A partir des données de deux études cas-témoins menées en France respectivement entre 2003 et 2004 puis entre 2010 et 2011, cette étude évalue l'association entre un tabagisme parental une année avant et pendant la grossesse, une consommation d'alcool, de thé et de café pendant la grossesse et le risque de tumeur cérébrale chez l'enfant (510 cas)

Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE, France)

Bailey, Helen D. ; Lacour, Brigitte ; Guerrini-Rousseau, Léa ; Bertozzi, Anne-Isabelle ; Leblond, Pierre ; Faure-Conter, Cecile ; Pellier, Isabelle ; Freycon, Claire ; Doz, Francois ; Puget, Stéphanie ; Ducassou, Stéphane ; Orsi, Laurent ; Clavel, Jacqueline

Purpose : To investigate whether parental smoking around the time of pregnancy or maternal consumption of beverages (alcohol, coffee, or tea) during pregnancy were associated with the risk of CBT. Methods : We pooled data from two French national population-based case–control studies with similar designs conducted in 2003–2004 and 2010–2011. The mothers of 510 CBT cases (directly recruited from the national childhood cancer register) and 3,102 controls aged under 15 years, frequency matched by [...]

Menée aux Etats-Unis à partir de données portant sur 50 884 femmes âgées entre 35 et 74 ans, cette étude évalue l'effet d'une pratique épisodique d'alcoolisation excessive sur l'association entre une consommation d'alcool mesurée tout au long de la vie et le risque de développer un cancer du sein (durée moyenne de suivi : 6,4 ans ; 1 843 cas)

Binge drinking modifies the association between lifetime alcohol intake and breast cancer risk in moderate drinkers

Alexandra J. White, ; Lisa A. DeRoo, ; Clarice R. Weinberg, ; Dale P. Sandler

The prevalence of binge drinking is rising in the United States. While alcohol is a breast cancer risk factor, less is known about the impact of episodic heavy drinking. Breast cancer-free women, ages 35–74, were enrolled in the Sister Study from 2003–2009 (n = 50,884). United States or Puerto Rico residents who had a sister with breast cancer were eligible. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for breast cancer. 1,843 [...]

Menée en Italie à partir de données portant sur 536 patients atteints d'un lymphome non hodgkinien et sur 984 témoins entre 1999 et 2014, cette étude évalue l'association entre un indicateur caractérisant une alimentation pro-inflammatoire et le risque de développer la maladie

Dietary inflammatory index and non-Hodgkin lymphoma risk in an Italian case–control study

Shivappa, Nitin ; Hebert, James R. ; Taborelli, Martina ; Montella, Maurizio ; Libra, Massimo ; Zucchetto, Antonella ; Crispo, Anna ; Grimaldi, Maria ; La Vecchia, Carlo ; Serraino, Diego ; Polesel, Jerry

Background : While dietary factors have been shown to play an important etiologic role in non-Hodgkin lymphoma (NHL), little is known about the association between inflammatory properties of diet and NHL risk. Methods : We explored the association between the dietary inflammatory index (DII) and NHL risk in a multicenter Italian case–control study conducted between 1999 and 2014. Cases were 536 subjects with incident, histologically confirmed NHL from three areas in Italy. Controls were 984 [...]

A partir des données de la cohorte " Women's Health Initiative" incluant 87 042 participantes, cette étude évalue l'association entre des modifications d'alimentation, mesurées à partir d'un indicateur caractérisant une alimentation pro-inflammatoire, et le risque de développer un cancer colorectal après la ménopause (durée médiane de suivi : 16,2 ans ; 1 038 cas)

Changes in the inflammatory potential of diet over time and risk of colorectal cancer in postmenopausal women

Fred K. Tabung, ; Susan E. Steck, ; Yunsheng Ma, ; Angela D. Liese, ; Jiajia Zhang, ; Dorothy S. Lane, ; Gloria Y. F. Ho, ; Lifang Hou, ; Linda Snetselaar, ; Judith K. Ockene

We examined the associations between changes in dietary inflammatory potential and risk of colorectal cancer (CRC) in 87,042 postmenopausal women recruited from 1993–1998 into the Women's Health Initiative. Food frequency questionnaire data were used to compute patterns of change in dietary inflammatory index (DII) scores and cumulative average DII scores over 3 years. Cox regression models were used to estimate hazard ratios for CRC risk. After a median 16.2 years follow-up, 1,038 CRC cases [...]

Menée en Italie à partir de données portant sur 946 patients atteints d'un cancer du pharynx ou de la cavité buccale et sur 2 492 témoins, cette étude évalue l'association entre un indicateur caractérisant une alimentation pro-inflammatoire et le risque de développer la maladie

Inflammatory potential of diet and risk of oral and pharyngeal cancer in a large case-control study from Italy

Shivappa, Nitin ; Hebert, James R. ; Rosato, Valentina ; Garavello, Werner ; Serraino, Diego ; La Vecchia, Carlo

Diet and inflammation have been suggested to be important risk factors for oral and pharyngeal cancer. We examined the association between dietary inflammatory index (DII™) and oral and pharyngeal cancer in a large case-control study conducted between 1992 and 2009 in Italy. This study included 946 cases with incident, histologically confirmed oral and pharyngeal cancer, and 2,492 controls hospitalized for acute non-neoplastic diseases. The DII was computed based on dietary intake assessed by a [...]

Menée aux Etats-Unis à partir de données portant sur 9 951 hommes, cette étude évalue l'association entre une exposition professionnelle, sur la période 1942-1972, à du chlorure de vinyle ou du polychlorure de vinyle et le risque de décès par angiosarcome du foie ou par carcinome hépatocellulaire

Quantitative estimated exposure to vinyl chloride and risk of angiosarcoma of the liver and hepatocellular cancer in the US industry-wide vinyl chloride cohort: mortality update through 2013

Mundt, Kenneth A ; Dell, Linda D ; Crawford, Lori ; Gallagher, Alexa E

Objective : To evaluate mortality risks of angiosarcoma of the liver (ASL), primary hepatocellular carcinoma (HCC) and other cancers among 9951 men employed between 1942 and 1972 at 35 US vinyl chloride (VC) or polyvinyl chloride plants followed for mortality through 31 December 2013. Methods : SMR and time-dependent Cox proportional hazards analyses were used to evaluate mortality risks by cumulative VC exposure. Results : Liver cancer mortality was elevated (SMR=2.87, 95% CI 2.40 to 3.40), [...]

Menée en France à partir de données portant sur 1 196 patients atteints d'un mésothéliome pleural et sur 2 369 témoins, cette étude évalue l'association entre une exposition professionnelle à l'amiante et le risque de développer la maladie, en fonction de l'évolution des doses reçues

Dose-time-response association between occupational asbestos exposure and pleural mesothelioma

Lacourt, Aude ; Lévêque, Emilie ; Guichard, Elie ; Gilg Soit Ilg, Anabelle ; Sylvestre, Marie-Pierre ; Leffondre, Karen

Objectives : Early occupational exposure to asbestos has been shown to be associated with an increased risk of pleural mesothelioma (PM), which suggests that the timing of exposure might play a role in the dose–response relationship. However, none studies has evaluated the relative impact of increasing the annual intensity of occupational exposure to asbestos at each time of the whole exposure history. Yet such evaluation would allow the comparison of the risks of PM associated with different [...]

Menée en France à partir de données portant sur 2 926 patients atteints d'un cancer du poumon et sur 3 555 témoins, cette étude évalue l'association entre une exposition professionnelle à des endotoxines et le risque de cancer du poumon

Occupational exposure to endotoxins and lung cancer risk: results of the ICARE Study

Ben Khedher, Soumaya ; Neri, Monica ; Guida, Florence ; Matrat, Mireille ; Cenée, Sylvie ; Sanchez, Marie ; Menvielle, Gwenn ; Molinié, Florence ; Luce, Danièle ; Stücker, Isabelle

Objectives : To investigate the role of occupational exposure to endotoxins in lung cancer in a French population-based case–control study (ICARE (Investigation of occupational and environmental causes of respiratory cancers)). Methods : Detailed information was collected on the occupational history and smoking habits from 2926 patients with histologically confirmed lung cancer and 3555 matched controls. We evaluated each subject’s endotoxin exposure after cross referencing International [...]

A partir de données internationales portant sur 4 386 patientes atteintes d'un cancer du poumon et sur 4 177 témoins, cette étude évalue l'association entre des facteurs menstruels et reproductifs et le risque de développer la maladie

Menstrual and reproductive factors and lung cancer risk: A pooled analysis from the international lung cancer consortium

Ben Khedher, Soumaya ; Neri, Monica ; Papadopoulos, Alexandra ; Christiani, David C. ; Diao, Nancy ; Harris, Curtis C. ; Olivo-Marston, Susan ; Schwartz, Ann G. ; Cote, Michele ; Koushik, Anita ; Siemiatycki, Jack ; Landi, Maria Teresa ; Hung, Rayjean J. ; McLaughlin, John ; Duell, Eric J. ; Andrew, Angeline S. ; Orlow, Irene ; Park, Bernard J. ; Brenner, Hermann ; Saum, Kai-Uwe ; Pesatori, Angela C. ; Stücker, Isabelle

Many clinical features of lung cancer are different in women and men. Sex steroid hormones exert effects in nonreproductive organs, such as the lungs. The association between menstrual and childbearing factors and the risk of lung cancer among women is still debated. We performed a pooled analysis of eight studies contributing to the International Lung Cancer Consortium (4,386 cases and 4,177 controls). Pooled associations between menstrual or reproductive factors and lung cancer were estimated [...]