Menée en Chine, au Japon et en Corée auprès de 1 446 patients atteints d'un cancer de l'estomac et auprès de 1 796 témoins, cette étude analyse, en fonction de la présence d'une infection par Helicobacter pylori, l'association entre le tabagisme et le risque de développer la maladie

Smoking, Helicobacter pylori serology, and gastric cancer risk in prospective studies from China, Japan, and Korea

Butt, Julia ; Varga, Matthew G ; Wang, Tianyi ; Tsugane, Shoichiro ; Shimazu, Taichi ; Zheng, Wei ; Abnet, Christian C. ; Yoo, Keun-Young ; Park, Sue K. ; Kim, Jeongseon ; Jee, Sun Ha ; Qiao, You-Lin ; Shu, Xiao-Ou ; Waterboer, Tim ; Pawlita, Michael ; Epplein, Meira

Smoking is an established risk factor for gastric cancer development. In this study, we aimed to assess prospectively the association of smoking with gastric cancer risk in 1,446 non-cardia gastric cancer cases and 1,796 controls from China, Japan, and Korea with consideration of H. pylori infection as a potential effect modifier. Applying logistic regression models stratified by study and adjusted for age and sex we found that current, but not former, smoking was significantly associated with [...]

Menée aux Etats-Unis à partir de données portant sur 53 195 fumeurs et 62 842 non-fumeurs, cette étude analyse l'association entre l'indice de masse corporelle, les variations de poids, la consommation d'alcool ou le niveau d'activité physique et le risque global de cancer, en fonction du statut tabagique

Preventable incidence of carcinoma associated with adiposity, alcohol and physical inactivity according to smoking status in the United States

Song, Mingyang ; Giovannucci, Edward

The changing profile of lifestyles and their intricate relationships with smoking indicate the importance of accounting for smoking status when assessing cancer preventability. We assessed the association of body mass index, weight change, alcohol intake and physical activity with risk of total carcinoma among 53,195 smokers and 62,842 nonsmokers in two prospective cohorts. Then, leveraging the national prevalence estimates, we calculated the population attributable risk (PAR) for healthy [...]

Menée aux Etats-Unis auprès de 700 et 196 patientes atteintes d'un cancer de l'ovaire et incluses dans deux cohortes prospectives, cette étude analyse l'association entre une alimentation riche en graisses et le risque de développer la maladie

Adult Dietary Fat Intake and Ovarian Cancer Risk

Rice, Megan S. ; Poole, Elizabeth M. ; Willett, Walter C. ; Tworoger, Shelley S.

The association of dietary fat intake with ovarian cancer risk has been inconsistent across populations. We examined dietary fat intake, overall and by type, and ovarian cancer risk in two prospective cohort studies. We assessed long-term dietary fat intake among Nurses' Health Study (NHS) and NHSII participants using food frequency questionnaires administered every 2–4 years beginning in 1984 and 1991, respectively. We examined cumulative energy-adjusted intake of total fat, specific types of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2019 (12 études ; 30 810 cas), cette méta-analyse évalue l'association entre un comportement sédentaire (temps passé assis ou devant la télévision) et le risque de cancer de la prostate

Sedentary behavior and prostate cancer: a systematic review and meta-analysis of prospective cohort studies

Berger, Felix F. ; Leitzmann, Michael F ; Hillreiner, Andrea ; Sedlmeier, Anja M. ; Prokopidi-Danisch, Maria Eleni ; Burger, Maximilian ; Jochem, Carmen

Prostate cancer is the second most common cancer in men worldwide, and sedentary behavior is widespread, yet reviews and meta-analyses summarizing the role of sedentary behavior as a potential risk factor for prostate cancer are scarce. We searched PubMed, Web of Science, and Cochrane databases for relevant articles up to January 2019. We pooled maximally adjusted risk estimates in a random effects model and performed meta-regression meta-analysis, assessed heterogeneity and publication bias [...]

A partir d'une revue systématique de la littérature publiée entre 1992 et 2018 (12 études), cette méta-analyse évalue le risque de cancer chez les personnes travaillant dans l'industrie du verre

Cancer in glass workers: a systematic review and meta-analysis

Lehnert, Martin ; Behrens, Thomas ; Tulowietzki, Justus ; Guldner, Karlheinz ; Brüning, Thomas ; Taeger, Dirk

Purpose : Due to a potential exposure to several definite or probable carcinogens, the IARC classified manufacturing of art glass, glass containers, and pressed ware as probably carcinogenic to humans in 1993 (Group 2A). Purpose of this study was to update the evidence from recently published scientific reports. Methods : We searched for peer-reviewed articles published between 1993 and 2018 and combined result in terms of a meta-analysis. Overall, we considered twelve articles for a [...]

A partir des données de onze études internationales incluant au total 9 723 patients pédiatriques atteints d'une leucémie et 17 099 témoins (âge au diagnostic : moins de 15 ans), cette étude analyse l'association entre une exposition professionnelle des parents à des champs électromagnétiques d'extrêmement basses fréquences (EBF) et le risque de leucémie chez leurs enfants

Parental occupational exposure to low-frequency magnetic fields and risk of leukaemia in the offspring: findings from the Childhood Leukaemia International Consortium (CLIC)

Talibov, Madar ; Olsson, Ann ; Bailey, Helen ; Erdmann, Friederike ; Metayer, Catherine ; Magnani, Corrado ; Petridou, Eleni ; Auvinen, Anssi ; Spector, Logan ; Clavel, Jacqueline ; Roman, Eve ; Dockerty, John ; Nikkilä, Atte ; Lohi, Olli ; Kang, Alice ; Psaltopoulou, Theodora ; Miligi, Lucia ; Vila, Javier ; Cardis, Elisabeth ; Schüz, Joachim

Objectives : Previously published studies on parental occupational exposure to extremely low-frequency magnetic fields (ELF-MF) and risk of acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML) in their offspring were inconsistent. We therefore evaluated this question within the Childhood Leukemia International Consortium. Methods : We pooled 11 case–control studies including 9723 childhood leukaemia cases and 17 099 controls. Parental occupational ELF-MF exposure was estimated [...]

Menée au Canada sur la période 2001-2015 à partir de données portant sur près de 5 millions de personnes, cette étude analyse l'association entre une exposition à la pollution de l'air ambiant (particules fines, dioxyde d'azote et ozone) et le risque de cancer du poumon (100 146 cas) ou du sein (91 146 cas)

Exposure to ambient air pollution and the incidence of lung cancer and breast cancer in the Ontario Population Health and Environment Cohort

Bai, Li ; Shin, Saeha ; Burnett, Richard T. ; Kwong, Jeffrey C. ; Hystad, Perry ; van Donkelaar, Aaron ; Goldberg, Mark S. ; Lavigne, Eric ; Weichenthal, Scott ; Martin, Randall V. ; Copes, Ray ; Kopp, Alexander ; Chen, Hong

Lung and female breast cancers are highly prevalent worldwide. Although the association between exposure to ambient fine particulate matter (PM2.5) and lung cancer has been recognized, there is less evidence for associations with other common air pollutants such as nitrogen dioxide (NO2) and ozone (O3). Even less is known about potential associations between these pollutants and breast cancer. We conducted a population-based cohort study to investigate the associations of chronic exposure to [...]

Menée à l'aide d'échantillons sanguins prélevés sur 250 femmes atteintes d'un cancer papillaire de la thyroïde et sur 250 témoins (âge moyen : 51 ans), cette étude analyse l'association entre une exposition à certains polluants (polybromodiphényléthers ou biphényles polybromés) et le risque de développer la maladie

Exposure to Polybrominated Diphenyl Ethers and a Polybrominated Biphenyl and Risk of Thyroid Cancer in Women: Single and Multi-Pollutant Approaches

Deziel, Nicole C. ; Alfonso-Garrido, Javier ; Warren, Joshua L. ; Huang, Huang ; Sjodin, Andreas ; Zhang, Yawei

Background : Thyroid cancer incidence is the most rapidly increasing malignancy; rates are three times higher in women than men. Thyroid-hormone disrupting flame-retardant chemicals, including polybrominated diphenyl ethers (PBDE) and polybrominated biphenyls (PBB), may contribute to this trend. Methods : We investigated the relationship between PBDE/PBB exposure and papillary thyroid cancer (PTC) in 250 incident female papillary thyroid cancer cases and 250 female controls frequency-matched on [...]

Cet article analyse l'association entre une utilisation de bougies parfumées et le risque de cancer de la vessie

Scented candles as an unrecognised factor that increases the risk of bladder cancer; is there enough evidence to raise a red flag?

Adamowicz, Jan ; Juszczak, Kajetan ; Poletajew, Slawomir ; van Breda, Shane Vontelin ; Pokrywczynska, Marta ; Drewa, Tomasz

The causes of bladder cancer are not yet fully uncovered however the research has identified a number of factors that may increase the risk of developing this kind of cancer. The chemical carcinogenesis of bladder cancer due to chronic exposure to aromatic hydrocarbons is a well-established fact. The identification of this correlation led to an improvement of safety measures in chemical industry and a gradual decrease of bladder cancer cases among workers. Nevertheless, in the majority of [...]

Menée à l'aide de biopsies réalisées sur 77 patients atteints d'un cancer du poumon non à petites cellules récemment diagnostiqué (75.8% d'hommes), cette étude analyse le rôle de l'ADN du papillomavirus humain dans la tumorigenèse pulmonaire

Human papillomavirus is not associated to non-small cell lung cancer: data from a prospective cross-sectional study

Silva, Estela Maria ; Mariano, Vânia Sammartino ; Pastrez, Paula Roberta Aguiar ; Pinto, Miguel Cordoba ; Nunes, Emily Montosa ; Sichero, Laura ; Villa, Luisa Lina ; Scapulatempo-Neto, Cristovam ; Syrjanen, Kari Juhani ; Longatto-Filho, Adhemar

Background : The pathogenesis of lung cancer is triggered by a combination of genetic and environmental factors, being the tobacco smoke the most important risk factor. Nevertheless, the incidence of lung cancer in non-smokers is gradually increasing, which demands the search for different other etiological factors such as occupational exposure, previous lung disease, diet among others. In the early 80’s a theory linked specific types of human papillomavirus (HPV) to lung cancer due to [...]

Menée en Chine sur la période 1997-2010 auprès de 223 467 personnes infectées par le virus de l'hépatite C et âgées d'au moins 18 ans (durée de suivi : 3 052 132 personnes-années), cette étude analyse l'association entre la prise de médicaments à base de plantes contenant de l'acide aristolochique et le risque de cancer primitif du foie (25 502 cas)

Herbal Medicine Containing Aristolochic Acid and the Risk of Primary Liver Cancer in Patients with Hepatitis C Virus Infection

Chen, Chi-Jen ; Yang, Yao-Hsu ; Lin, Meng-Hung ; Lee, Chuan-Pin ; Tsan, Yu-Tse ; Lai, Ming-Nan ; Yang, Hsiao-Yu ; Doyle, Pat ; Ho, Wen-Chao ; Chen, Pau-Chung

Background : To investigate the association between taking herbal medicine (HM) containing aristolochic acid (AA) and the risk of primary liver cancer (PLC) among patients with hepatitis C virus (HCV)-infection. Methods : This is a prospective study for the long-term follow up of a nationwide population-based cohort of patients aged 18 years or older diagnosed with HCV infection during 1997-2010. A total of 223,467 HCV-infected patients were identified using the National Health Insurance [...]

Menée en Suède à partir de données de registres portant sur 1 340 097 femmes ayant eu un premier enfant entre 1982 et 2012, cette étude analyse l'association entre un recours à la procréation médicalement assistée et le risque de cancer de l'ovaire ou de tumeur à la limite de la malignité (1 738 cas)

Assisted reproductive technology and risk of ovarian cancer and borderline tumors in parous women: a population-based cohort study

Lundberg, Frida E. ; Johansson, Anna L. V. ; Rodriguez-Wallberg, Kenny ; Gemzell-Danielsson, Kristina ; Iliadou, Anastasia N.

The study aimed to investigate if assisted reproductive technology (ART) treatment or a diagnosis of infertility were associated with the risk of ovarian cancer or borderline ovarian tumors (BOT) in parous women. In a population-based register study of 1,340,097 women with a first live birth in Sweden 1982–2012, the relationship between ART treatments, infertility and incidence of ovarian cancer or BOT were investigated using Cox regression analysis. In the cohort, 38,025 women gave birth [...]

Menée aux Etats-Unis auprès de 111 533 personnes bénéficiant de l'assurance maladie Medicare, âgées de plus de 65 ans et ayant débuté un traitement anti-hypertenseur sur la période 2007-2013 (durée médiane de suivi : 2,2 ans), cette étude évalue l'association entre différents types d'inhibiteurs (thiazides, bêta-bloquants, inhibiteurs des canaux calciques, ...) et le risque à court terme de cancer colorectal

Renin-Angiotensin-Aldosterone System-Based Antihypertensive Agents and the Risk of Colorectal Cancer Among Medicare Beneficiaries

Htoo, Phyo T ; Stürmer, Til ; Jonsson-Funk, Michele ; Pate, Virginia ; Simpson, Ross J Jr. ; Lund, Jennifer L

Background : Biologic evidence suggests that angiotensin II may play a role in tumor progression or growth. We compared the short-term colorectal cancer (CRC) risk among initiators of angiotensin converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) versus guideline-recommended clinical alternatives (beta blockers, calcium channel blockers [CCB], and thiazides). Methods : We conducted a new-user cohort study on U.S. Medicare beneficiaries aged over 65 years, who initiated [...]

A partir d'une revue systématique de la littérature publiée entre janvier 2001 et août 2017 (13 articles), cette étude évalue les facteurs médicaux et comportementaux associés à un syndrome myélodysplasique

Medical Conditions and Modifiable Risk Factors for Myelodysplastic Syndrome: A Systematic Review

Sweeney, Marina R. ; Applebaum, Katie M. ; Arem, Hannah ; Braffett, Barbara H. ; Poynter, Jenny N. ; Robien, Kim

Background : The aim of this systematic review was to evaluate medical conditions and modifiable risk factors for myelodysplastic syndromes (MDS) using the 2001 or 2008 World Health Organization (WHO) diagnostic criteria. Methods : PubMed, MEDLINE, and Scopus databases were searched for studies published between January 2001 and August 2017. Study characteristics and findings were abstracted for each article. Results : Thirteen articles (4 cohort, 9 case–control) met the inclusion criteria. [...]

Menée auprès de 4 557 patientes atteintes d'un cancer du sein (âge au diagnostic : 20-69 ans), cette étude analyse l'association entre un diabète de type 2, des médicaments antidiabétiques et le risque de développer la maladie, par statut des récepteurs ER/PR/HER2

Relationship between diabetes and diabetes medications and risk of different molecular subtypes of breast cancer

Chen, Hongjie ; Cook, Linda S. ; Tang, Mei-Tzu C. ; Hill, Deirdre A. ; Wiggins, Charles L. ; Li, Christopher I.

Background : Type II diabetes and certain diabetes treatments have been observed to impact breast cancer risk. However, their associations with different breast cancer molecular subtype defined by estrogen receptor (ER)/progesterone receptor (PR)/human epidermal growth factor receptor-2 (HER2) status is unclear. Methods : We conducted a retrospective multi-center population-based case-case study consisting of 4,557 breast cancer cases to evaluate the impact of type II diabetes and diabetes [...]

Menée par questionnaire auprès de 33 609 femmes (âge moyen : 58,7 ans ; durée moyenne de suivi : 8,3 ans), cette étude analyse l'association entre une utilisation de talc sur la zone génitale, des douches vaginales et le risque de cancer de l'utérus (271 cas)

Perineal Talc Use, Douching, and the Risk of Uterine Cancer

O’Brien, Katie M. ; D’Aloisio, Aimee A. ; Shi, Min ; Murphy, John D. ; Sandler, Dale P. ; Weinberg, Clarice R.

Background : Perineal talc use and douching could affect risk of uterine cancer through several possible pathways, including inflammation response, microbiota changes, or endocrine disruption. Two previous cohort studies of the association between talc use and uterine cancer have reported weak positive associations, but we know of no previous evaluations of the relationship between douching and uterine cancer. Methods : Using a large prospective cohort, we examined the relationship between [...]

Menée à l'aide du séquençage du génome entier de 1 380 personnes ayant survécu à un lymphome diagnostiqué durant l'enfance (âge médian au diagnostic : 13,4 ans), cette étude identifie 13 mutations constitutionnelles de BRCA associées au risque de développer la maladie

Association of Germline BRCA2 Mutations With the Risk of Pediatric or Adolescent Non–Hodgkin Lymphoma

Wang, Zhaoming ; Wilson, Carmen L. ; Armstrong, Gregory T. ; Hudson, Melissa M. ; Zhang, Jinghui ; Nichols, Kim E. ; Robison, Leslie L.

In a previous report from the St Jude Lifetime (SJLIFE) study, BRCA2 (GenBank U43746.1) was the third most frequently mutated gene (14 occurrences) among 3006 survivors of childhood cancer, with the highest number observed among survivors of lymphoma (7 [1.2%] of 586). To further investigate BRCA2 as a potential predisposition gene for pediatric or adolescent lymphoma, we analyzed 794 additional survivors of lymphoma from the SJLIFE study and Childhood Cancer Survivor Study cohorts, using [...]

Menée en Italie à partir de l'analyse de l'ADN d'échantillons sanguins et tissulaires prélevés sur 102 patients atteints d'un mélanome primaire multiple (âge médian au diagnostic : 52-55 ans ; durée de suivi : 8 ans), cette étude identifie des mutations constitutionnelles ou somatiques associées au risque de développer la maladie

Germline and somatic mutations in patients with multiple primary melanomas: a next generation sequencing study

Casula, Milena ; Paliogiannis, Panagiotis ; Ayala, Fabrizio ; De Giorgi, Vincenzo ; Stanganelli, Ignazio ; Mandalà, Mario ; Colombino, Maria ; Manca, Antonella ; Sini, Maria Cristina ; Caracò, Corrado ; Ascierto, Paolo Antonio ; Satta, Rosanna Rita ; Dedola, Maria Filomena ; Denti, Salvatore ; Fedeli, Maria Antonietta ; Montesu, Maria Antonietta ; Profili, Stefano ; Scotto, Tiziana ; Sini, Germana ; Tanda, Francesco ; Lissia, Amelia ; Cossu, Antonio ; Palmieri, Giuseppe ; Ghiorzo, Paola ; Queirolo, Paola ; Quaglino, Pietro ; Botti, Gerardo ; Sileni, Vanna Chiarion ; Di Giacomo, Anna Maria ; Melanoma Unit of, Sassari ; for the Italian Melanoma, Intergroup

Introduction : Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germline mutation have been describe in Caucasian populations. The aim of this study was to investigate the incidence, the distribution patterns and the impact of known and unknown germline and somatic mutations in patients with MPM from Italy. Materials and methods : [...]

Couplée aux données de la cohorte EPIC portant sur 569 patients atteints d'un cancer du côlon et sur 569 témoins, cette étude prospective analyse l'association entre le niveau plasmatique d'acides biliaires mesuré avant le diagnostic et le risque de développer la maladie

Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study

Kühn, Tilman ; Stepien, Magdalena ; López-Nogueroles, Marina ; Machado, Antje Damms ; Sookthai, Disorn ; Johnson, Theron ; Roca, Marta ; Hüsing, Anika ; Maldonado, Sandra González ; Cross, Amanda J ; Murphy, Neil ; Freisling, Heinz ; Rinaldi, Sabina ; Scalbert, Augustin ; Fedirco, Veronika ; Severi, Gianluca ; Boutron-Ruault, Marie-Christine ; Mancini, Francesca Romana ; Sowah, Solomon A ; Boeing, Heiner ; Jakszyn, Paula ; Sánchez, María-José ; Merino, Susana ; Colorado-Yohar, Sandra ; Barricarte, Aurelio ; Khaw, Kay Tee ; Schmidt, Julie A ; Perez-Cornago, Aurora ; Trichopoulou, Antonia ; Karakatsani, Anna ; Thriskos, Paschalis ; Palli, Domenico ; Agnoli, Claudia ; Tumino, Rosario ; Sacerdote, Carlotta ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; van Gils, Carla H ; Heath, Alicia ; Gunter, Marc J ; Riboli, Elio ; Lahoz, Agustín ; Jenab, Mazda ; Kaaks, Rudolf

Background : Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. Methods : Associations between pre-diagnostic plasma levels of 17 primary, secondary and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid [...]

Menée au Royaume-Uni à partir de données portant sur 28 980 patients atteints d'un cancer colorectal et sur 137 077 témoins, cette étude évalue l'association entre l'utilisation d'antibiotiques oraux et le risque de développer la maladie

Oral antibiotic use and risk of colorectal cancer in the United Kingdom, 1989–2012: a matched case–control study

Zhang, Jiajia ; Haines, Charles ; Watson, Alastair J. M. ; Hart, Andrew R. ; Platt, Mary Jane ; Pardoll, Drew M. ; Cosgrove, Sara E. ; Gebo, Kelly A. ; Sears, Cynthia L.

Background : Microbiome dysbiosis predisposes to colorectal cancer (CRC), but a population-based study of oral antibiotic exposure and risk patterns is lacking. Objective : To assess the association between oral antibiotic use and CRC risk. Design : A matched case–control study (incident CRC cases and up to five matched controls) was performed using the Clinical Practice Research Datalink from 1989 to 2012. Results : 28 980 CRC cases and 137 077 controls were identified. Oral antibiotic use was [...]

Menée en Islande sur la période 1968-1996 à l'aide de questionnaires et d'échantillons sanguins prélevés sur 9 606 femmes (âge moyen : 53 ans ; durée moyenne de suivi : 28,4 ans), cette étude analyse l'association entre un diabète de type 2 ou un surpoids et le risque de cancer du sein (728 cas)

Type 2 diabetes and obesity in midlife and breast cancer risk in the Reykjavik cohort

Maskarinec, Gertraud ; Haraldsdóttir, Álfheiður ; Einarsdóttir, Kristjana ; Aspelund, Thor ; Tryggvadottir, Laufey ; Harris, Tamara B. ; Gudnason, Vilmundur ; Torfadottir, Johanna E.

Purpose : As obesity and type 2 diabetes (T2D) have been increasing worldwide, we investigated their association with breast cancer incidence in the Reykjavik Study. Methods : During 1968–1996, approximately 10,000 women (mean age = 53 ± 9 years) completed questionnaires and donated blood samples. T2D status was classified according to self-report (n = 140) and glucose levels (n  = 154) at cohort entry. A linkage with the Icelandic Cancer Registry provided breast cancer incidence through 2015. [...]

Menée auprès de 223 femmes atteintes d'un cancer du sein invasif ou in situ et 399 témoins, cette étude analyse l'association entre la densité mammaire et le risque de cancer du sein, par statut des marqueurs CD44, CD24 et ALDH1A1 des cellules souches cancéreuses

Associations of mammographic breast density with breast stem cell marker-defined breast cancer subtypes

Yaghjyan, Lusine ; Esnakula, Ashwini K. ; Scott, Christopher G. ; Wijayabahu, Akemi T. ; Jensen, Matthew R. ; Vachon, Celine M.

Purpose : High mammographic breast density is a strong, well-established breast cancer risk factor. Whether stem cells may explain high breast cancer risk in dense breasts is unknown. We investigated the association between breast density and breast cancer risk by the status of stem cell markers CD44, CD24, and ALDH1A1 in the tumor. Methods : We included 223 women with primary invasive or in situ breast cancer and 399 age-matched controls from Mayo Clinic Mammography Study. Percent breast [...]

Menée en France par entretiens auprès de mères de 509 enfants atteints d'une tumeur cérébrale (âge : inférieur à 15 ans) et auprès de 3 102 témoins, cette étude analyse les facteurs génétiques et héréditaires associés au risque de développer la maladie

Family history of cancer and the risk of childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE)

Vidart d’Egurbide Bagazgoïtia, Nicolas ; Bailey, Helen D. ; Orsi, Laurent ; Guerrini-Rousseau, Léa ; Bertozzi, Anne-Isabelle ; Faure-Conter, Cecile ; Leblond, Pierre ; Pellier, Isabelle ; Freycon, Claire ; Doz, Francois ; Puget, Stéphanie ; Ducassou, Stéphane ; Lacour, Brigitte ; Clavel, Jacqueline

Purpose : Although some specific genetic syndromes such as neurofibromatosis (NF) have been identified as risk factor of childhood brain tumors (CBT), the potential role of inherited susceptibility in CBT has yet to be elucidated. Methods : To further investigate this, we conducted a pooled analysis of two nationwide case–control studies ESCALE and ESTELLE. The mothers of 509 CBT cases and 3,102 controls aged under 15 years who resided in France at diagnosis/interview, frequency-matched by age [...]