Menée à l'aide de données danoises portant sur 41 928 personnes (durée médiane de suivi : 15 ans), cette étude analyse l'association entre une consommation d'aliments biologiques et le risque de cancer (9 675 cas)

Organic food consumption and the incidence of cancer in the Danish diet, cancer and health cohort

Andersen, Julie Louise Munk ; Frederiksen, Kirsten ; Hansen, Johnni ; Kyrø, Cecilie ; Overvad, Kim ; Tjønneland, Anne ; Olsen, Anja ; Raaschou-Nielsen, Ole

Purpose: Expected beneficial health effects is a major reason why people purchase organically produced foods, although the existing evidence is limited. We investigated if organic food consumption, overall and by specific food groups, is associated with the incidence of cancer. Methods: We used data from the Danish Diet, Cancer and Health cohort. Organic food consumption was reported for vegetables, fruits, dairy products, eggs, meat, and bread and cereal products. Consumption was summarized [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2022 (29 études, 18 836 patients), cette méta-analyse évalue l'association entre le type de viande consommée et le risque de cancer de la vessie

Meat Intake and the Risk of Bladder Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Yu, Jinchuan ; Li, Haigui ; Liu, Zhengxiang ; Wang, Ting ; Zhou, Fuding ; Ma, Shaodi ; Chen, Baochun ; Chen, Wenjun

The evidence for the association between meat intake and the risk of bladder cancer (BC) is still inconclusive. A total of 29 studies involving 1,475,125 participants and 18,836 cases of BC were included in the meta-analysis. Among these studies, 11 reported total meat intake, 20 reported red meat intake, 19 reported processed meat intake, 15 reported white meat intake, and 15 reported fish intake. The results suggested that there was an overall increase in BC risk associated with total meat [...]

Menée à partir de données d'incidences 2010-2016 de six régions du Kenya, de l'Ouganda et de la Tanzanie, cette étude analyse l'association entre une exposition au parasite du paludisme Plasmodium falciparum chez les enfants et le risque de lymphome endémique de Burkitt

Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falciparum infections in Uganda, Tanzania, and Kenya

Broen, Kelly ; Dickens, Joey ; Trangucci, Rob ; Ogwang, Martin D. ; Tenge, Constance N. ; Masalu, Nestory ; Reynolds, Steven J. ; Kawira, Esther ; Kerchan, Patrick ; Were, Pamela A. ; Kuremu, Robert T. ; Wekesa, Walter N. ; Kinyera, Tobias ; Otim, Isaac ; Legason, Ismail D. ; Nabalende, Hadija ; Buller, Ian D. ; Ayers, Leona W. ; Bhatia, Kishor ; Biggar, Robert J. ; Goedert, James J. ; Wilson, Mark L. ; Mbulaiteye, Sam M. ; Zelner, Jon

Endemic Burkitt lymphoma (eBL) is a pediatric cancer coendemic with malaria in sub-Saharan Africa, suggesting an etiological link between them. However, previous cross-sectional studies of limited geographic areas have not found a convincing association. We used spatially detailed data from the Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM) study to assess this relationship. EMBLEM is a case–control study of eBL from 2010 through 2016 in six regions of Kenya, [...]

Menée à partir de données 1984-2015 de registres scandinaves portant sur 3 303 880 femmes (durée moyenne de suivi : 14,4 personnes-années), cette étude analyse l'association entre un recours aux techniques de reproduction assistée et le risque de cancer de l'ovaire (2 683 cas)

Risk of ovarian cancer in women who give birth after assisted reproductive technology (ART)—a registry-based Nordic cohort study with follow-up from first pregnancy

Sandvei, Marie Søfteland ; Pinborg, Anja ; Gissler, Mika ; Bergh, Christina ; Romundstad, Liv Bente ; van Leeuwen, Flora E. ; Spaan, Mandy ; Tiitinen, Aila ; Wennerholm, Ulla-Britt ; Henningsen, Anna-Karina ; Opdahl, Signe

Background: There is concern that assisted reproductive technology (ART) may increase ovarian cancer risk, but previous studies are inconclusive. We compared ovarian cancer risk for women who gave birth after ART vs natural conception. Methods: Through linkage of nationwide registry data, we followed 3,303,880 initially nulliparous women in Denmark (1994–2014), Finland (1990–2014), Norway (1984–2015) and Sweden (1985–2015) from first pregnancy ≥22 weeks to ovarian cancer, emigration, death or [...]

Menée à l'aide de données internationales portant sur 2 211 femmes présentant un variant pathogène de BRCA1/2, cette étude analyse leur risque de développer un cancer entre 50 et 75 ans (379 cas)

The risks of cancer in older women with BRCA pathogenic variants: How far have we come?

Metcalfe, Kelly A. ; Gronwald, Jacek ; Tung, Nadine M. ; McCuaig, Jeanna M. ; Eisen, Andrea ; Elser, Christine ; Foulkes, William D. ; Neuhausen, Susan L. ; Senter, Leigha ; Moller, Pal ; Bordeleau, Louise ; Fruscio, Robert ; Velsher, Lea ; Zakalik, Dana ; Olopade, Olufunmilayo I. ; Eng, Charis ; Pal, Tuya ; Cullinane, Carey A. ; Couch, Fergus J. ; Kotsopoulos, Joanne ; Sun, Ping ; Lubinski, Jan ; Narod, Steven A.

Background: The purpose of this study was to estimate the cumulative risks of all cancers in women from 50 to 75 years of age with a BRCA1 or BRCA2 pathogenic variant. Methods: Participants were women with BRCA1 or BRCA2 pathogenic variants from 85 centers in 16 countries. Women were eligible if they had no cancer before the age of 50 years. Participants completed a baseline questionnaire and follow-up questionnaires every 2 years. Women were followed from age 50 until a diagnosis of cancer, [...]

Cette étude passe en revue les données actuelles sur l'association entre un diabète sucré et le risque de cancer du pancréas

The relationship between diabetes mellitus and pancreatic cancer - Diabetes mellitus as a red flag for pancreatic cancer

Popovic, Katarina ; Smolović, Brigita ; Martinović, Milica ; Vučković, Ljiljana

The relationship between diabetes mellitus (DM) and pancreatic cancer is complex- DM is both a risk factor and early sign of pancreatic cancer. DM is a risk factor for pancreatic cancer because it increases insulin resistance, intrapancreatic concentrations of insulin, and the bioavailability of IGF, subsequently promoting ductal cell proliferation. Accordingly, treatment targeting the insulin/IGF pathway is the focus of many researchers. Antidiabetic drugs modify the risk for pancreatic [...]

Menée à partir de données de consortia portant sur 44 346 témoins et 33 756 patients atteints d'un cancer colorectal, cette étude d'association sur le génome entier identifie de nouveaux loci de susceptibilité au cancer colorectal lié au tabagisme

Genome-wide interaction study with smoking for colorectal cancer risk identifies novel genetic loci related to tumor suppression, inflammation and immune response

Carreras-Torres, Robert ; Kim, Andre E. ; Lin, Yi ; Díez-Obrero, Virginia ; Bien, Stephanie A. ; Qu, Conghui ; Wang, Jun ; Dimou, Niki ; Aglago, Elom Kouassivi ; Albanes, Demetrius ; Arndt, Volker ; Baurley, James W. ; Berndt, Sonja I. ; Bézieau, Stéphane ; Bishop, D Timothy. ; Bouras, Emmanouil ; Brenner, Hermann ; Budiarto, Arif ; Campbell, Peter T. ; Casey, Graham ; Chan, Andrew T. ; Chang-Claude, Jenny ; Chen, Xuechen ; Conti, David V. ; Dampier, Christopher H. ; Devall, Matthew AM. ; Drew, David A. ; Figueiredo, Jane C. ; Gallinger, steven ; Giles, Graham G. ; Gruber, Stephen B. ; Gsur, Andrea ; Gunter, Marc J. ; Harrison, Tabitha A. ; Hidaka, Akihisa ; Hoffmeister, Michael ; Huyghe, Jeroen R. ; Jenkins, Mark A. ; Jordahl, Kristina M. ; Kawaguchi, Eric ; Keku, Temitope O. ; Kundaje, Anshul ; Le Marchand, Loic ; Lewinger, Juan Pablo ; Li, Li ; Mahesworo, Bharuno ; Morrison, John L. ; Murphy, Neil ; Nan, Hongmei ; Nassir, Rami ; Newcomb, Polly A. ; Obón-Santacana, Mireia ; Ogino, Shuji ; Ose, Jennifer ; Pai, Rish K. ; Palmer, Julie R. ; Papadimitriou, Nikos ; Pardamean, Bens ; Peoples, Anita R. ; Pharoah, Paul D.P. ; Platz, Elizabeth A. ; Rennert, Gad ; Ruiz-Narvaez, Edward ; Sakoda, Lori C. ; Scacheri, Peter C. ; Schmit, Stephanie L. ; Schoen, Robert E. ; Shcherbina, Anna ; Slattery, Martha L. ; Stern, Mariana C. ; Su, Yu-Ru ; Tangen, Catherine M. ; Thomas, Duncan C. ; Tian, Yu ; Tsilidis, Konstantinos K. ; Ulrich, Cornelia M. ; van Duijnhoven, Fränzel J B. ; Van Guelpen, Bethany ; Visvanathan, Kala ; Vodicka, Pavel ; Cenggoro, Tjeng Wawan ; Weinstein, Stephanie J. ; White, Emily ; Wolk, Alicja ; Woods, Michael O. ; Hsu, Li ; Peters, Ulrike ; Moreno, Víctor ; Gauderman, W James.

Background: Tobacco smoking is an established risk factor for colorectal cancer (CRC). However, genetically-defined population subgroups may have increased susceptibility to smoking-related effects on CRC. Methods: A genome-wide interaction scan was performed including 33,756 CRC cases and 44,346 controls from three genetic consortia. Results: Evidence of an interaction was observed between smoking status (ever vs never smokers) and a locus on 3p12.1 (rs9880919, p=4.58x10-8), with higher [...]

Menée en Allemagne sur la période 2003-2017 auprès de 9 169 personnes (âge médian : 69 ans ; 61 % d'hommes), cette étude analyse l'association entre l'indice de masse corporelle et le risque de cancer colorectal, en fonction du score de risque polygénique

Assessment of Body Mass Index, Polygenic Risk Score, and Development of Colorectal Cancer

Chen, Xuechen ; Li, Hengjing ; Mandic, Marko ; Hoffmeister, Michael ; Brenner, Hermann

Excess weight, the prevalence of which is high and increasing in many countries, is linked to multiple adverse health outcomes, including increased colorectal cancer (CRC) risk. Better communication of health risks associated with excess weight might support efforts of prevention.To evaluate the individual and joint associations of body mass index (BMI) and polygenic risk with CRC, to assess potential interactions among them, and to quantify by how much increased polygenic risk for CRC can be [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2022 (20 études), cette méta-analyse évalue l'association entre l'eczéma et le risque de cancer du cerveau en fonction de l'âge

Eczema as a protective factor for brain cancer: a meta-analysis

Zhu, Yun ; Teng, Yirong ; Xu, Shuangyan ; Xu, Yinde ; Zhu, Boheng ; Yan, Weimin ; Liu, Jie

Background: Brain cancer is one of the most aggressive cancer types owing to poor treatment effects. Epidemiological studies have demonstrated that allergies may increase the disease risk. Therefore, this study evaluated the association between eczema and the risk of various brain cancers. Methods: We systematically searched the PubMed and Embase databases from their inception until June 23, 2022. Two reviewers independently reviewed and screened the articles, extracted data, assessed the study [...]