A partir d'une revue de la littérature, cette étude analyse les facteurs associés à l'utilisation et à l'efficacité des opioïdes dispensés par voie nasale chez les enfants et adolescents atteints d'un cancer

Intranasal therapy with opioids for children and adolescents with cancer: results from clinical studies

Triarico, Silvia ; Capozza, Michele Antonio ; Mastrangelo, Stefano ; Attinà, Giorgio ; Maurizi, Palma ; Ruggiero, Antonio

Opioids are essential for the treatment of pain, which is a serious symptom for children and adolescents affected by cancer. Intranasal opioids may be very useful for the treatment of breakthrough pain in children and adolescents with cancer, for their little invasiveness, ease of administration, rapid onset of action, and high bioavailability. Intranasal drug delivery may be influenced by anatomical and physiological factors (nasal mucosa absorption area, mucociliary clearance, enzymatic [...]

Menée aux Etats-Unis à partir de données portant sur 152 patientes atteintes d'un cancer du sein de stade I à IIIA, cette étude analyse les facteurs associés aux troubles du sommeil et à une fatigue, avant et pendant la chimiothérapie

Sleep disturbance and cancer-related fatigue symptom cluster in breast cancer patients undergoing chemotherapy

Fox, Rina S. ; Ancoli-Israel, Sonia ; Roesch, Scott C. ; Merz, Erin L. ; Mills, Sarah D. ; Wells, Kristen J. ; Sadler, Georgia Robins ; Malcarne, Vanessa L.

Purpose : Sleep disturbance and cancer-related fatigue (CRF) are among the most commonly reported symptoms associated with breast cancer and its treatment. This study identified symptom cluster groups of breast cancer patients based on multidimensional assessment of sleep disturbance and CRF prior to and during chemotherapy. Methods : Participants were 152 women with stage I–IIIA breast cancer. Data were collected before chemotherapy (T1) and during the final week of the fourth chemotherapy [...]

Menée à partir des données de l'Organisation Mondiale de la Santé portant sur la période 1990-2017, cette étude présente la mortalité par cancer pour l'année 2015 (24 localisations de cancer) dans 36 pays européens

Cancer mortality in Europe in 2015, and an overview of trends since 1990

Bertuccio, P ; Alicandro, G ; Malvezzi, M ; Carioli, G ; Boffetta, P ; Levi, F ; La Vecchia, C ; Negri, E

Background : Cancer mortality in Europe has been decreasing since the late 1980s or 1990s though with different patterns in many areas. In this work, we updated trends in cancer mortality in Europe. Methods : We extracted data from the World Health Organization mortality database for 24 cancer sites, 36 European countries and the European Union (EU) as a whole over the 1990-2017 period. We computed age-standardized death rates per 100,000 population and we performed a joinpoint regression [...]

Menée à partir des données de l'Organisation Mondiale de la Santé sur la période 1970-2015, cette étude analyse l'évolution de la mortalité par cancer chez des patients âgés de plus de 65 ans, dans 11 pays (Europe, Amérique, Asie)

Cancer mortality in the elderly in 11 countries worldwide, 1970-2015

Carioli, G ; Malvezzi, M ; Bertuccio, P ; Hashim, D ; Waxman, S ; Negri, E ; Boffetta, P ; La Vecchia, C

Population ageing results in an increasing cancer burden in the elderly. We aimed to evaluate time-trends in cancer mortality for adults aged 65 and over for 17 major cancer-types and all cancer combined in 11 countries worldwide over the period 1970-2015.We obtained cancer death certification and population figures from the WHO and PAHO databases. We computed age-standardized (world standard population) rates for individuals aged 65 and over, and applied joinpoint regression [...]

Menée aux Etats-Unis à partir de données portant sur 157 625 participants, cette étude de cohorte estime la mortalité toutes causes confondues et la mortalité par cancer en lien avec une utilisation d'inhibiteurs de la pompe à protons

Estimates of all cause mortality and cause specific mortality associated with proton pump inhibitors among US veterans: cohort study

Xie, Yan ; Bowe, Benjamin ; Yan, Yan ; Xian, Hong ; Li, Tingting ; Al-Aly, Ziyad

Objective :To estimate all cause mortality and cause specific mortality among patients taking proton pump inhibitors (PPIs). Design: Longitudinal observational cohort study. Setting :US Department of Veterans Affairs. Participants :New users of PPIs (n=157 625) or H2 blockers (n=56 842). Main outcome measures :All cause mortality and cause specific mortality associated with taking PPIs (values reported as number of attributable deaths per 1000 patients taking PPIs). Results :There were 45.20 [...]

Menée à partir de données de 13 études portant sur 10 805 patients atteints d'un lymphome non hodgkinien et sur 14 026 témoins, cette étude analyse l'association entre transfusion sanguine et risque de développer la maladie

Blood transfusion history and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis

Cerhan, James R. ; Kane, Eleanor ; Vajdic, Claire M. ; Linet, Martha S. ; Monnereau, Alain ; Bernstein, Leslie ; de Sanjose, Silvia ; Chiu, Brian C.-H ; Spinelli, John J. ; Maso, Luigino Dal ; Zhang, Yawei ; Larrabee, Beth R. ; Cozen, Wendy ; Smith, Alexandra G. ; Clavel, Jacqueline ; Serraino, Diego ; Zheng, Tongzhang ; Holly, Elizabeth A. ; Weisenberger, Dennis D. ; Slager, Susan L. ; Bracci, Paige M.

Purpose : To conduct a pooled analysis assessing the association of blood transfusion with risk of non-Hodgkin lymphoma (NHL). Methods : We used harmonized data from 13 case–control studies (10,805 cases, 14,026 controls) in the InterLymph Consortium. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using unconditional logistic regression, adjusted for study design variables. Results : Among non-Hispanic whites (NHW), history of any transfusion was inversely associated with [...]

Menée aux Etats-Unis, cette étude analyse les disparités géographiques dans l'évolution de l'incidence du cancer colorectal chez les personnes âgées de 20 à 49 ans et identifie les facteurs de risque associés, sur la période 1995-2015

State variation in early-onset colorectal cancer in the United States, 1995-2015

Siegel, Rebecca L ; Medhanie, Genet A ; Fedewa, Stacey A ; Jemal, Ahmedin

The extent to which the increase in early-onset colorectal cancer (CRC) in the US varies geographically is unknown. We analyzed changes in CRC incidence and risk factors among people 20-49 years by state using high-quality population-based cancer registry data provided by the North American Association of Central Cancer Registries and national survey data, respectively. Early-onset CRC incidence was mostly stable among blacks and Hispanics, but increased in 40/47 states among [...]

Menée en France auprès de 103 familles présentant des mutations héréditaires des gènes BRCA1/2 ou MMR, cette étude identifie les facteurs cliniques, familiaux et psychologiques associés à la participation à des tests génétiques et à la communication des résultats au sein de la famille

Psychosocial and clinical factors of probands impacting intrafamilial disclosure and uptake of genetic testing among 103 French families with BRCA1/2 or MMR gene mutations

Alegre, Nathalie ; Vande Perre, Pierre ; Bignon, Yves Jean ; Michel, Aude ; Galibert, Virginie ; Mophawe, Ornellia ; Corsini, Carole ; Coupier, Isabelle ; Chiesa, Jean ; Robert, Laura ; Bernhard, Lydie ; Picot, Marie-Christine ; Bertet, Héléna ; Macioce, Valérie ; Bastide, Noëlle ; Solassol, Jérôme ; Rey, Jean Marc ; Thomas, Frédéric ; Carton, Solange ; Pujol, Pascal

Objective : Intrafamilial disclosure of hereditary cancer predisposition in BRCA1/2 and mismatch repair gene (MMR) syndromes allows appropriate prevention strategies in at‐risk relatives. We previously showed in a nationwide study that the uptake of genetic targeted testing (GTT) in these families was only 30%. We aimed to identify the clinical and psychosocial factors affecting the probands’ intrafamilial disclosure and relatives’ uptake of GTT in BRCA1/2 or MMR syndromes. Methods : We [...]

Menée aux Pays-Bas auprès de patients atteints d'un méningiome et auprès de témoins, cette étude analyse l'association entre les fonctions cognitives objectivement mesurées par des tests neuropsychologiques et le fonctionnement cognitif auto-déclaré, avant et après un traitement chirurgical

Subjective cognitive functioning in patients with a meningioma: its course and association with objective cognitive functioning and psychological symptoms

van Lonkhuizen, Pearl J.C. ; Rijnen, Sophie J.M. ; van der Linden, Sophie D. ; Rutten, Geert-Jan M. ; Gehring, Karin ; Sitskoorn, Margriet M.

Objective : Although meningioma patients show deficits in objective cognitive functioning (OCF) measured with neuropsychological tests, subjective cognitive functioning (SCF) has received little attention. We investigate SCF from pre‐ to post‐surgery and its associations with OCF, psychological, sociodemographic, and clinical characteristics. Methods : SCF was measured using the Cognitive Failures Questionnaire (CFQ) one day before (T0), and three (T3) and twelve months (T12) after surgery. [...]

Mené dans un contexte américain, cet essai compare le rapport coût-efficacité de deux stratégies de prévention des nausées et vomissements induits par une chimiothérapie hautement émétisante chez des patients atteints d'un cancer, l'une à base de nétupitant, palonosétron et dexaméthasone (NEPA) et l'autre à base d'aprépitant, granisétron et dexaméthasone (APR + GRAN)

Cost-effectiveness of a fixed combination of netupitant and palonosetron (NEPA) relative to aprepitant plus granisetron (APR + GRAN) for prophylaxis of chemotherapy-induced nausea and vomiting (CINV): a trial-based analysis

Botteman, Marc ; Nickel, Katharina ; Corman, Shelby ; Turini, Marco ; Binder, Gary

Purpose : To assess, from a United States (US) perspective, the cost-effectiveness of chemotherapy-induced nausea and vomiting (CINV) prophylaxis using a single dose of netupitant and palonosetron in a fixed combination (NEPA) versus aprepitant plus granisetron (APR + GRAN), each in combination with dexamethasone, in chemotherapy-naïve patients receiving highly emetogenic chemotherapy (HEC). Methods : We analyzed patient-level outcomes over a 5-day post-HEC period from a randomized, [...]

Menée au Canada par enquête auprès de 746 médecins spécialisés en soins palliatifs (531 répondants), cette étude analyse leurs opinions et leurs pratiques en matière de soins palliatifs dispensés précocement aux patients atteints d'un cancer

Practices and opinions of specialized palliative care physicians regarding early palliative care in oncology

Sorensen, Anna ; Wentlandt, Kirsten ; Le, Lisa W. ; Swami, Nadia ; Hannon, Breffni ; Rodin, Gary ; Krzyzanowska, Monika K. ; Zimmermann, Camilla

Purpose : To describe the practices and opinions of specialized palliative care (SPC) physicians regarding early palliative care for patients with cancer, determine characteristics associated with receiving early referrals; and solicit opinions regarding renaming the specialty “supportive care.” Methods : The survey was distributed by mail and e-mail to physicians who had previously self-identified as providing palliative care. SPC physicians were defined as receiving palliative care referrals [...]