Menée à l'aide d'un modèle murin d'épithélium hypopharyngé exposé aux nitrosamines de la fumée de tabac et à un extrait de bile, cette étude analyse le risque de cancer des voies aérodigestives chez les fumeurs souffrant de reflux biliaire

Noxious Combination of Tobacco Smoke Nitrosamines with Bile, Deoxycholic Acid, Promotes Hypopharyngeal Squamous Cell Carcinoma, via NFκB, In Vivo

Vageli, Dimitra P. ; Doukas, Panagiotis G. ; Doukas, Sotirios G. ; Tsatsakis, Aristidis ; Judson, Benjamin L.

Tobacco smoking is the most known risk factor for hypopharyngeal cancer. Bile reflux has recently been documented as an independent risk factor for NFκB-mediated hypopharyngeal squamous cell carcinoma. However, the carcinogenic effect of tobacco smoke on the hypopharynx and its combination with bile has not yet been proven by direct evidence. We investigated whether in vivo chronic exposure (12–14 weeks) of murine (C57Bl/6J) hypopharyngeal epithelium to tobacco smoke components (TSC) [...]

Menée au Brésil auprès de 1 045 personnes (âge : 18-75 ans), cette étude multicentrique analyse l'association entre une consommation d'aliments transformés ou ultra-transformés et le risque d'adénocarcinome de l'estomac (354 cas)

Consumption of processed and ultra-processed foods by patients with stomach adenocarcinoma: a multicentric case–control study in the Amazon and southeast regions of Brazil

Peres, Stela V. ; Silva, Diego R. M. ; Coimbra, Felipe J. F. ; Fagundes, Marcela A. ; Auzier, Jamille J. N. ; Pelosof, Adriane G. ; Araujo, Marília S. ; Assumpção, Paulo P. ; Curado, Maria P.

Purpose: There is limited information about the dietary habits associated with stomach adenocarcinoma in the Brazilian population, so our purpose is to analyze the consumption of processed and ultra-processed foods by patients with stomach adenocarcinoma in Brazil. Methods: A multicentric hospital-based case–control study was conducted in São Paulo (southeastern region) and Belém (Amazon region) of Brazil with 1,045 individuals, both sexes, between 18 and 75 years old. In São Paulo, there were [...]

Menée en France sur la période 2003-2005 auprès de 13 481 hommes exposés à l'amiante dans le cadre de leur activité professionnelle (durée de suivi : 10 ans), cette étude analyse l'association entre cette exposition et l'incidence ou la mortalité des cancers de la tête et du cou (sauf cancer du larynx), en fonction de la présence de plaques pleurales

Head and neck cancer and asbestos exposure

Clin, Bénédicte ; Gramond, Celine ; Thaon, Isabelle ; Brochard, Patrick ; Delva, Fleur ; Chammings, Soizick ; Gislard, Antoine ; Laurent, François ; Paris, Christophe ; Lacourt, Aude ; Pairon, Jean-Claude

Objectives: The aim of this study was to analyse, within a French cohort of workers previously occupationally exposed to asbestos, incidence and mortality from various sites of head and neck cancers (larynx excluded) and to examine the potential link of these cancers with pleural plaques. Methods: A 10-year follow-up study was conducted in the 13 481 male subjects included in the cohort between October 2003 and December 2005. Asbestos exposure was assessed by industrial hygienist analysis of a [...]

Menée à l'aide de données de la cohorte "Sister Study" portant sur 50 884 femmes américaines âgées de 35 à 74 ans, cette étude analyse l'association entre une exposition à la radioactivité des particules ambiantes résidentielles et le risque de cancer du sein

Exposure to Particle Radioactivity and Breast Cancer Risk in the Sister Study: A U.S.-Wide Prospective Cohort

Alexandra J. White ; Allyson M. Gregoire ; Jared A. Fisher ; Danielle N. Medgyesi ; Longxiang Li ; Petros Koutrakis ; Dale P. Sandler ; Rena R. Jones

Outdoor air pollution has been classified as a human carcinogen. The evidence for breast cancer risk is accumulating although the specific constituents driving the association are not well explored. Particulate matter can be a vector for radioactive isotopes, most of which arise from naturally occurring radon gas, which has been associated with a higher risk of breast and lung cancer. We evaluated the association between residential ambient particle radioactivity (PR), a radiometric [...]

Menée à partir de données d'une étude portant sur 52 276 personnes (âge : 18-98 ans), cette étude analyse l'association entre le profil d'évolution de la concentration en protéine C réactive sur la période 2006-2010 et le risque de cancer, par localisation

C-Reactive Protein Trajectories and the Risk of All Cancer Types: A Prospective Cohort Study

Liu, Tong ; Zhang, Qingsong ; Song, Chunhua ; Siyin, Sarah Tan ; Chen, Shuohua ; Zhang, Qi ; Song, Mengmeng ; Cao, Liying ; Shi, Hanping

A single CRP measurement is insufficient to examine the association of long-term patterns of CRP concentration with cancer risk. We prospectively examined the relationship between CRP trajectory patterns and new-onset cancers among 52 276 participants. Latent mixture modeling was used to identify CRP trajectories. Cox proportional hazards regression models were used to evaluate the association between CRP trajectory patterns and the risk of overall and specific-site cancer. Four CRP [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données de bases américaines portant sur 1 413 patients pédiatriques atteints d'une tumeur des cellules germinales, 1 220 parents biologiques et 1 022 témoins non apparentés, puis répliquée à l'aide de données de la "UK Biobank" portant sur 1 589 témoins et 396 adultes atteints d'un cancer du testicule, cette étude analyse l'association entre la longueur des télomères des leucocytes et le risque de tumeur des cellules germinales chez l'enfant et l'adulte

Predicted leukocyte telomere length and risk of germ cell tumours

Cigan, Shannon S. ; Meredith, John J. ; Kelley, Ava C. ; Yang, Tianzhong ; Langer, Erica K. ; Hooten, Anthony J. ; Lane, John A. ; Cole, Benjamin R. ; Krailo, Mark ; Frazier, A. Lindsay ; Pankratz, Nathan ; Poynter, Jenny N.

Background: Genetically predicted leukocyte telomere length (LTL) has been evaluated in several studies of childhood and adult cancer. We test whether genetically predicted longer LTL is associated with germ cell tumours (GCT) in children and adults. Methods: Paediatric GCT samples were obtained from a Children’s Oncology Group study and state biobank programs in California and Michigan (N = 1413 cases, 1220 biological parents and 1022 unrelated controls). Replication analysis included 396 [...]

Menée à partir de données de cohortes, d'une étude d'association sur le génome entier et des registres américains des cancers portant au total sur 203 787 patients atteints d'un cancer du pancréas, cette étude analyse l'effet de l'âge sur l'association entre 5 facteurs avérés (tabagisme, obésité, diabète, taille et groupe sanguin) et le risque de développer la maladie

The age-dependent association of risk factors with pancreatic cancer

Yuan, C. ; Kim, J. ; Wang, Q. L. ; Lee, A. A. ; Babic, A. ; Amundadottir, L. T. ; Klein, A. P. ; Li, D. ; McCullough, M. L. ; Petersen, G. M. ; Risch, H. A. ; Stolzenberg-Solomon, R. Z. ; Perez, K. ; Ng, K. ; Giovannucci, E. L. ; Stampfer, M. J. ; Kraft, P. ; Wolpin, B. M.

Background: Pancreatic cancer presents as advanced disease in >80% of patients; yet, appropriate ages to consider prevention and early detection strategies are poorly defined. We investigated age-specific associations and attributable risks of pancreatic cancer for established modifiable and non-modifiable risk factors. Patients and methods: We included 167 483 participants from 2 prospective US cohort studies with 1190 incident cases of pancreatic cancer during >30 years of follow-up; 5107 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en octobre 2021 (9 études, 32 810 patients), cette méta-analyse évalue l'association entre l'indice glycémique des aliments, la charge glycémique et le risque de cancer du poumon

Dietary glycemic index, glycemic load intake, and risk of lung cancer: A meta-analysis of observational studies

Zhu, Lin ; Shu, Yang ; Liu, Chao ; Zhu, Yawen ; Xiao, Yao ; Ran, Jing ; Zhang, Chunxia

Objective: This meta-analysis evaluated the relationship between dietary glycemic index (GI), glycemic load (GL), and lung cancer risk, which has been controversial in previous studies. Methods: We searched online literature databases such as PubMed, Embase, Web of Science, and Cochrane Library for relevant studies published up to October 2021 in English only. We included case-control and cohort studies that reported relative risks (RRs) and 95% confidence intervals (CI) for the associations [...]

Menée à partir de données portant sur 9 756 patients atteints d'un cancer colorectal et 9 985 témoins, cette étude analyse l'association entre le diabète sucré et le risque de cancer colorectal selon le sous-type moléculaire

Diabetes mellitus in relation to colorectal tumor molecular subtypes - a pooled analysis of more than 9,000 cases

Harlid, Sophia ; Van Guelpen, Bethany ; Qu, Conghui ; Gylling, Björn ; Aglago, Elom K ; Amitay, Efrat L ; Brenner, Hermann ; Buchanan, Daniel D ; Campbell, Peter T ; Cao, Yin ; Chan, Andrew T ; Chang-Claude, Jenny ; Drew, David A ; Figueiredo, Jane C ; French, Amy J ; Gallinger, steven ; Giannakis, Marios ; Giles, Graham G ; Gunter, Marc J ; Hoffmeister, Michael ; Hsu, Li ; Jenkins, Mark A ; Lin, Yi ; Moreno, Víctor ; Murphy, Neil ; Newcomb, Polly A ; Newton, Christina C ; Nowak, Jonathan A ; Obón-Santacana, Mireia ; Ogino, Shuji ; Potter, John D ; Song, Mingyang ; Steinfelder, Robert S ; Sun, Wei ; Thibodeau, Stephen N ; Toland, Amanda E ; Ugai, Tomotaka ; Um, Caroline Y ; Woods, Michael O ; Phipps, Amanda I ; Harrison, Tabitha ; Peters, Ulrike

Diabetes is an established risk factor for colorectal cancer. However, colorectal cancer is a heterogeneous disease and it is not well understood whether diabetes is more strongly associated with some tumor molecular subtypes than others. A better understanding of the association between diabetes and colorectal cancer according to molecular subtypes could provide important insights into the biology of this association. We used data on lifestyle and clinical characteristics from the Colorectal [...]

A partir d'une revue systématique de la littérature publiée entre 1993 et 2017 (3 méta-analyses), cette étude évalue l'influence de la méthode d'évaluation de l'exposition professionnelle aux pesticides sur les estimations du risque associé de cancer de la prostate, de lymphome non hodgkinien ou de maladie de Parkinson

Impact of occupational pesticide exposure assessment method on risk estimates for prostate cancer, non-Hodgkin’s lymphoma and Parkinson’s disease: results of three meta-analyses

Ohlander, Johan ; Fuhrimann, Samuel ; Basinas, Ioannis ; Cherrie, John W ; Galea, Karen S ; Povey, Andrew C ; van Tongeren, Martie ; Harding, Anne-Helen ; Jones, Kate ; Vermeulen, Roel ; Huss, Anke ; Kromhout, Hans

Assessment of occupational pesticide exposure in epidemiological studies of chronic diseases is challenging. Biomonitoring of current pesticide levels might not correlate with past exposure relevant to disease aetiology, and indirect methods often rely on workers’ imperfect recall of exposures, or job titles. We investigated how the applied exposure assessment method influenced risk estimates for some chronic diseases. In three meta-analyses the influence of exposure assessment method type on [...]