Menée au Canada auprès de 16 752 personnes ayant été employées au cours de la période 1932-1980 dans une mine d'uranium ou dans une usine de traitement et de raffinage de radium (91,6 % d'hommes), cette étude analyse l'association entre l'exposition au radon ou aux rayons gamma et le risque de cancer du poumon (594 cas), par type histologique

Association between exposures to radon and gamma-ray radiation and histologic type of lung cancer in Eldorado uranium mining and milling workers from Canada

Zablotska, Lydia B. ; Lane, Rachel S. D. ; Randhawa, Kristi

Background: The authors assessed the association between radon decay products (RDP) exposure and histologic types of incident lung cancer in a cohort of 16,752 (91.6% male) Eldorado uranium workers who were first employed from 1932 to 1980 and were followed through 1969–1999. Methods: Substantially revised identifying information and RDP exposures were obtained on workers from the Port Radium and Beaverlodge uranium mines and from the Port Hope radium and uranium refinery and processing [...]

Menée à partir de données 1997-2016 du ministère taïwanais du travail et du registre des cancers portant sur 331 967 témoins et 3 248 patientes atteintes d'un cancer du sein, cette étude identifie des produits chimiques de l'environnement professionnel associés au risque de cancer du sein

Breast cancer incidence in a national cohort of female workers exposed to special health hazards in Taiwan: a retrospective case-cohort study of ~ 300,000 occupational records spanning 20 years

Chuang, Yun-Shiuan ; Lee, Chun-Ying ; Lin, Pei-Chen ; Pan, Chih-Hong ; Hsieh, Hui-Min ; Wu, Chia-Fang ; Wu, Ming-Tsang

Objective: Breast cancer is the most common cancer among women worldwide. In Taiwan, workers exposed to any of 31 hazardous chemicals or carcinogens in the work environment are designated as especially exposed workers (EEWs) by Taiwan’s Ministry of Labor. We assessed the risk of breast cancer in this nationwide female EEW cohort. Methods: We conducted a nationwide retrospective study of 4,774,295 workers combining data collected from Taiwan's Ministry of Labor’s EEW database between 1997 and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2021 (14 études, 24 269 patients), cette méta-analyse évalue, en fonction du traitement reçu (ténofovir ou entécavir), l'association entre une hépatite B chronique et le risque de carcinome hépatocellulaire

Risk of Hepatocellular Carcinoma With Tenofovir vs Entecavir Treatment for Chronic Hepatitis B Virus: A Reconstructed Individual Patient Data Meta-analysis

Tan, Darren Jun Hao ; Ng, Cheng Han ; Tay, Phoebe Wen Lin ; Syn, Nicholas ; Muthiah, Mark D. ; Lim, Wen Hui ; Tang, Ansel Shao Pin ; Lim, Kai En ; Lim, Grace En Hui ; Tamaki, Nobuharu ; Kim, Beom Kyung ; Teng, Margaret Li Peng ; Fung, James ; Loomba, Rohit ; Nguyen, Mindie H. ; Huang, Daniel Q.

Conventional meta-analyses with aggregated study-level data have yielded conflicting results for the comparative effectiveness of tenofovir disoproxil fumarate vs entecavir in reducing hepatocellular carcinoma (HCC) risk among patients with chronic hepatitis B virus. Within-study heterogeneity, between-study heterogeneity, and the inability of conventional meta-analyses to capture time-to-event data were associated with these results.To perform a reconstructed individual patient data [...]

Menée en Afrique de l'Est à l'aide des données de 2 études portant sur 906 témoins et 849 patients atteints d'un carcinome épidermoïde de l'oesophage, cette étude analyse l'association entre une exposition thermique lors de la consommation de thé, de café et/ou de bouillie et le risque de développer la maladie

A very-hot food and beverage thermal exposure index and esophageal cancer risk in Malawi and Tanzania: findings from the ESCCAPE case–control studies

Masukume, Gwinyai ; Mmbaga, Blandina T. ; Dzamalala, Charles P. ; Mlombe, Yohannie B. ; Finch, Peter ; Nyakunga-Maro, Gissela ; Mremi, Alex ; Middleton, Daniel R. S. ; Narh, Clement T. ; Chasimpha, Steady J. D. ; Abedi-Ardekani, Behnoush ; Menya, Diana ; Schüz, Joachim ; McCormack, Valerie

Background: Consumption of very-hot beverages/food is a probable carcinogen. In East Africa, we investigated esophageal squamous cell carcinoma (ESCC) risk in relation to four thermal exposure metrics separately and in a combined score. Methods: From the ESCCAPE case–control studies in Blantyre, Malawi (2017-20) and Kilimanjaro, Tanzania (2015-19), we used logistic regression models adjusted for country, age, sex, alcohol and tobacco, to estimate odds ratios (ORs) and 95% confidence intervals [...]

Menée auprès de 464 témoins et 173 personnes ayant survécu 5 ans à un lymphome de Hodgkin, cette étude analyse l'effet de la dose de radiothérapie thoracique reçue sur le risque de cancer du sein

Radiotherapy-related dose and irradiated volume effects on breast cancer risk among Hodgkin lymphoma survivors

Roberti, Sander ; van Leeuwen, Flora E ; Ronckers, Cécile M ; Krul, Inge M ; de Vathaire, Florent ; Veres, Cristina ; Diallo, Ibrahima ; Janus, Cécile P M ; Aleman, Berthe M P ; Russell, Nicola S ; Hauptmann, Michael

Breast cancer (BC) risk is increased among Hodgkin lymphoma (HL) survivors treated with chest radiotherapy. Case-control studies showed a linear radiation dose-response relationship for estimated dose to the breast tumor location. However, these relative risks cannot be used for absolute risk prediction of BC anywhere in the breasts. Furthermore, the independent and joint effects of radiation dose and irradiated volumes are unclear. Therefore, we examined the effects of mean breast dose and [...]

Menée aux Etats-Unis à l'aide de données de registres portant sur les femmes nées entre 1947 et 1971, cette étude analyse l'association entre une exposition in utero au diéthylstilbestrol et le risque d'adénocarcinome à cellules claires du vagin et du col de l'utérus, en fonction de l'âge

Risk of clear-cell adenocarcinoma of the vagina and cervix among US women with potential exposure to diethylstilbestrol in utero

White, Mary C. ; Weir, Hannah K. ; Soman, Ashwini V. ; Peipins, Lucy A. ; Thompson, Trevor D.

Purpose: Women exposed to diethylstilbestrol (DES) in utero were at elevated risk of clear-cell adenocarcinoma of the vagina and cervix (CCA) as young women. Previous research suggested that this elevated risk of CCA may persist into adulthood. We extended a published analysis to measure CCA risk as these women aged. Methods: Standardized incidence ratios (SIR) compared CCA risk among women born from 1947 through 1971 (the DES-era) to CCA risk among the comparison group of women born prior to [...]

Menée au Danemark à partir de données 1968-2018 portant sur 2,5 millions de femmes, cette étude analyse l'effet de la grossesse sur le risque de cancer de l'ovaire

Pregnancy duration and ovarian cancer risk: a 50-year nationwide cohort study

Husby, Anders ; Wohlfahrt, Jan ; Melbye, Mads

A woman's reproductive history is strongly associated with her risk of ovarian cancer. However, it is unclear how pregnancies of different duration impact a woman's ovarian cancer risk, and therefore, what part of a pregnancy explains the protective effect. Using a cohort of all Danish women followed from 1968 to 2018, with prospectively registered information on reproductive history (eg, gestational duration of pregnancies, tubal ligation and resection, and hormonal pharmaceutical use), we [...]

Menée aux Etats-Unis auprès de 1 529 femmes non ménopausées (durée médiane de suivi : 6,1 ans), cette étude analyse l'association entre le taux d'hormone anti-müllérienne (AMH) et le risque de cancer du sein (84 cas)

Anti-Müllerian hormone levels and breast cancer risk in the study of women’s health across the nation

Grimes, Nydjie P. ; Bertone-Johnson, Elizabeth R. ; Whitcomb, Brian W. ; Sievert, Lynnette L. ; Crawford, Sybil L. ; Gold, Ellen B. ; Avis, Nancy E. ; Greendale, Gail A. ; Santoro, Nanette ; Habel, Laurel A. ; Reeves, Katherine W.

Purpose: The relation of premenopausal anti-Müllerian hormone (AMH) levels with breast cancer risk has been evaluated in a few studies, but primarily in non-Hispanic White women. Methods: We evaluated the association of AMH levels with breast cancer risk in Study of Women’s Health Across the Nation (SWAN), a multi-ethnic cohort of women. At enrollment, participants had an intact uterus and ≥ 1 ovary, and ≥ 1 menstrual period in the last 3 months. AMH at first measurement was assessed in 1,529 [...]