Menée auprès d'une cohorte de 108 136 femmes ménopausées (durée médiane de suivi : 17,9 ans), cette étude évalue l'association entre la qualité du mode de vie, mesurée par un système de score prenant en compte des facteurs de santé (alimentation, consommation d'alcool, niveau d'activité physique, indice de masse corporelle, statut tabagique), et le risque de cancer de l'endomètre (1 435 cas) et de l'ovaire (904 cas)

A Healthy Lifestyle Index in Relation to Risk of Endometrial and Ovarian Cancer Among Women in the Women's Health Initiative Study

Arthur, Rhonda ; Brasky, Theodore M. ; Crane, Tracy E. ; Felix, Ashley S. ; Kaunitz, Andrew ; Shadyab, Aladdin H. ; Qi, Lihong ; Wassertheil-Smoller, Sylvia ; Rohan, Thomas E.

Lifestyle-related factors influence risk of endometrial and ovarian cancers, but few studies have examined their joint associations with risk of these cancers. Using multivariable Cox regression models, we assessed the association of a healthy lifestyle index ((HLI) - a composite score (range 0-20) involving diet, alcohol consumption, physical activity, body mass index and smoking; higher scores represent healthier behavior) - with risk of endometrial and ovarian cancers among 108,136 [...]

Menée en France à partir de deux vagues d'enquêtes réalisées en 2016 et 2017 auprès de 2 046 et 1 999 adolescents âgés de 12 à 17 ans, cette étude analyse l'évolution des perceptions vis-à-vis du tabagisme et des comportements tabagiques après l'introduction d'une loi imposant l'augmentation de la taille des avertissements sanitaires graphiques sur les paquets neutres

Plain tobacco packaging, increased graphic health warnings and adolescents’ perceptions and initiation of smoking: DePICT, a French nationwide study

El-Khoury Lesueur, Fabienne ; Bolze, Camille ; Gomajee, Ramchandar ; White, Vicki ; Melchior, Maria

Background : Plain packaging (PP) of tobacco products and increased graphic warnings may contribute to lower attractiveness of smoking, particularly among youths. In France, this policy was introduced on 1 January 2017. We examined changes in smoking-related perceptions and behaviours among a nationwide sample of French adolescents before (2016) and 1 year post (2017) implementation. Methods : DePICT is a two-wave cross-sectional national telephone survey of adolescents aged 12–17 years per [...]

Mené aux Etats-Unis auprès de 25 871 participants (durée médiane de suivi : 5,3 ans ; âge des hommes : 50 ans ou plus ; âge des femmes : 55 ans ou plus), cet essai randomisé évalue l'effet d'une supplémentation quotidienne en vitamine D sur le risque de cancer (1 617 cas) et le risque de maladie cardiovasculaire (805 cas)

Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Manson, JoAnn E. ; Cook, Nancy R. ; Lee, I. Min ; Christen, William ; Bassuk, Shari S. ; Mora, Samia ; Gibson, Heike ; Gordon, David ; Copeland, Trisha ; D’Agostino, Denise ; Friedenberg, Georgina ; Ridge, Claire ; Bubes, Vadim ; Giovannucci, Edward L. ; Willett, Walter C. ; Buring, Julie E.

Background : It is unclear whether supplementation with vitamin D reduces the risk of cancer or cardiovascular disease, and data from randomized trials are limited. Methods : We conducted a nationwide, randomized, placebo-controlled trial, with a two-by-two factorial design, of vitamin D3 (cholecalciferol) at a dose of 2000 IU per day and marine n−3 (also called omega-3) fatty acids at a dose of 1 g per day for the prevention of cancer and cardiovascular disease among men 50 years of age or [...]

Menée au Danemark à partir d'une revue des articles de presse publiés entre 2006 et 2009 et à partir de données statistiques, cette étude identifie les facteurs démographiques associés à la couverture vaccinale contre le papillomavirus humain.

Stronger responders—uptake and decline of HPV-vaccination in Denmark

Lübker, Charlotte Lynderup ; Lynge, Elsebeth

Background : The purpose of this study was to identify the stronger responders behind the fluctuating coverage with the HPV-vaccine in Denmark in order to facilitate information campaigns targeted at specific subgroups. Methods : Newspaper articles published from 2006 to 2009 with information about coverage with the HPV-vaccine in Denmark were identified from the database Infomedia.dk. Vaccination coverage of recent years was retrieved from the publically accessible statistics from the State’s [...]