Menée à partir de données portant sur 252 patients atteints d'un cancer et recevant une chimiothérapie, cette étude transversale analyse la prévalence d'une constipation liée au traitement anticancéreux et évalue l'impact de cette constipation sur la qualité de vie

Prevalence of constipation in patients undergoing chemotherapy and the effect of constipation on quality of life

Pehlivan, Zeynep ; Nural, Nesrin

Objective : This study was conducted as a descriptive and cross-sectional study to determine the prevalence of constipation and the impact of constipation on quality of life in patients receiving outpatient chemotherapy. Materials and methods : The data of the study were collected from 252 patients who applied to the outpatient chemotherapy unit of a university hospital between January 2021 and March 2021. The data were collected using the “Patient Information Form,” “Eastern Cooperative [...]

A partir d'une revue systématique de la littérature (24 études qualitatives), cette étude analyse les expériences d'auto-prise en charge d'un lymphoedème chez des patientes ayant survécu à un cancer du sein

Experiences of breast cancer survivors with lymphedema self-management: a systematic review of qualitative studies

Fu, Xin ; Lu, Qian ; Pang, Dong ; Shen, Aomei ; Shih, Yi-An ; Wei, Xiaoxia

Purpose : This study systematically identified, evaluated, and synthesized qualitative literature on the experiences of breast cancer survivors with lymphedema self-management. Methods : This systematic review followed the Joanna Briggs Institute meta-aggregation approach and was guided by the ENTREQ, graded according to the ConQual approach, and evaluated using the Joanna Briggs Institute Qualitative Assessment and Review Instrument (JBI-QARI). Qualitative studies related to the experiences in [...]

Menée à partir de données portant sur 672 patients atteints d'un cancer (durée médiane de suivi : 13 mois), cette étude identifie les facteurs associés à la survenue d'événements cardiovasculaires majeurs en lien avec une utilisation d'inhibiteurs de point de contrôle immunitaire

Incidence of Cardiovascular Events in Patients Treated With Immune Checkpoint Inhibitors

Dorien Laenens ; Yuling Yu ; Béatrice Santens ; Johanna Jacobs ; Benoit Beuselinck ; Oliver Bechter ; Els Wauters ; Jan Staessen ; Stefan Janssens ; Lucas Van Aelst

PURPOSE : In rare cases, immune checkpoint inhibitors (ICIs) cause immune-mediated myocarditis. However, true incidence of other major adverse cardiovascular events (MACEs) after ICI treatment remains unknown, mainly because late occurring side effects are rarely reported in prospective clinical trials. The aims of this study were (1) to identify incidence and risk factors of MACE in a real-life ICI-treated cancer cohort and (2) to compare incidence rates with patients with cancer who are not [...]

Menée à partir des données de deux cohortes prospectives incluant un total de 1 003 patientes ayant survécu à un cancer de l'ovaire, cette étude analyse l'association entre des habitudes alimentaires, avant et après le diagnostic, et la mortalité

Pre-diagnosis and post-diagnosis dietary patterns and survival in women with ovarian cancer

Sasamoto, Naoko ; Wang, Tianyi ; Townsend, Mary K. ; Eliassen, A. Heather ; Tabung, Fred K. ; Giovannucci, Edward L. ; Matulonis, Ursula A. ; Terry, Kathryn L. ; Tworoger, Shelley S. ; Harris, Holly R.

Background : Evidence is limited on inflammation-related dietary patterns and mortality in ovarian cancer survivors. Methods : We examined the associations between pre- and post-diagnosis dietary patterns, including change in diet from before to after diagnosis, and mortality among 1003 ovarian cancer survivors in two prospective cohort studies. Dietary pattern scores for empirical dietary inflammatory pattern (EDIP) and Alternative Healthy Eating Index (AHEI) were calculated based on food [...]

Menée à partir de données portant sur des patients atteints d'un cancer de la prostate (durée médiane de suivi : 6,4 ans), cette étude analyse l'association entre des modes de vie et comportements alimentaires favorisant une hyperinsulinémie et une inflammation, et le risque de progression de la maladie ainsi que la mortalité

Post-diagnostic Inflammatory, Hyperinsulinemic, and Insulin Resistant Diets and Lifestyles and the Risk of Prostate Cancer Progression and Mortality

Langlais, Crystal S. ; Graff, Rebecca E. ; Van Blarigan, Erin L. ; Kenfield, Stacey A. ; Neuhaus, John ; Tabung, Fred K. ; Cowan, Janet E. ; Broering, Jeanette M. ; Carroll, Peter ; Chan, June M.

Background: Inflammatory and insulin pathways have been linked to prostate cancer (PC); post-diagnostic behaviors activating these pathways may lead to poor outcomes. The empirical dietary inflammation pattern (EDIP), indices for hyperinsulinemia (EDIH) and insulin resistance (EDIR), and associated lifestyle indices (ELIH, ELIR) predict biomarkers of inflammation (EDIP: IL-6, TNFaR2, CRP) and insulin secretion (EDIH/ELIH: c-peptide; EDIR/ELIR: TAG:HDL) from whole foods and behaviors. Methods: [...]

Menée à partir de données portant sur 3 322 patientes atteintes d'un cancer du sein et incluses dans un essai de phase III, cette étude d'association sur le génome entier identifie 2 loci de susceptibilité à une leucopénie ou une neutropénie après une chimiothérapie

Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Patients with Breast Cancer

Fasching, Peter A. ; Liu, Duan ; Scully, Steve ; Ingle, James N. ; Lyra, Paulo C., Jr. ; Rack, Brigitte ; Hein, Alexander ; Ekici, Arif B. ; Reis, André ; Schneeweiss, Andreas ; Tesch, Hans ; Fehm, Tanja N. ; Heinrich, Georg ; Beckmann, Matthias W. ; Ruebner, Matthias ; Huebner, Hanna ; Lambrechts, Diether ; Madden, Ebony ; Shen, Jess ; Romm, Jane ; Doheny, Kim ; Jenkins, Gregory D. ; Carlson, Erin E. ; Li, Liang ; Fridley, Brooke L. ; Cunningham, Julie M. ; Janni, Wolfgang ; Monteiro, Alvaro N.A. ; Schaid, Daniel J. ; Häberle, Lothar ; Weinshilboum, Richard M. ; Wang, Liewei

Purpose: To identify molecular predictors of grade 3/4 neutropenic or leukopenic events (NLE) after chemotherapy using a genome-wide association study (GWAS). Experimental Design: A GWAS was performed on patients in the phase III chemotherapy study SUCCESS-A (n = 3,322). Genotyping was done using the Illumina HumanOmniExpress-12v1 array. Findings were functionally validated with cell culture models and the genotypes and gene expression of possible causative genes were correlated with clinical [...]

Menée aux Etats-Unis à partir de données portant sur 30 021 patientes ayant survécu à un cancer du sein diagnostiqué entre 2000 et 2012, cette étude analyse l'effet, sur la survie spécifique à 5 ans, d'une grossesse (553 cas) ou d'un recours aux technologies de procréation assistée (189 cas)

Survival outcomes following pregnancy or assisted reproductive technologies after breast cancer: A population-based study

Rauh-Hain, J. Alejandro ; Zubizarreta, Jose ; Nitecki, Roni ; Melamed, Alexander ; Fu, Shuangshuang ; Jorgensen, Kirsten ; Brady, Paula C. ; Baker, Valerie L. ; Chavez-MacGregor, Mariana ; Giordano, Sharon H. ; Keating, Nancy L.

Background : This study sought to determine the impact of pregnancy or assisted reproductive technologies (ART) on breast-cancer-specific survival among breast cancer survivors. Methods : The authors performed a cohort study using a novel data linkage from the California Cancer Registry, the California birth cohort, and the Society for Assisted Reproductive Technology Clinic Outcome Reporting System data sets. They performed risk-set matching in women with stages I–III breast cancer diagnosed [...]

Menée aux Etats-Unis auprès de 1 327 patients atteints d'un cancer de la tête et du cou, cette étude transversale analyse la présence de problèmes liés à une consommation d'alcool et de tabac au moment du diagnostic puis analyse l'impact de ces comportements sur la qualité de vie pendant la première année suivant le diagnostic

Problem alcohol and tobacco use in head and neck cancer patients at diagnosis: associations with health-related quality of life

Howren, M. Bryant ; Christensen, Alan J. ; Pagedar, Nitin A.

Purpose : Problem alcohol and tobacco use in patients with head and neck cancer (HNC) frequently co-occur and each are associated with poor outcomes including health-related quality of life (HRQOL). The purpose of this descriptive exploratory study was to identify the prevalence of these co-occurring behaviors and associations with HNC-specific HRQOL within the first year of diagnosis in a large sample of patients with HNC. Methods : Cross-sectional study examined prevalence of co-occurring [...]

A partir d'une revue systématique de la littérature publiée entre 1990 et 2021, cette méta-analyse évalue la présence de symptômes d'anxiété et de dépression chez des patients atteints d'un cancer et stomisés

The prevalence of anxiety and depression in patients with ostomy: A systematic review and meta-analysis

Ashghali farahani, Mansoureh ; Sargolzaei, Mohammad Sadegh ; Shariatpanahi, Shabnam ; Hasanpour dehkordi, Ali ; Dalvand, Pegah ; Heidari-Beni, Farshad

Aim : The prevalence of anxiety and depression in patients with ostomy is reported differently. The aim of this systematic review and meta-analysis is to estimate the global prevalence of anxiety and depression in patients with ostomy. Method : A systematic search of Embase, Proquest, Scopus, PubMed and Web of Science (ISI) databases was conducted from January 1990 up to May 5th, 2021. A total of 3392 records were retrieved and 18 studies were ultimately included. Two reviewers independently [...]

Menée par questionnaire auprès de 209 patients atteints d'un cancer d'origine primitive inconnue, cette étude analyse l'association entre leur détresse psychologique, leur compréhension du diagnostic et leur sentiment d'incertitude vis-à-vis de la maladie

Psychological distress, understanding of cancer and illness uncertainty in patients with Cancer of Unknown Primary

Wolyniec, Kamil ; Sharp, Jessica ; Fisher, Krista ; Tothill, Richard W. ; Bowtell, David ; Mileshkin, Linda ; Schofield, Penelope

Objective : Patients diagnosed with Cancer of Unknown Primary (CUP) experience high levels of psychological distress and report poor understanding of their cancer. We aimed to investigate: (1) if CUP patients with poorer understanding of their cancer diagnosis and testing experience more symptoms of psychological distress than those with better understanding; (2) if the relationship between patients’ understanding of their cancer and psychological distress is mediated by illness uncertainty; [...]

Menée au Japon par questionnaire auprès de 388 professionnels de santé en oncologie, cette étude analyse leurs perceptions des difficultés pour prendre en charge les patients atteints d'un cancer et souffrant de troubles psychiques

Issues of cancer care in people with mental disorders as perceived by cancer care providers: A quantitative questionnaire survey

Yamada, Yuto ; Fujiwara, Masaki ; Etoh, Tsuyoshi ; Wada, Riho ; Inoue, Shinichiro ; Kodama, Masafumi ; Yoshimura, Yusaku ; Horii, Shigeo ; Matsushita, Takanori ; Fujimori, Maiko ; Shimazu, Taichi ; Nakaya, Naoki ; Hinotsu, Shiro ; Tabata, Masahiro ; Tamura, Kenji ; Uchitomi, Yosuke ; Yamada, Norihito ; Inagaki, Masatoshi

Objectives : To reduce cancer care disparities, this study aimed to clarify the difficulties in cancer care for people with mental disorders as perceived by cancer care providers. Methods : Cancer care providers at 17 designated cancer hospitals in Japan were surveyed using mail questionnaires. Respondents were asked to rate 29 items related to difficulties or insufficiencies in cancer care for patients with mental disorders on a five-point Likert scale. We analyzed the proportion of [...]

Menée aux Etats-Unis par questionnaire auprès de 88 patients atteints d'un cancer colorectal, cette étude analyse l'association entre des symptômes d'anxiété ou de dépression et l'intensité de la douleur, de la fatigue ou le niveau de protéine C réactive

Depression and anxiety in colorectal cancer patients: Ties to pain, fatigue, and inflammation

Renna, Megan E. ; Shrout, M. Rosie ; Madison, Annelise A. ; Alfano, Catherine M. ; Povoski, Stephen P. ; Lipari, Adele M. ; Carson III, William E. ; Malarkey, William B. ; Kiecolt-Glaser, Janice K.

Objective : Colorectal cancer poses a significant threat to both psychological and physical health. This study examined relationships between anxiety and depressive symptoms with pain, fatigue, and inflammation among colorectal patients. Methods : Colorectal cancer patients (n = 88, stages 0-IV) completed a laboratory-based study visit before undergoing adjuvant cancer treatment. Patients completed questionnaires assessing depressive, anxiety, pain, and fatigue symptoms. A blood sample was also [...]

Menée au Canada à partir de données portant sur 1 988 patients atteints d'un cancer du pancréas de stade avancé, cette étude compare le rapport coût-efficacité d'un traitement de première ligne combinant gemcitabine et nab-paclitaxel par rapport à une chimiothérapie de type FOLFIRINOX

Real-world cost-effectiveness of first-line gemcitabine + nab-paclitaxel versus FOLFIRINOX in patients with advanced pancreatic cancer

Arciero, Vanessa ; Luo, Jin ; Parmar, Ambica ; Dai, Wei Fang ; Beca, Jaclyn M. ; Raphael, Michael J. ; Isaranuwatchai, Wanrudee ; Habbous, Steven ; Tadrous, Mina ; Earle, Craig C. ; Biagi, Jim J. ; Mittmann, Nicole ; Arias, Jessica ; Gavura, Scott ; Chan, Kelvin K. W.

There are no randomized control trials (RCTs) comparing gemcitabine and nab-paclitaxel (Gem-Nab) and FOLFIRINOX for advanced pancreatic cancer (APC). While it is well known that RCT-based efficacy often does not translate to real-world effectiveness, there is limited literature investigating comparative cost-effectiveness of Gem-Nab versus FOLFIRINOX for APC. We aimed to examine the real-world cost-effectiveness of Gem-Nab versus FOLFIRINOX for APC in Ontario, Canada.This study compared [...]

Menée en France auprès de 117 patients atteints d'un cancer, cette étude analyse, en fonction de l'âge des patients (avant ou après 70 ans), l'intérêt d'un outil numérique pour déclarer des symptômes

Effectiveness of a digital telemonitoring platform for cancer care of older patients: the ConnectElderlyPatientToDoctor study

Rivière, Clémentine ; Brureau, Laurent ; Parnot, Charles ; Becherirat, Selma ; Duverger, Claire ; Picchi, Hugo ; Le Roy, Audrey ; Vuagnat, Perrine ; Schernberg, Antoine ; Vanquaethem, Hélène ; Helissey, Carole

While telemedicine has been shown to improve the quality of care for cancer patients, it remains underused for older patients (OP), partly due to the assumption that OPs are unabled or unwilling to use digital tools. However, more than 50% of new cancers are diagnosed in people over 70. The ConnectElderlyPatientToDoctor study aimed to evaluate the OP compliance with the use of the digital telemonitoring platform Cureety in oncology. All cancer patients followed at the Military Hospital Bégin [...]