Menée aux Pays-Bas par questionnaires auprès de 83 patients ayant survécu à un cancer diagnostiqué entre l'âge de 18 et de 35 ans et sur des témoins en population, cette étude évalue la prévalence d'une fatigue excessive et son effet sur la qualité de vie

Prevalence and impact of severe fatigue in adolescent and young adult cancer patients in comparison with population-based controls

Poort, Hanneke ; Kaal, Suzanne E. J. ; Knoop, Hans ; Jansen, Rosemarie ; Prins, Judith B. ; Manten-Horst, Eveliene ; Servaes, Petra ; Husson, Olga ; van der Graaf, Winette T. A.

Purpose : The current study determined the prevalence of severe fatigue in adolescent and young adult (AYA) cancer patients (aged 18–35 years at diagnosis) consulting a multidisciplinary AYA team in comparison with gender- and age-matched population-based controls. In addition, impact of severe fatigue on quality of life and correlates of fatigue severity were examined. Methods : AYAs with cancer (n = 83) completed questionnaires including the Checklist Individual Strength (CIS-fatigue), [...]

Mené sur 60 patients atteints d'un cancer de stade avancé et recevant des soins palliatifs, cet essai randomisé évalue l'efficacité d'un programme de kinésithérapie pour réduire leurs symptômes de fatigue liée à la maladie

Physiotherapy programme reduces fatigue in patients with advanced cancer receiving palliative care: randomized controlled trial

Pyszora, Anna ; Budzyński, Jacek ; Wójcik, Agnieszka ; Prokop, Anna ; Krajnik, Małgorzata

Purpose : Cancer-related fatigue (CRF) is a common and relevant symptom in patients with advanced cancer that significantly decreases their quality of life. The aim of this study was to evaluate the effect of a physiotherapy programme on CRF and other symptoms in patients diagnosed with advanced cancer. Methods : The study was designed as a randomized controlled trial. Sixty patients diagnosed with advanced cancer receiving palliative care were randomized into two groups: the treatment group (n [...]

Menée au Royaume-Uni à partir de données portant sur 17 844 patientes atteintes d'un cancer du sein et par enquête auprès de 6 405 d'entre elles, cette étude évalue l'association entre la survenue de complications chirurgicales après une mastectomie et une reconstruction mammaire et leur qualité de vie psychique et physique

The association between complications and quality of life after mastectomy and breast reconstruction for breast cancer

Browne, John P. ; Jeevan, Ranjeet ; Gulliver-Clarke, Carmel ; Pereira, Jerome ; Caddy, Christopher M. ; van der Meulen, Jan H. P.

BACKGROUND: Medical treatment for breast cancer is associated with substantial toxicity and patient burden. There is less known about the impact of surgical complications. Understanding this impact could provide important information for patients when they are considering surgical options. METHODS: Between 2008 and 2009, the UK National Mastectomy and Breast Reconstruction Audit recorded surgical complications for a prospective cohort of 17,844 women treated for breast cancer at 270 hospitals; [...]

A partir des données des registres américains des cancers, cette étude analyse l'incidence des cancers rares (moins de 6 cas par 100 000 personnes par an) et évalue la survie

The burden of rare cancers in the United States

DeSantis, Carol E. ; Kramer, Joan L. ; Jemal, Ahmedin

There are limited published data on the burden of rare cancers in the United States. By using data from the North American Association of Central Cancer Registries and the Surveillance, Epidemiology, and End Results program, the authors provide information on incidence rates, stage at diagnosis, and survival for more than 100 rare cancers (defined as an incidence of fewer than 6 cases per 100,000 individuals per year) in the United States. Overall, approximately 20% of patients with cancer in [...]

Menée en France à partir de données portant sur 696 patients atteints de cancer entre 2009 et 2016, cette étude de cohorte prospective analyse les facteurs associés à des changements d'habitudes dans leur alimentation et leur consommation d'alcool, avant et après le diagnostic de la maladie

Modifications in dietary and alcohol intakes between before and after cancer diagnosis: Results from the prospective population-based NutriNet-Santé cohort

Fassier, Philippine ; Zelek, Laurent ; Lécuyer, Lucie ; Bachmann, Patrick ; Touillaud, Marina ; Druesne-Pecollo, Nathalie ; Galan, Pilar ; Cohen, Patrice ; Hoarau, Hélène ; Latino-Martel, Paule ; Kesse-Guyot, Emmanuelle ; Baudry, Julia ; Hercberg, Serge ; Deschasaux, Mélanie ; Touvier, Mathilde

Postdiagnosis diet and alcohol consumption may be associated with cancer prognosis, recurrence and mortality. Our aim was to investigate food, nutrient and alcohol intake variations between before and after cancer diagnosis and their determinants in a prospective cohort. Subjects (n = 696) were incident cancer cases diagnosed in the NutriNet-Santé cohort between 2009 and 2016. Food, nutrient and alcohol intakes were prospectively collected using repeated nonconsecutive 24-hr dietary records [...]

Cette étude passe en revue les effet de l'âge du patient atteint de cancer sur l'adhésion à un traitement anticancéreux dispensé par voie orale et présente des recommandations pour améliorer cette adhésion

Adherence to Oral Cancer Therapy in Older Adults: The International Society of Geriatric Oncology (SIOG) Taskforce Recommendations

Rachelle Mislang, Anna ; Wildes, Tanya M. ; Kanesvaran, Ravindran ; Baldini, Capucine ; Holmes, Holly M. ; Nightingale, Ginah ; Coolbrandt, Annemarie ; Biganzoli, Laura

There is an increasing trend towards using oral systemic therapy in patients with cancer. Compared to parenteral therapy, oral cancer agents offer convenience, have similar efficacy, and are preferred by patients, consequently making its use appealing in older adults. However, adherence is required to ensure its efficacy and to avoid compromising treatment outcomes, especially when the treatment goal is curative, or in case of symptomatic/rapidly progressing disease, where dose-intensity is [...]

Menée aux Pays-Bas à partir de données portant sur 6 165 patients ayant survécu 5 ans à un cancer pédiatrique diagnostiqué entre 1963 et 2001, cette étude de cohorte évalue le risque à long terme de second cancer, en lien avec la chimiothérapie reçue (durée médiane de suivi : 20,7 ans ; 291 nouveaux cas de cancers)

Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy

Jop C. Teepen ; Flora E. van Leeuwen ; Wim J. Tissing ; Eline van Dulmen-den Broeder ; Marry M. van den Heuvel-Eibrink ; Helena J. van der Pal ; Jacqueline J. Loonen ; Dorine Bresters ; Birgitta Versluys ; Sebastian J.C.M.M. Neggers ; Monique W.M. Jaspers ; Michael Hauptmann ; Margriet van der Heiden-van der Loo ; Otto Visser ; Leontien C.M. Kremer ; Cécile M. Ronckers ; on behalf of the DCOG LATER Study Group

Purpose : Childhood cancer survivors (CCSs) are at increased risk for subsequent malignant neoplasms (SMNs). We evaluated the long-term risk of SMNs in a well-characterized cohort of 5-year CCSs, with a particular focus on individual chemotherapeutic agents and solid cancer risk. Methods : The Dutch Childhood Cancer Oncology Group–Long-Term Effects After Childhood Cancer cohort includes 6,165 5-year CCSs diagnosed between 1963 and 2001 in the Netherlands. SMNs were identified by linkages with [...]

A partir des données du registre néerlandais des cancers portant sur la période 2010-2014, cette étude analyse les traitements et la survie de patients atteints d'un cancer du poumon non à petites cellules de stade IIIb selon la classification internationale TNM-7 (43 762 patients)

Patterns of care and outcomes for stage IIIB non-small cell lung cancer in the TNM-7 era: results from the Netherlands Cancer Registry

Dickhoff, C. ; Dahele, M. ; Smit, E. F. ; Paul, M. A. ; Senan, S. ; Hartemink, K. J. ; Damhuis, R. A.

Objectives : There is limited data on the pattern of care for locally advanced, clinical (c) IIIB non-small cell lung cancer (NSCLC) in the TNM-7 staging era. The primary aim of this study was to investigate national patterns of care and outcomes in the Netherlands, with a secondary focus on the use of surgery. Material and Methods : Data from patients treated for TNM-7 cIIIB NSCLC between 2010-2014, was extracted from the Netherlands Cancer Registry (NCR). Survival data was obtained from the [...]

Menée en Islande sur la période 1970-2004, cette étude analyse l'évolution de l'incidence du cancer du côlon, des traitements et de la survie (1 962 cas)

Why is colon cancer survival improving by time? A nationwide survival analysis spanning 35 years

Snaebjornsson, Petur ; Jonasson, Larus ; Olafsdottir, Elinborg J. ; van Grieken, Nicole C. T. ; Moller, Pall H. ; Theodors, Asgeir ; Jonsson, Thorvaldur ; Meijer, Gerrit A. ; Jonasson, Jon G.

There is limited information present to explain temporal improvements in colon cancer survival. This nationwide study investigates the temporal changes in survival over a 35-year period (1970–2004) in Iceland and uses incidence, mortality, surgery rate, stage distribution, lymph node yield, tumor location and histological type to find explanations for these changes. Patients diagnosed with colon cancer in Iceland 1970–2004 were identified (n = 1962). All histopathology was reassessed. [...]

A partir des données des registres américains des cancers, cette étude présente une estimation de la prévalence du cancer du sein de stade métastatique en 2017 et évalue la survie relative à 5 ans (154 794 patientes)

Estimation of the Number of Women Living with Metastatic Breast Cancer in the United States

Mariotto, Angela B. ; Etzioni, Ruth ; Hurlbert, Marc ; Penberthy, Lynne ; Mayer, Musa

Background: Distant metastatic breast cancer (MBC), including metastases found at diagnosis (de novo) and those occurring later (recurrence), represents the most severe form of the disease, when resource utilization is most intensive. Yet, the number of women living with MBC in the United States is unknown. The objective of this article is to use population-based data to estimate the prevalence of MBC. Methods: We used a back-calculation method to estimate MBC prevalence from U.S. breast cancer [...]

Menée en Suède à partir de données portant sur 244 261 patients atteints d'un cancer diagnostiqué entre 2004 et 2009, cette étude de cohorte évalue l'association entre l'apparition de troubles psychiques après le diagnostic de la maladie et la mortalité spécifique

First-onset Mental Disorders after Cancer Diagnosis and Cancer-specific Mortality: a Nationwide Cohort Study

J. Zhu, ; F. Fang, ; A. Sjölander, ; K. Fall, ; H.O. Adami, ; U. Valdimarsdóttir

BACKGROUND: The diagnosis of cancer is strongly associated with the risk of mental disorders even in patients with no previous history of mental disorders. Accumulating data suggest that mental distress may accelerate tumor progression. We hypothesized therefore that mental disorders after a cancer diagnosis may increase the risk of cancer-specific mortality. PATIENTS AND METHODS: We conducted a nationwide cohort study including 244,261 cancer patients diagnosed in Sweden during 2004-2009 and [...]

Menée en Allemagne auprès de 4 719 patients ayant survécu plus de 10 ans à un cancer de la prostate après une prostatectomie radicale (âge moyen : 75,2 ans), cette étude analyse les facteurs associés à des symptômes d'anxiété et de dépression (durée médiane de suivi : 11,5 ans)

Prostate cancer-related anxiety in long-term survivors after radical prostatectomy

Meissner, Valentin H. ; Herkommer, Kathleen ; Marten-Mittag, Birgitt ; Gschwend, Jurgen E. ; Dinkel, Andreas

Purpose : Knowledge of the psychological distress of long- and very long-term (>10 years) prostate cancer (PC) survivors is limited. This study intended to examine the parameters influencing anxiety related to prostate-specific antigen (PSA) and PC in long-term survivors after radical prostatectomy. Methods : We surveyed 4719 PC survivors from the German multicenter prospective database “Familial Prostate Cancer.” We evaluated the association of PC-related anxiety (MAX-PC) with sociodemographic [...]

A partir d'une revue systématique de la littérature (23 articles dont 15 essais randomisés), cette étude analyse l'efficacité de différentes psychothérapies destinées aux patientes atteintes d'un cancer du sein de stade métastatique, en prenant en compte notamment le mode d'intervention (en groupe ou individuelle), leur durée, leur objectif principal, l'adhésion des patientes, etc.

A systematic review of psychotherapeutic interventions for women with metastatic breast cancer: Context matters

Beatty, Lisa ; Kemp, Emma ; Butow, Phyllis ; Girgis, Afaf ; Schofield, Penelope ; Turner, Jane ; Hulbert-Williams, Nicholas J. ; Levesque, Janelle V. ; Koczwara, Bogda

Objectives: To summarise the evidence-base of psychological interventions for women with metastatic breast cancer, by mode of delivery (group, individual, or low-intensity interventions). To synthesise data regarding core intervention-elements (eg, intervention duration) and context factors (trial setting, uptake and adherence, and demographic characteristics). Methods: Four databases were searched (inception-May 2016): MEDLINE (OvidSP), PsycINFO (OvidSP), CINAHL (EBSCO), and SCOPUS; reference [...]

Cet article fait le point sur les coûts des nouveaux médicaments anticancéreux et passe en revue les enjeux liés aux disparités d'accès à ces traitements au niveau mondial

Economics of Cancer Medicines: For Whose Benefit?

Gyawali, Bishal ; Sullivan, Richard

Although new cancer drugs are continually getting approved and used, the value that these drugs add is very debatable. Because of the skyrocketing cost of the new drugs, each new approval represents a multibillion market. However, unlike other branches of economics, cancer drugs are intricately associated with socio-political issues, emotional overlay, public pressure, industry manipulation and propaganda. In this article, we review the value added by new cancer drugs and examine the [...]

Menée en Australie, en Allemagne, en Italie et en Espagne à partir de données portant sur 362 patients atteints d'un mélanome cutané de stade métastatique et traités par ipilimumab, cette étude rétrospective analyse les coûts associés à l'utilisation des ressources de santé (hospitalisations, visites médicales,...)

Health Care Resource Utilization and Associated Costs Among Metastatic Cutaneous Melanoma Patients Treated with Ipilimumab (INTUITION Study)

McArthur, Grant A. ; Mohr, Peter ; Ascierto, Paolo Antonio ; Arance, Ana ; Banos Hernaez, Ana ; Kaskel, Peter ; Weichenthal, Michael ; Shinde, Reshma ; Stevinson, Kendall

Background : There are limited real‐world data on health care resource utilization (HCRU) among advanced melanoma patients. The objective of this study was to describe HCRU and health care costs associated with the management of advanced melanoma patients receiving ipilimumab. Methods : This retrospective multinational, observational study included advanced melanoma patients from Australia, Germany, Italy, and Spain who had received at least 1 dose of ipilimumab. Data extracted from medical [...]

A partir de données d'une enquête menée auprès de 349 hématologues en 2015, cette étude américaine analyse leurs pratiques et leurs opinions relatives au recours à des services hospitaliers pour leurs patients atteints d'un cancer du sang en fin de vie

Why are patients with blood cancers more likely to die without hospice?

Odejide, Oreofe O. ; Cronin, Angel M. ; Earle, Craig C. ; Tulsky, James A. ; Abel, Gregory A.

BACKGROUND: Although patients with blood cancers have significantly lower rates of hospice use than those with solid malignancies, data explaining this gap in end-of-life care are sparse. METHODS: In 2015, we conducted a mailed survey of a randomly selected sample of hematologic oncologists in the United States to characterize their perspectives regarding the utility and adequacy of hospice for blood cancer patients, as well as factors that might impact referral patterns. Simultaneous provision [...]