A partir d'une revue systématique de la littérature (13 études), cette étude analyse l'efficacité d'outils permettant aux enfants atteints de cancer et âgés de moins de 8 ans de déclarer leurs symptômes

Self-report of symptoms in children with cancer younger than 8 years of age: a systematic review

Tomlinson, D. ; Tigelaar, L. ; Hyslop, S. ; Lazor, T. ; Dupuis, L. L. ; Griener, K. ; Oliveria, J. ; Sung, L.

Objective : The study’s objective was to summarize the psychometric evaluation of self-report symptom instruments used in children with cancer younger than 8 years of age. Methods : We conducted electronic searches of Ovid Medline, EMBASE, PsycInfo, Science Citation, Social Science Citation (Web of Science), and CINAHL. We included studies of children with cancer in which their self-report symptoms had been quantified and in which results were described for those younger than 8 years of age. [...]

Mené sur 263 patients atteints de cancer et souffrant d'une perte de poids ou d'une anorexie, cet essai randomisé évalue l'efficacité, du point de vue d'une prise de poids égale ou supérieure à 10 % pendant le premier mois de traitement, et la toxicité de la créatine, un dérivé d'acide aminé naturel

Double-Blind, Placebo-Controlled Randomized Trial of Creatine for the Cancer Anorexia/Weight Loss Syndrome (N02C4): an Alliance Trial

A. Jatoi, ; P.D. Steen, ; P.J. Atherton, ; D.F. Moore, Jr., ; K.M. Rowland, Jr., ; N.A. Le-Lindqwister, ; C.S. Adonizio, ; A.J. Jaslowski, ; J. Sloan, ; C. Loprinzi

BACKGROUND: Multiple pilot studies, including one in colorectal cancer patients, suggest that creatine, an amino acid derivative, augments muscle, improves strength, and thereby could palliate the cancer anorexia/weight loss syndrome. PATIENTS AND METHODS: In this randomized, double-blind, placebo-controlled trial, incurable patients with this syndrome were assigned creatine (20 gram per day load x 5 days followed by 2 grams per day orally) versus identical placebo. Patients were weighed once a [...]

A partir d'une revue systématique de la littérature (23 articles), cette étude évalue les difficultés rencontrées, lors de leur retour au travail, par de jeunes adultes ayant survécu à un cancer (âge : 15-39 ans)

Young adult cancer survivors and work: a systematic review

Stone, Dawn S. ; Ganz, Patricia A. ; Pavlish, Carol ; Robbins, Wendie A.

Context : Sixty-three percent of cancer survivors continue to work, or return to work after treatment. Among this population, work ability and challenges encountered in the workplace by young adult cancer survivors have not been well established. Purpose : The purposes of the study are to describe what is currently known about work-related issues for young adult cancer survivors diagnosed between ages 15 and 39, to identify gaps in the research literature, and to suggest interventions or [...]

Mené sur 90 patientes ayant survécu à un cancer du sein, cet essai randomisé compare l'efficacité d'une pratique de Tai Chi Chih et d'une psychothérapie comportementale pour traiter les troubles du sommeil

Tai Chi Chih Compared With Cognitive Behavioral Therapy for the Treatment of Insomnia in Survivors of Breast Cancer: A Randomized, Partially Blinded, Noninferiority Trial

Michael R. Irwin ; Richard Olmstead ; Carmen Carrillo ; Nina Sadeghi ; Perry Nicassio ; Patricia A. Ganz ; Julienne E. Bower

Purpose : Cognitive behavioral therapy for insomnia (CBT-I) and Tai Chi Chih (TCC), a movement meditation, improve insomnia symptoms. Here, we evaluated whether TCC is noninferior to CBT-I for the treatment of insomnia in survivors of breast cancer. Patients and Methods : This was a randomized, partially blinded, noninferiority trial that involved survivors of breast cancer with insomnia who were recruited from the Los Angeles community from April 2008 to July 2012. After a 2-month phase-in [...]

Cette étude passe en revue les facteurs associés au risque d'insuffisance rénale aiguë chez les patients atteints de cancer, notamment en lien avec le type et le stade de la maladie, la présence de comorbidités et le type de traitements reçus

Acute Kidney Injury in Patients with Cancer

Rosner, Mitchell H. ; Perazella, Mark A.

The incidence of acute kidney injury, which is common in patients with cancer, depends on the type and stage of cancer, the treatment regimen, and coexisting conditions. This review provides an overview of acute kidney injury in patients with cancer.

Menée au Canada à partir de données portant sur la période 1992-2010 et sur 6 685 patients atteints d'un lymphome cutané à cellules T, cette étude analyse l'évolution géographique de l'incidence de la maladie et de la mortalité spécifique

Comprehensive analysis of cutaneous T-cell lymphoma (CTCL) incidence and mortality in Canada reveals changing trends and geographic clustering for this malignancy

Ghazawi, Feras M. ; Netchiporouk, Elena ; Rahme, Elham ; Tsang, Matthew ; Moreau, Linda ; Glassman, Steven ; Provost, Nathalie ; Gilbert, Martin ; Jean, Sara-Elizabeth ; Pehr, Kevin ; Sasseville, Denis ; Litvinov, Ivan V.

BACKGROUND: Previous reports of geographic clustering of cutaneous T-cell lymphoma (CTCL) in Texas, Pittsburgh, and Sweden as well as the occurrence of CTCL in married couples and family members raise a possibility of the existence of an external and potentially preventable trigger(s) for this rare skin cancer. METHODS: The authors studied CTCL incidence and mortality in Canada using 3 distinct population-based cancer databases. Data on patients' sex, age at the time of diagnosis, subtype of [...]

A partir des donnés du registre danois des cancers portant sur 4 419 patientes atteintes d'un cancer épithélial de l'ovaire et âgées de 30 à 84 ans, cette étude évalue l'association entre une utilisation de statines après le diagnostic et la mortalité

Statin use and mortality among ovarian cancer patients: A population-based cohort study

Verdoodt, Freija ; Kjær Hansen, Merete ; Kjaer, Susanne K. ; Pottegård, Anton ; Friis, Søren ; Dehlendorff, Christian

Statin use has been suggested to improve prognosis in cancer patients, however, for ovarian cancer, the evidence is sparse. From the Danish Cancer Registry, we identified patients aged 30–84 years with a histologically verified first diagnosis of epithelial ovarian cancer between 2000 and 2013. Data on filled prescriptions, death, and potential confounding factors were obtained from nationwide registers. Cox proportional hazard regression models were used to calculate hazard ratios (HRs) and [...]

Menée en Autriche à partir de données portant sur 624 patients atteints d'un cancer du poumon et de métastases cérébrales (âge médian : 61 ans), cette étude de cohorte rétrospective évalue l'association entre l'indice de masse corporelle et la survie globale

Decreased body mass index is associated with impaired survival in lung cancer patients with brain metastases: A retrospective analysis of 624 patients

Masel, E. K. ; Berghoff, A. S. ; Füreder, L. M. ; Heicappell, P. ; Schlieter, F. ; Widhalm, G. ; Gatterbauer, B. ; Dieckmann, U. ; Birner, P. ; Bartsch, R. ; Schur, S. ; Watzke, H. H. ; Zielinski, C. C. ; Preusser, M.

Body mass index (BMI) is a prognostic factor in several cancer types. We investigated the prognostic role of BMI in a large patient cohort with newly diagnosed lung cancer brain metastases (BM) between 1990 and 2013. BMI at diagnosis of BM and graded prognostic assessment (GPA) were calculated. Definitions were underweight (BMI <18.50), weight within normal range (BMI 18.50–24.99) and overweight (BMI ≥ 25.00). A total of 624 patients (men 401/624 [64.3%]; women 223/624 [35.7%]; median age of 61 [...]

Menée au Royaume-Uni à partir de données portant sur 4 512 patients atteints d'un cancer colorectal, cette étude de cohorte analyse l'association entre la présence de comorbidités et le délai avant le diagnostic de la maladie par le médecin généraliste

Comorbid conditions delay diagnosis of colorectal cancer: a cohort study using electronic primary care records

Mounce, Luke T. A. ; Price, Sarah ; Valderas, Jose M. ; Hamilton, William

Background:Pre-existing non-cancer conditions may complicate and delay colorectal cancer diagnosis. Method:Incident cases (aged greater than or equal to 40 years, 2007–2009) with colorectal cancer were identified in the Clinical Practice Research Datalink, UK. Diagnostic interval was defined as time from first symptomatic presentation of colorectal cancer to diagnosis. Comorbid conditions were classified as ‘competing demands’ (unrelated to colorectal cancer) or ‘alternative explanations’ [...]

Menée aux Etats-Unis auprès de 254 enfants atteints d'un cancer et auprès de 202 enfants ayant eu une grave maladie, cette étude analyse leurs perceptions relatives au diagnostic d'un cancer en tant qu'événement induisant un stress post-traumatique

Cancer as a stressful life event: Perceptions of children with cancer and their peers

Sharp, Katianne M. Howard ; Lindwall, Jennifer J. ; Willard, Victoria W. ; Long, Alanna M. ; Martin-Elbahesh, Karen M. ; Phipps, Sean

BACKGROUND: The medical traumatic stress model is commonly applied to childhood cancer, assuming that the diagnosis of cancer is a traumatic event. However, to the authors' knowledge, little is known regarding what specifically children perceive as stressful about cancer or how it compares with other stressful events more often experienced by children. METHODS: Children with cancer (254 children) and demographically similar peers without a history of serious illness (202 children) identified [...]

Menée au Canada auprès de 430 patients atteints de cancer, cette étude évalue l'association entre un sentiment de démoralisation, des troubles psychiques et des idées suicidaires

The association of demoralization with mental disorders and suicidal ideation in patients with cancer

Vehling, Sigrun ; Kissane, David W. ; Lo, Christopher ; Glaesmer, Heide ; Hartung, Tim J. ; Rodin, Gary ; Mehnert, Anja

BACKGROUND: Demoralization refers to a state in which there is a perceived inability to cope, that is associated with a sense of disheartenment and a loss of hope and meaning. This study investigated the co-occurrence versus independence of demoralization with mental disorders and suicidal ideation to evaluate its features as a concept of distress in the context of severe illness. METHODS: In a cross-sectional sample of 430 mixed cancer patients, we assessed demoralization with the [...]

Menée aux Etats-Unis par enquête auprès de 934 patients ayant survécu à long terme à un cancer de la prostate diagnostiqué entre 1994 et 1995, cette étude analyse les facteurs associés à un sentiment de regret vis-à-vis des décisions thérapeutiques (durée moyenne de suivi : 15 ans)

Treatment Decision Regret Among Long-Term Survivors of Localized Prostate Cancer: Results From the Prostate Cancer Outcomes Study

Richard M. Hoffman ; Mary Lo ; Jack A. Clark ; Peter C. Albertsen ; Michael J. Barry ; Michael Goodman ; David F. Penson ; Janet L. Stanford ; Antoinette M. Stroup ; Ann S. Hamilton

Purpose : To determine the demographic, clinical, decision-making, and quality-of-life factors that are associated with treatment decision regret among long-term survivors of localized prostate cancer. Patients and Methods : We evaluated men who were age ≤ 75 years when diagnosed with localized prostate cancer between October 1994 and October 1995 in one of six SEER tumor registries and who completed a 15-year follow-up survey. The survey obtained demographic, socioeconomic, and clinical data [...]

Menée au niveau mondial dans 152 pays, cette étude analyse les coûts directs et indirects (dépenses de santé et perte de productivité) associés aux maladies attribuables au tabac pour l'année 2012

Global economic cost of smoking-attributable diseases

Goodchild, Mark ; Nargis, Nigar ; Tursan d'Espaignet, Edouard

Background : The detrimental impact of smoking on health has been widely documented since the 1960s. Numerous studies have also quantified the economic cost that smoking imposes on society. However, these studies have mostly been in high income countries, with limited documentation from developing countries. The aim of this paper is to measure the economic cost of smoking-attributable diseases in countries throughout the world, including in low- and middle-income settings. Methods : The Cost of [...]

Menée dans un contexte chinois à partir des données d'un essai de phase III, cette étude analyse le rapport coût-efficacité de l'ajout du bévacizumab à un traitement de première ligne combinant pémétrexed et cisplatine pour les patients atteints d'un mésothéliome pleural malin

Cost-effectiveness analysis of additional bevacizumab to pemetrexed plus cisplatin for malignant pleural mesothelioma based on the MAPS trial

Zhan, Mei ; Zheng, Hanrui ; Xu, Ting ; Yang, Yu ; Li, Qiu

Purpose : Malignant pleural mesothelioma (MPM) is a rare malignancy, and pemetrexed/cisplatin (PC) is the gold standard first-line regime. This study evaluated the cost-effectiveness of the addition of bevacizumab to PC (with maintenance bevacizumab) for unresectable MPM based on a phase III trial that showed a survival benefit compared with chemotherapy alone. Methods : To estimate the incremental cost-effectiveness ratio (ICER) of the incorporation of bevacizumab, a Markov model based on the [...]

A partir de données d'une enquête française menée en 2010 auprès de 3 359 participants âgés de 15 à 75 ans, cette étude analyse leurs perceptions relatives aux risques liés à une consommation d'alcool, notamment sur le risque de cancer

Alcohol and cancer: risk perception and risk denial beliefs among the French general population

Aurélie Bocquier, ; Lisa Fressard, ; Pierre Verger, ; Stéphane Legleye, ; Patrick Peretti-Watel

Background: Worldwide, millions of deaths each year are attributed to alcohol. We sought to examine French people’s beliefs about the risks of alcohol, their correlates, and their associations with alcohol use. Methods: Data came from the 2010 Baromètre Cancer survey, a random cross-sectional telephone survey of the French general population (n = 3359 individuals aged 15–75 years). Using principal component analysis of seven beliefs about alcohol risks, we built two scores (one assessing risk [...]

Menée au Canada auprès de 180 patients atteints d'un cancer de stade avancé (âge moyen : 62 ans), cette étude analyse l'efficacité d'un programme pluridisciplinaire mis en place dans des unités de soins palliatifs pour améliorer leurs symptômes auto-déclarés de détresse psychologique

Reported distress in patients living with advanced cancer: changes pre-post interdisciplinary palliative rehabilitation

Feldstain, Andrea ; MacDonald, Neil ; Bhargava, Ravi ; Chasen, Martin

Purpose : Patients are living extended life with advanced cancer making it chronic rather than imminently terminal. Literature on the experience of living with advanced cancer is emerging, indicating ongoing polysymptomatic burden, lack of information, burnout (patients and caregivers), and emotional concerns, all of which contribute to emotional distress. The interdisciplinary Ottawa Palliative Rehabilitation Program (PRP) offers a scarce clinical resource for this population. The current [...]