Cette étude passe en revue les enjeux liés à la prise en charge d'une cachexie chez les patients atteints d'un cancer

Cancer cachexia, a clinical challenge

Argilés, Josep M. ; Busquets, Sílvia ; López-Soriano, Francisco Javier

Purpose of review The aim of this article is to review the metabolic background of the cachectic syndrome and to analyze the recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Recent findings The main changes associated with the development of this multiorganic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. Among the most promising approaches for the treatment of cachexia include the use of ghrelin [...]

Menée en France à partir de données portant sur 1 119 patients âgés de plus de 65 ans et atteints d'un cancer (âge moyen : 73,9 ans ; 73 % des patients atteints d'une tumeur solide), cette étude multicentrique analyse l'utilisation du filgrastim pour prévenir une neutropénie induite par la chimiothérapie

Filgrastim prophylaxis in elderly cancer patients in the real-life setting: a French multicenter observational study, the TULIP study

Laribi, Kamel ; Badinand, Delphine ; Janoray, Philippe ; Benabed, Khaled ; Mouysset, Jean-Loup ; Fabre, Elizabeth ; Monchecourt, Françoise ; Diab, Rafik

Purpose : Few studies are currently available among elderly patients, justifying the need for better understanding of daily medical practices in terms of use of growth factors to prevent chemotherapy (CT)-induced neutropenia. The primary objective of this study was to describe the use of filgrastim in the elderly. Methods : Cancer patients aged 65 years and above, undergoing CT and initiating a prophylactic treatment with filgrastim, were enrolled. Patients were followed according to routine [...]

Menée en Pologne auprès de 46 patients ayant survécu à une tumeur cérébrale (âge : 4,5 à 29 ans), de 104 témoins et de leurs parents (150 parents), cette étude analyse la qualité de vie des patients ayant survécu à une tumeur cérébrale, puis analyse l'impact de la maladie sur la qualité de vie des parents

Quality of Life in Survivors of Childhood Brain Tumour and the association of children's diseases on quality of their parents life

Musiol, Katarzyna ; Bulska, Weronika ; Brożek, Paulina ; Oślizło, Barbara ; Ryzak, Stella ; Dubiel, Justyna ; Sobol-Milejska, Grażyna

Objective : Evaluation of children's quality of life (QoL) after finished brain tumour treatment and the association of children's diseases on quality of their parents life. Methods : The study group was consisted of 46 children after brain tumour treatment (aged 4,5 – 29 years). The control group was composed of 104 students of primary, secondary and high schools. 150 (104+46) parents were included in the study. Standardized QoL questionnaires (PEDsQL‐4.0, WHOQOL‐BREF) were used. Survivors’ [...]

A partir des données des registres américains des cancers portant sur 235 541 adolescents et jeunes adultes atteints d'un cancer diagnostiqué entre 1973 et 2015 (âge : 15-39 ans), cette étude analyse la mortalité non liée au cancer (période de suivi : 3,1 millions personnes-années ; 12 948 décès par autre cause que le cancer)

Noncancer mortality among adolescents and young adults with cancer

Anderson, Chelsea ; Lund, Jennifer L. ; Weaver, Mark A. ; Wood, William A. ; Olshan, Andrew F. ; Nichols, Hazel B.

Background : Relative to the general population, cancer patients and survivors may have an elevated risk of mortality from noncancer causes, such as cardiovascular disease and infections, but few studies have examined rates of noncancer mortality among patients diagnosed as adolescents and young adults (AYAs) (ages 15-39 years). Methods : The Surveillance, Epidemiology, and End Results database was used to identify AYA patients who were diagnosed with a first malignant cancer between 1973 and [...]

A partir des données de l'Organisation Mondiale de la Santé et de la base Eurostat sur la période 1970-2014, cette étude présente une projection de la mortalité par cancer en Europe pour l'année 2019, en mettant en avant la mortalité par cancer du sein

European cancer mortality predictions for the year 2019 with focus on breast cancer

Carioli, G ; Malvezzi, M ; La Vecchia, C ; Negri, E ; Bertuccio, P ; Boffetta, P ; Levi, F

Background : To overcome the lag with which cancer statistics become available, we predicted numbers of deaths and rates from all cancers and selected cancer sites for 2019 in the European Union (EU). Materials and methods : We retrieved cancer death certifications and population data from the World Health Organization and Eurostat databases for 1970–2014. We obtained estimates for 2019 with a linear regression on number of deaths over the most recent trend period identified by a logarithmic [...]

Menée au Danemark à partir de données portant sur 1 026 patients, cette étude analyse les disparités socioéconomiques dans l'inclusion des patients dans des essais cliniques de phase I

Socioeconomic Differences in Referral to Phase I Cancer Clinical Trials: A Danish Matched Cancer Case-Control Study

Katrine Toubro Gad ; Christoffer Johansen ; Anne Katrine Duun-Henriksen ; Anja Krøyer ; Maja Halgren Olsen ; Ulrik Lassen ; Morten Mau-Sørensen ; Susanne Oksberg Dalton

PURPOSE : In this nationwide registry study, we investigated socioeconomic and structural patterns in referral to phase I cancer trials in a case-control study design. METHODS : Personal identification numbers on all Danish patients referred to the Danish Phase I Unit at Rigshospitalet from 2005 to 2016, and a control group matched on age, sex, type of cancer, year of diagnosis, and time from diagnosis to referral ensured individual-level linkage between several registries. We examined the [...]

A partir des données des registres américains des cancers portant sur 371 patients afro-américains atteints d'un cancer du sein ou de la prostate et souffrant d'une hémoglobinopathie, cette étude analyse le risque d'événement indésirable sévère nécessitant une hospitalisation ou une visite dans les services d'urgence

Serious adverse events in African–American cancer patients with sickle cell trait and inherited haemoglobinopathies in a SEER-Medicare claims cohort

Hoag, Jessica R. ; Andemariam, Biree ; Wang, Xiaoyan ; Gregorio, David I. ; Jones, Beth A. ; Sporn, Jonathan ; Salner, Andrew L. ; Swede, Helen

African–American (AA) cancer patients have long-experienced worse outcomes compared to non-Hispanic whites (NHW). No studies to date have evaluated the prognostic impact of sickle cell trait (SCT) and other inherited haemoglobinopathies, of which several are disproportionately high in the AA population. In a cohort analysis of treated patients diagnosed with breast or prostate cancer in the linked SEER-Medicare database, the relative risk (RR) for ≥1 serious adverse events (AEs), defined as [...]

Menée à partir des données GLOBOCAN pour l'année 2012, cette étude estime, pour la région de la Méditerranée orientale, la proportion des cancers liés au mode de vie et à des facteurs environnementaux

Proportion of cancers attributable to major lifestyle and environmental risk factors in the Eastern Mediterranean region

Kulhánová, Ivana ; Znaor, Ariana ; Shield, Kevin D ; Arnold, Melina ; Vignat, Jérôme ; Charafeddine, Maya ; Fadhil, Ibtihal ; Fouad, Heba ; Al-Omari, Amal ; Al-Zahrani, Ali Saeed ; El-Basmy, Amani ; Shamseddine, Ali ; Bray, Freddie ; Soerjomataram, Isabelle

Cancer is a major contributing cause of morbidity and mortality in the Eastern Mediterranean region. The aim of the current study was to estimate the cancer burden attributable to major lifestyle and environmental risk factors. We used age-, sex- and site-specific incidence estimates for 2012 from IARC's GLOBOCAN, and assessed the following risk factors: smoking, alcohol, high body mass index, insufficient physical activity, diet, suboptimal breastfeeding, infections, and air pollution. The [...]

Menée à partir des données des registres américains des cancers portant sur 144 patients atteints d'un lymphome primitif du système nerveux central, cette étude analyse, selon la présence d'une infection par le VIH, les traitements reçus et la survie associée (survie globale et survie sans progression)

Primary central nervous system lymphoma in patients with and without HIV infection: a multicenter study and comparison with U.S national data

Dandachi, Dima ; Ostrom, Quinn T. ; Chong, Insun ; Serpa, Jose A. ; Giordano, Thomas P. ; Kruchko, Carol ; Barnholtz-Sloan, Jill S. ; Fowler, Nathan ; Colen, Rivka R. ; Morón, Fanny E.

Purpose : Primary central nervous system lymphoma (PCNSL) in patients living with HIV (PLWH) is a distinct entity; however, the management is adopted from patients without HIV. The study aims to examine the differences in presentation, treatment, and outcomes of PCNSL patients with or without HIV. Methods : We retrospectively compared the characteristics of 144 patients with PCNSL with and without HIV, and analyzed factors associated with overall and progression-free survival. Results were [...]

A partir des données GLOBOCAN sur la période 2008-2012, cette étude présente une estimation de l'incidence du lymphome non hodgkinien dans 185 pays pour l'année 2018

Global patterns and trends in the incidence of non-Hodgkin lymphoma

Miranda-Filho, Adalberto ; Piñeros, Marion ; Znaor, Ariana ; Marcos-Gragera, Rafael ; Steliarova-Foucher, Eva ; Bray, Freddie

Purpose : Despite an increasing understanding of the pathology and genetics of non-Hodgkin lymphoma (NHL), global reports on variations in the incidence of NHL remain limited in their number and scope. Methods : To provide a situation analysis, national incidence estimates for NHL in 185 countries for the year 2018 were obtained from the GLOBOCAN database. We also used recorded incidence data from Cancer Incidence in Five Continents (CI5) plus for years of diagnosis 1980–2012 to examine [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2018 (8 articles, 551 patients), cette méta-analyse évalue l'association entre l'allongement alternatif des télomères et le risque de décès chez des patients atteints d'un sarcome des tissus mous

Alternative lengthening of telomeres (ALT) influences survival in soft tissue sarcomas: a systematic review with meta-analysis

Lawlor, Rita T. ; Veronese, Nicola ; Pea, Antonio ; Nottegar, Alessia ; Smith, Lee ; Pilati, Camilla ; Demurtas, Jacopo ; Fassan, Matteo ; Cheng, Liang ; Luchini, Claudio

Background : Alternative lengthening of telomeres (ALT) is a telomerase-independent mechanism used by a broad range of neoplasms to maintain telomere length, permitting uncontrolled replication during their progression. ALT has been described in different types of sarcoma, but a comprehensive analysis of its clinical significance is still lacking. Therefore, we provide here the first meta-analysis on this topic. Methods : We searched SCOPUS and PubMed through July 2018 to identify all studies [...]

Mené en Suède à partir de données portant sur 847 patientes atteintes d'un cancer du sein diagnostiqué entre 1992 et 2012 (âge : 34-84 ans), cette étude analyse l'association entre la pratique d'une activité physique après le diagnostic et la survie

Physical activity and survival following breast cancer

Johnsson, Anna ; Broberg, Per ; Krüger, Ute ; Johnsson, Anders ; Tornberg, Åsa B ; Olsson, Håkan

Introduction : Physical activity (PA) leads to improved survival in women following the diagnosis of breast cancer, but it is less clear whether PA has equally positive effects regardless of age at diagnosis. The purpose of our study was to evaluate the association between post-diagnosis PA and survival in women aged below or over 55 years at diagnosis. Methods : From a prospective population-based cohort of Swedish women, we included 847 women, aged 34–84 years, who were diagnosed with breast [...]

Menée à partir des données du registre californien des cancers, cette étude analyse, en fonction du sous-type de la maladie (ER+, PR+ et HER2-), les caractéristiques démographiques et clinico-pathologiques chez des patientes atteintes d'un cancer du sein triple positif et la mortalité associée

Differences in clinicopatholgic characteristics and risk of mortality between the triple positive and ER+/PR+/HER2− breast cancer subtypes

Parise, Carol A. ; Caggiano, Vincent

Purpose : This study compared the demographic and clinicopathologic characteristics and risk of mortality between the triple positive (TP) and ER+/PR+/HER2− breast cancer subtypes. Methods : Cases of first primary female invasive TP and ER+/PR+/HER2− breast cancer were obtained from the California Cancer Registry. Logistic regression analysis was used to compare differences in factors associated with the TP versus the ER+/PR+/HER2− subtype. Cox regression was used to compute the adjusted risk [...]

Mené sur 743 patients atteints d'un cancer localisé de la prostate, cet essai randomisé évalue l'intérêt d'une intervention destinée à améliorer la satisfaction du patient vis-à-vis des soins reçus et vis-à-vis de la décision thérapeutique

Patient-Centered Preference Assessment to Improve Satisfaction With Care Among Patients With Localized Prostate Cancer: A Randomized Controlled Trial

Ravishankar Jayadevappa ; Sumedha Chhatre ; Joseph J. Gallo ; Marsha Wittink ; Knashawn H. Morales ; David I. Lee ; Thomas J. Guzzo ; Neha Vapiwala ; Yu-Ning Wong ; Diane K. Newman ; Keith Van Arsdalen ; S. Bruce Malkowicz ; J. Sanford Schwartz ; Alan J. Wein

PURPOSE : To study the effectiveness of the Patient Preferences for Prostate Cancer Care (PreProCare) intervention in improving the primary outcome of satisfaction with care and secondary outcomes of satisfaction with decision, decision regret, and treatment choice among patients with localized prostate cancer. METHODS : In this multicenter randomized controlled study, we randomly assigned patients with localized prostate cancer to the PreProCare intervention or usual care. Outcomes were [...]

A partir d'une revue systématique de la littérature (35 études), cette étude analyse les différents facteurs (socio-démographiques, inflammatoires, liés au mode de vie, etc.) associés à une dépression chez des patients atteints d'un cancer de la tête et du cou

Factors associated with depression over time in head and neck cancer patients: a systematic review

Korsten, Laura H.A. ; Jansen, Femke ; de Haan, Ben J.F. ; Sent, Danielle ; Cuijpers, Pim ; Leemans, C. René ; Verdonck-de Leeuw, Irma M.

Objective : To systematically review the literature on factors associated with a clinical diagnosis of depression or symptoms of depression (depression) among head and neck cancer (HNC) patients. Methods : The search was conducted in Pubmed, PsycINFO, and CINAHL. Studies were included if they investigated factors associated with depression among HNC patients, were of prospective or longitudinal nature, and English full-text was available. The search, data extraction, and quality assessment were [...]

Menée en France et aux Etats-Unis à partir de données portant sur 292 patients atteints d'un cancer de stade avancé (143 patients français, 149 patients américains), cette étude analyse, dans ces deux pays, la fréquence et l'intensité d'une détresse liée à des difficultés financières, et analyse l'association entre les symptômes de détresse et la qualité de vie

Inequalities in Financial Distress, Symptoms, and Quality of Life Among Patients with Advanced Cancer in France and the U.S

Barbaret, Cécile ; Delgado‐Guay, Marvin O. ; Sanchez, Stéphane ; Brosse, Christelle ; Ruer, Murielle ; Monsarrat, Léa ; Michaud, Patrick ; Schott, Anne Marie ; Bruera, Eduardo ; Filbet, Marilene

Background : Financial distress (FD) is common among patients with advanced cancer. Our purpose was to compare the frequency and intensity of FD and its associations with symptom distress and quality of life (QOL) in these patients in France and the U.S. Materials and Methods : In this secondary analysis of two cross‐sectional studies, we assessed data on 292 patients who received cancer care at a public hospital or a comprehensive cancer center in France (143 patients) or the U.S. (149 [...]

A partir d'une revue systématique de la littérature publiée entre 2008 et 2018 (63 articles), cette étude analyse au niveau mondial les coûts de santé directs et indirects liés à la consommation de tabac et à une exposition passive au tabac

Tobacco Cost of Illness Studies: A Systematic Review

Makate, Marshall ; Norman, Richard ; Whetton, Steve ; Dey, Tania ; Allsop, Steve ; Tait, Robert J ; Scollo, Michelle ; Banks, Emily ; Roche, Ann ; Pidd, Ken

Introduction : To identify studies reporting costs arising from tobacco use and detail their 1) economic approaches, 2) health outcomes, and 3) other cost areas included. Methods : PubMed, SCOPUS, Cochrane Library, EconLit, and Google scholar for studies published between 2008 and April 2018 in English. Eligible papers reported tobacco-related costs and included all tobacco-using populations (multi-national, national, sub-populations and involuntary smokers). All economic approaches that [...]

Menée aux Etats-Unis auprès de 233 infirmières en oncologie, cette étude analyse l'efficacité d'un programme pédagogique sur internet pour améliorer leurs connaissances et leurs compétences en communication relatives à des sujets liés à la reproduction (risque d'infertilité, techniques de préservation de la fertilité, sexualité, etc.) auprès de patients adolescents ou jeunes adultes atteints d'un cancer

Impact of a Web-Based Reproductive Health Training Program: ENRICH (Educating Nurses about Reproductive Issues in Cancer Healthcare)

Quinn, Gwendolyn P. ; Bowman Curci, Meghan ; Reich, Richard R. ; Gwede, Clement K. ; Meade, Cathy D. ; The ENRICH/ECHO Working Group ; Vadaparampil, Susan T.

Purpose : Educating Nurses about Reproductive Issues in Cancer Healthcare (ENRICH) is a web-based training program to assist oncology nurses with timely communication and relevant information regarding reproductive health issues (e.g., risk of infertility, fertility preservation, sexual health) to adolescent and young adult (AYA) patients and survivors. This manuscript describes impact on knowledge, perceived communication skills, and practice behaviors. Methods : The 8- module course [...]

Mené auprès de 119 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'intérêt d'une intervention psycho-pédagogique destinée à promouvoir des consultations et des tests génétiques afin de déterminer leur statut BRCA

A Randomized Controlled Intervention to Promote Readiness to Genetic Counseling for Breast Cancer Survivors

Kasting, Monica L. ; Conley, Claire C. ; Hoogland, Aasha I. ; Scherr, Courtney L. ; Kim, Jongphil ; Thapa, Ram ; Reblin, Maija ; Meade, Cathy D. ; Lee, M. Catherine ; Pal, Tuya ; Quinn, Gwendolyn P. ; Vadaparampil, Susan T.

Objective : Breast cancer (BC) survivors with a genetic mutation are at higher risk for subsequent cancer; knowing genetic risk status could help survivors make decisions about follow‐up screening. Uptake of genetic counseling and testing (GC/GT) to determine BRCA status is low among high risk BC survivors. This study assessed feasibility, acceptability, and preliminary efficacy of a newly developed psychoeducational intervention (PEI) for GC/GT. Methods : High risk BC survivors (N=119) [...]