Menée en Suède à l'aide de questionnaires auprès de 101 235 participants dont 12 559 personnes atteintes d'un cancer, cette étude analyse l'association entre une consommation de lait fermenté ou non, de fromage ou de beurre et le risque de développer la maladie

Dairy Products and Cancer Risk in a Northern Sweden Population

Nilsson, Lena M. ; Winkvist, Anna ; Esberg, Anders ; Jansson, Jan-Håkan ; Wennberg, Patrik ; Van Guelpen, Bethany ; Johansson, Ingegerd

The role of dairy products in cancer is unclear. We assessed consumption of fermented milk, non-fermented milk, cheese, and butter, estimated from semi-quantitative food frequency questionnaires, in relation to prospective risk of breast, prostate, colorectal, smoking-, and obesity-related cancers in 101,235 subjects, including 12,552 cancer cases, in the population-based Northern Sweden Health and Disease Study. Most analyses (n?=?20) rendered null results. In men, we observed an increased [...]

Menée à partir de données de la cohorte française "NutriNet-Santé" portant sur 101 257 participants (âge moyen : 42,2 ans ; durée médiane de suivi : 5,1 ans), cette étude analyse l'association entre une consommation de boissons sucrées ou édulcorées et le risque global de cancer (2 193 cas), le risque de cancer du sein, de cancer de la prostate ou de cancer colorectal

Sugary drink consumption and risk of cancer: results from NutriNet-Santé prospective cohort

Chazelas, Eloi ; Srour, Bernard ; Desmetz, Elisa ; Kesse-Guyot, Emmanuelle ; Julia, Chantal ; Deschamps, Valérie ; Druesne-Pecollo, Nathalie ; Galan, Pilar ; Hercberg, Serge ; Latino-Martel, Paule ; Deschasaux, Mélanie ; Touvier, Mathilde

Objective : To assess the associations between the consumption of sugary drinks (such as sugar sweetened beverages and 100% fruit juices), artificially sweetened beverages, and the risk of cancer. Design : Population based prospective cohort study. Setting and participants : Overall, 101 257 participants aged 18 and over (mean age 42.2, SD 14.4; median follow-up time 5.1 years) from the French NutriNet-Santé cohort (2009-2017) were included. Consumptions of sugary drinks and artificially [...]

A partir d'une revue systématique de la littérature publiée jusqu'en décembre 2018 (12 études), cette méta-analyse évalue l'association entre l'apport en graisses et le risque de trois principaux types de cancer de la peau (carcinome basocellulaire, carcinome épidermoïde et mélanome cutané)

Dietary Fat Intake and the Risk of Skin Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Ruan, Liang ; Cheng, Shuang-Ping ; Zhu, Qi-Xing

We conducted a meta-analysis to evaluate the association between fat intake and the risk of three major types of skin cancer including basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and cutaneous malignant melanoma (CMM). A comprehensive search of PubMed and EMBASE was performed to identify all relevant observational studies published up to December 1, 2018. Specific odds ratio (OR) or relative risk (RR) estimates for the highest versus the lowest intake of dietary fat and 95% [...]

A partir d'une revue de la littérature publiée jusqu'en mars 2018 (26 études ; 220 952 individus), cette méta-analyse évalue l'association entre une consommation de produits laitiers et le risque de cancer de la vessie

Dairy Product Consumption and Bladder Cancer Risk: A Meta-Analysis

Wu, Jianhua ; Yu, Yi ; Huang, Liqi ; Li, Zirui ; Guo, Penghui ; Xu, Yuan Wen

To explore the potential relationship between dairy product consumption and bladder cancer risk, we retrieved eligible studies published up to March 15, 2018, via online database search and manual review of the selected articles. Summary relative risk (RR) estimates were calculated using random-effects models based on high to low intake values. Inter-study heterogeneity was explored using stratified analyses of study design, geographic region, or whether studies adjusted for the confounders [...]

Menée à partir de données françaises, américaines et norvégiennes portant sur 316 270 agriculteurs et ouvriers agricoles, cette méta-analyse évalue l'association entre l'élevage d’espèces animales spécifiques et le risque de cancer lymphohématopoïétique, par sous-types

Animal farming and the risk of lymphohaematopoietic cancers: a meta-analysis of three cohort studies within the AGRICOH consortium

El-Zaemey, Sonia ; Schinasi, Leah ; Ferro, Gilles ; Tual, Séverine ; Lebailly, Pierre ; Baldi, Isabelle ; Nordby, Karl-Christian ; Kjærheim, Kristina ; Schüz, Joachim ; Monnereau, Alain ; Brouwer, Maartje ; Koutros, Stella ; Hofmann, Jonathan ; Kristensen, Petter ; Kromhout, Hans ; Leon, Maria ; Beane Freeman, Laura E

Animal farming entails a variety of potential exposures, including infectious agents, endotoxins and pesticides, which may play a role in the aetiology of lymphohaematopoietic cancers (LHCs). The aim of this study was to assess whether farming specific animal species is associated with the risk of overall LHC or its subtypes. Data from three prospective cohort studies in the USA, France and Norway which are part of the Agricultural Cohort consortium and which collected information about animal [...]

Menée sur la période 2000-2015 en Italie à partir de registres régionaux portant sur 2 321 témoins et sur 227 personnes atteintes d'un mésothéliome péritonéal (âge : 35-79 ans), cette étude analyse l'association entre une exposition à l'amiante et le risque de développer la maladie

Peritoneal mesothelioma and asbestos exposure: a population-based case–control study in Lombardy, Italy

Consonni, Dario ; Calvi, Cristina ; De Matteis, Sara ; Mirabelli, Dario ; Landi, Maria Teresa ; Caporaso, Neil E ; Peters, Susan ; Vermeulen, Roel ; Kromhout, Hans ; Dallari, Barbara ; Pesatori, Angela Cecilia ; Riboldi, Luciano ; Mensi, Carolina

Objectives : Asbestos is the main risk factor for peritoneal mesothelioma (PeM). However, due to its rarity, PeM has rarely been investigated in community-based studies. We examined the association between asbestos exposure and PeM risk in a general population in Lombardy, Italy. Methods : From the regional mesothelioma registry, we selected PeM cases diagnosed in 2000–2015. Population controls (matched by area, gender and age) came from two case–control studies in Lombardy on lung cancer [...]

Menée sur la période 2013-2017 en Chine auprès de 622 témoins et 622 personnes atteintes d'un cancer de l'estomac, cette étude analyse le rôle des facteurs sociodémographiques et du mode de vie dans le développement du cancer gastrique

Sociodemographic and Lifestyle Factors in Relation to Gastric Cancer in a High-Risk Region of China: A Matched Case–Control Study

Lin, Yulan ; Wu, Chuancheng ; Yan, Wei ; Guo, Saixiong ; Lin, Su ; Liu, Baoying

Objectives : To explore the role of sociodemographic and lifestyle factors in the development of gastric cancer in a high-risk region of China. Methods : In a case?control study, all newly diagnosed patients with gastric cancer were compared with healthy controls matched (1:1) by sex, age (±3?years), and place of residence during 2013-2017. Results : A total of 622 gastric cancer and 622 healthy controls were included. Larger household size (>4 family members) appeared to decrease gastric [...]

Menée au Canada auprès de 1 214 506 femmes ayant accouché entre 1989 et 2016 (durée de suivi : 19 251 851 personnes-années), cette étude analyse l'association entre le fait d'avoir un bébé présentant des anomalies congénitales et le risque de cancer précoce chez la mère

Future risk of cancer in women who have children with birth defects

Auger, Nathalie ; Little, Julian ; Arbour, Laura ; Bilodeau-Bertrand, Marianne ; Mayrand, Marie-Hélène

Purpose : We studied whether having an infant with birth defects was associated with the risk of maternal cancer. Methods : We carried out a longitudinal cohort study of 1,214,506 women who delivered infants between 1989 and 2016 in Quebec, Canada. We identified women whose infants had birth defects, and followed the mothers over time to identify cancers up to 28 years after delivery. We used Cox regression to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association [...]

A partir de données portant au total sur 9 087 témoins et 2 299 personnes atteintes de leucémie aiguë lymphoblastique, cette étude d'association sur le génome entier identifie, chez les enfants présentant ou non une trisomie 21, un locus de susceptibilité à la maladie sur le chromosome 21

Heritable variation at the chromosome 21 gene ERG is associated with acute lymphoblastic leukemia risk in children with and without Down syndrome

De Smith, Adam J. ; Walsh, Kyle M. ; Morimoto, Libby M. ; Francis, Stephen S. ; Hansen, Helen M. ; Jeon, Soyoung ; Gonseth, Semira ; Chen, Minhui ; Sun, Hanxiao ; Luna-Fineman, Sandra ; Antillon, Federico ; Girón, Verónica ; Kang, Alice Y. ; Smirnov, Ivan ; Shao, Xiaorong ; Whitehead, Todd P. ; Barcellos, Lisa F. ; Jolly, Kent W. ; Healy, Jasmine ; Laverdière, Caroline ; Sinnett, Daniel ; Taub, Jeffrey W. ; Birch, Jillian M. ; Thompson, Pamela D. ; Pombo-de-Oliveira, Maria S. ; Spector, Logan G. ; DeWan, Andrew T. ; Mueller, Beth A. ; Chiang, Charleston ; Metayer, Catherine ; Ma, Xiaomei ; Wiemels, Joseph L.

Children of Latino ancestry have ~1.6-fold increased risk of acute lymphoblastic leukemia (ALL) relative to non-Latino white children, partly explained by the higher frequency of common heritable ALL risk alleles at ARID5B, GATA3, and PIP4K2A in Latinos. However, the etiologies of the increased ALL risk in Latinos have not been fully elucidated. We previously performed a large, multi-ethnic genome-wide association study (GWAS) of childhood ALL, including 3,263 cases of which ~60% were of Latino [...]

Menée auprès de 158 patients ayant des antécédents familiaux de cancer de l'ovaire (non liés à la mutation BRCA1/2) (âge médian : 49 ans), puis validée à l'aide de données issues du projet "The Cancer Genome Atlas" portant sur 381 personnes atteintes d'un cancer de l'ovaire et sur 27 173 témoins, cette étude de séquençage de l'exome entier identifie 2 nouveaux gènes de prédisposition à la maladie (ANKRD11 et POLE)

Whole-exome sequencing of ovarian cancer families uncovers putative predisposition genes

Zhu, Qianqian ; Zhang, Jianmin ; Chen, Yanmin ; Hu, Qiang ; Shen, He ; Huang, Ruea-Yea ; Liu, Qian ; Kaur, Jasmine ; Long, Mark ; Battaglia, Sebastiano ; Eng, Kevin H. ; Lele, Shashikant B. ; Zsiros, Emese ; Villella, Jeannine ; Lugade, Amit ; Yao, Song ; Liu, Song ; Moysich, Kirsten ; Odunsi, Kunle O.

Despite the identification of several ovarian cancer (OC) predisposition genes, a large proportion of familial OC risk remains unexplained. We adopted a two-stage design to identify new OC predisposition genes. We first carried out a large germline whole-exome sequencing study on 158 patients from 140 families with significant OC history, but without evidence of genetic predisposition due to BRCA1/2. We then evaluated the potential candidate genes in a large case–control association study [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données génétiques portant sur 7 264 témoins et 7 110 personnes atteintes d'un cancer du pancréas, cette étude d'association sur le phénome entier identifie des facteurs de risque de la maladie

A phenome-wide Mendelian randomization study of pancreatic cancer using summary genetic data

Langdon, Ryan J ; Richmond, Rebecca C ; Hemani, Gibran ; Zheng, Jie ; Wade, Kaitlin H ; Carreras-Torres, Robert ; Johannson, Mattias ; Brennan, Paul ; Wootton, Robyn E ; Munafò, Marcus R ; Davey Smith, George ; Relton, Caroline L. ; Vincent, Emma E ; Martin, Richard M. ; Haycock, Philip

Background : The 5-year mortality rate for pancreatic cancer is amongst the highest of all cancers. Greater understanding of underlying causes could inform population-wide intervention strategies for prevention. Summary genetic data from genome-wide association studies (GWAS) have become available for thousands of phenotypes. These data can be exploited in Mendelian randomization (MR) phenome-wide association studies (PheWAS) to efficiently screen the phenome for potential determinants of [...]

Menée en Chine notamment à l'aide du séquençage de l'exome entier et de données portant au total sur 9 593 témoins et 7 204 femmes atteintes d'un cancer du sein, cette étude identifie un nouveau variant (rs139379666) du gène ATM associé au risque de développer la maladie

Discovery of a Pathogenic Variant rs139379666 (p. P2974L) in ATM for Breast Cancer Risk in Chinese Populations

Guo, Xingyi ; Lin, Weiqiang ; Bai, Mengqiu ; Li, Hongzhi ; Wen, Wanqing ; Zeng, Chenjie ; Chen, Zhishan ; He, Jing ; Chen, Jianghua ; Cai, Qiuyin ; Long, Jirong ; Jia, Wei-Hua ; Shu, Xiao-Ou ; Zheng, Wei

Background : Pathogenic variants in susceptibility genes lead to increased breast cancer risk. Methods : To identify coding variants associated with breast cancer risk, we conducted whole-exome sequencing in genomic DNA samples from 831 breast cancer cases and 839 controls of Chinese women. We also genotyped samples, including 4,580 breast cancer cases and 6,695 controls, using whole exome-chip arrays. We further performed a replication study using a Multi-Ethnic Global Array in samples from [...]

Menée en Suède auprès de 43 810 femmes âgées de 30 à 79 ans, cette étude analyse la relation entre la variation annuelle de la densité mammographique et le risque de cancer du sein, puis analyse l'effet de cette variation sur l'association entre la densité mammographique initiale et le risque de développer la maladie (563 cas)

Mammographic Density Change and Risk of Breast Cancer

Azam, Shadi ; Eriksson, Mikael ; Sjölander, Arvid ; Hellgren, Roxanna ; Gabrielson, Marike ; Czene, Kamila ; Hall, Per

We examined the association between annual mammographic density change (MDC) and breast cancer (BC) risk, and how annual MDC influences the association between baseline mammographic density (MD) and BC risk.We used the KARMA cohort of Swedish women (N = 43,810) aged 30–79 years with full access to BC risk factors and mammograms. MD was measured as dense area (cm2) and percent MD using the STRATUS method. We used the contralateral mammogram for women with BC, and randomly selected a mammogram [...]