Menée au Japon sur 50 patients atteints d'un cancer gastro-intestinal et souffrant de cachexie, cette étude évalue l'efficacité, du point de vue de la proportion de patients dont la masse maigre corporelle reste stable ou augmente, et la toxicité de l'anamoréline

A multicenter, open-label, single-arm study of anamorelin (ONO-7643) in advanced gastrointestinal cancer patients with cancer cachexia

Hamauchi, Satoshi ; Furuse, Junji ; Takano, Toshimi ; Munemoto, Yoshinori ; Furuya, Ken ; Baba, Hideo ; Takeuchi, Manabu ; Choda, Yasuhiro ; Higashiguchi, Takashi ; Naito, Tateaki ; Muro, Kei ; Takayama, Koichi ; Oyama, Shusuke ; Takiguchi, Toru ; Komura, Naoyuki ; Tamura, Kazuo

Background : Cancer cachexia is characterized by weight loss and is associated with increased morbidity and mortality in patients with cancer. Anamorelin (ONO-7643; ANAM) is a novel and selective ghrelin receptor agonist that improves appetite, lean body mass (LBM), body weight, and anorexia. Methods : This multicenter, open-label, single-arm study investigated the efficacy and safety of 100 mg anamorelin in 50 Japanese patients with advanced and unresectable gastrointestinal (colorectal, [...]

Cette étude présente les recommandations d'un groupe d'experts international pour le traitement de la constipation chez des patients atteints d'un cancer de stade avancé

MASCC recommendations on the management of constipation in patients with advanced cancer

Davies, Andrew ; Leach, Charlotte ; Caponero, Ricardo ; Dickman, Andrew ; Fuchs, David ; Paice, Judith ; Emmanuel, Anton

Purpose : The Palliative Care Study Group of the Multinational Association for Supportive Care in Cancer formed a subgroup to develop evidence-based recommendations on the management of constipation in patients with advanced cancer. Methods : These recommendations were developed in accordance with the MASCC Guidelines Policy. A search strategy for Medline was developed, and the Cochrane Database of Systematic Reviews and the Cochrane Central Register of Controlled Trials were explored for [...]

Menée à partir d'une revue de la littérature publiée entre 1980 et 2018, cette méta-analyse évalue l'efficacité d'interventions à base d'exercices physiques pour améliorer la qualité du sommeil chez des patients atteints d'un cancer

Meta-analysis: Exercise intervention for sleep problems in cancer patients

Fang, Yuan-Yuan ; Hung, Chia-Tai ; Chan, Jui-Chun ; Huang, Sheng-Miauh ; Lee, Yun-Hsiang

Background : Sleep problems cause physical and mental distress and may influence the survival of cancer patients. Objectives : This study aimed to explore the efficacy of exercise intervention to improve sleep in cancer patients. Methods : Published papers from 1980 to 2018 were searched. Results : The major findings included (a) exercise intervention had small positive effects on enhancing total subjective sleep quality (TSSQ; g = 0.38, 95% CI = 0.21–0.54) and objective sleep onset latency (g [...]

Cette étude analyse les recommandations actualisées de l'"American Society of Clinical Oncology" concernant la prévention et le traitement d'une thrombose veineuse chez les patients atteints d'un cancer

Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update

Nigel S. Key ; Alok A. Khorana ; Nicole M. Kuderer ; Kari Bohlke ; Agnes Y.Y. Lee ; Juan I. Arcelus ; Sandra L. Wong ; Edward P. Balaban ; Christopher R. Flowers ; Charles W. Francis ; Leigh E. Gates ; Ajay K. Kakkar ; Mark N. Levine ; Howard A. Liebman ; Margaret A. Tempero ; Gary H. Lyman ; Anna Falanga

PURPOSE : To provide updated recommendations about prophylaxis and treatment of venous thromboembolism (VTE) in patients with cancer. METHODS : PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and meta-analyses of RCTs published from August 1, 2014, through December 4, 2018. ASCO convened an Expert Panel to review the evidence and revise previous recommendations as needed. RESULTS : The systematic review included 35 publications on VTE prophylaxis and [...]

Menée aux Etats-Unis entre 2010 et 2017 par enquête auprès de 115 091 participants, cette étude analyse les facteurs associés à la présence de douleurs chroniques chez les patients ayant survécu à un cancer

Prevalence of chronic pain among cancer survivors in the United States, 2010-2017

Sanford, Nina N. ; Sher, David J. ; Butler, Santino S. ; Xu, Xiaohan ; Ahn, Chul ; Aizer, Ayal A. ; Mahal, Brandon A.

Background : There are a growing number of cancer survivors in the United States who are at risk for chronic pain due to cancer disease and treatments. The prevalence of chronic pain among cancer survivors has not been comprehensively reported. Methods : This study used data from the National Health Interview Survey (2010-2017) to compare the prevalence of chronic pain between participants with a cancer diagnosis and participants without one. Adjusted odds ratios (AORs) of having chronic pain [...]

Menée en Grèce à partir de données portant sur 122 patients atteints d'un cancer et souffrant d'une neuropathie périphérique induite par la chimiothérapie, cette étude de cohorte identifie les facteurs associés au risque de chute

Assessing risk factors of falls in cancer patients with chemotherapy-induced peripheral neurotoxicity

Argyriou, Andreas A. ; Bruna, Jordi ; Anastopoulou, Garifallia G. ; Velasco, Roser ; Litsardopoulos, Pantelis ; Kalofonos, Haralabos P.

Aim : To identify the risk factors of falls in a well-characterized cohort of cancer patients with chemotherapy-induced peripheral neurotoxicity (CIPN). Patients and methods : We studied 122 cancer patients experiencing any grade of CIPN, following completion of different chemotherapeutic regimens for various non-hematological malignancies. The results of the clinical examination were summarized by means of the Total Neuropathy Score—clinical version (TNSc®). A neurophysiological examination [...]

Menée aux Etats-Unis auprès de 160 patients atteints d'un myélome multiple récidivant ou réfractaire, cette étude analyse les facteurs associés à leur satisfaction concernant les traitements reçus

Patient-Reported Factors in Treatment Satisfaction in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Chari, Ajai ; Romanus, Dorothy ; DasMahapatra, Pronabesh ; Hoole, Michael ; Lowe, Maria ; Curran, Chris ; Campbell, Scott ; Bell, Jill A.

Background : Therapy choices in relapsed/refractory multiple myeloma (RRMM) should consider patient satisfaction with treatment, because it is associated with adherence to therapy, health outcomes, and medical safety. The primary objective of this pilot cross‐sectional observational study was to ascertain factors associated with patient‐reported treatment satisfaction in RRMM. Patients and Methods : Patients with a self‐reported diagnosis of RRMM recruited from PatientsLikeMe, MyelomaCrowd, and [...]

Mené sur 409 patientes atteintes d'un cancer du sein (243 en surpoids et 166 de poids normal), cet essai randomisé évalue l'efficacité, du point de vue du changement de poids au 12ème mois, de deux programmes de contrôle du poids débutés après le diagnostic, l'un mené à domicile et non supervisé, l'autre supervisé et dispensé collectivement

The effectiveness of home versus community-based weight control programmes initiated soon after breast cancer diagnosis: a randomised controlled trial

Harvie, Michelle ; Pegington, Mary ; McMullan, Debbie ; Bundred, Nigel ; Livingstone, Karen ; Campbell, Anna ; Wolstenholme, Jane ; Lovato, Eleanora ; Campbell, Helen ; Adams, Judith ; Speed, Sean ; Morris, Julie ; Howell, Sacha ; Howell, Anthony

Background : Breast cancer diagnosis may be a teachable moment for lifestyle behaviour change and to prevent adjuvant therapy associated weight gain. We assessed the acceptability and effectiveness of two weight control programmes initiated soon after breast cancer diagnosis to reduce weight amongst overweight or obese women and prevent gains in normal-weight women. Methods : Overweight or obese (n = 243) and normal weight (n = 166) women were randomised to a three-month unsupervised home [...]

Mené sur 240 patientes atteintes d'un cancer du sein, cet essai randomisé évalue l'intérêt, du point de vue de l'achèvement du traitement, de la réduction du risque de thrombocytopénie et du taux d'hospitalisations, d'un programme supervisé d'exercices physiques pendant la chimiothérapie

Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial

Mijwel, Sara ; Bolam, Kate A. ; Gerrevall, Jacob ; Foukakis, Theodoros ; Wengström, Yvonne ; Rundqvist, Helene

Background : Exercise during chemotherapy is suggested to provide clinical benefits, including improved chemotherapy completion. Despite this, few randomized controlled exercise trials have reported on such clinical endpoints. From the OptiTrain trial we previously showed positive effects on physiological and health‐related outcomes after 16 weeks of supervised exercise in patients with breast cancer undergoing chemotherapy. Here, we examined the effects of exercise on rates of chemotherapy [...]

A partir d'une revue systématique de la littérature (9 articles), cette étude analyse l'intérêt de la marche nordique pour améliorer la santé physique et réduire les symptômes chez des patientes atteintes d'un cancer du sein

Nordic walking for women with breast cancer: A systematic review

Sánchez-Lastra, Miguel A. ; Torres, Jorge ; Martínez-Lemos, Iván ; Ayán, Carlos

Nordic walking (NW) seems to be an interesting rehabilitation strategy for women with breast cancer (BC). No review article that has synthesised and summarised the existing scientific evidence about the effect of NW on BC survivors has been published so far. A systematic review was conducted aimed at identifying the characteristics and methodological quality of the studies that have analysed the effects of NW on women with BC. The critical appraisal of the randomised controlled trials (RCTs) [...]

Mené sur 351 patientes ayant survécu à un cancer du sein et en surpoids, cet essai randomisé évalue l'intérêt, pour diminuer le volume d'un lymphœdème, d'un programme d'aide à la perte de poids et d'exercices physiques à domicile

Effect of Home-Based Exercise and Weight Loss Programs on Breast Cancer–Related Lymphedema Outcomes Among Overweight Breast Cancer Survivors: The WISER Survivor Randomized Clinical Trial

Schmitz, Kathryn H. ; Troxel, Andrea B. ; Dean, Lorraine T. ; DeMichele, Angela ; Brown, Justin C. ; Sturgeon, Kathleen ; Zhang, Zi ; Evangelisti, Margaret ; Spinelli, Bryan ; Kallan, Michael J. ; Denlinger, Crystal ; Cheville, Andrea ; Winkels, Renate M. ; Chodosh, Lewis ; Sarwer, David B.

Importance : To our knowledge, no randomized clinical trials have assessed the effects of the combination of weight loss and home-based exercise programs on lymphedema outcomes. Objective : To assess weight loss, home-based exercise, and the combination of weight loss and home-based exercise with clinical lymphedema outcomes among overweight breast cancer survivors. Design, Setting, and Participants : This randomized clinical trial (Women in Steady Exercise Research [WISER] Survivor clinical [...]

A partir d'une revue systématique de la littérature publiée entre mars et avril 2019 (44 études, 16 683 patientes), cette identifie les facteurs associés à la qualité de vie chez des patientes ayant reçu une reconstruction mammaire après une mastectomie

A Systematic Review of Factors Affecting Quality of Life After Post-Mastectomy Breast Reconstruction in Women with Breast Cancer

Sousa, Helena ; Castro, Sónia ; Abreu, Joaquim ; Pereira, M. Graça

Objective : The aim of this study is to present a broader perspective of factors affecting the quality of life after post-mastectomy breast reconstruction in women with breast cancer by considering these patients’ self-reported outcomes. Methods : The search was performed from March 29 to April 19, 2019, on the following databases: PsycInfo; Web of Science Core Collection, Current Contents Connect, Derwent Innovations Index, KCI-Korean Journal Database, Russian Science Citation Index, SciELO [...]

Mené sur 136 patients atteints d'un gliome traité par témozolomide, cet essai de phase II évalue l'efficacité, du point de vue de l'absence d'épisode émétique ou d'utilisation de médicament antiémétique à 7 jours, de l'ajout d'aprépitant à l'ondansétron pendant 5 jours

Randomized open-label phase II trial of 5-day aprepitant plus ondansetron compared to ondansetron alone in the prevention of chemotherapy-induced nausea-vomiting (CINV) in glioma patients receiving adjuvant temozolomide

Patel, Mallika P. ; Woodring, Sarah ; Randazzo, Dina M. ; Friedman, Henry S. ; Desjardins, Annick ; Healy, Patrick ; Herndon, James E. ; McSherry, Frances ; Lipp, Eric S. ; Miller, Elizabeth ; Peters, Katherine B. ; Affronti, Mary Lou

Purpose : CINV remains a distressing side effect experienced by glioma patients receiving multi-day temozolomide therapy, in spite of guideline-based antiemetic therapy with selective serotonin-receptor-antagonists. Antiemetic research with aprepitant has routinely excluded glioma patients. In this randomized open-label phase II study, use of a nonstandard 5-day regimen of aprepitant for glioma patients was investigated. Methods : One hundred thirty-six glioma patients receiving their first [...]

Menée aux Etats-Unis par questionnaire auprès de 1 723 patientes âgées ayant survécu à un cancer (âge : 73-88 ans) et de 11 145 témoins, cette étude analyse l'effet d'un antécédent de cancer sur les fonctions physiques et la mortalité toutes causes confondues

Effects of cancer history on functional age and mortality

Blair, Cindy K. ; Jacobs Jr, David R. ; Demark-Wahnefried, Wendy ; Cohen, Harvey J. ; Morey, Miriam C. ; Robien, Kim ; Lazovich, DeAnn

Background : Cancer, its treatment, and associated adverse effects may accelerate the functional aging of cancer survivors. In the current study, the authors used geriatric assessment (GA) to compare the functional age of long-term cancer survivors with that of similarly aged women without a cancer history, and to examine whether functional age influences all-cause mortality differently between these 2 groups. Methods : Participants included 1723 cancer survivors and 11,145 age-matched, [...]

Menée à partir des données des registres américains des cancers et de la base Medicare portant sur 308 268 patients atteints d'un cancer diagnostiqué entre 1996 et 2012, cette étude analyse l'association entre les traitements anticancéreux, le risque de récidive et la mortalité chez les patients âgés de plus de 65 ans, selon la présence d'une infection par le VIH (288 patients)

HIV Infection, Cancer Treatment Regimens, and Cancer Outcomes Among Elderly Adults in the United States

Coghill, Anna E. ; Suneja, Gita ; Rositch, Anne F. ; Shiels, Meredith S. ; Engels, Eric A.

HIV-infected patients with cancer have an elevated cancer-specific mortality rate compared with HIV-uninfected patients with cancer. However, to our knowledge, studies describing this association have not adjusted in detail for cancer treatment, despite evidence of suboptimal cancer treatment in the setting of HIV.To compare cancer-specific mortality in HIV-infected and HIV-uninfected patients with cancer after adjusting for available data on receipt of specific cancer treatments.We used [...]

A partir d'une revue systématique de la littérature publiée avant février 2019 (12 articles), cette étude analyse l'association entre l'alimentation, des recommandations nutritionnelles et les fonctions cognitives chez des adultes ayant survécu à un cancer

The relationship between diet and cognitive function in adult cancer survivors: a systematic review

Coro, Daniel ; Hutchinson, Amanda ; Dahlenburg, Sophie ; Banks, Siobhan ; Coates, Alison

Purpose : To perform a systematic review identifying how dietary factors are related to cognitive function in cancer survivors who are not currently undergoing primary treatment. Methods : Using the PRISMA framework, a search was conducted for studies published before February 2019 across multiple databases, identifying 2304 unique articles. Twelve met final inclusion criteria and were evaluated through narrative synthesis. This review was registered with the International Prospective Register [...]

Menée aux Etats-Unis, cette étude analyse les données d'incidence de cancer et de mortalité spécifique chez des personnes âgées de plus de 85 ans, pour l'année 2019

Cancer statistics for adults aged 85 years and older, 2019

DeSantis, Carol E. ; Miller, Kimberly D. ; Dale, William ; Mohile, Supriya G. ; Cohen, Harvey J. ; Leach, Corinne R. ; Goding Sauer, Ann ; Jemal, Ahmedin ; Siegel, Rebecca L.

Adults aged 85 years and older, the “oldest old,” are the fastest-growing age group in the United States, yet relatively little is known about their cancer burden. Combining data from the National Cancer Institute, the North American Association of Central Cancer Registries, and the National Center for Health Statistics, the authors provide comprehensive information on cancer occurrence in adults aged 85 years and older. In 2019, there will be approximately 140,690 cancer cases diagnosed and [...]

Menée à partir des données des registres américains des cancers sur la période 2000-2016, cette étude analyse l'évolution de la distribution par tranche d'âge des cancers associés à l'obésité (2 665 574 cas)

Changes in Age Distribution of Obesity-Associated Cancers

Koroukian, Siran M. ; Dong, Weichuan ; Berger, Nathan A.

Importance : Recent studies have documented an association between overweight and obesity and certain cancers, as well as an increased incidence of obesity-associated cancers (OACs) in younger individuals. However, although important for cancer-control efforts, it is not known which subgroups of the population are most affected by these changes. Objective : To examine temporal shifts in age distribution of OACs and non-OACs across race/ethnicity- and sex-specific strata. Design, Setting, and [...]

Menée à partir des données de la cohorte européenne EPIC portant sur 45 009 participants, cette étude analyse l'association entre une consommation de produits laitiers et la mortalité toutes causes confondues, par cancer et par maladie cardiovasculaire (durée médiane de suivi : 14,9 ans ; 2 468 décès)

Associations of dairy product consumption with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)–Italy cohort

Pala, Valeria ; Sieri, Sabina ; Chiodini, Paolo ; Masala, Giovanna ; Palli, Domenico ; Mattiello, Amalia ; Panico, Salvatore ; Tumino, Rosario ; Frasca, Graziella ; Fasanelli, Francesca ; Ricceri, Fulvio ; Agnoli, Claudia ; Grioni, Sara ; Krogh, Vittorio

The relation of dairy product consumption to health and mortality is controversial.We investigated associations of consumption of various dairy products with mortality in the Italian cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)–Italy study.Dairy product consumption was assessed by validated semiquantitative FFQs. Multivariable Cox models stratified by center, age, and sex and adjusted for confounders estimated associations of milk (total, full fat, and [...]

Menée au Canada à partir de données portant sur 2 204 patients ayant survécu à une leucémie pédiatrique diagnostiquée entre 1992 et 2015 et sur 11 020 témoins, cette étude de cohorte rétrospective analyse le risque d'infections en lien avec les traitements anticancéreux

Long-Term Risk of Infections After Treatment of Childhood Leukemia: A Population-Based Cohort Study Using Administrative Health Data

Marie-Claude Pelland-Marcotte ; Jason D. Pole ; Jeremiah Hwee ; Rinku Sutradhar ; Michelle Science ; Paul C. Nathan ; Lillian Sung

PURPOSE : Infections are a frequent complication during childhood leukemia treatment. Little is known about the infectious risk in survivors. We compared the relative rate (RR) of infections after treatment completion between pediatric leukemia survivors and the general population. METHODS : We performed a retrospective, population-based cohort study of children diagnosed with leukemia between 1992 and 2015 in Ontario, Canada, who were alive and relapse free 30 days after treatment completion [...]

Menée à partir de données portant sur 805 309 patients asiatiques atteints d'un myélome multiple, cette étude analyse l'association entre l'indice de masse corporelle, une pratique tabagique, une consommation d'alcool et la mortalité spécifique (période de suivi :10 221 623 personnes-années)

Association of BMI, smoking and alcohol with multiple myeloma mortality in Asians: a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium

Ugai, Tomotaka ; Ito, Hidemi ; Oze, Isao ; Saito, Eiko ; Rahman, Md Shafiur ; Boffetta, Paolo ; Gupta, Prakash C ; Sawada, Norie ; Tamakoshi, Akiko ; Shu, Xiao-Ou ; Koh, Woon-Puay ; Gao, Yu-Tang ; Sadakane, Atsuko ; Tsuji, Ichiro ; Park, Sue K. ; Nagata, Chisato ; You, San-Lin ; Pednekar, Mangesh S. ; Tsugane, Shoichiro ; Cai, Hui ; Yuan, Jian-Min ; Xiang, Yong-Bing ; Ozasa, Kotaro ; Tomata, Yasutake ; Kanemura, Seiki ; Sugawara, Yumi ; Wada, Keiko ; Chen, Chien-Jen ; Yoo, Keun-Young ; Chia, Kee Seng ; Ahsan, Habibul ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee ; Potter, John D. ; Matsuo, Keitaro

Background : To date, few epidemiological studies have been conducted to elucidate lifestyle-related risk factors for multiple myeloma (MM) in Asia. We investigated the association of body mass index (BMI), smoking, and alcohol intake with the risk of MM mortality through a pooled analysis of more than 800,000 participants in the Asia Cohort Consortium. Methods : The analysis included 805,309 participants contributing 10,221,623 person-years of accumulated follow-up across Asia Cohort [...]

Menée aux Etats-Unis à partir de données portant sur 3 262 patients atteints d'un cancer colorectal de stade I à III, cette étude de cohorte analyse l'association entre l'adiposité abdominale et la mortalité

The Association of Abdominal Adiposity with Mortality in Patients with Stage I-III Colorectal Cancer

Brown, Justin C ; Caan, Bette J ; Prado, Carla M ; Feliciano, Elizabeth M Cespedes ; Xiao, Jingjie ; Kroenke, Candyce H ; Meyerhardt, Jeffrey A

Background : The quantity and distribution of adipose tissue may be prognostic measures of mortality in colorectal cancer patients and such associations may vary by patient sex. Methods : This cohort included 3,262 stage I-III colorectal cancer patients. Visceral and subcutaneous adipose tissues were quantified using computed tomography. The primary endpoint was all-cause mortality. Restricted cubic splines estimated statistical associations with two-sided P values. Results : Visceral adipose [...]

Menée aux Etats-Unis et couplée à un essai de phase III incluant 1 218 patients atteints d'un cancer colorectal de stade métastatique, cette étude de cohorte prospective évalue l'efficacité, du point de vue de la survie globale, de la survie sans progression et de la survenue d'événements indésirables liés au traitement, de la pratique d'une activité physique

Associations of Physical Activity With Survival and Progression in Metastatic Colorectal Cancer: Results From Cancer and Leukemia Group B (Alliance)/SWOG 80405

Brendan J. Guercio ; Sui Zhang ; Fang-Shu Ou ; Alan P. Venook ; Donna Niedzwiecki ; Heinz-Josef Lenz ; Federico Innocenti ; Bert H. O’Neil ; James E. Shaw ; Blase N. Polite ; Howard S. Hochster ; James N. Atkins ; Richard M. Goldberg ; Kaori Sato ; Kimmie Ng ; Erin Van Blarigan ; Robert J. Mayer ; Charles D. Blanke ; Eileen M. O’Reilly ; Charles S. Fuchs ; Jeffrey A. Meyerhardt

PURPOSE : Regular physical activity is associated with reduced risk of recurrence and mortality in patients with nonmetastatic colorectal cancer. Its influence on patients with advanced/metastatic colorectal cancer (mCRC) has been largely unexplored. PATIENTS AND METHODS : We conducted a prospective cohort study nested in Cancer and Leukemia Group B (Alliance)/SWOG 80405 (ClinicalTrials.gov identifier: NCT00265850), a National Cancer Institute–sponsored phase III trial of systemic therapy for [...]

A partir d'une revue systématique de la littérature (12 études de cohorte prospectives, 32 846 patients), cette méta-analyse évalue l'association entre une consommation d'alcool, avant et après le diagnostic, et la survie chez des patients atteints d'un cancer colorectal

Association between alcohol consumption and survival in colorectal cancer: A meta-analysis

Kim, Youngyo ; Je, Youjin ; Giovannucci, Edward L.

Background: Although an association between alcohol consumption and risk of colorectal cancer is well-established, little is known about the association between alcohol consumption and colorectal cancer survival. We conducted a meta-analysis of prospective cohort studies to quantitatively assess this association. Methods: Data searches were performed using PubMed and ISI Web of Science databases through December 2018. We estimated pooled relative risks (RRs) with 95% CI using random-effects [...]

Menée à partir de données portant sur 2 943 patientes américaines ayant survécu à un cancer du sein non métastatique (âge moyen : 56 ans), cette étude analyse l'association entre la répartition du tissu adipeux (adiposité viscérale, sous-cutanée, intramusculaire) et le risque de maladie cardiovasculaire (durée médiane de suivi : 6 ans ; 328 cas)

Adipose Tissue Distribution and Cardiovascular Disease Risk Among Breast Cancer Survivors

Elizabeth M. Cespedes Feliciano ; Wendy Y. Chen ; Patrick T. Bradshaw ; Carla M. Prado ; Stacey Alexeeff ; Kathleen B. Albers ; Adrienne L. Castillo ; Bette J. Caan

PURPOSE : Cardiovascular disease (CVD) is a major source of morbidity and mortality among breast cancer survivors. Although body mass index (BMI) is associated with CVD risk, adipose tissue distribution may better identify patients with a high risk of CVD after breast cancer. METHODS : Among 2,943 patients with nonmetastatic breast cancer without prior CVD, we used International Classification of Diseases (9th and 10th revisions) codes to identify incidence of nonfatal stroke, myocardial [...]

Menée au Danemark auprès de 2 311 332 femmes nées entre 1935 et 2002 (durée moyenne de suivi : 24,8 ans), cette étude analyse l'association entre la durée de la grossesse et le risque de cancer de l'endomètre (6 743 cas)

Pregnancy duration and endometrial cancer risk: nationwide cohort study

Husby, Anders ; Wohlfahrt, Jan ; Melbye, Mads

Objective : To explore the association between pregnancy duration and risk of endometrial cancer. Design : Nationwide register based cohort study. Setting : Denmark. Participants : All Danish women born from 1935 to 2002. Main outcome measures : Relative risk (incidence rate ratio) of endometrial cancer by pregnancy number, type, and duration, estimated using log-linear Poisson regression. Results : Among 2 311 332 Danish women with 3 947 650 pregnancies, 6743 women developed endometrial cancer [...]

Menée à partir des données des registres américains des cancers, cette étude analyse l'évolution, sur la période 1973-2013, de l'incidence du carcinome à petites cellules de la tête et du cou et les facteurs associés à la survie des patients

Small Cell and Squamous Cell Carcinomas of the Head and Neck: Comparing Incidence and Survival Trends Based on Surveillance, Epidemiology, and End Results (SEER) Data

Bean, Marta B. ; Liu, Yuan ; Jiang, Renjain ; Steuer, Conor Ernst ; Patel, Mihir ; McDonald, Mark William ; Higgins, Kristin Ann ; Beitler, Jonathan Jay ; Shin, Dong Moon ; Saba, Nabil F.

Background : Small cell carcinomas of the head and neck (SmCCHNs) are rare neoplasms with an unfavorable prognosis. Population‐based data describing survival and prognostic factors for SmCCHN are limited. Methods : Data were obtained from the U.S. National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database for 1973–2013. Patient and tumor‐related characteristics for SmCCHN were compared with those for squamous cell carcinoma of the head and neck (SCCHN). Survival was [...]

Menée à partir des données des registres américains des cancers portant sur 12 017 patients atteints d'un carcinome épidermoïde du pharynx (oropharynx, hypopharynx, rhinopharynx) diagnostiqué entre 2013 et 2014, cette étude analyse les facteurs associés à l'incidence du carcinome épidermoïde de l'oropharynx lié à une infection par le papilllomavirus humain, et la mortalité associée

Incidence and Demographic Burden of HPV-associated Oropharyngeal Head and Neck Cancers in the United States

Mahal, Brandon A ; Catalano, Paul J. ; Haddad, Robert I ; Hanna, Glenn J ; Kass, Jason I ; Schoenfeld, Jonathan D. ; Tishler, Roy B ; Margalit, Danielle N

Background: Human papillomavirus (HPV)-positive oropharyngeal head and neck squamous cell carcinoma (OPSCC) is increasing in the United States (US). Current epidemiologic assessments of the national burden of HPV-positive OPSCC are needed. Methods: The Surveillance, Epidemiology, and End Results (SEER) HPV Status Database included 12,017 patients with head and neck squamous cell carcinoma (HNSCC) of pharyngeal subsites including OPSCC and non-OPSCC HNSCC subsites (hypopharynx, nasopharynx, and [...]

Menée en Allemagne par questionnaire auprès de 514 adolescents et jeunes adultes atteints d'un cancer (âge moyen : 29,6 ans), cette étude analyse l'évolution des facteurs associés au risque d'anxiété et de dépression

Anxiety and depression in young adult German cancer patients: time course and associated factors

Geue, Kristina ; Göbel, Philipp ; Leuteritz, Katja ; Nowe, Erik ; Sender, Annekathrin ; Stöbel-Richter, Yve ; Friedrich, Michael

Objective : Cancer in young adulthood is a non-normative and critical life event. The experience of having cancer can have a strong impact on the mental health of young adults. This study investigated anxiety and depression in young adult cancer patients, examining changes over time and determining associated factors. Methods : Young cancer patients (18-39 years at time of diagnosis, diagnosis <4 years) were examined. Anxiety and depression were measured at two time points (t2=12 months after [...]

A partir d'une revue systématique de la littérature (77 articles), cette étude analyse les facteurs psychologiques associés à l'utilisation d'internet (spontanée ou recommandée par les professionnels de santé) par les patients atteints d'un cancer

A systematic and comprehensive review of internet use in cancer patients: psychological factors

Lleras de Frutos, María ; Casellas-Grau, Anna ; Sumalla, Enric C. ; de Gracia, Marta ; Borràs, Josep M. ; Ochoa Arnedo, Cristian

Introduction : Online resources are changing patient-professional relationship and care delivery by empowering patients to engage in decisions in order to cope with their illness and modify behaviors. This review analyses the psychological factors associated with spontaneous and health professional-guided internet use in cancer patients. Methods : Searches were performed in the PubMed (MEDLINE), PsycINFO, and Scopus databases. Studies were included if they involved cancer patients or focused on [...]

Mené en Allemagne auprès de 925 patients atteints d'un cancer et hospitalisés, cette étude analyse les facteurs associés à la baisse de l'utilisation de soins psychologiques pendant leur hospitalisation

Factors associated with the decline of psychological support in hospitalized patients with cancer

Pichler, Theresia ; Dinkel, Andreas ; Marten-Mittag, Birgitt ; Hermelink, Kerstin ; Telzerow, Eva ; Ackermann, Ulrike ; Belka, Claus ; Combs, Stephanie ; Gratzke, Christian ; Gschwend, Jurgen ; Harbeck, Nadia ; Heinemann, Volker ; Herkommer, Kathleen ; Kiechle, Marion ; Mahner, Sven ; Pigorsch, Steffi ; Rauch, Josephine ; Stief, Christian ; Beckmann, Jürgen ; Heußner, Pia ; Herschbach, Peter

Objective : Many distressed cancer patients do not want or, finally, do not use psychological support. This study aimed at identifying factors associated with the decline of psychological support during hospital stay. Methods : This cross-sectional study included inpatients with different cancer diagnoses. Distress was assessed using the short form of the Questionnaire on Stress in Cancer Patients-Revised (QSC-R10) and the Distress Thermometer (DT). Multivariable logistic regression was used to [...]

Menée au Royaume-Uni auprès de 128 patientes ayant survécu à un cancer du sein, cette étude qualitative analyse leurs expériences liées à leur image corporelle après une mastectomie et/ou une reconstruction mammaire

Women's initial experiences of their appearance after mastectomy and/or breast reconstruction: A qualitative study

Herring, B. ; Paraskeva, N. ; Tollow, P. ; Harcourt, D.

Objective : Surgical procedures intended to treat breast cancer or reduce risk of developing the disease typically result in changes to appearance and scarring of the breast area, and any donor sites. The longer‐term impact of these changes on body image and quality of life are well documented, but research in this field has failed to explore women's initial experiences of their appearance after surgery. This study used a qualitative approach to gain insight and better understand the [...]

Menée dans un contexte britannique, cette étude analyse les coûts associés au séquençage du génome chez des patients atteints d'un cancer ou d'une maladie rare

The complete costs of genome sequencing: a microcosting study in cancer and rare diseases from a single center in the United Kingdom

Schwarze, Katharina ; Buchanan, James ; Fermont, Jilles M. ; Dreau, Helene ; Tilley, Mark W. ; Taylor, John M. ; Antoniou, Pavlos ; Knight, Samantha J. L. ; Camps, Carme ; Pentony, Melissa M. ; Kvikstad, Erika M. ; Harris, Steve ; Popitsch, Niko ; Pagnamenta, Alistair T. ; Schuh, Anna ; Taylor, Jenny C. ; Wordsworth, Sarah

Purpose : The translation of genome sequencing into routine health care has been slow, partly because of concerns about affordability. The aspirational cost of sequencing a genome is $1000, but there is little evidence to support this estimate. We estimate the cost of using genome sequencing in routine clinical care in patients with cancer or rare diseases. Methods : We performed a microcosting study of Illumina-based genome sequencing in a UK National Health Service laboratory processing 399 [...]

Menée dans un contexte chinois, cette étude compare le rapport coût-efficacité du pembrolizumab en monothérapie et d'une chimiothérapie en traitement de première ligne chez des patients atteints d'un cancer du poumon non à petites cellules de stade localement avancé ou métastatique et dont les tumeurs expriment PD-L1 avec un score de proportion tumorale différent

Cost-effectiveness Analysis of Pembrolizumab monotherapy and Chemotherapy in the Non-small-cell Lung Cancer with different PD-L1 Tumor Proportion Scores

Zhou, Kexun ; Jiang, Chenlu ; Li, Qiu

Objectives : This study aimed to assess the cost-effectiveness of pembrolizumab monotherapy compared with chemotherapy as first-line treatment in patients with locally advanced or metastatic non-small-cell lung cancer (NSCLC) with different tumor proportion scores (TPS), from perspectives of payers in China. Materials and Methods : Basic information was derived from the KEYNOTE-042 trial. A Markov model was developed to simulate the process of NSCLC. Model inputs were based on published [...]

Menée dans un contexte américain, cette étude analyse les facteurs associés aux coûts restant à la charge de patientes ayant survécu à un cancer du sein, selon la présence d'un lymphœdème

Drivers of cost differences between US breast cancer survivors with or without lymphedema

Dean, Lorraine T. ; Ransome, Yusuf ; Frasso-Jaramillo, Livia ; Moss, Shadiya L. ; Zhang, Yuehan ; Ashing, Kimlin ; Denis, Gerald V. ; Frick, Kevin D. ; Visvanathan, Kala ; Schmitz, Kathryn H.

Purpose : Breast cancer–related lymphedema is an adverse effect of breast cancer surgery affecting nearly 30% of US breast cancer survivors (BCS). Our previous analysis showed that, even 12 years after cancer treatment, out-of-pocket healthcare costs for BCS with lymphedema remained higher than for BCS without lymphedema; however, only half of the cost difference was lymphedema-related. This follow-up analysis examines what, above and beyond lymphedema, contributes to cost differences. Methods [...]

A partir des données de 11 revues systématiques de la littérature (87 publications, 15 381 participants), cette étude analyse l'efficacité des outils destinés à améliorer, pendant les consultations, la communication entre le médecin et son patient atteint d'un cancer

Tools to facilitate communication during physician-patient consultations in cancer care: An overview of systematic reviews

Licqurish, Sharon M. ; Cook, Olivia Y. ; Pattuwage, Loyal P. ; Saunders, Christobel ; Jefford, Michael ; Koczwara, Bogda ; Johnson, Claire E. ; Emery, Jon D.

Tools have been developed to facilitate communication and support information exchange between people diagnosed with cancer and their physicians. Patient-reported outcome measures, question prompt lists, patient-held records, tape recordings of consultations, decision aids, and survivorship care plans have all been promoted as potential tools, and there is extensive literature exploring their impact on patient outcomes. Eleven systematic reviews of studies evaluating tools to facilitate [...]

Menée en Suède par enquête auprès de professionnels de santé travaillant dans des services de soins palliatifs, cette étude analyse l'utilisation de faibles doses de méthadone en complément d'autres opioïdes pour soulager la douleur liée au cancer chez des patients en fin de vie

The Use of Low-Dose Methadone as Add-On to Regular Opioid Therapy in Cancer-Related Pain at End of Life: A National Swedish Survey in Specialized Palliative Care

Per Fürst ; Staffan Lundström ; Pål Klepstad ; Peter Strang

Background: Low-dose methadone in addition to another ongoing opioid therapy is a promising approach for managing complex cancer-related pain and is, despite limited evidence, used in clinical practice. Objective: To investigate the use of low-dose methadone in specialized palliative care in Sweden. Design: Specialized palliative care services in Sweden answered a survey regarding methadone use in individual patients over 12 months. Setting/Subjects: The survey was an add-on to the Swedish [...]

Menée à partir des données des registres américains des cancers et de la base Medicare portant sur 69 414 patients atteints d'un cancer du poumon non à petites cellules de stade métastatique, cette étude identifie les facteurs associés à l'utilisation de soins palliatifs

Utilization pattern and service settings of palliative care for patients with metastatic non–small-cell lung cancer

Huo, Jinhai ; Hong, Young-Rock ; Turner, Kea ; Bian, Jiang ; Grewal, Reetu ; Wilkie, Diana J.

Background : Although the benefits of palliative care for patients with cancer has been well established, the current utilization pattern remains largely unknown. The authors investigated the temporal trends and service settings of palliative care among Medicare beneficiaries with newly diagnosed, metastatic non–small‐cell lung cancer (NSCLC). Methods : In total, 69,414 patients with NSCLC were identified between January 1, 2001 and December 31, 2013 from the Surveillance, Epidemiology, and End [...]

Cet article présente les recommandations d'un groupe d'experts de l'"American Society of Clinical Oncology Research" concernant l'inclusion, dans les essais cliniques, de biopsies destinées à la recherche scientifique

Ethical Framework for Including Research Biopsies in Oncology Clinical Trials: American Society of Clinical Oncology Research Statement

Levit, Laura A. ; Peppercorn, Jeffrey M. ; Tam, Alda L. ; Marron, Jonathan M. ; Mathews, Debra J. H. ; Levit, Kathryn ; Roach, Nancy ; Ratain, Mark J.

In contrast to clinical biopsies, where tissue is collected to inform patient care, research biopsies are performed for scientific purposes to potentially enhance understanding of the biologic bases of cancer and drug action, thereby improving diagnosis and treatment, but they may offer no direct benefit to participants and have known risks. The widespread use of research biopsies that do not have the potential to directly benefit participants has come under scrutiny, with critics raising [...]

Menée aux Etats-Unis, cette étude analyse les paiements des industries pharmaceutiques et de matériel médical versés aux 53 médecins directeurs des 16 centres du National Cancer Institute et évalue les conflits d'intérêts sur la période 2015-2017

Industry Payments to Physician Directors of National Cancer Institute–Designated Cancer Centers, 2015-2017

Carr, David ; Welch, H. Gilbert

National Cancer Institute (NCI)–designated cancer centers shape cancer care in the United States and are supported by substantial public funds (in fiscal year 2018, $330 million in core funding for 70 cancer centers).1 Cancer care is also shaped by industry, because developing new cancer therapeutics represents a major market opportunity. Industry payments to academic physicians risk blurring the line between innovation and the evaluation of new therapies. We used Open Payments data from the [...]

A partir d'une revue de la littérature, cette étude plaide pour le développement d'essais cliniques permettant de mieux évaluer l'association entre la pratique d'une activité physique, le risque de cancer et la survie

Development of Exercise as Interception Therapy for Cancer: A Review

Iyengar, Neil M. ; Jones, Lee W.

Importance : Observational data linking physical activity and exercise exposure with reduced risk of either development or progression of cancer have fueled interest in the initiation of large-scale definitive trials to test the association of exercise therapy with disease outcomes. However, several major knowledge gaps impede the rational and optimal design of such trials. Observations :Critical requirements underpinning the success of several recent contemporary anticancer agents have [...]

Cette étude présente des recommandations internationales concernant l'organisation et la mise en place de soins de suivi à long terme dédiés aux enfants, adolescents et jeunes adultes ayant survécu à un cancer

Evidence-based recommendations for the organization of long-term follow-up care for childhood and adolescent cancer survivors: a report from the PanCareSurFup Guidelines Working Group

Michel, Gisela ; Mulder, Renée L. ; van der Pal, Helena J. H. ; Skinner, Roderick ; Bárdi, Edit ; Brown, Morven C. ; Vetsch, Janine ; Frey, Eva ; Windsor, Rachael ; Kremer, Leontien C. M. ; Levitt, Gill

Purpose : To facilitate the implementation of long-term follow-up (LTFU) care and improve equality of care for childhood, adolescent, and young adult (CAYA) cancer survivors, the PanCareSurFup Guidelines Working Group developed evidence-based recommendations for the organization of LTFU. Methods : We established an international multidisciplinary guideline panel. A systematic review of the literature published from 1999 to 2017 was completed to answer six clinical questions. The guideline panel [...]

Cette étude plaide pour une approche pluridisciplinaire coordonnée lors des choix en matière de préservation de la fertilité chez des patientes atteintes d'une tumeur hématologique

Preserving fertility in female patients with hematological malignancies: A multidisciplinary oncofertility approach

Salama, M ; Anazodo, A ; Woodruff, T K

Oncofertility is a new interdisciplinary field at the intersection of oncology and reproductive medicine that expands fertility options for young cancer patients. The most common forms of hematological malignancies that occur in girls and young women and therefore necessitate oncofertility care are acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma (HL).Aggressive gonadotoxic anticancer regimens including alkylating chemotherapy and [...]

Cet article américain présente des pistes d'amélioration de l'utilisation des registres des cancers dans la recherche et la lutte contre la maladie

Unlocking the potential of population-based cancer registries

Tucker, Thomas C. ; Durbin, Eric B. ; McDowell, Jaclyn K. ; Huang, Bin

Population‐based cancer registries have improved dramatically over the last 2 decades. These central cancer registries provide a critical framework that can elevate the science of cancer research. There have also been important technical and scientific advances that help to unlock the potential of population‐based cancer registries. These advances include improvements in probabilistic record linkage, refinements in natural language processing, the ability to perform genomic sequencing on [...]