Menée à partir de données de la "UK Biobank" portant sur 399 575 personnes (âge moyen : 56,2 ans : 55 % de femmes ; durée moyenne de suivi : 11,8 ans), cette étude analyse l'association entre la présence conjointe de deux facteurs (adiposité et consommation d'alcool) et le risque de cancer lié à l'alcool (17 617 cas) et à l'obésité (20 214 cas)

Joint association of alcohol consumption and adiposity with alcohol- and obesity-related cancer in a population sample of 399,575 UK adults

Inan-Eroglu, Elif ; Huang, Bo-Huei ; Sarich, Peter ; Nassar, Natasha ; Stamatakis, Emmanuel

Obesity and alcohol consumption are both important modifiable risk factors for cancer. We examined the joint association of adiposity and alcohol consumption with alcohol- and obesity-related cancer incidence. This prospective cohort study included cancer-free UK Biobank participants aged 40–69 years. Alcohol consumption was categorised based on current UK guidelines into four groups. We defined three markers of adiposity: body fat percentage (BF %), waist circumference and BMI and categorised [...]

Menée notamment à partir de données des registres américains des cancers portant sur les adultes atteints d'un cancer colorectal d'apparition précoce diagnostiqué sur la période 1977-2016, cette étude analyse l'association entre des facteurs alimentaires, le tabagisme ou la consommation d'alcool et l'augmentation de l'incidence de la maladie depuis les années 1990

Dietary Factors and Early-Onset Colorectal Cancer in the United States—an Ecologic Analysis

Chen, Jianjiu ; Zhang, Isabella L. ; Terry, Mary Beth ; Yang, Wan

Incidence of early-onset colorectal cancer (EOCRC; e.g., diagnosed before age 50) in the United States has increased substantially since the 1990s but the underlying reasons remain unclear.We examined the ecologic associations between dietary factors and EOCRC incidence in adults aged 25–49 during 1977–2016 in the United States, using negative binomial regression models, accounting for age, period, and race. The models also incorporated an age-mean centering (AMC) approach to address potential [...]

Menée en Italie auprès de 305 témoins et 304 patients atteints d'un mélanome cutané, cette étude analyse l'association entre une exposition professionnelle à l'arsenic, au mercure ou aux ultraviolets et le risque de développer la maladie

Occupational exposure to arsenic, mercury and UV radiation and risk of melanoma: a case–control study from Italy

Collatuzzo, Giulia ; Boffetta, Paolo ; Dika, Emi ; Visci, Giovanni ; Zunarelli, Carlotta ; Mastroeni, Simona ; Antonelli, Gianluca ; Fortes, Cristina

Background: Melanoma is mainly caused by sunlight radiation, but other environmental risk factors are not well known. We investigated the association between cutaneous melanoma and occupational exposure to arsenic, mercury and UV radiation. Methods: A hospital-based case–control study was conducted in the inpatient wards of IDI-San Carlo Rome, Italy, including 304 incident cases of cutaneous melanoma and 305 frequency-matched controls. Detailed sociodemographic, clinical and host-related [...]

Menée à partir de données de 6 cohortes européennes portant au total sur 199 719 femmes, cette étude analyse l'association entre une exposition à la pollution de l'air (NO2, PM 2.5, carbone suie, O3) et le risque de cancer du sein (9 659 cas)

Breast Cancer Incidence in Relation to Long-Term Low-Level Exposure to Air Pollution in the ELAPSE Pooled Cohort

Hvidtfeldt, Ulla Arthur ; Chen, Jie ; Rodopoulou, Sophia ; Strak, Maciej ; de Hoogh, Kees ; Andersen, Zorana J. ; Bellander, Tom ; Brandt, Jørgen ; Fecht, Daniela ; Forastiere, Francesco ; Gulliver, John ; Hertel, Ole ; Hoffmann, Barbara H. ; Katsouyanni, Klea ; Ketzel, Matthias ; Brynedal, Boel ; Leander, Karin ; Ljungman, Petter L.S. ; Magnusson, Patrik K.E. ; Nagel, Gabriele ; Pershagen, Göran ; Rizzuto, Debora ; Boutron-Ruault, Marie-Christine ; Samoli, Evangelia ; So, Rina ; Stafoggia, Massimo ; Tjønneland, Anne ; Vermeulen, Roel ; Verschuren, W.M. Monique ; Weinmayr, Gudrun ; Wolf, Kathrin ; Zhang, Jiawei ; Zitt, Emanuel ; Brunekreef, Bert ; Hoek, Gerard ; Raaschou-Nielsen, Ole

Established risk factors for breast cancer include genetic disposition, reproductive factors, hormone therapy, and lifestyle-related factors such as alcohol consumption, physical inactivity, smoking, and obesity. More recently a role of environmental exposures, including air pollution, has also been suggested. The aim of this study, was to investigate the relationship between long-term air pollution exposure and breast cancer incidence.We conducted a pooled analysis among six European cohorts [...]

Menée sur la période 2016-2018 auprès de 234 témoins et 117 patients atteints d'un cancer du foie (âge moyen : 62,7 ans ; 68 % d'hommes), cette étude analyse l'association entre une consommation d'opium et le risque de développer la maladie

Opium Use and the Risk of Liver Cancer: A Case–Control Study

Marzban, Maryam ; Mohebbi, Elham ; Haghdoost, AliAkbar ; Aryaie, Mohammad ; Zahedi, Mohammad Javad ; Khazaei, Zaher ; Gholizade, Mohamad ; Naghibzadeh-Tahami, Ahmad

Limited evidence is available to acknowledge the association between opium use and liver cancer. In a case–control study, we recruited 117 cases of primary liver cancer (PLC) and 234 age and sex-matched neighborhood controls from 2016 to 2018. We calculated odds ratios (OR) for opium use and 95% confidence intervals (95% CI), using conditional logistic regressions. Compared with non-users the adjusted OR (AOR, 95% CI) for opium use was 6.5 (95% CI, 2.87–13.44). Compared with people who had no [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2022 (11 études), cette méta-analyse évalue l'association entre une utilisation d'inhibiteurs de l'enzyme de conversion de l'angiotensine (IECA) et le risque de cancer du poumon

Association between angiotensin-converting enzyme inhibitors and the risk of lung cancer: a systematic review and meta-analysis

Wu, Zhenchao ; Yao, Taikang ; Wang, Zilu ; Liu, Beibei ; Wu, Nan ; Lu, Ming ; Shen, Ning

Background: The association between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung cancer risk remains controversial. This study evaluated the association between the use of ACEIs and lung cancer risk. Methods: Records from five databases were searched from inception to 26 January 2022. Clinical studies involving persons aged ≥18 years with at least one year of follow-up and reporting adverse events, including lung cancer, were recorded with separate outcome reports [...]

Menée au Danemark à partir de données 1978-2018 du registre national des pathologies portant sur 5 000 patientes présentant une tumeur de l'ovaire à la limite de la malignité (durée de suivi : jusqu'à 41 ans), cette étude analyse le risque de développer un cancer non ovarien chez ces femmes par rapport à la population générale

Risk of non-ovarian cancer in a nationwide-based study of nearly 5,000 women with borderline ovarian tumors in Denmark

Hannibal, Charlotte G. ; Baandrup, Louise ; Hertzum-Larsen, Rasmus ; Vang, Russell ; Kurman, Robert J. ; Frederiksen, Kirsten ; Kjaer, Susanne K.

Evidence regarding cancer risk after borderline ovarian tumors (BOTs) is limited. We conducted a nationwide cohort study examining the incidence of non-ovarian cancers in women with serous or mucinous BOTs compared to the general female population with up to 41 years of follow-up. Through the nationwide Pathology Registry, we identified nearly 5,000 women with BOTs (2,506 serous and 2,493 mucinous) in Denmark, 1978–2018. We computed standardized incidence ratios (SIRs) with 95% confidence [...]

Menée à partir de données de l'Assurance maladie coréenne portant sur 6 795 738 personnes ayant réalisé un examen de santé en 2009 (durée moyenne de suivi : 8,2 ans), cette étude analyse l'association entre la présence d'un syndrome métabolique et le risque de carcinome épidermoïde de l'oesophage (6 414 cas)

Association Between Metabolic Syndrome and Risk of Esophageal Cancer: a Nationwide Population-Based Study

Lee, Ji Eun ; Han, Kyungdo ; Yoo, Juhwan ; Yeo, Yohwan ; Cho, In Young ; Cho, Belong ; Park, Jin-ho ; Shin, Dong Wook ; Cho, Jong Ho ; Park, Yong-Moon

Metabolic syndrome (MetS) is believed to increase the risk of esophageal cancer. However, most studies have been conducted in Western countries, focusing on esophageal adenocarcinoma (EAC). We aimed to investigate the association between MetS and risk of esophageal cancer in nationally representative large dataset in Korea, where esophageal squamous cell carcinoma (ESCC) is predominant.We analyzed the health examinations and claims data from the Korean National Health Insurance Service (NHIS). [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données 1995-2017 portant sur 62 453 Norvégiens (durée médiane de suivi : 21,1 ans), cette étude analyse l'association entre l'indice de masse corporelle et le risque de cancer du poumon (1 009 cas)

Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches

Jiang, Lin ; Sun, Yi-Qian ; Brumpton, Ben Michael ; Langhammer, Arnulf ; Chen, Yue ; Mai, Xiao-Mei

Background: Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may clarify the nature of the association. Aims: We studied the causal association between BMI and lung cancer incidence using observational and MR approaches. Methods: We followed up 62,453 cancer-free Norwegian adults from 1995–97 (HUNT2) until 2017. BMI at baseline in HUNT2 was [...]

Menée auprès de 1 010 témoins et 1 010 patients atteints d'un cancer colorectal (durée médiane de suivi : 12,3 ans); cette étude analyse l'association entre les niveaux circulants de la ghréline ou du peptide YY et le risque de cancer colorectal, par sous-type anatomique et moléculaire

Plasma concentrations of gut hormones acyl ghrelin and Peptide YY and subsequent risk of colorectal cancer and molecular tumor subtypes

Bodén, Stina ; Harbs, Justin ; Sundkvist, Anneli ; Fuchs, Klara ; Myte, Robin ; Gylling, Björn ; Zingmark, Carl ; Löfgren Burström, Anna ; Palmqvist, Richard ; Harlid, Sophia ; Van Guelpen, Bethany

Obesity and metabolic dysfunction are implicated in colorectal cancer development. Appetite-regulating gut hormones might have a role in colorectal cancer risk. We investigated whether circulating levels of the gut hormones ghrelin (analyzed as acyl ghrelin) and Peptide YY (PYY) were associated with subsequent colorectal cancer risk, including clinical and molecular tumor subtypes. We also provide descriptive data on these hormones in relation to background participant characteristics and [...]