témoins et 6 420 patients pédiatriques atteints d'un cancer, cette étude analyse l'association entre une pré-éclampsie pendant la grossesse, les médicaments antihypertenseurs utilisés et le risque de cancer chez l'enfant

Preeclampsia, antihypertensive medication use in pregnancy and risk of childhood cancer in offspring

Askins, Lexie ; Orimoloye, Helen T. ; Deng, Chuanjie ; Hansen, Johnni ; Olsen, Jorn ; Ritz, Beate ; Janzen, Carla ; Heck, Julia E.

Purpose: Preeclampsia is a serious pregnancy complication that presents a significant risk to both the mother and the fetus. Preeclampsia and medications associated with its treatment are potentially linked to increased childhood cancer risk. Therefore, we examined the association between preeclampsia, antihypertensive medications, and childhood cancer in offspring. Methods: Cases (n = 6,420) and controls (n = 160,484) were obtained from Danish national registries. We performed conditional [...]

Menée à partir de données 1995-2011 du registre des cancers du Texas portant sur 37 735 témoins et 7 547 patients atteints d'un cancer pédiatrique, cette étude analyse l'association entre la croissance foetale et le risque de cancer chez l'enfant

Fetal growth and pediatric cancer: A pan-cancer analysis in 7000 cases and 37 000 controls

Hoang, Thanh T. ; Schraw, Jeremy M. ; Peckham-Gregory, Erin C. ; Scheurer, Michael E. ; Lupo, Philip J.

Birth weight is an established risk factor for some pediatric cancers but is dependent on gestational age and sex. Furthermore, it is unclear how associations may differ by infant sex, age at diagnosis, maternal race/ethnicity and maternal nativity status. We examined the association between size for gestation and a spectrum of pediatric cancers registered in the Texas Cancer Registry from 1995 to 2011. We analyzed up to 7547 cases and 37 735 controls. Analyses were conducted using logistic [...]

A partir de données d'un consortium portant sur 319 613 personnes dont 25 803 sont atteintes d'un cancer, cette méta-analyse évalue l'association entre la dépression ou l'anxiété et le risque de cancer par localisation

Depression, anxiety, and the risk of cancer: An individual participant data meta-analysis

van Tuijl, Lonneke A. ; Basten, Maartje ; Pan, Kuan-Yu ; Vermeulen, Roel ; Portengen, Lützen ; de Graeff, Alexander ; Dekker, Joost ; Geerlings, Mirjam I. ; Hoogendoorn, Adriaan ; Lamers, Femke ; Voogd, Adri C. ; Abell, Jessica ; Awadalla, Philip ; Beekman, Aartjan T. F. ; Bjerkeset, Ottar ; Boyd, Andy ; Cui, Yunsong ; Frank, Philipp ; Galenkamp, Henrike ; Garssen, Bert ; Hellingman, Sean ; Huisman, Martijn ; Huss, Anke ; de Jong, Trynke R. ; Keats, Melanie R. ; Kok, Almar A. L. ; Krokstad, Steinar ; van Leeuwen, Flora E. ; Luik, Annemarie I. ; Noisel, Nolwenn ; Onland-Moret, N. Charlotte ; Payette, Yves ; Penninx, Brenda W. J. H. ; Rissanen, Ina ; Roest, Annelieke M. ; Ruiter, Rikje ; Schoevers, Robert A. ; Soave, David ; Spaan, Mandy ; Steptoe, Andrew ; Stronks, Karien ; Sund, Erik R. ; Sweeney, Ellen ; Twait, Emma L. ; Teyhan, Alison ; Verschuren, W. M. Monique ; van der Willik, Kimberly D. ; Rosmalen, Judith G. M. ; Ranchor, Adelita V.

Background: Depression and anxiety have long been hypothesized to be related to an increased cancer risk. Despite the great amount of research that has been conducted, findings are inconclusive. To provide a stronger basis for addressing the associations between depression, anxiety, and the incidence of various cancer types (overall, breast, lung, prostate, colorectal, alcohol-related, and smoking-related cancers), individual participant data (IPD) meta-analyses were performed within the [...]

Menée en Finlande à l'aide d'échantillons d'ADN mitochondrial collectés auprès de 107 témoins et 107 patients atteints d'un lymphome non hodgkinien, cette étude analyse l'association entre la proportion de l'ADN mitochondrial présentant des fragmentations et le risque de développer la maladie

Mitochondrial DNA Fragmentation and Risk of Non-Hodgkin Lymphoma

Hosgood, H. Dean, III ; Davitt, Meghan ; Cawthon, Richard ; Weinstein, Stephanie J. ; Blechter, Batel ; Wong, Jason Y.Y. ; Rahman, Mohammad L. ; Hu, Wei ; Mannisto, Satu ; Albanes, Demetrius ; Rothman, Nathaniel ; Lan, Qing

Research suggests that increased mitochondrial DNA copy number (mtDNAcn) is associated with increased risk of non-Hodgkin lymphoma (NHL); however, no studies to date have evaluated whether the mitochondrial DNA fraction with breaks (mtDNAfb) is associated with risk of NHL.To evaluate the association of mtDNAfb with NHL risk.This nested case-control study, which used prospectively collected samples as part of baseline enrollment (from 1985 through 1988) of 29 133 men who smoked for the [...]

Menée à l'aide de donnée de la "Multiethnic Cohort" portant 192 424 personnes (durée moyenne de suivi : 19,2 ans), cette étude analyse l'association entre l'indice de masse corporelle, un diabète de type 2 et le risque de lymphome non hodgkinien (3 472 cas)

Association of Obesity and Type 2 Diabetes with Non-Hodgkin Lymphoma: The Multiethnic Cohort

Maskarinec, Gertraud ; Brown, Sayaka M. ; Lee, Jordyn ; Bogumil, David ; Walsh, Catherine ; Haiman, Christopher A. ; Setiawan, Veronica Wendy. ; Shvetsov, Yurii B. ; Le Marchand, Loic

Background: Given the role of the immune system in Non-Hodgkin Lymphoma (NHL) etiology, obesity and type 2 diabetes (T2D) may impact NHL development. We examined the association of body mass index (BMI) and T2D with NHL in the Multiethnic Cohort (MEC). Methods: The MEC recruited >215,000 participants in Hawaii and Los Angeles from five racial/ethnic groups; NHL cases were identified through cancer registry linkages. T2D status, and BMI at age 21 and cohort entry were derived from repeated [...]

Menée à l'aide de données 2006-2020 de la "UK Biobank" portant sur 232 908 femmes, cette étude analyse l'association entre des marqueurs de la fonction rénale et le risque de cancer de l'ovaire (1 110 cas)

The Association of Kidney Function and Inflammatory Biomarkers with Epithelial Ovarian Cancer Risk

Hathaway, Cassandra A. ; Townsend, Mary K. ; Sklar, Elliot M. ; Thomas-Purcell, Kamilah B. ; Terry, Kathryn L. ; Trabert, Britton ; Tworoger, Shelley S.

Background: One of the mechanisms of ovarian tumorigenesis is through inflammation. Kidney dysfunction is associated with increased inflammation; thus we assessed its relationship with ovarian cancer risk. Methods: In prospectively collected samples, we evaluated the association of kidney function markers and C reactive protein (CRP) with ovarian cancer risk in the UK Biobank. We used multivariable-adjusted Cox proportional hazards models to evaluate quartiles of serum and urine markers with [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2021 (6 études, 15 211 patients), cette méta-analyse évalue l'association entre le somatotype avant l'âge de 18 ans et le risque de cancer du sein

Dose response relationship between breast cancer and somatotypes during childhood: a systematic review and meta-analysis

Dou, Yuqi ; Chen, Botian ; Yu, Xue ; Xin, Qinghua ; Ma, Defu

Objectives: This study aims to evaluate the relationship between breast cancer and somatotypes during early life by meta-analysis and give the corresponding advice. Methods: Observational studies till April 5, 2021, which explore women with/without breast cancer who used the Stunkard Figure Rating Scale/Sørensen Somatotypes to evaluate their somatotype before 18 years of age and distant breast cancer risk were included. Using random/fixed-effect models, the pooled relative risks (RRs) and 95% [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de la "UK Biobank" portant sur 345 caractères génétiques héréditaires, cette étude évalue leur association avec le risque de cancer du poumon

Heritable Traits and Lung Cancer Risk: A Two-Sample Mendelian Randomization Study

Pettit, Rowland W. ; Byun, Jinyoung ; Han, Younghun ; Ostrom, Quinn T. ; Coarfa, Cristian ; Bondy, Melissa L. ; Amos, Christopher I.

Introduction: Lung cancer is a complex polygenic disorder. Analysis with Mendelian randomization (MR) allows for genetically predicted risks to be estimated between exposures and outcomes. Methods: We analyzed 345 heritable traits from the United Kingdom biobank and estimated their associated effects on lung cancer outcomes using two sample MR. In addition to estimating effects with overall lung cancer, adenocarcinoma, small cell and squamous cell lung cancers, we performed conditional effect [...]

Menée à partir de données d'études d'association sur le génome entier, cette étude examine la relation entre le tabagisme, la méthylation de l'ADN et le risque de cancer colorectal

Dissecting the pathogenic effects of smoking and its hallmarks in blood DNA methylation on colorectal cancer risk

Zhou, Xuan ; Xiao, Qian ; Jiang, Fangyuan ; Sun, Jing ; Wang, Lijuan ; Yu, Lili ; Zhou, Yajing ; Zhao, Jianhui ; Zhang, Han ; Yuan, Shuai ; Timofeeva, Maria ; Spiliopoulou, Athina ; Mesa-Eguiagaray, Ines ; Farrington, Susan M. ; Law, Philip J. ; Houlston, Richard S. ; Ding, Kefeng ; Dunlop, Malcolm G. ; Theodoratou, Evropi ; Li, Xue

Background : Tobacco smoking is suggested as a risk factor for colorectal cancer (CRC), but the complex relationship and the potential pathway are not fully understood. Methods : We performed two-sample Mendelian randomisation (MR) analyses with genetic instruments for smoking behaviours and related DNA methylation in blood and summary-level GWAS data of colorectal cancer to disentangle the relationship. Colocalization analyses and prospective gene-environment interaction analyses were also [...]