A partir d'une revue systématique de la littérature (59 essais), cette méta-analyse évalue l'intérêt de l'acupuncture et des thérapies dérivées de cette pratique (électro-acupuncture, neurostimulation électrique transcutanée) pour soulager la douleur liée à la maladie pendant les soins palliatifs chez des patients atteints d'un cancer

Acupuncture and Derived Therapies for Pain in Palliative Cancer Management: Systematic Review and Meta-Analysis Based on Single-Arm and Controlled Trials

Background: Acupuncture is a classical complementary therapy, but benefits in palliative cancer pain are still unclear due to lack of consistent evidence. Objectives: To comprehensively evaluate the effectiveness of acupuncture and derived therapies (such as electroacupuncture, laser acupuncture, and transcutaneous electrical nerve stimulation) for analgesia in palliative cancer care based on both single-arm and controlled trials. Design: Eight databases were searched from inception to August [...]

Menée en Corée auprès de 611 patients atteints d'un cancer (âge médian : 58 ans), cette étude prospective analyse l'efficacité du pegteograstim pour prévenir une neutropénie fébrile et une neutropénie induite par la chimiothérapie

Pegteograstim prophylaxis for chemotherapy-induced neutropenia and febrile neutropenia: a prospective, observational, postmarketing surveillance study in Korea

Cheon, Jaekyung ; Im, Hyeon-Su ; Shin, Ho-Jin ; Kim, Inho ; Lee, Won Sik ; Lee, Kyung-Hun ; Park, Seong Kyu ; Kim, Min Kyoung ; Choi, Un Jong ; Kim, Jung Han ; Lee, IlKyun ; Jo, Jae-Cheol

Purpose : This observational study aimed to evaluate the safety and efficacy of pegteograstim prophylaxis in patients with lymphoma and solid malignancies. Methods : This study was conducted at 18 sites in Korea between November 2015 and August 2018. Results : In total, 611 patients (female, 61.2%) with a median age of 58 (range, 18–88) years were included. Most patients had lymphomas (n = 371, 60.7%) and breast cancer (n = 230, 37.6%) and were administered R-CHOP21 (rituximab, [...]

A partir d'une revue systématique de la littérature (14 articles), cette étude analyse les caractéristiques des interventions dédiées à l'amélioration du mode de vie (amélioration de l'alimentation et de l'activité physique) chez des patients ayant survécu à un cancer et les membres de leurs familles

A systematic scoping review of post-treatment lifestyle interventions for adult cancer survivors and family members

Ellis, Katrina R. ; Raji, Dolapo ; Olaniran, Marianne ; Alick, Candice ; Nichols, Darlene ; Allicock, Marlyn

Purpose : Supporting the health of cancer survivors and their families from diagnosis through survivorship is a recognized priority. However, the extent to which health promotion efforts after the completion of acute treatment attend to the needs of adult survivors and families is unclear. This systematic scoping review summarizes the key characteristics of post-treatment lifestyle interventions aiming to improve diet, physical activity, and/or weight-related outcomes for adult cancer survivors [...]

Menée en Belgique par questionnaire auprès de professionnels de santé, cette étude observationnelle analyse l'organisation des soins de support pour les patients atteints d'un cancer

Supportive care for cancer patients: a survey of available settings and current practices in Belgium

Fontaine, Christel ; Echterbille, Marie-Aline ; Klastersky, Jean ; on behalf of the, Bsmo Supportive Care Working Group

Introduction : The increasing number of cancer diagnoses and deaths underlines the importance of supportive and palliative care. It is defined as “all the care and the support necessary for patients throughout their illness.” Aim : To evaluate the current status of the supportive and palliative care organization in Belgium. Methods : The Belgian Society of Medical Oncology (BSMO) supportive care task force conducted an observational study by sending a 31-point questionnaire to medical doctors [...]

Menée en Australie par enquête en ligne auprès de patients atteints d'un cancer et de leurs aidants, cette étude analyse leurs expériences et leurs besoins en matière de soutien nutritionnel

Patient and carer experiences of nutrition in cancer care: a mixed-methods study

Loeliger, Jenelle ; Dewar, Sarah ; Kiss, Nicole ; Drosdowsky, Allison ; Stewart, Jane

Purpose : Evidence-based guidelines exist to guide health professionals and services about cancer nutrition care; however, the views of cancer patients and carers are not well understood. This study aimed to understand the experience and needs of cancer patients and carers regarding nutrition care across the care continuum. Methods : Using a mixed-methods approach, cancer patients and carers completed a cross-sectional online survey and focus groups. Participants were recruited through health [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2020 (19 essais randomisés), cette étude analyse l'intérêt des interventions à base d'exercices physiques pour prévenir et traiter les symptômes d'une neuropathie périphérique induite par la chimiothérapie chez des patients atteints d'un cancer

A systematic review of behavioural and exercise interventions for the prevention and management of chemotherapy-induced peripheral neuropathy symptoms

Tanay, Mary Anne Lagmay ; Armes, Jo ; Moss-Morris, Rona ; Rafferty, Anne Marie ; Robert, Glenn

Background : Chemotherapy-induced peripheral neuropathy (CIPN) can result in functional difficulties. Pharmacological interventions used to prevent CIPN either show low efficacy or lack evidence to support their use and to date, duloxetine remains the only recommended treatment for painful CIPN. Non-pharmacological interventions such as exercise and behavioural interventions for CIPN exist. Purpose : The aims were to (1) identify and appraise evidence on existing behavioural and exercise [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2020, cette méta-analyse évalue la prévalence de la fatigue chez des patients atteints d'un cancer, analyse l'intérêt de programmes d'activité physique dispensés dans des Centres de santé communautaire ainsi que la participation des patients

Community-based exercise programs and cancer-related fatigue: a systematic review and meta-analysis

Wagoner, Chad W. ; Lee, Jordan T. ; Battaglini, Claudio L.

Purpose : To explore the prevalence of cancer-related fatigue (CRF) within community-based exercise programs and to determine the overall impact that participation in community-based exercise programs have on CRF. Methods : Literature searches were performed in March and updated in April of 2020. Studies that were community-based in adult cancer populations and reported CRF outcomes were included. Mean and standard deviations for CRF from 12 studies were extracted in order to compute a pooled [...]

Mené aux Etats-Unis sur 315 patients ayant survécu à un cancer colorectal et présentant des douleurs et des symptômes de détresse psychologique, cet essai randomisé évalue la faisabilité et l'intérêt d'une intervention de psychothérapie comportementale dispensée par téléphone pour développer des compétences permettant de faire face à la douleur et de la prendre en charge, ainsi que d'améliorer la qualité de vie

Feasibility, engagement, and acceptability of a behavioral pain management intervention for colorectal cancer survivors with pain and psychological distress: data from a pilot randomized controlled trial

Kelleher, Sarah A. ; Fisher, Hannah M. ; Winger, Joseph G. ; Somers, Tamara J. ; Uronis, Hope E. ; Wright, Arianna N. ; Keefe, Francis J.

Purpose : Colorectal cancer survivors report pain and psychological distress to be burdensome long-term cancer consequences. Quality cancer survivorship care includes interventions for managing these symptoms. Yet, no studies have tested the efficacy of an accessible behavioral intervention for colorectal cancer survivors with pain and comorbid psychological distress. This paper reports on the feasibility (i.e., accrual, attrition, and adherence to study procedures), engagement, acceptability, [...]

Menée aux Pays-Bas auprès de patients ayant survécu à un cancer de la tête et du cou, cette étude transversale identifie leurs déficiences physiques (ouverture de la bouche, fonction du cou et des épaules, force de préhension, niveau de mobilité et capacité de marche, ...) et leurs besoins de soins

Identifying unmet needs and limitations in physical health in survivors of Head and Neck Cancer

van Hinte, Gerben ; Leijendekkers, Ruud A. ; Merkx, Matthias A.W. ; Takes, Robert P. ; Nijhuis-van der Sanden, Maria W.G. ; Speksnijder, Caroline M.

Objective : To gain insight into the level of unmet needs and limitations in physical health experienced by survivors of head and neck cancer, and to evaluate whether unmet needs in physical health and limitations in physical performance are associated. Materials and methods : In this cross‐sectional study, unmet needs were measured with Supportive Care Needs Surveys (SCNS‐SF34, SCNS‐HNC). Limitations in physical health were measured for maximal mouth opening, neck and shoulder function, hand [...]

Menée en Allemagne à partir des données de 7 registres des cancers portant sur des patients atteints d'un cancer diagnostiqué entre 1998 et 2014, cette étude analyse les disparités socioéconomiques dans la survie

Small-area analysis on socioeconomic inequalities in cancer survival for 25 cancer sites in Germany

Finke, Isabelle ; Behrens, Gundula ; Maier, Werner ; Schwettmann, Lars ; Pritzkuleit, Ron ; Holleczek, Bernd ; Kajüter, Hiltraud ; Gerken, Michael ; Mattutat, Johann ; Emrich, Katharina ; Jansen, Lina ; Brenner, Hermann ; German Cancer Survival Working Group

Socioeconomic inequalities in cancer survival have been reported in various countries but it is uncertain to what extent they persist in countries with relatively comprehensive health insurance coverage such as Germany. We investigated the association between area-based socioeconomic deprivation on municipality level and cancer survival for 25 cancer sites in Germany. We used data from seven population-based cancer registries (covering 32 million inhabitants). Patients diagnosed in 1998-2014 [...]

Menée aux Etats-Unis à partir de données portant sur 11 776 699 patients atteints d'un cancer diagnostiqué entre 2003 et 2016, cette étude analyse le stade de la maladie au diagnostic, les traitements reçus et la survie, chez les patients transgenres (589 cas)

Cancer Stage, Treatment, and Survival among Transgender Patients in the United States

Jackson, Sarah S ; Han, Xuesong ; Mao, Ziling ; Nogueira, Leticia ; Suneja, Gita ; Jemal, Ahmedin ; Shiels, Meredith S

Background : Transgender persons face many barriers to healthcare that may delay cancer diagnosis and treatment, possibly resulting in decreased survival. Yet, data on cancer in this population are limited. We examined cancer stage at diagnosis, treatment, and survival among transgender patients compared to cisgender patients in the National Cancer Database (NCDB). Methods : Gender (male, female, or transgender) was extracted from medical records from patients diagnosed with cancer between [...]

Menée aux Etats-Unis auprès de 30 403 patients ayant survécu à un cancer, cette étude analyse l'association entre leurs capacités auto-déclarées à se déplacer et marcher (capacités de mobilité) et la mortalité

Ambulatory Function and Mortality among Cancer Survivors in the NIH-AARP Diet and Health Study

Salerno, Elizabeth A. ; Saint-Maurice, Pedro F. ; Willis, Erik A. ; Moore, Steven C. ; DiPietro, Loretta ; Matthews, Charles E.

Background: There is limited evidence describing associations between cancer and function in diverse cancer types and its relationship with mortality. We investigated the relationship between cancer and poor ambulatory function and associations between ambulatory function and subsequent mortality. Methods: Participants included 233,135 adults (n = 30,403 cancer and n = 202,732 cancer free) in the NIH-American Association of Retired Persons Diet and Health Study (1994–1996) who self-reported [...]

Menée au Japon à partir de données portant sur 275 720 patients atteints d'un cancer récemment diagnostiqué, cette étude analyse l'existence d'un cancer antérieur et ses caractéristiques

Increasing trends in the prevalence of prior cancer in newly diagnosed lung, stomach, colorectal, breast, cervical, and corpus uterine cancer patients: a population-based study

Sato, Akira ; Matsubayashi, Keisuke ; Morishima, Toshitaka ; Nakata, Kayo ; Kawakami, Koji ; Miyashiro, Isao

Background : Cancer survivors are frequently excluded from clinical research, resulting in their omission from the development of many cancer treatment strategies. Quantifying the prevalence of prior cancer in newly diagnosed cancer patients can inform research and clinical practice. This study aimed to describe the prevalence, characteristics, and trends of prior cancer in newly diagnosed cancer patients in Japan. Methods : Using Osaka Cancer Registry data, we examined the prevalence, [...]

A partir d'une revue systématique de la littérature (11 études), cette méta-analyse évalue l'effet de l'activité physique sur la survie globale des patients atteints d'un cancer de stade avancé

The effects of physical activity on overall survival among advanced cancer patients: a systematic review and meta-analysis

Takemura, Naomi ; Chan, Siu Ling ; Smith, Robert ; Cheung, Denise Shuk Ting ; Lin, Chia-Chin

Background : The survival rates of advanced cancer patients remain low despite clinical therapy advancements. However, physical activity showed promising effects in improving cancer outcomes. This review aimed to systematically evaluate and synthesize the effects on overall mortality of post-diagnosis physical activity in advanced cancer patients. Methods : A systematic search of six English databases (PubMed, EMBASE, CINAHL, PsycINFO, The Cochrane Central Register of Controlled Trials, and [...]

Cette étude analyse l'association entre l'efficacité des inhibiteurs de points de contrôle immunitaire anti-PD-1/PD-L1 et des altérations génomiques, chez des patients atteints d'un carcinome à cellules rénales de stade avancé, en fonction de l'indice de masse corporelle

Assessment of Immune Checkpoint Inhibitors and Genomic Alterations by Body Mass Index in Advanced Renal Cell Carcinoma

Lalani, Aly-Khan A. ; Bakouny, Ziad ; Farah, Subrina ; Donskov, Frede ; Dudani, Shaan ; Heng, Daniel Y. C. ; Choueiri, Toni K.

An elevated body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) has been associated with an increased risk of renal cell carcinoma (RCC). Previously, higher BMI was shown to be a positive prognostic factor for patients with metastatic clear cell RCC (mRCC) who were treated during the vascular endothelial growth factor (VEGF)–targeted therapy era. However, the treatment landscape has shifted to include immune checkpoint inhibitors (ICIs) for most [...]

Menée auprès de 87 patients atteints d'un cancer de stade métastatique et inclus dans des essais de phase I, cette étude analyse la présence et les caractéristiques d'une détresse psychologique

Psychological distress in patients with metastatic cancer enrolling on phase I clinical trials

Hunt, Alexandra ; Handorf, Elizabeth ; Blau, Matthew ; Chertock, Yana ; Fang, Carolyn ; Hall, Michael J. ; Jain, Rishi

Purpose : Psychological distress is common in patients with cancer and is associated with lower quality-of-life (QOL). Although distress among oncology outpatients undergoing standard therapy has been widely studied, few studies have evaluated distress among patients enrolling on Phase I therapeutic clinical trials. Thus, we aimed to characterize levels of distress and types of stressors in patients enrolling on Phase I clinical trials. Methods : Participants completed the National [...]

Menée en France auprès de 2 293 patients âgés atteints d'un cancer (âge médian : 80 ans), cette étude de cohorte évalue l'intérêt d'un outil permettant de détecter la présence d'une dépression avant le début des traitements anticancéreux

Diagnostic Performance of the 4-item Geriatric Depression Scale for Depression Screening in Older Patients with Cancer: The ELCAPA Cohort Study

Lafont, Charlotte ; Chah Wakilian, Anne ; Lemogne, Cédric ; Gouraud, Clément ; Fossey-Diaz, Virginie ; Orvoen, Galdric ; Lhuillier, Nathalie ; Paillaud, Elena ; Bastuji-Garin, Sylvie ; Zebachi, Sonia ; Hanon, Olivier ; Goldwasser, François ; Boudou-Rouquette, Pascaline ; Canoui-Poitrine, Florence

Background : In older patients with cancer, depression is difficult to assess because of its heterogeneous clinical expression. The 4‐item version of the Geriatric Depression Scale (GDS‐4) is quick and easy to administer but has not been validated in this population. The present study was designed to test the diagnostic performance of the GDS‐4 in a French cohort of older patients with cancer before treatment. Materials and Methods : Our cross‐sectional analysis of data from the Elderly Cancer [...]

Menée aux Etats-Unis, cette étude transversale rétrospective analyse l'utilisation des medias sociaux, par les aidants de jeunes adultes atteints d'un cancer (âge des aidants : 18-39 ans), pour obtenir du soutien

Social support enactments on social media during the first 6 months of young adult cancer caregiving

Warner, Echo L. ; Kirchhoff, Anne C. ; Wilson, Andrew ; Cloyes, Kristin G. ; Sun, Ye ; Waters, Austin R. ; Nelson, Taylor ; Ellington, Lee

Purpose : To explore how family/friend young adult cancer caregivers (YACC) used social media for social support in a cross-sectional retrospective mixed-methods study. Methods : Eligible YACC were recruited online and in-person from September 2017 to June 2018, were 18–39 years, used social media weekly, and cared for an adult cancer patient diagnosed 6 months–5 years prior (N = 34). Social media posts were randomly sampled, and content analyzed for five types of social support (emotional, [...]

Menée au Danemark par questionnaire auprès de 130 participants, cette étude analyse l'effet, sur leur santé psychique, de l'annonce de résultats anormaux après un dépistage de cancer du poumon par tomodensitométrie (durée de suivi : 3 mois)

Psychosocial consequences of a three-month follow-up after receiving an abnormal lung cancer CT-screening result: a longitudinal survey

Damhus, Christina Sadolin ; Quentin, Julie Greve ; Malmqvist, Jessica ; Siersma, Volkert ; Brodersen, John

Background : Participation in lung cancer CT-screening can be associated with a need for follow-up procedures. The screening and waiting for test results introduce the risk of experiencing psychosocial consequences. Therefore, the aims of this study were: 1) To investigate if the psychosocial consequences changed from before an annual screening round to before a three-month follow-up CT-scan in participants with a positive screening result. 2) To investigate potential differences in [...]

Menée au Canada à partir de données portant sur 145 709 adultes (âge médian : 78 ans), cette étude de cohorte compare, chez les patients atteints d'un cancer et les patients atteints d'une autre maladie au stade terminal, leur intégration dans des programmes de soins palliatifs pendant leur dernière année de vie et l'organisation de ces programmes

Comparison of Palliative Care Delivery in the Last Year of Life Between Adults With Terminal Noncancer Illness or Cancer

Quinn, Kieran L. ; Wegier, Peter ; Stukel, Therese A. ; Huang, Anjie ; Bell, Chaim M. ; Tanuseputro, Peter

Importance : Palliative care improves health outcomes, but studies of the differences in the delivery of palliative care to patients with different types of serious illness are lacking. Objective : To examine the delivery of palliative care among adults in their last year of life who died of terminal noncancer illness compared with those who died of cancer. Design, Setting, and Participants : This population-based cohort study used linked health administrative data of adults who received [...]

Menée en Allemagne auprès de 500 patients atteints d'un cancer qualifié comme incurable au moment du diagnostic (âge moyen : 64,2 ans), cette étude observationnelle analyse l'évolution de leurs symptômes, leurs besoins en soins de support et en soins palliatifs (durée de suivi : 12 mois)

Symptom burden and palliative care needs of patients with incurable cancer at diagnosis and during the disease course

Vogt, Jeannette ; Beyer, Franziska ; Sistermanns, Jochen ; Kuon, Jonas ; Kahl, Christoph ; Alt-Epping, Bernd ; Stevens, Susanne ; Ahlborn, Miriam ; George, Christian ; Heider, Andrea ; Tienken, Maria ; Loquai, Carmen ; Stahlhut, Kerstin ; Ruellan, Anne ; Kubin, Thomas ; Dietz, Andreas ; Oechsle, Karin ; Mehnert-Theuerkauf, Anja ; van Oorschot, Birgitt ; Thomas, Michael ; Ortmann, Olaf ; Engel, Christoph ; Lordick, Florian ; the Arbeitsgemeinschaft Palliativmedizin of the German Cancer Society

Background : Although current guidelines advocate early integration of palliative care, symptom burden and palliative care needs of patients at diagnosis of incurable cancer and along the disease trajectory are understudied. Material and Methods : We assessed distress, symptom burden, quality of life, and supportive care needs in patients with newly diagnosed incurable cancer in a prospective longitudinal observational multicentre study. Patients were evaluated using validated self‐report [...]