Mené sur 139 patientes atteintes d'un cancer primitif du sein et recevant une chimiothérapie adjuvante à base d'anthracyclines, cet essai évalue l'efficacité, du point de vue de la perte de cheveux mesurée à l'aide d'un système de score par les patientes trois semaines après le traitement, et la sécurité d'un système de refroidissement du cuir chevelu pendant la chimiothérapie adjuvante

Preventing chemotherapy-induced alopecia: a prospective clinical trial on the efficacy and safety of a scalp-cooling system in early breast cancer patients treated with anthracyclines

Munzone, Elisabetta ; Bagnardi, Vincenzo ; Campennì, Giuseppe ; Mazzocco, Ketti ; Pagan, Eleonora ; Tramacere, Andrea ; Masiero, Marianna ; Iorfida, Monica ; Mazza, Manuelita ; Montagna, Emilia ; Cancello, Giuseppe ; Bianco, Nadia ; Palazzo, Antonella ; Cardillo, Anna ; Dellapasqua, Silvia ; Sangalli, Claudia ; Pettini, Greta ; Pravettoni, Gabriella ; Colleoni, Marco ; Veronesi, Paolo

Background : Chemotherapy-induced alopecia (CIA) is a distressing side effect of cancer therapy. The trial aimed to assess feasibility and effectiveness of scalp-cooling system DigniCap® to prevent CIA in primary breast cancer patients receiving an anthracycline containing adjuvant chemotherapy (CT). Methods : Hair loss (HL) was evaluated by patient self-assessment and by the physician according to the Dean’s scale at baseline and after each cycle of CT. The primary efficacy endpoint was the [...]

Menée aux Etats-Unis à partir d'une enquête réalisée auprès de 103 patients ayant reçu un traitement pour un cancer (âge : 9 à 26 ans) et menée à l'aide des données du registre de vaccination de l'Etat de Géorgie, cette étude identifie les facteurs associés à l'intention de se faire vacciner contre le papillomavirus humain puis analyse la relation entre cette intention et le fait de débuter ultérieurement le schéma de vaccination

Intent and subsequent initiation of human papillomavirus vaccine among young cancer survivors

Cherven, Brooke ; Castellino, Sharon M. ; Chen, Yanjun ; Wong, F. Lennie ; York, Jocelyn M. ; Wasilewski-Masker, Karen ; Hudson, Melissa M. ; Bhatia, Smita ; Klosky, James L. ; Landier, Wendy

Background : Despite an increased risk of subsequent human papillomavirus (HPV)–related malignancies, HPV vaccine initiation rates among cancer survivors remain critically low. The purpose of this study was to determine the relationship between HPV vaccine intent and subsequent vaccine initiation among cancer survivors by linking data from a cross-sectional survey with state-based immunization registry records. Methods : Cancer survivors who were 9 to 26 years old were surveyed 1 to 5 years [...]

Menée en Corée du Sud à partir de données portant sur 53 231 patients, dont 23 811 atteints d'un cancer du sein, 19 170 d'un cancer de la prostate et 10 250 d'un myélome multiple, cette étude analyse sur les 12 dernières années l'incidence d'événements osseux liés à des métastases ayant pour origine l'une de ces trois maladies

Incidence of skeletal-related events in patients with breast or prostate cancer-induced bone metastasis or multiple myeloma: A 12-year longitudinal nationwide healthcare database study

Baek, Yeon-Hee ; Jeon, Ha-Lim ; Oh, In-Sun ; Yang, Hyowon ; Park, Jeehye ; Shin, Ju-Young

Background : This study examined the incidence of skeletal-related events (SRE) among patients with breast cancer (BC)- or prostate cancer (PC)-induced bone metastasis or multiple myeloma (MM) based on a population-based, 12-year healthcare database. Methods : Patients aged ≥18 years with bone metastasis from BC or PC or with MM between 2004 and 2015 were included. SRE was defined as pathologic fracture, spinal cord compression, radiation, or surgery to bone. Patients were followed-up from the [...]

A partir d'une revue de la littérature scientifique portant sur les données des registres des cancers, cette étude analyse en Europe, en Australie et aux Etats-Unis sur la période 1960-2012 l'évolution de l'incidence des cancers dont le site primitif est inconnu, puis identifie les facteurs expliquant les variations observées

The currently declining incidence of cancer of unknown primary

Rassy, Elie ; Pavlidis, Nicholas

Cancer of unknown primary (CUP) is a heterogeneous group of metastatic cancers for which a primary tumor cannot be identified after a standardized work-up. The biology of CUP has not been fully elucidated and epidemiologic data may be helpful in this regard. The variations in the incidence-rate over time and between countries reflect changes in the risk factors for CUP, incidence trends of the primary tumors that potentially contribute to the burden of CUP and changes in the diagnostic [...]

Menée à partir des données du registre suisse des cancers pédiatriques, cette étude analyse, sur la période 1985-2014, l'évolution de l'incidence de différents types de cancers chez les enfants âgés de 0 à 14 ans

Temporal trends in incidence of childhood cancer in Switzerland, 1985–2014

Sommer, Grit ; Schindler, Matthias ; Redmond, Shelagh ; Pfeiffer, Verena ; Konstantinoudis, Garyfallos ; Ammann, Roland A. ; Ansari, Marc ; Hengartner, Heinz ; Michel, Gisela ; Kuehni, Claudia E.

Background : Incidence of childhood cancer increased in most countries worldwide, but reasons are unclear. This study investigates trends of childhood cancer incidence in Switzerland from 1985 to 2014. Methods : We extracted data on all childhood cancer cases diagnosed at ages 0–14 years in Switzerland from the Swiss Childhood Cancer Registry. We included ICCC-3 main groups I-XII and calculated age-standardised, cumulative, and age-specific incidence for different diagnostic groups. We analysed [...]

Menée au Canada à partir des données de la "Canadian Cancer Society", cette étude estime pour l'année 2011 la fraction des cancers de la peau (hors mélanome) attribuable à une exposition professionnelle aux ultraviolets solaires

Burden of non-melanoma skin cancer attributable to occupational sun exposure in Canada

Peters, Cheryl E. ; Kim, J. ; Song, C. ; Heer, E. ; Arrandale, V. H. ; Pahwa, M. ; Labrèche, F. ; McLeod, C. B. ; Davies, H. W. ; Ge, C. B. ; Demers, P. A.

Purpose : Outdoor workers are exposed daily to solar ultraviolet radiation, an important contributor in the development of non-melanoma skin cancer. This study aimed to quantify the health burden of non-melanoma skin cancers among outdoor workers in Canada. Methods : Solar ultraviolet radiation exposure and estimates of exposure levels were applied to employment information from Canada census data to determine the exposed population in the risk exposure period (1961–2001). Risk estimates were [...]

Menée à partir d'échantillons tumoraux prélevés sur 291 patients atteints d'un cancer des amygdales palatines ou de la base de la langue, cette étude évalue dans 15 hôpitaux français la proportion de cancers oropharyngés liés aux papillomavirus humains (HPV) à haut risque oncogène

Prevalence and characteristics of HPV-driven oropharyngeal cancer in France

Mirghani, Haïtham ; Bellera, Carine ; Delaye, Jessy ; Dolivet, Gilles ; Fakhry, Nicolas ; Bozec, Alexandre ; Garrel, Renaud ; Malard, Olivier ; Jegoux, Franck ; Maingon, Philippe ; Sarini, Jérome ; Noël, Georges ; Duflo, Suzy ; Temam, Stephane ; Lefebvre, Jean-Louis ; Costes-Martineau, Valérie

Background : France has one of the highest incidence of head and neck cancers in Europe. Despite this, the epidemiological impact of high-risk human papilloma virus (HR-HPV) remains poorly investigated. Methods : We prospective assessed the proportion of oropharyngeal cancers due to HR-HPV in 15 hospitals throughout France. HPV-status was determined by p16-immunohistochemistry, and by detection of HPV-DNA using in situ hybridization. Cancers were classified as HPV-driven if both [...]

Menée en Italie à partir d'un questionnaire auprès de 128 femmes porteuses d'une mutation BRCA, cette étude identifie des facteurs associés au choix d'une mastectomie et/ou d'une salpingo-oophorectomie prophylactiques

Risk-reducing surgery in BRCA1/BRCA2 mutation carriers: Are there factors associated with the choice?

Manoukian, Siranoush ; Alfieri, Sara ; Bianchi, Elisabetta ; Peissel, Bernard ; Azzollini, Jacopo ; Borreani, Claudia

Objective : Female carriers of BRCA1/BRCA2 mutations (BRCAm) are at increased risk of developing breast and ovarian cancer. The main prevention options currently available consist in either clinical-radiological surveillance or risk-reducing surgery. This study investigated factors that might influence the choice of risk-reducing mastectomy (RRM) and/or salpingo-oophorectomy (RRSO) over surveillance in high-risk women. Methods : One hundred twenty‐eight BRCAm women, 75 (58.60%) cancer affected [...]