Menée aux Pays-Bas à partir de données portant sur 389 patients atteints du syndrome de Wernicke-Korsakoff lié à un alcoolisme chronique, cette étude de cohorte rétrospective analyse l'association entre une supplémentation en vitamine D en lien avec une malnutrition et un diagnostic de cancer (durée médiane de suivi : 3 ans)

Vitamin D supplementation following malnutrition associated with time-related increase of cancer diagnoses: A cohort study of 389 patients with Wernicke-Korsakoff syndrome

Wijnia, Jan W. ; Oudman, Erik ; Wierdsma, André I. ; Oey, Misha J. ; Bongers, Jeroen ; Postma, Albert

Background : Vitamin deficiencies may reflect less than optimal health in select populations. Our objective was to determine whether vitamin D supplementation (VDs) following malnutrition may be adversely related to cancer diagnoses in a select group of patients with alcoholic Wernicke-Korsakoff syndrome (WKS). Method : Retrospective, cohort study of all patients admitted to Slingedael Korsakoff center, from 1996 till 2018, subdivided into three predefined groups depending upon differences in [...]

Menée à partir des données de 13 études portant sur 5 911 patients atteints d'un cancer de la vessie et sur 16 172 témoins, cette étude internationale analyse l'association entre une consommation de café et le risque de développer la maladie, en prenant en compte le statut tabagique

The association between coffee consumption and bladder cancer in the BLadder cancer Epidemiology and Nutritional Determinants (BLEND) international pooled study

Yu, Evan Yi-Wen ; Wesselius, Anke ; van Osch, Frits ; Stern, Mariana Carla ; Jiang, Xuejuan ; Kellen, Eliane ; Lu, Chih-Ming ; Pohlabeln, Hermann ; Steineck, Gunnar ; Marshall, James ; Allam, Mohamed Farouk ; La Vecchia, Carlo ; Johnson, Kenneth C. ; Benhamou, Simone ; Zhang, Zuo-Feng ; Bosetti, Cristina ; Taylor, Jack A. ; Zeegers, Maurice P.

Background : Inconsistent results for coffee consumption and bladder cancer (BC) risk have been shown in epidemiological studies. This research aims to increase the understanding of the association between coffee consumption and BC risk by bringing together worldwide case–control studies on this topic. Methods : Data were collected from 13 case–control comprising of 5,911 cases and 16,172 controls. Pooled multivariate odds ratios (ORs), with corresponding 95% confidence intervals (CIs), were [...]

Menée en République Tchèque à partir de données portant sur 16 434 hommes ayant travaillé dans une mine souterraine d'uranium entre 1946 et 1976, cette étude analyse l'association entre une exposition professionnelle à du radon et à de l'uranium, le risque de cancer et la mortalité sur la période 1977–1992

Mortality and cancer incidence among underground uranium miners in the Czech Republic 1977–1992

Kelly-Reif, Kaitlin ; Sandler, Dale P ; Shore, David ; Schubauer-Berigan, Mary ; Troester, Melissa A ; Nylander-French, Leena ; Richardson, David B

Objectives : Uranium miners in P

Menée au Royaume-Uni auprès de 102 869 femmes entre 2003 et 2014, cette étude de cohorte analyse l'association entre un travail posté de nuit et le risque de cancer (durée médiane de suivi : 9,5 ans ; 2 059 cas de cancer invasif)

Night shift work and risk of breast cancer in women: the Generations Study cohort

Jones, Michael E. ; Schoemaker, Minouk J. ; McFadden, Emily C. ; Wright, Lauren B. ; Johns, Louise E. ; Swerdlow, Anthony J.

Background : It is plausible that night shift work could affect breast cancer risk, possibly by melatonin suppression or circadian clock disruption, but epidemiological evidence is inconclusive. Methods : Using serial questionnaires from the Generations Study cohort, we estimated hazard ratios (HR) and 95% confidence intervals (95%CI) for breast cancer in relation to being a night shift worker within the last 10 years, adjusted for potential confounders. Results : Among 102,869 women recruited [...]

Menée aux Etats-Unis à partir de données portant sur 64 170 participants, cette étude analyse l'association entre des allergies, de l'asthme et le risque de cancer, selon l'origine ethnique (période de suivi : 2002-2011 ; 3 628 cas)

Allergies and asthma in relation to cancer risk

Kantor, Elizabeth D. ; Hsu, Meier ; Du, Mengmeng ; Signorello, Lisa B

Background: Allergies and asthma, conditions commonly characterized by immunoglobulin E (IgE)-mediated atopic reactions, may decrease cancer risk via increases in immunosurveillance, but may increase risk due to persistent immune stimulation. Associations between allergies and asthma and cancer risk remain unclear, and it is unknown whether associations vary by race/ethnicity. Methods: We evaluated these associations in the Southern Community Cohort Study. At baseline (2002-2009), 64,170 [...]

Menée à partir de données portant sur 1 881 patients atteints d'une tumeur myéloproliférative Ph-, cette étude analyse l'association entre une utilisation de médicaments cytoréducteurs et le risque de second cancer (647 cas de second cancer)

Second cancer in Philadelphia negative myeloproliferative neoplasms (MPN-K). A nested case-control study

Barbui, Tiziano ; Ghirardi, Arianna ; Masciulli, Arianna ; Carobbio, Alessandra ; Palandri, Francesca ; Vianelli, Nicola ; De Stefano, Valerio ; Betti, Silvia ; Di Veroli, Ambra ; Iurlo, Alessandra ; Cattaneo, Daniele ; Delaini, Federica ; Bonifacio, Massimiliano ; Scaffidi, Luigi ; Patriarca, Andrea ; Rumi, Elisa ; Casetti, Ilaria Carola ; Stephenson, Clemency ; Guglielmelli, Paola ; Elli, Elena Maria ; Palova, Miroslava ; Bertolotti, Laura ; Erez, Daniel ; Gomez, Montse ; Wille, Kai ; Perez-Encinas, Manuel ; Lunghi, Francesca ; Angona, Anna ; Fox, Maria Laura ; Beggiato, Eloise ; Benevolo, Giulia ; Carli, Giuseppe ; Cacciola, Rossella ; McMullin, Mary Frances ; Tieghi, Alessia ; Recasens, Valle ; Marchetti, Monia ; Griesshammer, Martin ; Alvarez-Larran, Alberto ; Vannucchi, Alessandro Maria ; Finazzi, Guido

We conducted a large international nested case-control study including 1881 patients with Philadelphia-negative myeloproliferative neoplasms (MPN). Cases (n = 647) were patients with second cancer (SC: carcinoma, non-melanoma skin cancer, hematological second cancer, and melanoma) and controls (n = 1234) were patients without SC, matched with cases for sex, age at MPN diagnosis, date of MPN diagnosis, and MPN disease duration. The aim was to evaluate the risk of SC after exposure to [...]

Menée au Royaume-Uni à partir de données portant sur 12 779 hommes atteints d'un hypogonadisme tardif diagnostiqué entre 1995 et 2016, cette étude analyse l'association entre l'utilisation d'une thérapie de remplacement de la testostérone et le risque de cancer de la prostate (durée de suivi : 58 224 personnes-années ; 215 cas)

Testosterone Replacement Therapy and the Risk of Prostate Cancer in Men with Late-Onset Hypogonadism

Santella, Christina ; Renoux, Christel ; Yin, Hui ; Yu, Oriana H Y ; Azoulay, Laurent

The association between the use of testosterone replacement therapy (TRT) and prostate cancer remains uncertain. Thus, we investigated whether TRT is associated with an increased risk of prostate cancer in men with late-onset hypogonadism. We used the United Kingdom Clinical Practice Research Datalink to assemble a cohort of 12,779 men newly-diagnosed with hypogonadism between 1 January 1995 and 31 August 2016, with follow-up until 31 August 2017. Exposure to TRT was treated as a time-varying [...]

Menée aux Etats-Unis à partir de données portant sur 14 532 participants âgés de 45 à 64 ans, cette étude analyse l'association entre des critères anthropométriques liés à la taille (longueur des jambes, hauteur en position assise) et le risque de cancer colorectal (période de suivi : 1987-2012 ; 382 cas)

Association between greater leg length and increased incidence of colorectal cancer: the atherosclerosis risk in communities (ARIC) study

Onyeaghala, Guillaume ; Lutsey, Pamela L. ; Demerath, Ellen W. ; Folsom, Aaron R. ; Joshu, Corinne E. ; Platz, Elizabeth A. ; Prizment, Anna E.

Purpose : Previous studies have reported that taller people have an increased risk of colorectal cancer (CRC). We examined the association of two height components—leg length and sitting height—with CRC risk in 14,532 individuals aged 45–64 years in the Atherosclerosis Risk in Communities study. Methods : Anthropometrics were measured at baseline (1987–1989). Incident CRC cases (n = 382) were ascertained from 1987 to 2012. Cox proportional hazards regression was used to estimate [...]

Menée au Canada auprès de 4 331 femmes atteintes d'un cancer du sein (dont 1 503 femmes avant la ménopause) et de 4 271 témoins d'ascendance européenne, puis validée auprès de 3 766 Africaines et de 4 870 Chinoises, cette étude identifie, sur la région chromosomique 4q31.22, trois variants du locus de susceptibilité à la maladie avant la ménopause

Fine-mapping of a novel premenopausal breast cancer susceptibility locus at Chr4q31.22 in Caucasian women and validation in African and Chinese women

Kumaran, Mahalakshmi ; Ghosh, Sunita ; Joy, Anil A. ; Mackey, John R. ; Cass, Carol E. ; Zheng, Wei ; Yasui, Yutaka ; Damaraju, Sambasivarao

We previously identified a novel breast cancer susceptibility variant on chromosome 4q31.22 locus (rs1429142) conferring risk among women of European ancestry. Here, we report replication of findings, validation of the variant in diverse populations and fine-mapping of the associated locus in Caucasian population. The SNP rs1429142 (C/T, minor allele frequency 18%) showed association for the overall breast cancer risk in Stages 1–4 (n = 4,331 cases/4271 controls; p = 4.35 × 10−8; odds ratio, [...]