A partir d'une revue systématique de la littérature (19 études), cette étude analyse l'efficacité d'interventions à base d'exercices physiques pour améliorer la qualité de vie des patients atteints d'un cancer de stade avancé

Exercise interventions for individuals with advanced cancer : A systematic review

Dittus, Kim L. ; Gramling, Robert E. ; Ades, Philip A.

Despite improvements in therapy a large proportion of individuals with cancer will have a shortened life expectancy because of advanced or metastatic disease. Advances in therapy have however, extended life in those with advanced cancer thus heightening the importance of living well and preventing decline. The burdens of disease and cancer therapy impair aerobic fitness, strength, physical function and quality of life (QOL). Fatigue, the most common side effect of cancer and cancer therapy can [...]

Menée en Corée auprès de 65 patients atteints d'un cancer traité par chimiothérapie, cet essai de phase III évalue la possibilité de remplacer la dexaméthasone par la méthylprednisolone au cours d'un traitement antiémétique pour réduire l'intensité d'une myoclonie phrénoglottique (hoquet) liée à la dexaméthasone sans affecter l'efficacité du traitement

Antiemetic Corticosteroid Rotation from Dexamethasone to Methylprednisolone to Prevent Dexamethasone Induced Hiccup in Cancer Patients Treated with Chemotherapy : A Randomized, Single Blind, Crossover Phase III Trial

Go, Se Il ; Koo, Dong Hoe ; Kim, Seung Tae ; Song, Haa Na ; Kim, Rock Bum ; Jang, Joung Soon ; Oh, Sung Yong ; Lee, Kyung Hee ; Lee, Soon Il ; Kim, Seong Geun ; Park, Lee Chun ; Lee, Sang Cheol ; Park, Byeong Bae ; Ji, Jun Ho ; Yi, Seong Yoon ; Lee, Yun Gyoo ; Yun, Jina ; Bruera, Eduardo ; Hwang, In Gyu ; Kang, Jung Hun

Background : To assess whether the rotation of dexamethasone to methylprednisolone decreases the intensity of dexamethasone induced hiccup (DIH) in cancer patients treated with chemotherapy. Materials and Methods : Adult patients who experienced DIH within 3 days after the administration of dexamethasone as an antiemetic were screened. Eligible patients were randomly assigned to receive dexamethasone (n = 33) or methylprednisolone (n = 32) as an antiemetic (randomization phase). In the next [...]

Cet article passe en revue les études concernant la prise en charge des interactions médicamenteuses et des toxicités potentielles liées aux traitements par inhibiteurs de kinases CDK 4/6 dans le cancer du sein, puis présente des recommandations pratiques

Clinical Management of Potential Toxicities and Drug Interactions Related to Cyclin Dependent Kinase 4/6 Inhibitors in Breast Cancer : Practical Considerations and Recommendations

Spring, Laura M. ; Zangardi, Mark L. ; Moy, Beverly ; Bardia, Aditya

Aberrations of the cell cycle are pervasive in cancer, and selective cell cycle inhibition of cancer cells is a target of choice for a number of novel cancer therapeutics. Cyclin dependent kinases (CDKs) are key regulatory enzymes that control cell cycle transitions and the commitment to cell division. Palbociclib and ribociclib are both orally active, highly selective reversible inhibitors of CDK4 and CDK6 that are approved by the U.S. Food and Drug Administration (FDA) for hormone receptor [...]

Menée auprès d'une cohorte incluant 24 840 participantes âgées de 40 à 74 ans, cette étude analyse l'association entre l'âge à la première menstruation, l'indice de masse corporelle plus tard dans l'adolescence (16 ans ou plus) et la densité mammaire mesurée à l'aide de mammographies numériques plein champ

Age at menarche and late adolescent adiposity associated with mammographic density on processed digital mammograms in 24,840 women

Alexeeff, Stacey E. ; Odo, Nnaemeka ; Lipson, Jafi A. ; Achacoso, Ninah ; Rothstein, Joseph H. ; Yaffe, Martin J. ; Liang, Rhea Y. ; Acton, Luana ; McGuire, Valerie ; Whitmore, Alice S. ; Rubin, Daniel L. ; Sieh, Weiva ; Habel, Laurel A.

Background : High mammographic density is strongly associated with increased breast cancer risk. Some, but not all, risk factors for breast cancer are also associated with higher mammographic density. Methods : The study cohort (N=24,840) was drawn from the Research Program in Genes, Environment and Health of Kaiser Permanente Northern California and included non-Hispanic white females aged 40-74 years with a full-field digital mammogram (FFDM). Percent density (PD) and dense area (DA) were [...]

A partir des données du registre national irlandais des cancers portant sur 6 314 patientes atteintes d'un cancer du sein de stade I à III et à partir des données de prescriptions, cette étude évalue l'association entre l'utilisation de statines avant diagnostic et le statut ganglionnaire de la maladie ainsi que la mortalité spécifique ou la mortalité toutes causes confondues

Pre-diagnostic statin use, lymph node status and mortality in women with stages I-III breast cancer

Smith, Amelia ; Murphy, Laura ; Zgaga, Lina ; Barron, Thomas I. ; Bennett, Kathleen

Background : Recent meta-analyses suggest that pre-diagnostic statin use is associated with reduced breast cancer-specific mortality. Studies have shown that high breast tumour expression of the statin target (3-hydroxy-3-methylglutaryl coenzyme-A reductase) is associated with lymph-node negative cancer. Therefore, we examined the association between pre-diagnostic statin use and; lymph node status, breast cancer-specific and all-cause mortality. Methods : Women with stages I–III breast cancer [...]

Menée aux Etats-Unis auprès de 2 295 patientes infectées ou non par le VIH et effectuant un test Pap tous les 6 mois (durée médiane de suivi : 12,3 ans), cette étude multicentrique analyse, en fonction de la séropositivité, le taux à long terme de cancer du col de l'utérus

Cervical cancer incidence after up to 20 years of observation among women with HIV

Massad, L. Stewart ; Hessol, Nancy A. ; Darragh, Teresa M. ; Minkoff, Howard ; Colie, Christine ; Wright, Rodney L. ; Cohen, Mardge ; Seaberg, Eric C.

To estimate the incidence of invasive cervical cancer (ICC) across up to 21 years of follow-up among women with human immunodeficiency virus (HIV) and to compare it to that among HIV-uninfected women, we reviewed ICC diagnoses from a 20-year multi-site U.S. cohort study of HIV infected and uninfected women who had Pap testing every 6 months. Incidence rates were calculated and compared to those in HIV-negative women. Incidence ratios standardized to age-, sex-, race-, and calendar-year specific [...]

Menée à partir de données britanniques portant sur une cohorte de 3 058 patientes atteintes d'un cancer de l'endomètre diagnostiqué entre 1998 et 2010 (durée moyenne de suivi : 6,1 ans), cette étude évalue l'association entre l'utilisation après diagnostic de statines, de bêta-bloquants ou de faibles doses d'aspirine et la survie des patientes

Commonly used medications and endometrial cancer survival : a population-based cohort study

Sanni, Omolara B. ; Mc Menamin, Úna C. ; Cardwell, Chris R. ; Sharp, Linda ; Murray, Liam J. ; Coleman, Helen G.

Background : Increasing incidence and new indications for existing drugs make it important to identify new adjuvant therapies for endometrial cancer (EC). Methods : This is a prospective cohort study of 3058 newly diagnosed EC cases from 1998 to 2010, identified through record linkages between the UK Clinical Practice Research Datalink, the National Cancer Research Datalink and death registrations from the Office of National Statistics. Using Cox regression models, unadjusted and adjusted [...]

Menée à partir d'une enquête auprès de 61 cancérologues ou infirmières spécialisées, cette étude analyse les stratégies et les obstacles associés au repérage des patients présentant un risque de suicide

Oncologists', nurses', and social workers' strategies and barriers to identifying suicide risk in cancer patients

Granek, Leeat ; Nakash, Ora ; Ben-David, Merav ; Shapira, Shahar ; Ariad, Samuel

Objective : To identify oncologists', nurses', and social workers' strategies and barriers in identifying suicide risk in cancer patients. Methods : Sixty-one oncology healthcare professionals (HCPs) at 2 cancer centers were interviewed. We used the grounded theory method (GT) of data collection and analysis. Analysis involved line-by-line coding, and was inductive, with codes and categories emerging from participants' narratives. Results : The majority of oncologists and nurses reported that [...]

Menée au Canada à partir des données de registres médicaux portant sur 28 427 patientes atteintes d'un cancer du sein de stade précoce diagnostiqué entre 2006 et 2010, cette étude identifie les indicateurs à analyser en routine prioritairement pour améliorer la qualité des traitements systémiques

Setting Quality Improvement Priorities for Women Receiving Systemic Therapy for Early-Stage Breast Cancer by Using Population-Level Administrative Data

Enright, Katherine A. ; Taback, Nathan ; Powis, Melanie Lynn ; Gonzalez, Alejandro ; Yun, Lingsong ; Sutradhar, Rinku ; Trudeau, Maureen E. ; Booth, Christopher M. ; Krzyzanowska, Monika K.

Purpose : Routine evaluation of quality measures (QMs) can drive improvement in cancer systems by highlighting gaps in care. Targeting quality improvement at QMs that demonstrate substantial variation has the potential to make the largest impact at the population level. We developed an approach that uses both variation in performance and number of patients affected by the QM to set priorities for improving the quality of systemic therapy for women with early-stage breast cancer (EBC). Patients [...]