Menée en Corée auprès de 96 855 participants, cette étude de cohorte évalue l'association entre une pratique tabagique et le risque de cancer de la thyroïde (durée médiane de suivi : 5,9 ans ; période de suivi : 511 052 personnes-années ; 1 250 cas)

Cigarette smoking and thyroid cancer risk: a cohort study

Cho, Ara ; Chang, Yoosoo ; Ahn, Jiin ; Shin, Hocheol ; Ryu, Seungho

Background : We evaluated the association between smoking status and thyroid cancer risk and whether this association is mediated by body mass index (BMI) and thyroid-stimulating hormone (TSH). Methods : We performed a cohort study of 96,855 Korean adults who were followed annually or biennially for a median of 5.9 years. Results : During 511,052.9 person-years of follow-up, 1,250 participants developed thyroid cancer. In men, we observed a dose-dependent inverse association between current [...]

A partir d'une revue systématique de la littérature (8 études, 243 088 membres d'équipage de l'aviation), cette méta-analyse évalue le risque de cancer de la thyroïde chez les personnels navigants (période de suivi : 3 334 114 personnes-années)

Thyroid cancer risk in airline cockpit and cabin crew: a meta-analysis

Liu, George S. ; Cook, Austin ; Richardson, Michael ; Vail, Daniel ; Holsinger, F. Christopher ; Oakley-Girvan, Ingrid

Background : Airline crew are exposed to ionizing radiation as part of their occupation and have a documented increased risk of melanoma and cataracts. However, whether their occupation predisposes them to an increased risk of thyroid cancer is not established. The purpose of this systematic review and meta-analysis was to assess the risk of thyroid cancer in airline cockpit and cabin crew compared with the general population. Methods : The MEDLINE database accessed via PubMed and Cochrane [...]

A partir de données de 9 études portant sur 2 854 patients atteints d'un myélome multiple et sur 10 743 témoins, cette étude évalue l'association entre une exposition professionnelle à des hydrocarbures aromatiques (benzène, toluène, xylène) et le risque de développer la maladie

Pooled study of occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma

De Roos, Anneclaire J ; Spinelli, John ; Brown, Elizabeth B ; Atanackovic, Djordje ; Baris, Dalsu ; Bernstein, Leslie ; Bhatti, Parveen ; Camp, Nicola J ; Chiu, Brian C ; Clavel, Jacqueline ; Cozen, Wendy ; de Sanjose, Silvia ; Dosman, James A ; Hofmann, Jonathan N ; McLaughlin, John R ; Miligi, Lucia ; Monnereau, Alain ; Orsi, Laurent ; Purdue, Mark P ; Schinasi, Leah H ; Tricot, Guido J ; Wang, Sophia S ; Zhang, Yawei ; Birmann, Brenda M ; Cocco, Pierluigi

Objectives : To investigate the association between occupational exposure to aromatic hydrocarbon solvents and risk of multiple myeloma (MM) in a large, consortium-based study. Methods : We pooled data on 2854 cases and 10 743 controls from nine studies participating in the InterLymph consortium. Occupational exposures to benzene, toluene and xylene were assigned by a job–exposure matrix, coupled with ‘correction’ of exposure probability by self-reported or expert-assessed exposure from the [...]

A partir des données de trois études prospectives incluant 1 435 patientes atteintes d'un cancer du sein et 1 433 témoins, cette étude évalue l'association entre la concentration sanguine de cadmium et de plomb, et le risque de développer la maladie

Blood Levels of Cadmium and Lead in Relation to Breast Cancer Risk in Three Prospective Cohorts

Gaudet, Mia M. ; Deubler, Emily L. ; Kelly, Rachel S. ; Diver, W. Ryan ; Teras, Lauren R. ; Hodge, James M. ; Levine, Keith E. ; Haines, Laura G. ; Lundh, Thomas ; Lenner, Per ; Palli, Domenico ; Vineis, Paolo ; Bergdahl, Ingvar A. ; Gapstur, Susan M. ; Kyrtopoulos, Soterios A.

Cadmium and lead have been classified as carcinogens by the International Agency for Research on Cancer. However, their associations with breast cancer risk are unknown despite their persistence in the environment and ubiquitous human exposure. We examined associations of circulating levels of cadmium and lead with breast cancer risk in three case-control studies nested within the Cancer Prevention Study-II (CPS-II) LifeLink Cohort, European Prospective Investigation into Cancer and Nutrition – [...]

Menée en Norvège à partir de données portant sur 483 241 femmes âgées entre 50 et 69 ans, cette étude évalue l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause et le risque de cancer du sein, en prenant en compte les changements de poids tout au long de la vie (période de suivi : 2006-2013 ; 7 656 cas de cancer)

Menopausal hormone therapy and breast cancer risk: effect modification by body mass through life

Sandvei, Marie Søfteland ; Vatten, Lars J. ; Bjelland, Elisabeth Krefting ; Eskild, Anne ; Hofvind, Solveig ; Ursin, Giske ; Opdahl, Signe

It is not known whether increased breast cancer risk caused by menopausal hormone therapy (HT) depends on body mass patterns through life. In a prospective study of 483,241 Norwegian women aged 50–69 years at baseline, 7656 women developed breast cancer during follow-up (2006–2013). We combined baseline information on recalled body mass in childhood/adolescence and current (baseline) body mass index (BMI) to construct mutually exclusive life-course body mass patterns. We assessed associations [...]

Menée à partir de données portant sur 34 402 individus souffrant d'apnée du sommeil entre 2005 et 2014, cette étude évalue l'association entre ces troubles respiratoires nocturnes et le risque de cancer (1 517 cas)

Sleep apnea and subsequent cancer incidence

Sillah, Arthur ; Watson, Nathaniel F. ; Schwartz, Stephen M. ; Gozal, David ; Phipps, Amanda I.

Purpose : In vitro and animal models suggest that the physiological effects of sleep apnea could contribute to cancer risk, yet epidemiologic studies have been inconsistent. Methods : We identified a cohort of adults diagnosed with sleep apnea between 2005 and 2014 using regional administrative databases. Linking this cohort to a population-based cancer registry, we identified first incident cancers diagnosed after sleep apnea diagnosis through 2015. We calculated age–sex standardized cancer [...]

A partir des données des registres américains des cancers, cette étude analyse la part des différents facteurs de risque dans l'incidence du cancer du sein (notamment l'indice de masse corporelle, l'âge lors des premières règles, le nombre de naissances, l'âge à la première naissance) sur la période 1980-2008

Proportion of U.S. Trends in Breast Cancer Incidence Attributable to Long-term Changes in Risk Factor Distributions

Pfeiffer, Ruth M. ; Webb-Vargas, Yenny ; Wheeler, William ; Gail, Mitchell H.

Background: U.S. breast cancer incidence has been changing, as have distributions of risk factors, including body mass index (BMI), age-at-menarche, age-at-first-live-birth and number of live births. Methods: Using data for U.S. women from large nationally representative surveys, we estimated risk factor distributions from 1980-2008. To estimate ecologic associations with breast cancer incidence, we fitted Poisson models to age- and calendar-year-specific incidence data from the National Cancer [...]

Menée à partir des données du registre suédois des cancers familiaux, cette étude suggère que le cancer familial de l'ovaire a une étiologie commune avec un certain nombre d'autres cancers

Familial Ovarian Cancer Clusters with Other Cancers

Zheng, Guoqiao ; Yu, Hongyao ; Kanerva, Anna ; Försti, Asta ; Sundquist, Kristina ; Hemminki, Kari

Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patients affected by other cancers, and conversely, risks for other cancers in families with [...]

Menée aux Etats-Unis à partir de données portant sur 977 enfants atteints d'une leucémie lymphoblastique aiguë et sur 1 037 témoins, ainsi qu'à partir des données de 12 études, cette méta-analyse évalue l'association entre des allergies et le risque de développer la maladie

Allergies and childhood acute lymphoblastic leukemia: A case-control study and meta-analysis

Wallace, Amelia D. ; Francis, Stephen S ; Ma, Xiaomei ; McKean-Cowdin, Roberta ; Selvin, Steve ; Whitehead, Todd P ; Barcellos, Lisa F ; Kang, Alice Y ; Morimoto, Libby M. ; Moore, Theodore B. ; Wiemels, Joseph L. ; Metayer, Catherine

Background: Allergic disease is suspected to play a role in the development of childhood acute lymphoblastic leukemia (ALL). Studies conducted over the last several decades have yielded mixed results. Methods: We examined the association between allergy, a common immune-mediated disorder, and ALL in the California Childhood Leukemia Study (CCLS), a case-control study of 977 children diagnosed with ALL and 1037 matched controls (1995-2015). History of allergies in the first year of life was [...]

Menée à partir d'une technique de séquençage à haut débit sur 85 gènes de susceptibilité à la maladie prélevés dans l'ADN de 198 patients atteints d'un mélanome malin, cette étude analyse la présence et la fréquence de mutations constitutionnelles dans ces 85 gènes

Frequency of Germline Mutations in Cancer Susceptibility Genes in Malignant Mesothelioma

Vasiliki Panou ; Meghana Gadiraju ; Arthur Wolin ; Caroline M. Weipert ; Emily Skarda ; Aliya N. Husain ; Jyoti D. Patel ; Buerkley Rose ; Shannon R. Zhang ; Madison Weatherly ; Viswateja Nelakuditi ; Amy Knight Johnson ; Maria Helgeson ; David Fischer ; Arpita Desai ; Nanna Sulai ; Lauren Ritterhouse ; Oluf D. Røe ; Kiran K. Turaga ; Dezheng Huo ; Jeremy Segal ; Sabah Kadri ; Zejuan Li ; Hedy L. Kindler ; Jane E. Churpek

Purpose : The aim of the current study was to determine the prevalence and clinical predictors of germline cancer susceptibility mutations in patients with malignant mesothelioma (MM). Methods : We performed targeted capture and next-generation sequencing of 85 cancer susceptibility genes on germline DNA from 198 patients with pleural, peritoneal, and tunica vaginalis MM. Results : Twenty-four germline mutations were identified in 13 genes in 23 (12%) of 198 patients. BAP1 mutations were the [...]