A partir d'une revue systématique de la littérature publiée jusqu'en mars 2021 (26 études) et menée à l'aide d'une méthode de randomisation mendélienne et de 2 échantillons de données, cette méta-analyse évalue l'association entre la consommation d'alcool, la méthylation de l'ADN et l'incidence du cancer du sein

Alcohol consumption, blood DNA methylation and breast cancer: a Mendelian randomisation study

Zhou, Xuan ; Yu, Lili ; Wang, Lijuan ; Xiao, Jiarui ; Sun, Jing ; Zhou, Yajing ; Xu, Xiaolin ; Xu, Wanghong ; Spiliopoulou, Athina ; Timofeeva, Maria ; Zhang, Xiaomeng ; He, Yazhou ; Yang, Haomin ; Campbell, Harry ; Zhang, Ben ; Zhu, Yimin ; Theodoratou, Evropi ; Li, Xue

Alcohol intake is thought to be a risk factor for breast cancer, but the causal relationship and carcinogenic mechanisms are not clear. We performed an up-to-date meta-analysis of prospective studies to assess observational association, and then conducted MR analysis to make causal inference based on the genetic predisposition to alcohol consumption (“drinks per week”) and pathological drinking behaviours (“alcohol use disorder” and “problematic alcohol use”), as well as genetically predicted [...]

Menée en Corée auprès de 9 520 629 personnes âgées d'au moins 20 ans, cette étude analyse l'association entre la consommation d'alcool et le risque de cancer des voies biliaires (21 079 cas), en fonction de la quantité consommée et du statut glycémique

Light-to-Moderate Alcohol Consumption Increases the Risk of Biliary Tract Cancer in Prediabetes and Diabetes, but Not in Normoglycemic Status: A Nationwide Cohort Study

Joo-Hyun Park ; Jung Yong Hong ; Kyungdo Han ; Young Suk Park ; Joon Oh Park

PURPOSE: To determine whether the dose-response association between alcohol consumption and the risk of biliary tract cancer (BTC), including cholangiocarcinoma (CCA) and gallbladder cancer (GBC), differs according to glycemic status. PATIENTS AND METHODS: This nationwide cohort study included 9,520,629 individuals age ≥ 20 years without a history of cancer who underwent national health screening under the Korean National Health Insurance Service in 2009. The participants were followed up until [...]

Menée à l'aide de données de registres et d'une étude menée auprès de 50 665 applicateurs de pesticides (durée moyenne de suivi : 21 ans), cette étude analyse l'association entre une exposition professionnelle aux insecticides pyréthrinoïdes ou à la perméthrine et la mortalité globale ou spécifique

Use of permethrin and other pyrethroids and mortality in the Agricultural Health Study

Shrestha, Srishti ; Parks, Christine G ; Umbach, David M ; Hofmann, Jonathan N ; Beane Freeman, Laura E ; Blair, Aaron ; Sandler, Dale P

Objectives: Pyrethroid insecticides have been linked with multiple health outcomes. One study reported an association with increased all-cause and cardiovascular mortality. Given the widespread use of pyrethroids, these findings warrant confirmation. We explored associations of permethrin/pyrethroid use with overall and cause-specific mortality among 50 665 licensed pesticide applicators in the Agricultural Health Study. Methods: At enrolment (1993–1997), participants self-reported information [...]

Menée entre 1961 et 2005 en Finlande, Islande, Norvège et Suède auprès de témoins et de 125 060 patients atteints d'un cancer hématologique (lymphome non hodgkinien, leucémie lymphoïde chronique, myélome multiple), cette étude analyse l'association entre une exposition professionnelle aux champs électromagnétiques d'extrêmement basses fréquences et aux chocs électriques et le risque de lymphome

Malignant lymphoma and occupational exposure to extremely low frequency magnetic fields and electrical shocks: a nested case-control study in a cohort of four Nordic countries

Jalilian, Hamed ; Guxens, Mònica ; Heikkinen, Sanna ; Pukkala, Eero ; Huss, Anke ; Eshagh Hossaini, Seyed Kamal ; Kjærheim, Kristina ; Vermeulen, Roel

Background: Exposure to extremely low frequency magnetic fields (ELF-MFs) and electric shocks is a common occupational risk factor in many workplaces. Recent investigations have highlighted a possible association between such exposures and lymphoma risk. This study was carried out to further explore the association between occupational exposure to ELF-MFs and electric shocks and risk of lymphoma in a large Nordic census-based cohort. Methods: We included cases of non-Hodgkin's lymphoma (NHL, [...]

Menée in silico à l'aide de différentes bases de données sur les produits chimiques et leurs toxicités, cette étude identifie des produits chimiques et des mélanges, présents dans l'environnement quotidien, pouvant être associés au risque de cancer du sein

Environmental mixtures and breast cancer: identifying co-exposure patterns between understudied vs breast cancer-associated chemicals using chemical inventory informatics

Koval, Lauren E. ; Dionisio, Kathie L. ; Friedman, Katie Paul ; Isaacs, Kristin K. ; Rager, Julia E.

Background: Although evidence linking environmental chemicals to breast cancer is growing, mixtures-based exposure evaluations are lacking. Objective: This study aimed to identify environmental chemicals in use inventories that co-occur and share properties with chemicals that have association with breast cancer, highlighting exposure combinations that may alter disease risk. Methods: The occurrence of chemicals within chemical use categories was characterized using the Chemical and Products [...]

Menée à partir de données de la "UK Biobank" portant sur 451 143 personnes (âge : 40-70 ans ; 54,3 % de femmes ; durée moyenne de suivi : 11,6 ans), cette étude analyse le risque de cancer chez les porteurs des mutations homozygotes C282Y et H63D du gène HFE, en fonction du sexe

Hereditary hemochromatosis variant associations with incident non-liver malignancies: 11-year follow-up in UK Biobank

Atkins, Janice L. ; Pilling, Luke C. ; Torti, Suzy V. ; Torti, Frank M. ; Kuchel, George A. ; Melzer, David

Background: In European ancestry populations, iron overload disorder Hereditary Hemochromatosis (HH) is predominantly caused by HFE p.C282Y and p.H63D mutations. Male p.C282Y homozygotes have markedly increased hepatic malignancy incidence but risks for other cancers in male and female homozygotes are unclear. Methods: 451,143 UK Biobank European ancestry participants (aged 40-70 years; 54.3% female) were followed (mean 11.6 years) via hospital admissions and national cancer registries. We [...]

Menée à l'aide des données d'une méta-analyse d'association portant sur 10 156 patients atteints d'une tumeur germinale du testicule et 179 683 témoins, cette étude analyse l'association entre 273 polymorphismes à simple nucléotide de 28 gènes liés à la méthylation de l'ADN et le risque de développer la maladie

Association study between polymorphisms in DNA methylation-related genes and testicular germ cell tumor risk

Grasso, Chiara ; Popovic, Maja ; Isaevska, Elena ; Lazzarato, Fulvio ; Fiano, Valentina ; Zugna, Daniela ; Pluta, John ; Weathers, Benita ; D'Andrea, Kurt ; Almstrup, Kristian ; Anson-Cartwright, Lynn ; Bishop, D. Timothy. ; Chanock, Stephen J. ; Chen, Chu ; Cortessis, Victoria K. ; Dalgaard, Marlene D. ; Daneshmand, Siamak ; Ferlin, Alberto ; Foresta, Carlo ; Frone, Megan N. ; Gamulin, Marija ; Gietema, Jourik A. ; Greene, Mark H. ; Grotmol, Tom ; Hamilton, Robert J. ; Haugen, Trine B. ; Hauser, Russ ; Karlsson, Robert ; Kiemeney, Lambertus A. ; Lessel, Davor ; Lista, Patrizia ; Lothe, Ragnhild A. ; Loveday, Chey ; Meijer, Coby ; Nead, Kevin T. ; Nsengimana, Jeremie ; Skotheim, Rolf I. ; Turnbull, Clare ; Vaughn, David J. ; Wiklund, Fredrik ; Zheng, Tongzhang ; Zitella, Andrea ; Schwartz, Stephen M. ; McGlynn, Katherine A. ; Kanetsky, Peter A. ; Nathanson, Katherine L. ; Richiardi, Lorenzo

Background: Testicular germ cell tumors (TGCTs), histologically classified as seminomas and non-seminomas, are believed to arise from primordial gonocytes, with the maturation process blocked when are subjected to DNA methylation reprogramming. Single-nucleotide polymorphisms (SNPs) in DNA methylation machinery and folate-dependent one-carbon metabolism genes have been postulated to influence the proper establishment of DNA methylation. Methods: In this pathway-focused investigation we [...]