A partir d'une revue systématique de la littérature publiée jusqu'en mai 2016 (30 études), cette étude analyse les besoins de patients atteints d'un cancer (âge : entre 14 et 45 ans) concernant les soins de support liés à la problématique de la fertilité (information, discussions médecin/patient, soutien psychologique, accès aux services d'oncofertilité, etc)

A systematic review of patient oncofertility support needs in reproductive cancer patients aged 14 to 45 years of age

Logan, S. ; Perz, J. ; Ussher, J. M. ; Peate, M. ; Anazodo, A.

Objective: Decline in fertility potential brought about by a cancer diagnosis or cancer treatment is one of the biggest impacts to cancer patients' long-term quality of life. As such, the current manuscript aimed to systematically review the literature on oncofertility support needs for cancer patients of a reproductive age (14–45 years of age). Methods: A systematic review of the literature was conducted in May 2016 through the searching of electronic databases Medline, EMBASE, PSYCH Info, Web [...]

Menée aux Etats-Unis auprès de 187 patients adultes ayant survécu à un lymphome non hodgkinien pendant l'enfance, cette étude analyse leur détresse psychologique, leur fonctionnement neurocognitif et leur qualité de vie, en lien avec les traitements reçus

Neurocognitive, psychosocial, and quality-of-life outcomes in adult survivors of childhood non-Hodgkin lymphoma

Ehrhardt, Matthew J. ; Mulrooney, Daniel A. ; Li, Chenghong ; Baassiri, Malek J. ; Bjornard, Kari ; Sandlund, John T. ; Brinkman, Tara M. ; Huang, I. Chan ; Srivastava, Deo Kumar ; Ness, Kirsten K. ; Robison, Leslie L. ; Hudson, Melissa M. ; Krull, Kevin R.

BACKGROUND: Children with non-Hodgkin lymphoma (NHL) undergo treatment with central nervous system–directed therapy, the potentially neurotoxic effects of which have not been reported in NHL survivors. METHODS: NHL survivors (n = 187) participating in the St. Jude Lifetime Cohort who were 10 or more years from their diagnosis and were 18 years old or older underwent neurocognitive, emotional distress (Brief Symptom Inventory 18), and health-related quality of life (HRQOL) assessments (36-Item [...]

Menée en Allemagne à partir de données portant sur 1 239 patients atteints d'un cancer du poumon non à petites cellules de stade avancé, cette étude de cohorte analyse leur qualité de vie en fonction du choix et du nombre de traitements reçus

Treatment, outcome and quality of life of 1239 patients with advanced non-small cell lung cancer - final results from the prospective German TLK cohort study

von Verschuer, Ulla ; Schnell, Roland ; Tessen, Hans Werner ; Eggert, Jochen ; Binninger, Adrian ; Spring, Lisa ; Jänicke, Martina ; Marschner, Norbert

Objectives : Real-life data on advanced non-small cell lung cancer (NSCLC) are centrally important to complement the results from clinical trials and to improve the standard of care. We present data on the choice of systemic first- and second-line treatment, number of treatment lines, survival and longitudinal data on health-related quality of life (HRQOL) of patients treated by medical oncologists in Germany. Materials and methods : 1239 patients with advanced NSCLC were recruited at start of [...]

Menée aux Etats-Unis à partir de données portant sur 1 722 patients atteints d'un méningiome intracrânien et sur 1 622 témoins entre 2006 et 2013, cette étude analyse leur qualité de vie physique et psychologique après un traitement chirurgical

Quality of life after surgery for intracranial meningioma

Benz, Luke S. ; Wrensch, Margaret R. ; Schildkraut, Joellen M. ; Bondy, Melissa L. ; Warren, Joshua L. ; Wiemels, Joseph L. ; Claus, Elizabeth B.

BACKGROUND: To the authors' knowledge, limited data exist regarding long-term quality of life (QOL) for patients diagnosed with intracranial meningioma. METHODS: The data in the current study concerned 1722 meningioma cases diagnosed among residents of Connecticut, Massachusetts, California, Texas, and North Carolina from May 1, 2006 through March 14, 2013, and 1622 controls who were frequency matched to the cases by age, sex, and geography. These individuals were participants in a large, [...]

Menée au Royaume-Uni à partir de données portant sur 2 882 patients atteints d'un cancer du poumon, sur 757 patients atteints d'un cancer des voies aérodigestives supérieures et sur 1 733 patients atteints d'un cancer de la vessie entre 1999 et 2013, cette étude de cohorte rétrospective analyse l'association entre une cessation tabagique pendant l'année suivant le diagnostic et la mortalité spécifique

Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study

Koshiaris, C. ; Aveyard, P. ; Oke, J. ; Ryan, R. ; Szatkowski, L. ; Stevens, R. ; Farley, A.

Background: The aim was to examine the association between smoking cessation and prognosis in smoking-related cancer as it is unclear that cessation reduces mortality. Methods: In this retrospective cohort study from 1999 to 2013, we assessed the association between cessation during the first year after diagnosis and all-cause and cancer-specific mortality. Results: Of 2882 lung, 757 upper aero-digestive tract (UAT) and 1733 bladder cancer patients 27%, 29% and 21% of lung, UAT and bladder [...]

Menée à partir des analyses sanguines de 2 739 participants de la cohorte EPIC, de 1 632 patients atteints d'un cancer (sein, prostate, côlon-rectum ou poumon) et de 761 personnes décédées de la maladie, cette étude évalue l'association entre les niveaux d'albumine, de bilirubine ou d'acide urique et le risque de développer un cancer

Albumin, bilirubin, uric acid and cancer risk : results from a prospective population-based study

Kühn, Tilman ; Sookthai, Disorn ; Graf, Mirja E. ; Schubel, Ruth ; Freisling, Heinz ; Johnson, Theron ; Katzke, Verena ; Kaaks, Rudolf

Background : It has long been proposed that albumin, bilirubin and uric acid may inhibit cancer development due to their anti-oxidative properties. However, there is a lack of population-based studies on blood levels of these molecules and cancer risk. Methods : Associations between pre-diagnostic serum albumin, bilirubin and uric acid and the risks of common cancers as well as cancer death in the EPIC-Heidelberg cohort were evaluated by multivariable Cox regression analyses. A case–cohort [...]

Menée aux Etats-Unis à partir de données portant sur 18,9 millions de bénéficaires du système Medicare entre 2000 et 2008, cette étude de cohorte évalue l'association entre une exposition, sur le long terme, à des particules fines et la mortalité, par maladies respiratoires ou cardiovasculaires, et par cancer du poumon (4,2 millions de décès)

Long-Term PM2.5 Exposure and Respiratory, Cancer, and Cardiovascular Mortality in Older US Adults

Vivian C. Pun; ; Fatemeh Kazemiparkouhi; ; Justin Manjourides; ; Helen H. Suh

The impact of chronic exposure to fine particulate matter (particulate matter with an aerodynamic diameter less than or equal to 2.5

Menée en Angleterre à partir de données portant sur 2,5 millions de patients atteints de cancer entre 1998 et 2013, cette étude analyse l'effet du statut socioéconomique sur la survie

Estimating the impact of a cancer diagnosis on life expectancy by socio-economic group for a range of cancer types in England

Syriopoulou, Elisavet ; Bower, Hannah ; Andersson, Therese M. L. ; Lambert, Paul C. ; Rutherford, Mark J.

Background:Differences in cancer survival exist across socio-economic groups for many cancer types. Standard metrics fail to show the overall impact for patients and the population. Methods:The available data consist of a population of ~2.5 million patients and include all patients recorded as being diagnosed with melanoma, prostate, bladder, breast, colon, rectum, lung, ovarian and stomach cancers in England between 1998 and 2013. We estimated the average loss in expectation of life per [...]

A partir des données du registre danois des cancers sur la période 2000-2010, cette étude analyse l'association entre des facteurs associés au risque de maladie cardiovasculaire avant le diagnostic de cancer (hypertension, diabète, dyslipidémie), des chimiothérapies à base d'anthracyclines et le risque d'arrêt cardiaque chez des patients ayant survécu à un lymphome non hodgkinien (durée médiane de suivi : 2,5 ans)

Preexisting Cardiovascular Risk and Subsequent Heart Failure Among Non-Hodgkin Lymphoma Survivors

Talya Salz ; Emily C. Zabor ; Peter de Nully Brown ; Susanne Oksberg Dalton ; Nirupa J. Raghunathan ; Matthew J. Matasar ; Richard Steingart ; Andrew J. Vickers ; Peter Svenssen Munksgaard ; Kevin C. Oeffinger ; Christoffer Johansen

Purpose : The use of anthracycline chemotherapy is associated with heart failure (HF) among survivors of non-Hodgkin lymphoma (NHL). We aimed to understand the contribution of preexisting cardiovascular risk factors to HF risk among NHL survivors. Methods : Using Danish registries, we identified adults diagnosed with aggressive NHL from 2000 to 2010 and sex- and age-matched general-population controls. We assessed HF from 9 months after diagnosis through 2012. We used Cox regression analysis to [...]

A partir des données du registre guadeloupéen des cancers portant sur la période 2008-2013, cette étude analyse l'évolution de l'incidence du cancer de la prostate, de la survie et de la mortalité spécifique (3 295 cas)

Prostate cancer clinical presentation, incidence, mortality and survival in Guadeloupe over the period 2008–2013 from a population-based cancer registry

Deloumeaux, J. ; Bhakkan, B. ; Eyraud, R. ; Braud, F. ; Manip M’Ebobisse, N. ; Blanchet, P. ; Brureau, L.

Purpose : The Caribbean population of Guadeloupe has one of the highest incidence rates of prostate cancer worldwide. In 2008, a population-based cancer registry was set up for the monitoring of cancer incidence in the aftermath of the environmental pollution with chlordecone, a persistent organochlorine insecticide formerly used in banana plantations. We describe the clinical presentation, incidence, mortality and survival of prostate cancer for the period 2008–2013. Methods : The Guadeloupe [...]

Menée aux Etats-Unis à partir de données portant sur 115 208 patients atteints d'un cancer de la prostate à faible risque de récidive diagnostiqué entre 2010 et 2014, cette étude rétrospective analyse les facteurs associés à l'utilisation d'une surveillance active

Variation in the use of active surveillance for low-risk prostate cancer

Löppenberg, Björn ; Friedlander, David F. ; Krasnova, Anna ; Tam, Andrew ; Leow, Jeffrey J. ; Nguyen, Paul L. ; Barry, Hawa ; Lipsitz, Stuart R. ; Menon, Mani ; Abdollah, Firas ; Sammon, Jesse D. ; Sun, Maxine ; Choueiri, Toni K. ; Kibel, Adam S. ; Trinh, Quoc-Dien

BACKGROUND: This study assessed the use of active surveillance in men with low-risk prostate cancer and evaluated institutional factors associated with the receipt of active surveillance. METHODS: A retrospective, hospital-based cohort of 115,208 men with low-risk prostate cancer diagnosed between 2010 and 2014 was used. Multivariate and mixed effects models were used to examine variation and factors associated with active surveillance. RESULTS: During the study period, the use of active [...]

Menée en Allemagne à partir de données portant sur 2 910 patients ayant survécu à un cancer colorectal diagnostiqué entre 2003 et 2010, cette étude de cohorte évalue l'association entre les niveaux sériques de 25-hydroxyvitamine D et la survie à long terme (durée médiane de suivi: 4,8 ans ; 787 décès dont 573 décès par cancer colorectal)

Relationship of very low serum 25-hydroxyvitamin D3 levels with long-term survival in a large cohort of colorectal cancer patients from Germany

Maalmi, Haifa ; Walter, Viola ; Jansen, Lina ; Chang-Claude, Jenny ; Owen, Robert W. ; Ulrich, Alexis ; Schottker, Ben ; Hoffmeister, Michael ; Brenner, Hermann

To investigate the association of serum 25-hydroxyvitamin D (25(OH)D3) with survival in a large prospective cohort study of colorectal cancer (CRC) patients. The study population consisted of 2,910 patients diagnosed with CRC between 2003 and 2010 who participated in the DACHS study, a multicenter study from Germany with comprehensive long-term follow-up. 25(OH)D3 was determined in serum samples collected shortly after cancer diagnosis by High Performance Liquid Chromatography-Electro Spray [...]

Menée aux Pays-Bas par questionnaire auprès de 192 familles d'un enfant atteint de cancer, cette étude évalue la détresse psychologique des parents 1 mois et 6 mois après le diagnostic

Parental distress 6 months after a pediatric cancer diagnosis in relation to family psychosocial risk at diagnosis

Schepers, Sasja A. ; Sint Nicolaas, Simone M. ; Maurice-Stam, Heleen ; Haverman, Lotte ; Verhaak, Chris M. ; Grootenhuis, Martha A.

BACKGROUND: This study was aimed at assessing fathers' and mothers' distress 6 months after a pediatric cancer diagnosis and at determining whether this is related to the level of family psychosocial risk 1 month after the diagnosis. METHODS: A sample of 192 families completed the electronic Psychosocial Assessment Tool (ePAT) 1 month after the diagnosis. At 6 months after the diagnosis, 119 mothers and 98 fathers completed the Distress Thermometer for Parents (DT-P; of which n=132 had also [...]

Menée par enquête auprès de 189 correspondants de 82 pays, cette étude analyse l'efficacité, les coûts, les frais restant à charge du patient et l'accessibilité de plusieurs médicaments anticancéreux dans les pays à faibles et moyens revenus

ESMO International Consortium Study on the availability, out-of-pocket costs and accessibility of anti-neoplastic medicines in countries outside of Europe

N.I. Cherny, ; R. Sullivan, ; J. Torode, ; M. Saar, ; A. Eniu

Background: The availability and affordability of safe, effective, high-quality, affordable anti-cancer therapies are a core requirement for effective national cancer control plans. Method: Online survey based on a previously validated approach. The aims of the study were to evaluate: 1) the availability on national formulary of licensed anti-neoplastic medicines across the globe; 2) patient out-of-pocket costs for the medications; 3) the actual availability of the medication for a patient with [...]

Mené sur 60 patients atteints d'un myélome multiple et recevant une greffe autologue de cellules souches hématopoïétiques, cet essai randomisé évalue l'efficacité de l'acupuncture pour réduire les effets indésirables et les symptômes liés à la greffe

Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial

Deng, Gary ; Giralt, Sergio ; Chung, David J. ; Landau, Heather ; Siman, Jonathan ; Search, Benjamin ; Coleton, Marci ; Vertosick, Emily ; Shapiro, Nathan ; Chien, Christine ; Wang, Xin S. ; Cassileth, Barrie ; Mao, Jun J.

Purpose : Hematopoietic stem cell transplantation (HCT) is potentially curative for a number of hematologic malignancies, but is associated with high symptom burden. We conducted a randomized sham-controlled trial (RCT) to evaluate efficacy and safety of acupuncture as an integrative treatment for managing common symptoms during HCT. Methods : Adult patients with multiple myeloma undergoing high-dose melphalan followed by autologous HCT (AHCT) were randomized to receive either true or sham [...]