A partir d'une revue systématique de la littérature publiée jusqu'en mars 2019 (20 études ; 4 676 cas), cette méta-analyse évalue l'association entre le tabagisme (intensité et durée) et le risque de cancer de la vésicule biliaire

Should we consider gallbladder cancer a new smoking-related cancer? A comprehensive meta-analysis focused on dose–response relationships

Lugo, Alessandra ; Peveri, Giulia ; GALLUS, Silvano

The few studies on the association of smoking with gallbladder cancer risk have given conflicting results. Here, we provide the most accurate and up-to-date quantification of the effect of cigarette smoking on gallbladder cancer risk, and investigate for the first time the dose–response relationships. Using an innovative approach for the identification of publications, we conducted a systematic review and meta-analysis of epidemiological studies published until March 2019 on the association of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2018 (44 études), cette méta-analyse évalue l'association entre une exposition professionnelle à l'amiante et le risque de cancer colorectal ainsi que la mortalité spécifique

Exposure to asbestos and the risk of colorectal cancer mortality: a systematic review and meta-analysis

Kwak, Kyeongmin ; Paek, Domyung ; Zoh, Kyung Ehi

Asbestos exposure is associated with mesothelioma and cancer of the lung, larynx and ovary. However, the association between asbestos exposure and colorectal cancer is controversial despite several systematic reviews of the literature, including a number of meta-analyses. We performed a systematic review and meta-analysis to evaluate quantitatively the association between exposure to asbestos and colorectal cancer. We searched for articles on occupational asbestos exposure and colorectal cancer [...]

Menée aux Etats-Unis à partir de données de la cohorte "Sister study" portant sur 47 433 femmes (durée moyenne de suivi : 8,4 ans), cette étude analyse l'association entre une exposition à des particules fines (

Air Pollution, Clustering of Particulate Matter Components, and Breast Cancer in the Sister Study: A U.S.-Wide Cohort

Alexandra J. White ; Joshua P. Keller ; Shanshan Zhao ; Rachel Carroll ; Joel D. Kaufman ; Dale P. Sandler

Background : Particulate matter (PM) is a complex mixture. Geographic variations in PM may explain the lack of consistent associations with breast cancer. Objective : We aimed to evaluate the relationship between air pollution, PM components, and breast cancer risk in a United States-wide prospective cohort. Methods : We estimated annual average ambient residential levels of particulate matter <2.5   [...]

Menée sur la période 1992-2015 à partir de données de la cohorte EPIC portant sur 494 508 femmes, cette étude analyse l'association entre une utilisation de contraceptifs oraux ou d'un traitement hormonal substitutif et le risque de mélanome (2 466 cas)

Exogenous hormone use and cutaneous melanoma risk in women: The European Prospective Investigation into Cancer and Nutrition

Cervenka, Iris ; Al Rahmoun, Marie ; Mahamat-Saleh, Yahya ; Fournier, Agnès ; Boutron-Ruault, Marie-Christine ; Severi, Gianluca ; Caini, Saverio ; Palli, Domenico ; Ghiasvand, Reza ; Veierod, Marit B. ; Botteri, Edoardo ; Tjønneland, Anne ; Olsen, Anja ; Fortner, Renée T. ; Kaaks, Rudolf ; Schulze, Matthias B. ; Panico, Salvatore ; Trichopoulou, Antonia ; Dessinioti, Clio ; Niforou, Katerina ; Sieri, Sabina ; Tumino, Rosario ; Sacerdote, Carlotta ; Bueno-de-Mesquita, Bas ; Sandanger, Torkjel M. ; Colorado-Yohar, Sandra ; Sánchez, Maria J. ; Gil Majuelo, Leire ; Luján-Barroso, Leila ; Ardanaz, Eva ; Merino, Susana ; Isaksson, Karolin ; Butt, Salma ; Ljuslinder, Ingrid ; Jansson, Malin ; Travis, Ruth C. ; Khaw, Kay-Tee ; Weiderpass, Elisabete ; Dossus, Laure ; Rinaldi, Sabina ; Kvaskoff, Marina

Evidence suggests an influence of sex hormones on cutaneous melanoma risk, but epidemiologic findings are conflicting. We examined the associations between use of oral contraceptives (OCs) and menopausal hormone therapy (MHT) and melanoma risk in women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Information on exogenous hormone use at baseline was derived from [...]

Menée en Australie par questionnaire et à l'aide d'échantillons sanguins collectés auprès de 1 161 personnes (âge : 45-84 ans ; 57% de femmes), cette étude analyse l'association entre une exposition aux UV solaires et la présence d'anticorps anti-papillomavirus humains (37 types) associés aux lésions cutanées

High ambient solar UV correlates with greater beta HPV seropositivity in New South Wales, Australia

Kricker, Anne ; Weber, Marianne F ; Brenner, Nicole ; Banks, Emily ; Pawlita, Michael ; Sitas, Freddy ; Hodgkinson, Verity S ; Rahman, Bayzid ; van Kemenade, Cathelijne H ; Armstrong, Bruce K. ; Waterboer, Tim

Background : Human papillomavirus (HPV) infection is highly prevalent worldwide and may have a role, with sun exposure, in causing cutaneous squamous cell carcinoma. Little is known about the relationship of UV exposure and seroprevalence of cutaneous HPVs in the general population. Methods : Using multiplex serology, we estimated the seroprevalence of 23 beta and 7 gamma HPVs and 7 other antigens (mu HPV1, HPV63, nu HPV41, alpha HPV16; polyomaviruses HPyV7 and MCV; p53) in a population-based [...]

Menée au Danemark auprès de 126 174 personnes ayant déjà présenté une lésion anale (bénigne ou précancéreuse), cette étude analyse l'association entre le type de lésions et le risque de cancer anal, en fonction du statut sérologique au VIH

Risk of anal cancer following benign anal disease and anal cancer precursor lesions: A Danish nationwide cohort study

Faber, Mette Tuxen ; Frederiksen, Kirsten ; Palefsky, Joel ; Kjaer, Susanne K.

Background : Human papillomavirus (HPV) is associated with the majority of anal high-grade intraepithelial neoplasia (AIN) and anal cancers. Little is known about the risk of anal cancer following a diagnosis of benign anal disease and AIN. Methods : Using data from nationwide, population-based Danish registries, a cohort of 126,174 individuals with either non-neoplastic anal disease or AIN 1-3 during 1970-2016 was followed until first occasion of anal cancer. Information on HIV status was [...]

Menée en Norvège à l'aide d'échantillons sanguins prélevés sur 422 personnes atteintes d'un lymphone non hodgkinien et sur 434 témoins, cette étude analyse l'association entre les niveaux sériques des marqueurs d'activation immunitaire sCD27 et sCD30 et le risque de développer la maladie

Prediagnostic serum sCD27 and sCD30 in serial samples and risks of non-Hodgkin lymphoma subtypes

Purdue, Mark P. ; Lan, Qing ; Langseth, Hilde ; Grimsrud, Tom K. ; Hildesheim, Allan ; Rothman, Nathaniel

Elevated prediagnostic serum levels of the immune activation markers sCD27 and sCD30 have been associated with non-Hodgkin lymphoma (NHL). However, the use of a single sample per participant in these studies has limited etiologic inferences. We report findings, overall and by NHL subtype, from a case–control analysis (422 cases, 434 controls) within the Janus Serum Bank with two samples per subject collected on average 5 years apart. Chronic lymphocytic leukemia/small lymphocytic lymphoma [...]

A partir de données des cohortes "the Nurses’ Health Studies" portant sur 252 femmes atteintes d'un cancer de l'ovaire et sur 252 témoins (âge : 25-55 ans ; durée moyenne de suivi : 12,3 ans), cette étude analyse l'association entre les niveaux circulants de quatre groupes de lipides (lysophosphatidylcholines, phosphatidylcholines, céramides et sphingomyélines) et le risque de développer la maladie

Circulating Lysophosphatidylcholines, Phosphatidylcholines, Ceramides, and Sphingomyelins and Ovarian Cancer Risk: a 23-year Prospective Study

Zeleznik, Oana A ; Clish, Clary B ; Kraft, Peter ; Avila-Pancheco, Julian ; Eliassen, A Heather ; Tworoger, Shelley S

Experimental evidence supports a role of lipid dysregulation in ovarian cancer progression. We estimated associations with ovarian cancer risk for circulating levels of four lipid groups, previously hypothesized to be associated with ovarian cancer, measured 3-23 years before diagnosis.Analyses were conducted among cases (N = 252) and matched controls (N = 252) from the Nurses’ Health Studies. We used logistic regression adjusting for risk factors to investigate associations of [...]

Menée aux Etats-Unis auprès de 424 391 hommes et de 538 926 femmes âgés de 30 à 89 ans (durée médiane de suivi : 24,4 ans), cette étude analyse, en fonction de l'âge à l'évaluation, l'association entre l'indice de masse corporelle et la mortalité par cancer du pancréas (8 354 cas)

The Association of Body Mass Index with Pancreatic Cancer: Variation by Age at Body Mass Index Assessment

Jacobs, Eric J ; Newton, Christina C ; Patel, Alpa V ; Stevens, Victoria L ; Islami, Farhad ; Flanders, W Dana ; Gapstur, Susan M

Higher body mass index (BMI) is associated with increased risk of pancreatic cancer in epidemiologic studies but BMI has usually been assessed at older ages, potentially underestimating the full impact of excess weight. We examined the association between BMI and pancreatic cancer mortality among 963,317 adults aged 30-89 years at enrollment into Cancer Prevention Study-II in 1982. During follow-up through 2014, 8,354 participants died of pancreatic cancer. Hazard ratios (HRs) per 5 BMI-units, [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2018 (10 études ; 6 773 066 cas), cette méta-analyse évalue l'association entre la ligature des trompes et le risque de cancer de l'endomètre

Tubal ligation and endometrial Cancer risk: a global systematic review and meta-analysis

Loghmani, Laleh ; Saedi, Nafise ; Omani-Samani, Reza ; Safiri, Saeid ; Sepidarkish, Mahdi ; Maroufizadeh, Saman ; Esmailzadeh, Arezoo ; Shokrpour, Maryam ; Khedmati Morasae, Esmaeil ; Almasi-Hashiani, Amir

Background : Studies on relationship between tubal ligation and endometrial cancer have led to contradictory findings. In several studies, however, a reduced endometrial cancer risk was suggested following tubal ligation. Therefore, a systematic review and meta-analysis was conducted to examine the relationship between tubal ligation and endometrial cancer risk. Methods : In this systematic review and meta-analysis, PubMed/Medline, Web of Science, Scopus, Embase, and Google Scholar were [...]