Menée en Chine à partir de données portant sur 465 patients atteints d'un cancer du poumon de stade avancé, cette étude prospective analyse l'évolution de leur statut nutritionnel, avant et après 4 cycles de chimiothérapie

Nutritional status in patients with advanced lung cancer undergoing chemotherapy: a prospective observational study

Lin, Tie ; Yang, Jing ; Hong, Xuan ; Yang, ZhaoYang ; Ge, Ting ; Wang, Meng

Purpose: The consequences of malnutrition include increased risk of many complications. The assessment and management of nutritional problems are essential in supportive care of patients undergoing therapy. The primary objective of the present study was to assess changes in the nutritional status in lung cancer patients who had undergone chemotherapy. Patients and methods: Preliminary and post-chemotherapy assessments of patients? nutritional status and medical characteristics were conducted [...]

Menée en Corée à partir de données portant sur 55 patients atteints d'un cancer du côlon de stade II à III, cette étude analyse l'évolution du niveau d'activité physique durant les différents cycles de la chimiothérapie

Objectively measured physical activity during chemotherapy in colon cancer patients

Park, Hyuna ; Jung, Minkyu ; Kim, Min Jae ; Min, Jihee ; Lee, Choong-Kun ; Shin, Sang Joon ; Beom, Seung-Hoon ; Ahn, Joong Bae ; Jeon, Justin Y.

Purpose : Although adjuvant chemotherapy can have an impact on physical activity (PA), PA level has not been studied in patients with stage II–III colon cancer. This study investigated PA levels during and between chemotherapy cycles. Methods : We objectively measured PA levels for 2 weeks during the 2nd and 11th chemotherapy cycles. In addition, self-reported PA levels were assessed before chemotherapy initiation, during 2nd, 6th, and 12th chemotherapy cycles. This study included 22 men and 33 [...]

Menée en France à partir de données portant sur 4 262 patientes ayant survécu à un cancer du sein de stade précoce, cette étude prospective compare l'effet, sur les symptômes et la qualité de vie auto-déclarés 2 ans après le diagnostic, d'une hormonothérapie et d'une chimiothérapie

Differential impact of endocrine therapy and chemotherapy on quality of life of breast cancer survivors: a prospective patient-reported outcomes analysis

Ferreira, A R ; Di Meglio, A ; Pistilli, B ; Gbenou, A S ; El-Mouhebb, M ; Dauchy, S ; Charles, C ; Joly, F ; Everhard, S ; Lambertini, M ; Coutant, C ; Cottu, P ; Lerebours, F ; Petit, T ; Dalenc, F ; Rouanet, P ; Arnaud, A ; Martin, A ; Berille, J ; Ganz, P A ; Partridge, A H ; Delaloge, S ; Michiels, S ; Andre, F ; Vaz-Luis, I

Background : In early breast cancer (BC), there has been a trend to escalate endocrine therapy (ET) and to de-escalate chemotherapy (CT). However, the impact of ET versus CT on the quality of life (QoL) of early BC patients is unknown. Here, we characterize the independent contribution of ET and CT on patient-reported outcomes (PROs) at 2 years after diagnosis. Patients and methods : We prospectively collected PROs in 4262 eligible patients using the European Organization for Research and [...]

Mené sur 175 patientes atteintes d'un cancer du sein ER+ de stade métastatique, cet essai de phase III évalue l'efficacité de soins buccaux dispensés par un professionnel avant le début du traitement anticancéreux pour réduire le risque de mucite buccale induite par l'évérolimus

Oral Care Evaluation to Prevent Oral Mucositis in Estrogen Receptor-Positive Metastatic Breast Cancer Patients Treated with Everolimus (Oral Care-BC): A Randomized Controlled Phase III Trial

Niikura, Naoki ; Nakatukasa, Katsuhiko ; Amemiya, Takeshi ; Watanabe, Ken‐ichi ; Hata, Hironobu ; Kikawa, Yuichiro ; Taniike, Naoki ; Yamanaka, Takashi ; Mitsunaga, Sachiyo ; Nakagami, Kazuhiko ; Adachi, Moriyasu ; Kondo, Naoto ; Shibuya, Yasuyuki ; Hayashi, Naoki ; Naito, Mariko ; Kashiwabara, Kosuke ; Yamashita, Toshinari ; Umeda, Masahiro ; Mukai, Hirofumi ; Ota, Yoshihide

Background : The incidence of oral mucositis (any grade) after everolimus treatment is 58% in the general population and 81% in Asian patients. This study hypothesized that professional oral care (POC) before everolimus treatment could reduce the incidence of everolimus‐induced oral mucositis. Materials and Methods : This randomized, multicenter, open‐label, phase III study evaluated the efficacy of POC in preventing everolimus‐induced mucositis. Patients were randomized into POC and control [...]

Menée sur les 5 continents, cette étude internationale analyse les facteurs associés à l'évolution des disparités géographiques dans l'incidence du carcinome hépatocellulaire, sur la période 1978-2012

International trends in hepatocellular carcinoma incidence, 1978-2012

Petrick, Jessica L. ; Florio, Andrea A. ; Znaor, Ariana ; Ruggieri, David ; Laversanne, Mathieu ; Alvarez, Christian S. ; Ferlay, Jacques ; Valery, Patricia C. ; Bray, Freddie ; McGlynn, Katherine A.

Primary liver cancer, the major histology of which is hepatocellular carcinoma (HCC), is the second leading cause of cancer death worldwide. We comprehensively examine recent international trends of primary liver cancer and HCC incidence using population-based cancer registry data. Incidence for all primary liver cancer and for HCC by calendar time and birth cohort was examined for selected countries between 1978 and 2012. For each successive 5-year period, age-standardized incidence rates were [...]

Menée à partir des données des registres américains des cancers, cette étude analyse l'évolution des disparités ethniques et sexuelles dans l'incidence du cancer du foie sur la période 1992-2016

Changing trends in liver cancer incidence by race/ethnicity and sex in the US: 1992–2016

Salvatore, Maxwell ; Jeon, Jihyoun ; Meza, Rafael

Purpose : Liver cancer incidence continues to increase while incidence of most other cancers is decreasing. We analyze recent and long-term trends of US liver cancer incidence by race/ethnicity and sex to best understand where to focus preventive efforts. Methods : Liver cancer incidence rates from 1992 to 2016 were obtained from the Surveillance, Epidemiology, and End Results registry. Delay-adjusted age-standardized incidence trends by race/ethnicity and sex were analyzed using joinpoint [...]

Menée aux Etats-Unis à partir de données portant sur 2 265 adultes ayant survécu à un cancer pédiatrique (âge moyen : 32,5 ans), cette étude analyse l'association entre les caractéristiques du voisinage (ruralité, niveau socioéconomique,...) et l'obésité

Neighborhood effect and obesity in adult survivors of pediatric cancer: A report from the St. Jude Lifetime Cohort Study

Howell, Carrie R. ; Wilson, Carmen L. ; Yasui, Yutaka ; Srivastava, Deo Kumar ; Lu, Wei ; Bjornard, Kari L. ; Ehrhardt, Matthew J. ; Brinkman, Tara M. ; Chemaitilly, Wassim ; Hodges, Jason R. ; Lanctot, Jennifer Q. ; Robison, Leslie L. ; Hudson, Melissa M. ; Ness, Kirsten K.

Survivors of childhood cancer are at risk for obesity, a condition potentially modifiable if dietary intake and physical activity are optimized. These health behaviors are likely influenced by neighborhood of residence, a determinant of access to healthy, affordable food and safe and easy exercise opportunities. We examined associations between neighborhood level factors and obesity among survivors in the St. Jude Lifetime cohort and community comparison group members. Persons with residential [...]

A partir d'une revue de la littérature publiée entre 1998 et 2017 (37 études), cette étude analyse les expériences en termes d'accès aux soins et de besoins spécifiques en soins, chez des personnes issues des minorités sexuelles, atteintes d'un cancer ou ayant survécu à la maladie

Care delivery, patient experiences, and health outcomes among sexual and gender minority patients with cancer and survivors: A scoping review

Kent, Erin E. ; Wheldon, Christopher W. ; Smith, Ashley Wilder ; Srinivasan, Shobha ; Geiger, Ann M.

Sexual and gender minorities (SGMs) face a disproportionate burden of cancer, yet little is known about the experiences and specific needs of these underserved populations in cancer care delivery. The authors conducted a scoping review to characterize the literature on cancer care delivery, health outcomes, and health care experiences for patients with cancer and survivors identifying as SGM. In total, 1176 peer-reviewed citations were identified after a systematic search of the PubMed/Medline, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2019 (11 articles), cette étude met en évidence l'absence d'effet, sur la réduction des infections ou de la mortalité, d'un régime alimentaire conçu pour les patients neutropéniques atteints d'un cancer

Lack of Efficacy of the Neutropenic Diet in Decreasing Infections among Cancer Patients: A Systematic Review

Ramamoorthy, Venkataraghavan ; Rubens, Muni ; Appunni, Sandeep ; Saxena, Anshul ; McGranaghan, Peter ; Veledar, Emir ; Viamonte-Ros, Ana ; Shehadeh, Nancy ; Kaiser, Adeel ; Kotecha, Rupesh

The objective of this systematic review is to evaluate the existing evidence supporting the effectiveness of the neutropenic diet in decreasing infection and mortality among cancer patients. We searched MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Scopus for relevant articles published from database inception until March 2019. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed for this review. Individual studies were [...]

Menée en Angleterre à partir de données portant sur 1 590 477 patients atteints d'un cancer sur la période 2006-2015 (sein, côlon-rectum, poumon, mélanome et prostate), cette étude livre une estimation de la survie à 10 ans et souligne l'importance du choix des indicateurs pour évaluer les probabilités de décès par cancer et par autre cause

Conditional crude probabilities of death for English cancer patients

Wong, Kwok F. ; Lambert, Paul C. ; Mozumder, Sarwar I. ; Broggio, John ; Rutherford, Mark J.

Background : Cancer survival statistics are typically reported by using measures discounting the impact of other-cause mortality, such as net survival. This is a hypothetical measure and is interpreted as excluding the possibility of cancer patients dying from other causes. Crude probability of death partitions the all-cause probability of death into deaths from cancer and other causes. Methods : The National Cancer Registration and Analysis Service is the single cancer registry for England. In [...]

A partir d'une revue systématique de la littérature (12 études, 32 846 patients), cette méta-analyse évalue l'association entre une consommation d'alcool avant le diagnostic et la survie chez des patients atteints d'un cancer, selon l'intensité de la consommation

Association between Alcohol Consumption and Survival in Colorectal Cancer: A Meta-analysis

Kim, Youngyo ; Je, Youjin ; Giovannucci, Edward L.

Background: Although an association between alcohol consumption and risk of colorectal cancer is well established, little is known about the association between alcohol consumption and colorectal cancer survival. We conducted a meta-analysis of prospective cohort studies to quantitatively assess this association. Methods: Data searches were performed using PubMed and ISI Web of Science databases through December 2018. We estimated pooled RRs with 95% confidence intervals (CI) using [...]

Menée aux Etats-Unis à partir de données portant sur 2 435 patientes atteintes d'un cancer du sein, cette étude analyse, en fonction du critère ethnique et du lieu de résidence (milieu rural ou urbain), l'effet d'un diagnostic de cancer sur leur situation financière et professionnelle

Employment changes following breast cancer diagnosis: the effects of race and place

Spencer, Jennifer C ; Rotter, Jason S ; Eberth, Jan M ; Zahnd, Whitney E ; Vanderpool, Robin C ; Ko, Linda K ; Davis, Melinda M ; Troester, Melissa A ; Olshan, Andrew F ; Wheeler, Stephanie B

The financial implications of breast cancer diagnosis may be greater among rural and Black women. Women with incident breast cancer were recruited as part of the Carolina Breast Cancer Study. We compared unadjusted and adjusted prevalence of cancer-related job or income loss, and a composite measure of either outcome, by rural residence and stratified by race. 2,435 women were included, 11.7% were rural, 48.5% were Black, and 38.0% reported employment changes after diagnosis. Rural women more [...]

Menée en Suède à partir des données portant sur 5 625 patients ayant survécu 1 an à un cancer du testicule diagnostiqué entre 1980 et 2009, cette étude analyse le risque de second cancer en lien avec les différents traitements anticancéreux (durée médiane d'observation : 16,6 ans ; 572 cas de second cancer)

Continuing increased risk of second cancer in long-term testicular cancer survivors after treatment in the cisplatin era

Hellesnes, Ragnhild ; Kvammen, Øivind ; Myklebust, Tor Åge ; Bremnes, Roy Martin ; Karlsdottir, Ása ; Negaard, Helene F. S. ; Tandstad, Torgrim ; Wilsgaard, Tom ; Fosså, Sophie Dorothea ; Haugnes, Hege Sagstuen

Using complete information on total treatment burden, this population-based study aimed to investigate second cancer (SC) risk in testicular cancer survivors (TCS) treated in the cisplatin era. The Cancer Registry of Norway identified 5 625 1-year TCS diagnosed 1980-2009. Standardized incidence ratios (SIRs) were calculated to evaluate the total and site-specific incidence of SC compared with the general population. Cox regression analyses evaluated the effect of treatment on the risk of SC. [...]

Mené au Danemark sur 137 patientes ayant survécu à un cancer du sein et sur 13 patients ayant survécu à un cancer de la prostate, cet essai randomisé évalue l'efficacité d'une psychothérapie basée sur le concept de la pleine conscience et dispensée sur internet pour réduire les symptômes d'anxiété et de dépression

Internet-delivered Mindfulness-Based Cognitive Therapy for anxiety and depression in cancer survivors: A randomized controlled trial

Nissen, Eva Rames ; O'Connor, Maja ; Kaldo, Viktor ; Højris, Inger ; Borre, Michael ; Zachariae, Robert ; Mehlsen, Mimi

Objective : Internet-delivered interventions may alleviate distress in cancer survivors with limited access to psychological face‐to‐face treatment. In collaboration with a group of cancer survivors, we developed and tested the efficacy of a therapist‐assisted internet-delivered mindfulness-based cognitive therapy (iMBCT) program for anxiety and depression in cancer survivors. Methods : A total of 1282 cancer survivors were screened for anxiety and depression during their routine oncology [...]

Mené sur 262 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'efficacité, pour réduire leur peur de la récidive, d'une intervention d'auto-assistance personnalisée dispensée en ligne et basée sur les principes de la thérapie cognitive comportementale

No effect of CBT-based online self-help training to reduce fear of cancer recurrence: First results of the CAREST multicenter randomized controlled trial

van Helmondt, Sanne Jasperine ; van der Lee, Marije Liesbeth ; van Woezik, Rosalie Antonia Maria ; Lodder, Paul ; De Vries, Jolanda

Objective : Fear of cancer recurrence (FCR) is a common consequence of surviving cancer, therefore an easily accessible self‐help training could help many cancer survivors to deal with FCR at low costs. The CAncer REcurrence Self‐help Training [CAREST] trial evaluates the effectiveness of an online tailored self‐help training, based on evidence‐based cognitive behavioral therapy principles in breast cancer survivors. Also, possible predictors for benefitting from the online self‐help training [...]

A partir d'une revue de la littérature, cette étude présente les diverses méthodes d’analyse économique utilisées pour estimer les coûts et les bénéfices des programmes de santé publique aux Etats-Unis, puis analyse l’application de ces méthodes dans le cadre du Programme national de détection précoce du cancer du sein et du col de l'utérus

Economics of public health programs for underserved populations: a review of economic analysis of the National Breast and Cervical Cancer Early Detection Program

Khushalani, Jaya S. ; Trogdon, Justin G. ; Ekwueme, Donatus U. ; Yabroff, K. Robin

Purpose : The purpose of this paper is to provide a brief overview of economic analysis methods used in estimating the costs and benefits of public health programs and systematically review the application of these methods to the National Breast and Cervical Cancer Early Detection Program (NBCCEDP). Methods : Published literature on economic analyses of the NBCCEDP was systematically reviewed. The Consensus on Health Economic Criteria checklist was used to assess methodological quality of the [...]

Menée aux Etats-Unis à partir de données portant sur 383 patients décédés d'un cancer hématologique en 2014, cette étude de cohorte rétrospective analyse l'association entre l'intensité des soins dispensés en fin de vie et les caractéristiques des discussions (moment, lieu et implication du médecin) entre l'oncologue et le patient concernant les objectifs des soins

Goals of care discussions for patients with blood cancers: Association of person, place, and time with end-of-life care utilization

Odejide, Oreofe O. ; Uno, Hajime ; Murillo, Anays ; Tulsky, James A. ; Abel, Gregory A.

Background : Patients with blood cancers experience high‐intensity medical care near the end of life (EOL) and low rates of hospice use; attributes of goals of care (GOC) discussions may partly explain these outcomes. Methods : By using a retrospective cohort of patients with blood cancer who received care at Dana‐Farber Cancer Institute and died in 2014, the authors assessed the potential relationship between timing, location, and the involvement of hematologic oncologists in the first GOC [...]

Menée en Italie à partir de données portant sur 229 patients atteints d'un cancer thoracique, cette étude rétrospective analyse les facteurs cliniques et démographiques associés à leur prise en charge ambulatoire dans une unité de soins palliatifs

Outpatient Palliative Care and Thoracic Medical Oncology: referral criteria and clinical care pathways

Caraceni, Augusto ; Lo Dico, Silvia ; Zecca, Ernesto ; Brunelli, Cinzia ; Bracchi, Paola ; Mariani, Luigi ; Garassino, Marina C. ; Vitali, Milena

Objectives : Recent evidences show that early integration of palliative care (PC) with oncology has a positive impact on patients' quality of life, quality of care and costs. However, there is no consensus on outpatient referral criteria. Based on real world data, the aim of this study was to identify timing and factors associated to PC referral in patients with thoracic malignancies, and to describe their clinical care pathway. Material and Methods : This observational retrospective study [...]