Cette étude passe en revue la littérature publiée entre 2017 et 2021 (62 articles) concernant l'association entre une exposition aux pesticides et le risque de cancer

Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans, and paths forward

Cavalier, Haleigh ; Trasande, Leonardo ; Porta, Miquel

Knowledge on the role in cancer etiology of environmental exposures as pesticides is a pre-requisite for primary prevention. We review 62 epidemiological studies on exposure to pesticides and cancer risk in humans published from 2017 to 2021, with emphasis on new findings, methodological approaches, and gaps in the existing literature. While much of the recent evidence suggests causal relationships between pesticide exposure and cancer, the strongest evidence exists for acute myeloid leukemia [...]

Menée à l'aide de données 2000-2017 de plusieurs registres américains portant sur 247 318 patients ayant reçu une greffe d'organe, cette étude analyse l'association entre une infection par le cytomégalovirus (CMV) et le risque de cancer

Cancer risk associated with cytomegalovirus infection among solid organ transplant recipients in the United States

Geris, Jennifer M. ; Spector, Logan G. ; Pfeiffer, Ruth M. ; Limaye, Ajit P. ; Yu, Kelly J. ; Engels, Eric A.

Background: Cytomegalovirus (CMV) is among the most common viral infections after solid organ transplantation (SOT). Associations of CMV with cancer risk among SOT recipients have been incompletely evaluated. Methods: The authors used linked data from the US SOT registry and 32 cancer registries. Poisson regression was used to compare cancer incidence across CMV risk groups based on donor (D) and recipient (R) immunoglobulin G (IgG) serostatus: high risk (R-negative/D-positive), moderate risk [...]

Menée à partir de données des cohortes "the Nurses’ Health Study" et "the Health Professionals Follow-Up Study" portant sur 253 740 personnes (durée de suivi : jusqu'à 28 ans), cette étude analyse l'association entre des agents antihypertenseurs ou l'hypertension et le risque de cancer colorectal (5 671 cas) ainsi que la mortalité spécifique, en fonction de la durée d'utilisation des antihypertenseurs

Long-term use of antihypertensive medications, hypertension and colorectal cancer risk and mortality: a prospective cohort study

Zhang, Yin ; Song, Mingyang ; Chan, Andrew T. ; Meyerhardt, Jeffrey A. ; Willett, Walter C. ; Giovannucci, Edward L.

Background: Hypertension and the use of antihypertensive medications have been intensively investigated in relation to colorectal cancer (CRC). Prior epidemiologic studies have not been able to examine this topic with adequate confounding control and follow-up time, or disentangle the effects of antihypertensive agents and hypertension. Methods: Eligible participants in the Nurses’ Health Study and Health Professionals Follow-up Study were followed for up to 28 years, with repeat assessments of [...]

Menée sur la période 2012-2019 auprès de 3 783 personnes présentant des variants pathogènes de CHEK2 (91 % de femmes), cette étude compare les phénotypes des cancers en fonction des variants

Differences in Cancer Phenotypes Among Frequent CHEK2 Variants and Implications for Clinical Care—Checking CHEK2

Bychkovsky, Brittany L. ; Agaoglu, Nihat B. ; Horton, Carolyn ; Zhou, Jing ; Yussuf, Amal ; Hemyari, Parichehr ; Richardson, Marcy E. ; Young, Colin ; LaDuca, Holly ; McGuinness, Deborah L. ; Scheib, Rochelle ; Garber, Judy E. ; Rana, Huma Q.

Germline CHEK2 pathogenic variants (PVs) are frequently detected by multigene cancer panel testing (MGPT), but our understanding of PVs beyond c.1100del has been limited.To compare cancer phenotypes of frequent CHEK2 PVs individually and collectively by variant type.This retrospective cohort study was carried out in a single diagnostic testing laboratory from 2012 to 2019. Overall, 3783 participants with CHEK2 PVs identified via MGPT were included. Medical histories of cancer in participants [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2022 (8 études), cette méta-analyse évalue le risque de second cancer chez les hommes ayant survécu à un cancer du sein

Risk of developing a second primary cancer in male breast cancer survivors: a systematic review and meta-analysis

Allen, Isaac ; Hassan, Hend ; Sofianopoulou, Eleni ; Eccles, Diana ; Turnbull, Clare ; Tischkowitz, Marc ; Pharoah, Paul ; Antoniou, Antonis C.

Background: With increasing survival after cancer diagnoses, second primary cancers (SPCs) are becoming more prevalent. We investigated the incidence and site of non-breast SPC risks following male breast cancer (BC). Methods: PubMed, Embase and Web of Science were systematically searched for studies reporting standardised incidence ratios (SIRs) for SPCs published by March 2022. Meta-analyses used the generic inverse-variance method, assuming a random-effects model. We evaluated SIRs for [...]

Menée à l'aide de données de registres de 4 pays nordiques portant sur 67 903 témoins et 7 425 patientes atteintes d'un cancer de la thyroïde diagnostiqué au moins 2 ans après le dernier accouchement, cette étude analyse l'association entre des caractéristiques périnatales et le risque pour les patientes de développer la maladie

Maternal health, pregnancy and offspring factors, and maternal thyroid cancer risk: a Nordic population-based registry study

Kitahara, Cari M ; Daltveit, Dagrun Slettebø ; Ekbom, Anders ; Engeland, Anders ; Gissler, Mika ; Glimelius, Ingrid ; Grotmol, Tom ; Lagerros, Ylva Trolle ; Madanat-Harjuoja, Laura ; Männistö, Tuija ; Sørensen, Henrik Toft ; Troisi, Rebecca ; Bjørge, Tone

Thyroid cancer incidence is higher in women than men, especially during the reproductive years, for reasons that remain poorly understood. Using population-based registry data from four Nordic countries through 2015, we examined associations of perinatal characteristics with risk of maternal thyroid cancer. Cases were women diagnosed with thyroid cancer ≥2 years after last birth (n=7,425, 83% papillary). Cases were matched to controls (n=67,903) by mother’s birth year, country, and county of [...]

A partir d'une revue systématique de la littérature publiée entre 2017 et 2022 (38 articles), cette étude identifie les facteurs associés au risque de développer une seconde tumeur primitive chez les patients atteints d'un cancer de la tête et du cou

Factors associated with the development of second primary tumours in head and neck cancer patients

Salcedo-Bellido, Inmaculada ; Requena, Pilar ; Mateos, Rocío ; Ortega-Rico, Carmen ; Olmedo-Requena, Rocío ; Lozano-Lorca, Macarena ; Arrebola, Juan Pedro ; Barrios-Rodríguez, Rocío

Introduction: The development of second primary tumours (SPTs) is one of the main causes of low survival in patients with head and neck cancer (HNC). The aim of this study was to review the evidence about factors associated with developing SPTs in patients with HNC. Methods: An updated systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, and the search was performed in Pubmed and Scopus. Only original articles with a [...]