A partir d'une revue des essais randomisés, cette étude analyse l'efficacité des interventions nutritionnelles dédiées aux patients âgés et atteints d'un cancer gastro-intestinal (conseils alimentaires, supplémentation en acides gras oméga 3, nutrition parentérale)

Nutritional interventions in elderly gastrointestinal cancer patients: the evidence from randomized controlled trials

Bozzetti, Federico

Literature concerning nutritional interventions in elderly patients with gastrointestinal cancer, with special reference to randomized clinical trials, has been critically reviewed. This segment of oncologic population was found to be penalized by a high prevalence of malnutrition and sarcopenia which translated in an increased rate of toxicity from chemotherapy, poor compliance with oncologic treatments, and, finally, with a poor prognosis. Attempts to reverse this condition included a [...]

Menée aux Pays-Bas auprès de 113 patients atteints d'un cancer, cette étude de cohorte prospective évalue les facteurs liés aux dysfonctionnements du cou et de l'épaule après la fin des traitements anticancéreux (durée de suivi : 5 ans)

Factors influencing neck and shoulder function after oral oncology treatment: a five-year prospective cohort study in 113 patients

van Hinte, Gerben ; Wetzels, Jan-Willem G. H. ; Merkx, Matthias A. W. ; de Haan, Anton F. J. ; Koole, Ron ; Speksnijder, Caroline M.

Background : The aim of this study was to identify factors influencing shoulder and/or neck function in patients up to five years after treatment. Materials and methods : Lateral flexion of the neck, ipsilateral forward flexion, and abduction of the shoulder were measured. Potential factors were entered into a linear mixed model analysis to create a multivariate model for describing the results. Results : Predicted neck and shoulder function was negatively influenced by higher age before [...]

Menée au Royaume-Uni par entretiens auprès de 38 patients atteints d'un cancer de la prostate résistant à la castration de stade métastatique et de 12 soignants, puis menée par enquête en ligne auprès de 152 patients atteints de la même pathologie, cette étude analyse leur fatigue, leur qualité de vie et leur satisfaction vis-à-vis des traitements reçus (acétate d'abiratérone et prednisone ; enzalutamide)

Fatigue, treatment satisfaction and health-related quality of life among patients receiving novel drugs suppressing androgen signalling for the treatment of metastatic castrate-resistant prostate cancer

Dearden, Lindsay ; Shalet, Natalie ; Artenie, Cristiana ; Mills, Andrew ; Jackson, Claire ; Grant, Laura ; Gater, Adam

Clinical studies have demonstrated the benefits of abiraterone acetate + prednisone (AAP) and enzalutamide (ENZ) in significantly improving survival among metastatic castration-resistant prostate cancer (mCRPC) patients. However, evidence regarding patient's real-world experience, particularly with respect to fatigue, treatment satisfaction and health-related quality of life (HRQoL) is limited. Interviews were initially conducted with patients (n = 38) and carers (n = 12) to elicit qualitative [...]

Menée en France auprès de 414 patients ayant survécu à un cancer de la prostate, cette étude analyse l'association entre les traitements anticancéreux et leur désir sexuel, 2 ans après le diagnostic

Sexual desire of French representative prostate cancer survivors 2 years after diagnosis (the VICAN survey)

Girodet, Magali ; Bouhnik, Anne-Deborah ; Mancini, Julien ; Peretti-Watel, Patrick ; Bendiane, Marc-Karim ; Ray-Coquard, Isabelle ; Préau, Marie

Purpose : The prostate cancer impacts on the future life of survivors. The complexity of sexual health problems in prostate cancer survivors is underestimated or often reduced to the erectile dysfunction. Especially, factors influencing sexual desire of patients have to be more explored. This study aims to describe the therapeutic management of patients with prostate cancer and assess their sexual desire 2 years after diagnosis. Methods : This study is part of the National VICAN survey (Vie [...]

Menée au Royaume-Uni par entretiens auprès de trente femmes socioéconomiquement défavorisées et marginalisées, cette étude qualitative analyse les facteurs sociologiques, psychologiques, et leurs comportements de santé liés au risque de cancer

Cancer risk in socially marginalised women: An exploratory study

Hanson, Sarah ; Gilbert, Duncan ; Landy, Rebecca ; Okoli, Grace ; Guell, Cornelia

Background : Cancer is a leading cause of premature death in women worldwide, and is associated with socio-economic disadvantage. Yet many interventions designed to reduce risk and improve health fail to reach the most marginalised with the greatest needs. Our study focused on socially marginalised women at two women's centres that provide support and training to women in the judicial system or who have experienced domestic abuse. Methods : This qualitative study was framed within a [...]

Menée au Canada à partir de données portant sur 163 071 patients atteints d'un cancer diagnostiqué entre 2007 et 2014, cette étude évalue le risque de maladie rénale chronique ou d'insuffisance rénale aiguë en lien avec les traitements systémiques anticancéreux (10 880 cas)

Acute Kidney Injury in Patients Receiving Systemic Treatment for Cancer: A Population-Based Cohort Study

Kitchlu, Abhijat ; McArthur, Eric ; Amir, Eitan ; Booth, Christopher M. ; Sutradhar, Rinku ; Majeed, Habeeb ; Nash, Danielle M. ; Silver, Samuel A. ; Garg, Amit X. ; Chan, Christopher T. ; Kim, S. Joseph ; Wald, Ron

Background : Patients undergoing treatment for cancer are at increased risk of acute kidney injury (AKI). There are few data on AKI incidence and risk factors in the current era of cancer treatment. Methods : We conducted a population-based study of all patients initiating systemic therapy (chemotherapy or targeted agents) for a new cancer diagnosis in Ontario, Canada (2007–2014). The primary outcome was hospitalization with AKI or acute dialysis. We estimated the cumulative incidence of AKI [...]

Menée en Chine à partir de données portant sur 3 185 individus atteints de silicose entre 1981 et 2014, cette étude de cohorte historique évalue l'effet d'une cessation tabagique sur la mortalité par cancer du poumon (1 942 décès, 188 décès par cancer du poumon)

Smoking cessation sharply reduced lung cancer mortality in a historical cohort of 3185 Chinese silicotic workers from 1981 to 2014

Tse, Lap Ah ; Lin, Xiaona ; Li, Wentao ; Qiu, Hong ; Chan, Chi Kuen ; Wang, Feng ; Yu, Ignatius Tak-Sun ; Leung, Chi Chiu

Background : Population-based studies showed an over 50% decrease in lung cancer risk after quitting smoking for 5–6 years, but the beneficial effect in silicotics remains unknown. We aimed to rectify this knowledge gap using a large historical cohort of 3185 Chinese silicotics since 1981 and followed-up till 2014. Methods : Baseline information on workers’ socio-demographics, smoking habits, occupational history, and medical history was collected. Smoking status was reassessed during [...]

Menée en Suède à partir de données portant sur 14 150 patients atteints d'un cancer de la prostate diagnostiqué entre 1996 et 2011, cett étude évalue l'association entre le niveau sérique de glucose, de triglycérides et de cholestérol, et le risque de décès par cancer de la prostate

Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study

Arthur, Rhonda ; Møller, Henrik ; Garmo, Hans ; Häggström, Christel ; Holmberg, Lars ; Stattin, Pär ; Malmstrom, Hakan ; Lambe, Mats ; Hammar, Niklas ; Walldius, Goran ; Robinson, David ; Jungner, Ingmar ; Van Hemelrijck, Mieke

Purpose : Lifestyle-related conditions such as obesity are associated with prostate cancer progression, but the associations with hyperglycemia and dyslipidemia are unclear. This study, therefore, aims to examine the association of glucose, triglycerides, and total cholesterol with prostate cancer death. Methods : From the Swedish AMORIS cohort, we selected 14,150 men diagnosed with prostate cancer between 1996 and 2011 who had prediagnostic measurements of serum glucose, triglycerides, and [...]

Menée aux Etats-Unis à partir de données portant sur 3 262 patients atteints d'un cancer colorectal de stade I à III diagnostiqué entre 2006 et 2011, cette étude de cohorte rétrospective évalue l'association entre une stéatose hépatique non alcoolique et la mortalité spécifique (durée moyenne de suivi : 10 ans ; 879 décès dont 451 décès spécifiques)

Non-alcoholic fatty liver disease and colorectal cancer survival

Wu, Kana ; Zhai, Mike Z. ; Weltzien, Erin K. ; Cespedes Feliciano, Elizabeth M. ; Meyerhardt, Jeffrey A. ; Giovannucci, Edward ; Caan, Bette J.

Purpose : Liver diseases including non-alcoholic fatty liver disease (NAFLD) and ensuing alterations to the micro-environment may affect development of liver metastasis. Mirroring the rise in obesity rates, prevalence of NAFLD is increasing globally. Our objective was to examine the association between NAFLD and mortality in colorectal cancer patients. Methods : Colorectal Cancer-Sarcopenia and Near-term Survival (C-SCANS) is a retrospective cohort study which included 3,262 stage I–III [...]

Menée aux Etats-Unis à partir de données portant sur 266 804 participants âgés entre 51 et 70 ans, cette étude évalue l'évolution de l'association entre le niveau socioéconomique du voisinage et le risque de développer un cancer colorectal, sur la période 1990-2000

Ten-year change in neighborhood socioeconomic status and colorectal cancer

Zhang, Dong ; Matthews, Charles E. ; Powell-Wiley, Tiffany M. ; Xiao, Qian

Background : A growing body of research has demonstrated that individuals who live in neighborhoods with more severe socioeconomic deprivation may have higher risks for colorectal cancer (CRC). However, previous studies have examined neighborhood socioeconomic status (SES) at only 1 point in time, and it is unclear whether changes in neighborhood SES also can influence the risks of CRC. Methods : Cox regression analysis was used to examine different trajectories of change in neighborhood SES [...]

Menée à partir de données portant sur 1 881 patientes atteintes d'un cancer du sein de stade précoce, cette étude évalue le risque de neuropathie induite par la chimiothérapie en fonction de la catégorie d'âge (avant 55 ans, de 55 à 64 ans, plus de 65 ans)

Age and the Risk of Paclitaxel-Induced Neuropathy in Women with Early-Stage Breast Cancer (Alliance A151411): Results from 1,881 Patients from Cancer and Leukemia Group B (CALGB) 40101

Barginear, Myra ; Dueck, Amylou C. ; Allred, Jacob B. ; Bunnell, Craig ; Cohen, Harvey J. ; Freedman, Rachel A. ; Hurria, Arti ; Kimmick, Gretchen ; Le‐Rademacher, Jennifer G. ; Lichtman, Stuart ; Muss, Hyman B. ; Shulman, Lawrence N. ; Sitiki Copur, M. ; Biggs, David ; Ramaswamy, Bhuvaneswari ; Lafky, Jacqueline M. ; Jatoi, Aminah

A few previous studies report a direct relationship between older age and chemotherapy‐induced neuropathy. This study further evaluated this adverse event's age‐based risk.CALGB 40101 investigated adjuvant paclitaxel (80 mg/m2 once per week or 175 mg/m2 every 2 weeks) in patients with breast cancer and served as a platform for the current study that investigated age‐based differences in neuropathy. Grade 2 or worse neuropathy, as per Common Terminology Criteria for Adverse Events version 4, was [...]

Menée au Canada à partir de données portant sur 100 368 femmes âgées de plus de 67 ans et ayant utilisé des bisphosphonates, cette étude de cohorte évalue l'association entre une utlisation ultérieure de dénosumab et le risque de cancer du sein après la ménopause (1 271 cas)

Denosumab and breast cancer risk in postmenopausal women: a population-based cohort study

Giannakeas, Vasily ; Cadarette, Suzanne M. ; Ban, Joann K. ; Lipscombe, Lorraine ; Narod, Steven A. ; Kotsopoulos, Joanne

Background : Denosumab inhibits the receptor activator of nuclear factor

Menée aux Etats-Unis à partir de données portant sur 4 147 patientes atteintes d'un cancer invasif du sein diagnostiqué entre 1976 et 2008, cette étude de cohorte évalue l'association entre l'expression du récepteur des androgènes et la survie (durée médiane de suivi : 16,5 ans ; 806 décès spécifiques)

Androgen Receptor Expression and Breast Cancer Survival: Results From the Nurses’ Health Studies

Kensler, Kevin H. ; Poole, Elizabeth M. ; Heng, Yujing J. ; Collins, Laura C. ; Glass, Benjamin ; Beck, Andrew H. ; Hazra, Aditi ; Rosner, Bernard A. ; Eliassen, A. Heather ; Hankinson, Susan E. ; Winer, Eric P. ; Brown, Myles ; Tamimi, Rulla M.

Background : Hormone receptor signaling is critical in the progression of breast cancers, although the role of the androgen receptor (AR) remains unclear, particularly for estrogen receptor (ER)–negative tumors. This study assessed AR protein expression as a prognostic marker for breast cancer mortality. Methods : This study included 4147 pre- and postmenopausal women with invasive breast cancer from the Nurses’ Health Study (diagnosed 1976–2008) and Nurses’ Health Study II (1989–2008) cohorts. [...]

Menée dans 9 pays européens à partir de données portant sur 7 581 patientes atteintes d'un cancer du sein de stade précoce, cette étude évalue l'association entre l'âge, les comorbidités présentes au moment du diagnostic de cancer, le choix des traitements, le risque de récidive et la survie

Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer

Minicozzi, Pamela ; van Eycken, Liesbet ; Molinié, Florence ; Innos, Kaire ; Guevara, Marcela ; Marcos-Gragera, Rafael ; Castro, Clara ; Rapiti, Elisabetta ; Katalinic, Alexander ; Torrella, Ana ; Zagar, Tina ; Bielska-Lasota, Magdalena ; Rossi, Paolo Giorgi ; Larranaga, Nerea ; Bastos, Joana ; Sánchez, María José ; Sant, Milena

Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7,581 stage I/IIA cases diagnosed in 9 European countries in 2009−13, and 4 STs: surgery; breast-conserving surgery plus radiotherapy (BCS+RT); reconstruction after mastectomy; and [...]

A partir des données des registres américains des cancers portant sur 462 patients atteints d'une tumeur primitive maligne des glandes salivaires avec métastases pulmonaires entre 1988 et 2013, cette étude analyse les facteurs cliniques et thérapeutiques associés à la survie

Clinical, pathological and treatment factors associated with the survival of patients with primary pulmonary salivary gland-type tumors

Qin, Bao-Dong ; Jiao, Xiao-Dong ; Liu, Ke ; Wu, Ying ; He, Xi ; Liu, Jun ; Zang, Yuan-Sheng

Introduction : Primary pulmonary salivary gland-type tumors (p-SGTs) are rare, with poorly understood clinicopathological characteristics and survival. There are only few case reports or small case series, and factors associated with survival need to be identified. Methods : A population cohort study was conducted using data from patients with histologically diagnosed primary p-SGTs in the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2013. Propensity-matching [...]

Mené en Norvège sur 291 patients atteints de cancer et souffrant de réactions de stress face à la maladie (intrusions, évitement à l'effraction traumatique), d'une détresse psychologique (anxiété, dépression) ou d'une réactivité émotionnelle (impatience, hostilité), cet essai randomisé évalue l'efficacité d'une intervention individuelle de prise en charge du stress en deux étapes, et utilisant les techniques d'une psychothérapie comportementale

Early rehabilitation of cancer patients – an individual randomized stepped-care stress-management intervention

Arving, Cecilia ; Assmus, Jörg ; Thormodsen, Inger ; Berntsen, Sveinung ; Nordin, Karin

Objective : To evaluate the effects of an individual stepped-care stress-management intervention for cancer patients on cancer-related stress reactions (intrusion/avoidance), and secondarily on psychological distress (anxiety/depression) and emotional reactivity (impatience/hostility). Methods : Consecutively 291 cancer patients were included in a randomized controlled intervention study. Patients randomized to the intervention who did not report clinically significant stress levels (n=72) [...]

Mené au Danemark sur 258 aidants familiaux de patients atteints d'un cancer incurable, cet essai randomisé évalue l'efficacité d'une intervention à base de soutien psychologique pour la dyade et de soins palliatifs à domicile, pour soulager les symptômes d'anxiété et de dépression de l'aidant, avant et pendant la période de deuil

Effect of home-based specialised palliative care and dyadic psychological intervention on caregiver anxiety and depression: a randomised controlled trial

von Heymann-Horan, Annika ; Bidstrup, Pernille ; Guldin, Mai-Britt ; Sjøgren, Per ; Andersen, Elisabeth Anne Wreford ; von der Maase, Hans ; Kjellberg, Jakob ; Timm, Helle ; Johansen, Christoffer

Background : Specialised palliative care trials often fail to address intervention effects on caregiver anxiety and depression, particularly in bereavement. We evaluate effects of specialised palliative care and dyadic psychological intervention on caregiver anxiety and depression in a randomised controlled trial (RCT). Methods : Patients with incurable cancer and limited antineoplastic treatment options and their caregivers, recruited from a university hospital oncology department, were [...]

Menée aux Etats-Unis auprès de 69 patientes ayant survécu à un cancer du sein de stade précoce et de leurs conjoints, cette étude évalue l'association entre des comportements quotidiens visant à protéger son partenaire des contrariétés et préoccupations liées au cancer, l'intimité du couple et la peur de la récidive, après un traitement adjuvant

Everyday Protective Buffering Predicts Intimacy and Fear of Cancer Recurrence in Couples Coping with Early-Stage Breast Cancer

Perndorfer, Christine ; Soriano, Emily C. ; Siegel, Scott D. ; Laurenceau, Jean-Philippe

Objective: Patient and spouse/partner mutual self-disclosure is central for maintaining intimacy and cognitive processing when transitioning to life after cancer. Protective buffering inhibits self-disclosure and is defined as efforts to protect one's partner from upset and burden by hiding or denying cancer-related concerns. Intimacy and fear of cancer recurrence (FCR) are important determinants of individual and couple adaptation following cancer. Links between protective buffering and [...]

Mené à Taïwan sur 100 patients ayant survécu à un cancer de la tête et du cou, cet essai randomisé évalue l'efficacité d'un programme d'éducation à la santé pour inciter aux changements de comportements, améliorer les fonctions sociales et émotionnelles, réduire les symptômes de dépression et la peur des interactions sociales

Impact of a Behavior Change Program and Health Education on Social Interactions in Survivors of Head and Neck Cancer: Randomized Controlled Trial

Chen, Shu-Ching ; Huang, Bing-Shen ; Hung, Tsung-Min ; Lin, Chien-Yu ; Chang, Ya-Lan

Objective : The purpose of this study of survivors of head and neck cancer was to evaluate the effects of a behavior change program and health education on depression, fear of social interactions, avoidance of social interactions, physical function, and social-emotional function. Methods : This was a randomized controlled trial of 100 subjects, in which changes in the scores of several psychometric scales were recorded for an experimental group (behavior change program and health education) and [...]

A partir de données d'études précédemment publiées, cet article analyse les difficultés financières liées aux coûts de santé chez des patients ayant survécu à un cancer, identifie les facteurs de risque de ces difficultés et les interventions permettant de les réduire

Medical Financial Hardship among Cancer Survivors in the United States: What Do We Know? What Do We Need to Know?

Yabroff, K. Robin ; Zhao, Jingxuan ; Zheng, Zhiyuan ; Rai, Ashish ; Han, Xuesong

Rising costs of cancer care have led to increased concerns about medical financial hardship for cancer survivors and their families in the United States. In this commentary, we provide an overview of research describing medical financial hardship and introduce a conceptual framework for identifying risk factors and research gaps at the patient and family, provider and care team, health care system, employer, and state and national policy levels. We then use this framework to highlight [...]

Menée dans un contexte britannique, à partir des données d'un essai international de phase III comparant deux durées d'administration de l'oxaliplatine en traitement ajuvant chez 6 088 patients atteints d'un cancer colorectal de stade II ou III totalement réséqué, cette étude analyse le rapport coût-efficacité de ces deux durées d'administration (3 ou 6 mois)

SCOT: a comparison of cost-effectiveness from a large randomised phase III trial of two durations of adjuvant Oxaliplatin combination chemotherapy for colorectal cancer

Robles-Zurita, José ; Boyd, Kathleen A. ; Briggs, Andrew H. ; Iveson, Timothy ; Kerr, Rachel S. ; Saunders, Mark P. ; Cassidy, Jim ; Hollander, Niels Henrik ; Tabernero, Josep ; Segelov, Eva ; Glimelius, Bengt ; Harkin, Andrea ; Allan, Karen ; McQueen, John ; Pearson, Sarah ; Waterston, Ashita ; Medley, Louise ; Wilson, Charles ; Ellis, Richard ; Essapen, Sharadah ; Dhadda, Amandeep S. ; Hughes, Rob ; Falk, Stephen ; Raouf, Sherif ; Rees, Charlotte ; Olesen, Rene K. ; Propper, David ; Bridgewater, John ; Azzabi, Ashraf ; Farrugia, David ; Webb, Andrew ; Cunningham, David ; Hickish, Tamas ; Weaver, Andrew ; Gollins, Simon ; Wasan, Harpreet S. ; Paul, James

BACKGROUND : The Short Course Oncology Therapy (SCOT) study is an international, multicentre, non-inferiority randomised controlled trial assessing the efficacy, toxicity, and cost-effectiveness of 3 months (3 M) versus the usually given 6 months (6 M) of adjuvant chemotherapy in colorectal cancer. METHODS : In total, 6088 patients with fully resected high-risk stage II or stage III colorectal cancer were randomised and followed up for 3–8 years. The within-trial cost-effectiveness analysis [...]

Menée en Australie par entretiens auprès de 22 patients atteints de cancer et de 22 professionnels de santé, cette étude qualitative analyse leurs attitudes et leurs préoccupations relatives au consentement du patient pour participer à un essai clinique et pour donner leurs échantillons biologiques à une biobanque

“As Long as You Ask”: A Qualitative Study of Biobanking Consent—Oncology Patients’ and Health Care Professionals’ Attitudes, Motivations, and Experiences—the B-PPAE Study

Yip, Sonia ; Fleming, Jennifer ; Shepherd, Heather L. ; Walczak, Adam ; Clark, Jonathan ; Butow, Phyllis

Consent to biobanking remains controversial, with little empirical data to guide policy and practice. This study aimed to explore the attitudes, motivations, and concerns of both oncology patients and health care professionals (HCPs) regarding biobanking.Qualitative interviews were conducted with oncology patients and HCPs purposively selected from five Australian hospitals. Patients were invited to give biobanking consent as part of a clinical trial and/or for future research were eligible. [...]