Association of Human Papillomavirus Vaccination With the Incidence of Squamous Cell Carcinomas of the Anus in the US

Menée aux Etats-Unis à partir de données statistiques sur la période 2001-2018, cette étude analyse l'effet de la vaccination contre le papillomavirus humain sur l'incidence du carcinome épidermoïde de l'anus

Résumé en anglais

The incidence of squamous cell carcinomas of the anus (SCCA) has increased sharply within the US. Squamous cell carcinomas of the anus are likely vaccine preventable because approximately 90% of cases are associated with human papillomavirus (HPV) infection. However, the implications of the 2006 HPV vaccine licensure are unclear because previous assessments of SCCA incidence have low population coverage (28%-30%) and/or exclude in situ cases. We analyzed the 2001 to 2018 US Cancer Statistics database covering 98% of the US population to better examine SCCA incidence among vaccine-eligible cohorts and assess the potential consequences of HPV vaccination.