Menée par questionnaire auprès de 14 123 participants de l'essai "National Lung Screening Trial" (âge moyen : 61,6 ans), cette étude analyse l'association entre différentes caractéristiques des cigarettes consommées (niveau de goudron, non aromatisées ou menthol, présence de filtre ou non) et l'incidence du cancer du poumon, la mortalité spécifique et toutes causes confondues

Association of Cigarette Type With Lung Cancer Incidence and Mortality: Secondary Analysis of the National Lung Screening Trial

Tanner, Nichole T. ; Thomas, Nina A. ; Ward, Ralph ; Rojewski, Alana ; Gebregziabher, Mulugeta ; Toll, Benjamin ; Silvestri, Gerard A.

In response to increasing evidence implicating cigarette smoking as a cause of lung cancer in the 1950s, tobacco manufacturers introduced filtered and “lower-tar” cigarettes to allay consumer concerns, knowing they did not actually reduce health risks. Puncturing ventilation holes of varying sizes and numbers into the filter to dilute inhaled smoke became the optimum way to reduce tar yield.Despite these changes, smoking remains responsible for 80% to 90% of lung cancer diagnoses and 5-year [...]

Menée au Canada auprès de 320 patients fumeurs, atteints d'un cancer de la tête et du cou et ayant réalisé un test de dépistage du papillomavirus humain (âge moyen : 61,7 ans ; 78,7% d'hommes ; 41% HPV+), cette étude analyse l'association entre la durée d'exposition au tabac avant le diagnostic du cancer et le risque de développer la maladie, en fonction du statut HPV

Latency of tobacco smoking for head and neck cancer among HPV-positive and HPV-negative individuals

Madathil, Sreenath ; Rousseau, Marie-Claude ; Joseph, Lawrence ; Coutlée, François ; Schlecht, Nicolas F. ; Franco, Eduardo ; Nicolau, Belinda

Human papillomavirus (HPV) infection and tobacco smoking are well-known risk factors for head and neck cancers (HNC). Although an effect modification between oral HPV infection and tobacco smoking may exist, evidence is lacking on how they interact temporally. We investigated the latency and life course effects of tobacco smoking on risk of HNC among HPV-positive (HPV+ve) and negative (HPV-ve) individuals. We used data from 631 ever-smoker participants of a hospital-based case–control study [...]

Menée au Japon sur la période 1995-1999 auprès de 98 663 personnes (âge : 45-74 ans ; durée de suivi : 5 ans), cette étude analyse l'association entre une consommation de viande et de poisson et le risque de cancer des voies biliaires (379 cas)

Relationship between meat/fish consumption and biliary tract cancer: The Japan Public Health Center-based Prospective Study

Makiuchi, Takeshi ; Sobue, Tomotaka ; Kitamura, Tetsuhisa ; Ishihara, Junko ; Sawada, Norie ; Iwasaki, Motoki ; Yamaji, Taiki ; Shimazu, Taichi ; Tsugane, Shoichiro

Background : The effect of meat and fish consumption on cancer risk has been well studied in humans. However, studies related to biliary tract cancer (BTC) are scarce. Methods : We examined the association between meat and fish consumption and the risk of BTC in a population-based prospective cohort study in Japan. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using the Cox proportional hazard model. Results : During 1995-1999, 43,177 men and 49,323 women aged 45-74 [...]

Menée en Suède auprès de 731 patientes atteintes d'un cancer du sein et de 1 669 témoins, cette étude analyse l'association entre une exposition professionnelle aux solvants organiques et le risque de développer la maladie après la ménopause, selon le type de produit, l'intensité et la durée d'exposition

Investigating the risk of breast cancer among women exposed to chemicals: a nested case–control study using improved exposure estimates

Videnros, Cecilia ; Selander, Jenny ; Wiebert, Pernilla ; Albin, Maria ; Plato, Nils ; Borgquist, Signe ; Manjer, Jonas ; Gustavsson, Per

Purpose : The aim of this study was to examine if exposures to chemicals at the workplace were associated with an increased risk of postmenopausal breast cancer, using improved exposure estimates. Methods : The design is a case–control study, nested within a cohort of women from the Malmö Diet and Cancer Study. The study comprised 2400 women, 731 cases and 1669 matched controls, born 1923–1950 and living in Malmö, Sweden between 1991 and 1996. An occupational hygienist reclassified the [...]

Menée en France à partir de données portant sur 98 995 femmes âgées de 40 à 65 ans, cette étude de cohorte prospective analyse l'association entre une utilisation de progestatifs avant la ménopause et le risque de mélanome cutané (période de suivi : 1992-2008, 540 cas)

Premenopausal Use of Progestogens and Cutaneous Melanoma Risk: A French Prospective Cohort Study

Cervenka, Iris ; Rahmoun, Marie Al ; Mahamat-Saleh, Yahya ; Boutron-Ruault, Marie-Christine ; Fournier, Agnès ; Kvaskoff, Marina

The influence of sex hormones on melanoma risk has been suggested, but the influence of premenopausal use of progestogens on this cancer has never been investigated. E3N (Etude Epidémiologique auprès de femmes de l’Education Nationale) is a prospective cohort of 98,995 French women aged 40-65 years at inclusion. We used Cox models adjusted for age and melanoma risk factors. Over 1992-2008, 540 melanoma cases were ascertained among 79,558 women. We found a modest association between [...]

Menée en Suède auprès de 288 950 femmes de plus de 40 ans ayant reçu un traitement hormonal substitutif entre 2005 et 2012, cette étude analyse l'association entre les divers types de THS (type de molécules, mode d'administration, etc.) et le risque de cancer de l'ovaire (572 cas)

Menopausal hormone therapy treatment options and ovarian cancer risk: A Swedish prospective population-based matched-cohort study

Simin, Johanna ; Tamimi, Rulla M. ; Callens, Steven ; Engstrand, Lars ; Brusselaers, Nele

Although menopausal hormone therapy (MHT) seemingly increases the risk of ovarian cancer, evidence is insufficient whether the risk varies between various MHT formulations, regimens and administration modes. With the aim of filling these knowledge gaps, we investigated the effect of different MHT treatment options on the risk of ovarian cancer. This prospective Swedish population-based matched-cohort study included all women ≥40 years having used systemic MHT between 2005 and 2012 (288,950 [...]

A partir d'une revue systématique de la littérature publiée entre janvier 2000 et décembre 2017 (13 études), cette méta-analyse évalue l'association entre les caractéristiques de la flore vaginale et la présence d’infections à papillomavirus humains ou de lésions précancéreuses intraépithéliales

A meta-analysis of the relationship between vaginal microecology, human papillomavirus infection and cervical intraepithelial neoplasia

Liang, Yuejuan ; Chen, Mengjie ; Qin, Lu ; Wan, Bing ; Wang, He

Microecology is an emerging discipline in recent years. The female reproductive tract is an important microecological region, and its microecological environment can directly affect women’s cervical health. This meta-analysis aimed to analyze the effects of vaginal microecology on Human papillomavirus (HPV) infection and cervical intraepithelial neoplasia (CIN). PubMed and Web of Science were systematically searched for eligible publications from January 2000 to December 2017. Articles were [...]

Menée en Finlande à partir de données portant sur 2 029 patients atteints d'un cancer diagnostiqué avant l'âge de 20 ans entre 1996 et 2014 et portant sur 10 103 témoins, cette étude analyse l'association entre un diabète maternel diagnostiqué avant ou pendant la grossesse, des prescriptions d'insuline et/ou de metformine pendant la grossesse et le risque de développer la maladie chez l'enfant

Maternal Diabetes and Risk of Childhood Cancer in the Offspring

Seppälä, Laura K ; Vettenranta, Kim ; Pitkäniemi, Janne ; Hirvonen, Elli ; Leinonen, Maarit K ; Madanat-Harjuoja, Laura-Maria

An association between maternal diabetes, its medication and childhood cancer has not been previously explored in a registry-based setting. With a case-control design, we aimed to explore whether maternal diabetes is associated with an increased risk of childhood cancer in the offspring. Combining data from population-based registries, we analyzed a total of 2,029 cases, i.e. persons with childhood cancer diagnosed under the age of 20 years between years 1996-2014 and a total of 10,103 matched [...]

Menée à partir des données des cohortes "the Nurses’ Health Study" et "the Nurses’ Health Study II" portant au total sur 176 492 femmes (durée de suivi : 3 900 264 personnes-années), cette étude analyse l’association entre le nombre de nævi et le risque de cancer (23 004 cas), hormis les cancers de la peau

Cutaneous nevi and internal cancer risk: Results from two large prospective cohorts of US women

Li, Xin ; Wu, Wenting ; Giovannucci, Edward ; Stampfer, Meir J. ; Gao, Xiang ; Han, Jiali

Elevated cutaneous nevus number has been linked to longer telomeres. Recently, a large systematic Mendelian randomization study identified a significant positive association between telomere length and risk of cancer. Here, we hypothesized that higher nevus count, as a phenotypic marker of longer telomere, may be associated with increased risk of internal cancer, and prospectively examined the association between nevus count and total as well as site-specific cancer risk among participants in [...]

Couplée aux données de l'essai "Prostate, Lung, Colorectal, and Ovarian Cancer Screening" et portant sur 323 patients atteints d'un carcinome à cellules rénales et sur 323 témoins, cette étude analyse l'association entre le niveau sérique de protéine de liaison à la vitamine D et le risque de développer la maladie

Vitamin D Binding Protein and Risk of Renal Cell Carcinoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)

Kratzer, Tyler B. ; Weinstein, Stephanie J. ; Albanes, Demetrius ; Mondul, Alison M.

Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included women and non-smokers. We conducted a nested case‐control study in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Cases (n=323) were matched 1:1 to [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2018 (5 articles), cette étude analyse l'association entre les taux sanguin et tissulaire de sélénium et le risque de cancer de la thyroïde

Selenium and thyroid cancer: a systematic review

de Oliveira Maia, Mônica ; Batista, Bruna Aparecida Melo ; Sousa, Morgana Pinheiro ; de Souza, Luana Matos ; Maia, Carla Soraya Costa

The aim of the study was to investigate the association between blood and tissue levels of selenium and thyroid cancer through a systematic review. We searched for observational studies written in English, Spanish, and Portuguese indexed in PubMed, LILACS, and Scielo without date restriction, that evaluated the association between selenium levels in whole-blood, serum, or plasma and/or thyroid tissue and thyroid cancer, both in individuals with cancer of thyroid as in healthy individuals. Then [...]

Menée aux Etats-Unis à partir de données portant sur 457 337 personnes (âge : 50-71 ans), cette étude de cohorte estime, pour la période 1995-2015, la part des cancers papillaires de la thyroïde attribuable au surpoids ou à l'obésité (604 cas)

Impact of overweight and obesity on U.S. papillary thyroid cancer incidence trends (1995-2015)

Kitahara, Cari M ; Pfeiffer, Ruth M ; Sosa, Julie A ; Shiels, Meredith S

Since the early 1980s, papillary thyroid cancer (PTC) incidence rates and the prevalence of obesity, a risk factor for PTC, have increased substantially in the United States. We estimated the proportion of PTC incidence in the United States attributable to overweight/obesity during 1995-2015.NIH-AARP Diet and Health Study cohort data (n = 457,331 participants, 50-71 years and cancer-free at baseline) were used to estimate multivariable-adjusted hazard ratios (HRs) for PTC across body mass index [...]