A partir des données de 9 études prospectives incluant 424 152 participants, cette étude analyse l'association entre une utilisation de snus, un tabac suédois qui se chique, et le risque de cancer du pancréas (1 447 cas)

Use of moist oral snuff (snus) and pancreatic cancer: Pooled analysis of nine prospective observational studies

Araghi, Marzieh ; Rosaria Galanti, Maria ; Lundberg, Michael ; Lager, Anton ; Engstrom, Gunnar ; Alfredsson, Lars ; Knutsson, Anders ; Norberg, Margareta ; Sund, Malin ; Wennberg, Patrik ; Trolle Lagerros, Ylva ; Bellocco, Rino ; Pedersen, Nancy L. ; Östergren, Per-Olof ; Magnusson, Cecilia

While smoking is a well-established risk factor for pancreatic cancer, the effect of smokeless tobacco is less well understood. We used pooled individual data from the Swedish Collaboration on Health Effects of Snus Use to assess the association between Swedish snus use and the risk of pancreatic cancer. A total of 424,152 male participants from nine cohort studies were followed up for risk of pancreatic cancer through linkage to health registers. We used shared frailty models with random [...]

Menée aux Etats-Unis à partir de données portant sur 50 884 participantes âgées entre 35 et 74 ans, cette étude prospective évalue l'association entre le tabagisme, actif et passif, et le risque de cancer du sein, en fonction du moment de l'exposition au tabac (1 843 cas ; durée moyenne de suivi : 6,4 ans)

Breast cancer and exposure to tobacco smoke during potential windows of susceptibility

White, Alexandra J. ; D’Aloisio, Aimee A. ; Nichols, Hazel B. ; DeRoo, Lisa A. ; Sandler, Dale P.

Purpose : An association between smoking and breast cancer is unresolved, although a higher risk from exposure during windows of susceptibility has been proposed. The objective of this prospective study was to evaluate the association between tobacco smoke and breast cancer with a focus on timing of exposure, especially during early life. Methods : Sister study participants (n = 50,884) aged 35–74 were enrolled from 2003 to 2009. Women in the United States and Puerto Rico were eligible if they [...]

A partir des données de la cohorte "the Nurses’ Health Study II" incluant 93 835 participantes âgées entre 27 et 44 ans, cette étude prospective évalue l'association entre une consommation d'alcool et le risque de cancer du sein, en prenant en compte une consommation de folates d'origine alimentaire et des antécédents familiaux de cancer du sein (2 866 cas entre 1991 et 2011)

Alcohol consumption and breast cancer risk by family history of breast cancer and folate intake in younger women

Hyun Ja Kim, ; Seungyoun Jung, ; A. Heather Eliassen, ; Wendy Y. Chen, ; Walter C. Willett, ; Eunyoung Cho

To evaluate the association between alcohol consumption and breast cancer risk in younger women, and by family history of breast cancer and folate intake, we prospectively followed 93,835 U.S. women aged 27-44 years with alcohol consumption data in 1991 in the Nurses’ Health Study II. Alcohol and folate intake was measured by food frequency questionnaire repeated every 4 years. We documented 2,866 incident invasive breast cancer cases between 1991 and 2011. Alcohol consumption was not [...]

A partir des données de la cohorte "The Women's Health Initiative" incluant 74 870 participantes âgées entre 50 et 79 ans, cette étude évalue l'association entre une activité physique, le temps passé en situation assise et le risque de cancer colorectal après la ménopause (durée de suivi : 13 ans ; 1 145 cas)

Association of physical activity and sitting time with incident colorectal cancer in postmenopausal women

Gorczyca, Anna M. ; Eaton, Charles B. ; LaMonte, Michael J. ; Garcia, David O. ; Johnston, Jeanne D. ; He, Ka ; Bidulescu, Aurelian ; Goodman, Deborah ; Groessl, Erik ; Lane, Dorothy ; Stefanick, Marcia L. ; Newcomb, Polly ; Mouton, Charles ; Chomistek, Andrea K.

Findings from epidemiological studies have found that physical activity (PA) is associated with a lower risk of colorectal cancer (CRC). Recent studies have found an increased CRC risk with higher sitting time (ST); however, many studies did not include PA as a potential confounder. The objective of this project was to investigate the independent and combined associations of ST and PA with the risk of incident CRC, specifically colon and rectal cancer. Participants in the Women's Health [...]

A partir des données des cohortes "the Nurses’ Health Study" et "Health Professionals Follow-up Study" incluant 120 813 participants, cette étude prospective évalue l'association entre l'indice de masse corporelle et le risque de cancer colorectal par sous-type et en fonction du statut tumoral

Body mass index and risk of colorectal carcinoma subtypes classified by tumor differentiation status

Hanyuda, Akiko ; Cao, Yin ; Hamada, Tsuyoshi ; Nowak, Jonathan A. ; Qian, Zhi Rong ; Masugi, Yohei ; da Silva, Annacarolina ; Liu, Li ; Kosumi, Keisuke ; Soong, Thing Rinda ; Jhun, Iny ; Wu, Kana ; Zhang, Xuehong ; Song, Mingyang ; Meyerhardt, Jeffrey A. ; Chan, Andrew T. ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Ogino, Shuji ; Nishihara, Reiko

Previous studies suggest that abnormal energy balance status may dysregulate intestinal epithelial homeostasis and promote colorectal carcinogenesis, yet little is known about how host energy balance and obesity influence enterocyte differentiation during carcinogenesis. We hypothesized that the association between high body mass index (BMI) and colorectal carcinoma incidence might differ according to tumor histopathologic differentiation status. Using databases of the Nurses’ Health Study and [...]

A partir des données du registre suédois des cancers portant sur la période 1958-2012, cette étude de cohorte analyse le risque de cancer chez des salariées travaillant dans des laboratoires utilisant des produits chimiques (383 cas)

Cancer incidence in female laboratory employees: extended follow-up of a Swedish cohort study

Gustavsson, Per ; Andersson, Tomas ; Gustavsson, Annika ; Reuterwall, Christina

Objectives : Work in chemical laboratories is associated with exposure to chemicals, of which some are known or suspected carcinogens. A cohort study of laboratory workers in Stockholm followed until 1992 showed an excess of hematolymphatic malignancies in chemical laboratories and an excess of breast cancer among women working for more than 10 years in such laboratories. The follow-up of this cohort has now been extended by 20 years. Methods : The cohort comprised 2245 female laboratory [...]

Couplée à des cohortes belge, française et britannique de salariés travaillant dans l'industrie de l'uranium et du plutonium et portant sur 553 patients décédés d'un cancer du poumon et sur 1 333 témoins, cette étude évalue l'association entre une exposition à des radionucléides émettant des rayonnements alpha, le risque de développer la maladie et la mortalité spécifique

Risk of lung cancer mortality in nuclear workers from internal exposure to alpha particle-emitting radionuclides

Grellier, James ; Atkinson, Will ; Bérard, Philippe ; Bingham, Derek ; Birchall, Alan ; Blanchardon, Eric ; Bull, Richard ; Canu Guseva, Irina ; Challeton-de Vathaire, Cécile ; Cockerill, Rupert ; Do, Minh T ; Engels, Hilde ; Figuerola, Jordi ; Foster, Adrian ; Holmstock, Luc ; Hurtgen, Christian ; Laurier, Dominique ; Puncher, Matthew ; Riddell, Anthony E ; Samson, Eric ; Thierry-Chef, Isabelle ; Tirmarche, Margot ; Vrijheid, Martine ; Cardis, Elisabeth

Background: Carcinogenic risks of internal exposures to alpha-emitters (except radon) are poorly understood. Since exposure to alpha particles-particularly through inhalation-occurs in a range of settings, understanding consequent risks is a public health priority. We aimed to quantify dose-response relationships between lung dose from alpha-emitters and lung cancer in nuclear workers. Methods: We conducted a case-control study, nested within Belgian, French, and UK cohorts of uranium and [...]

Menée au Danemark à partir de données portant sur 51 283 participants sur la période 1987-2012, cette étude de cohorte évalue l'association entre une exposition à du bruit lié au trafic routier près du lieu de résidence (induisant stress et troubles du sommeil) et le risque de cancer colorectal (1 134 cas)

Modeled traffic noise at the residence and colorectal cancer incidence: a cohort study

Roswall, Nina ; Raaschou-Nielsen, Ole ; Ketzel, Matthias ; Overvad, Kim ; Halkjær, Jytte ; Sørensen, Mette

Purpose : Traffic noise has become an increasing public health concern, associated with pervasive negative health effects, most likely through pathways of sleep disruption and stress. Both sleep disruption and stress have been associated with colorectal cancer. The purpose of this study was to investigate the association between residential traffic noise and colorectal cancer incidence. Methods : Traffic noise was calculated for all residential addresses from 1987 to 2012 for 51,283 Danes in [...]

Menée en Finlande à partir de données portant sur 29 096 hommes fumeurs, cette étude prospective évalue l'association entre une maladie parodontale, la perte de dents et le risque de cancer du foie (durée moyenne de suivi : 17 ans ; 213 cas)

Tooth loss and liver cancer incidence in a Finnish cohort

Yang, Baiyu ; Petrick, Jessica L. ; Abnet, Christian C. ; Graubard, Barry I. ; Murphy, Gwen ; Weinstein, Stephanie J. ; Mannisto, Satu ; Albanes, Demetrius ; McGlynn, Katherine A.

Purpose : Periodontal disease, a major cause of tooth loss in adults, may have systemic effects and has been associated with higher risk of several cancer types. However, the associations of periodontal disease or tooth loss with liver cancer have only been examined prospectively in two studies, neither of which had sufficient statistical power. In addition, no studies assessed the potential confounding by viral hepatitis or Helicobacter pylori infection status. Methods : In this study, we [...]

Menée au Danemark à partir de données portant sur 29 098 patients atteints d'une capsulite rétractile sur la période 1995-2013, cette étude évalue l'association entre cette affection et le risque de cancer (2 572 cas de cancer)

Frozen shoulder and risk of cancer: a population-based cohort study

Pedersen, Alma B. ; Horváth-Puhó, Erzsébet ; Ehrenstein, Vera ; Rorth, Mikael ; Sorensen, Henrik T.

Background: Frozen shoulder might be a complication or a presenting symptom of cancer. We examined the risk of a cancer diagnosis after an incident diagnosis of frozen shoulder. Methods: We used prospectively collected data from Danish registries to identify patients with frozen shoulder during 1995–2013 and followed them for the development of cancer. Results: We observed 2572 incident cancers among 29 098 frozen shoulder patients. The expected number of incident cancers in the general [...]

A partir de données portant sur 868 patients atteints d'un cancer du pancréas puis répliquée sur 820 autres patients, cette étude d'association sur le génome entier identifie des polymorphismes à simple nucléotide de gènes associés au risque de developper la maladie

Genetic polymorphisms associated with pancreatic cancer survival: a genome-wide association study

Tang, Hongwei ; Wei, Peng ; Chang, Ping ; Li, Yanan ; Yan, Dong ; Liu, Chang ; Hassan, Manal ; Li, Donghui

Previous findings on the association of genetic factors and pancreatic cancer survival are limited and inconsistent. In a two-stage study, we analyzed the existing genome-wide association study dataset of 868 pancreatic cancer patients from MD Anderson Cancer Center in relation to overall survival using Cox regression. Top hits were selected for replication in another 820 patients from the same institution using the Taqman genotyping method. Functional annotation, pathway analysis and gene [...]

Couplée à une cohorte incluant 50 884 participantes et portant sur 457 patientes atteintes d'un cancer du sein et sur 910 témoins, cette étude évalue l'association entre un stress oxydant, mesuré par les concentrations dans les urines des F2-isoprostanes et de leurs métabolites, et le risque de développer la maladie avant la ménopause

Oxidative stress and breast cancer risk in premenopausal women

Nichols, Hazel B. ; Anderson, Chelsea ; White, Alexandra J. ; Milne, Ginger L. ; Sandler, Dale P.

Background. Detrimental effects of oxidative stress are widely recognized, but induction of apoptosis and senescence may also have benefits for cancer prevention. Recent studies suggest oxidative stress may be associated with lower breast cancer risk before menopause. Methods. We conducted a nested case-control study (N=457 cases, 910 controls) within the NIEHS Sister Study cohort of 50,884 women. Premenopausal women ages 35-54 were eligible for selection. We matched controls 2:1 to cases on [...]