A partir d'une revue systématique de la littérature (18 études de cohorte incluant plus de 2 millions de participants et 2 905 cas ; 8 études cas-témoins incluant au total 1 825 cas et 4 652 témoins), cette méta-analyse évalue l'association entre la quantité de café (décaféiné et non décaféiné) consommée quotidiennement et le risque de carcinome hépatocellulaire

Coffee, including caffeinated and decaffeinated coffee, and the risk of hepatocellular carcinoma : a systematic review and dose–response meta-analysis

Kennedy, Oliver John ; Roderick, Paul ; Buchanan, Ryan ; Fallowfield, Jonathan Andrew ; Hayes, Peter Clive ; Parkes, Julie

Objectives : To examine the association between coffee, including caffeinated and decaffeinated coffee, with hepatocellular carcinoma (HCC) and assess the influence of HCC aetiology and pre-existing liver disease. Design : We performed a systematic review and meta-analysis. We calculated relative risks (RRs) of HCC according to caffeinated and decaffeinated coffee consumption using a random-effects dose–response meta-analysis. We tested for modification of the effect estimate by HCC aetiology [...]

A partir d'une revue systématique de la littérature publiée entre 1996 et 2015 (22 études), cette méta-analyse évalue l'association entre la quantité de flavonoïdes et de lignanes consommée quotidiennement et la mortalité toutes causes confondues ainsi que le risque de décès par maladie cardiovasculaire

Dietary Flavonoid and Lignan Intake and Mortality in Prospective Cohort Studies : Systematic Review and Dose-Response Meta-Analysis

Grosso, G. ; Micek, A. ; Godos, J. ; Pajak, A. ; Sciacca, S. ; Galvano, F. ; Giovannucci, E. L.

Recent evidence has suggested that flavonoid and lignan intake may be associated with decreased risk of chronic and degenerative diseases. The aim of this meta-analysis was to assess the association between dietary flavonoid and lignan intake and all-cause and cardiovascular disease (CVD) mortality in prospective cohort studies. A systematic search was conducted in electronic databases to identify studies published from January 1996 to December 2015 that satisfied inclusion/exclusion criteria. [...]

Menée au Japon à partir de questionnaires auprès de 2 696 patients atteints d'un cancer colorectal et auprès de 13 480 témoins, cette étude évalue l'association entre la quantité de café consommée quotidiennement et le risque de cancer colorectal par sous-localisation anatomique

Coffee consumption and the risk of colorectal cancer by anatomical subsite in Japan : Results from the HERPACC studies

Senda Nakagawa, Hiroko ; Ito, Hidemi ; Hosono, Satoyo ; Oze, Isao ; Tanaka, Hideo ; Matsuo, Keitaro

Consumption of coffee, a popular beverage worldwide, has been associated with lower colorectal cancer (CRC) risk. Although CRC exhibits different biological characteristics by anatomical subsite, the possibly heterogeneous impact of coffee on CRC by anatomical subsite has remained unclear. Here, we conducted two case-control studies to examine the association between coffee consumption and CRC risk as well as risk by anatomic subsite among Japanese using data from the Hospital-based [...]

Menée aux Etats-Unis auprès de 2 532 patients atteints d'un myélome multiple diagnostiqué entre 1998 et 2008 et auprès de 12 660 témoins (âge : supérieur ou égal à 40 ans), cette étude évalue l'association entre l'utilisation de statines avant diagnostic et le risque de développer la maladie

Statin use and risk of multiple myeloma : An analysis from the cancer research network

Epstein, Mara M. ; Divine, George ; Chao, Chun R. ; Wells, Karen E. ; Feigelson, Heather Spencer ; Scholes, Delia ; Roblin, Douglas ; Ulcickas Yood, Marianne ; Engel, Lawrence S. ; Taylor, Andrew ; Fortuny, Joan ; Habel, Laurel A. ; Johnson, Christine C.

Animal and human data suggest statins may be protective against developing multiple myeloma; however, findings may be biased by the interrelationship with lipid levels. We investigated the association between statin use and risk of multiple myeloma in a large US population, with an emphasis on accounting for this potential bias. We conducted a case-control study nested within 6 US integrated healthcare systems participating in the National Cancer Institute-funded Cancer Research Network. Adults [...]

Menée à partir de données portant sur 6 655 patients présentant un risque de cancer de la prostate et ayant subi une biopsie dont les résultats se sont avérés négatifs, cette étude analyse la relation entre les niveaux sériques de différents lipides (cholestérol, LDL, HDL et triglycérides), l'utilisation de statines et la présence d'une inflammation aiguë ou chronique de la prostate

Statin Use, Serum Lipids, and Prostate Inflammation in Men with a Negative Prostate Biopsy : Results from the REDUCE Trial

Allott, Emma H. ; Howard, Lauren E. ; Vidal, Adriana C. ; Moreira, Daniel M. ; Castro-Santamaria, Ramiro ; Andriole, Gerald L. ; Freedland, Stephen J.

Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, particularly among men at increased prostate cancer risk but with a negative prostate biopsy. We examined associations between serum lipid levels, statin use, and histologic prostate inflammation using data from 6,655 men with a negative baseline prostate [...]