Mené sur 227 patients atteints d'un cancer, cet essai de phase IIb évalue l'efficacité, du point de vue de la fréquence des mouvements intestinaux spontanés, et la toxicité de la naldémédine dispensée pendant 14 jours pour traiter une constipation induite par les opioïdes

Phase IIb, Randomized, Double-Blind, Placebo-Controlled Study of Naldemedine for the Treatment of Opioid-Induced Constipation in Patients With Cancer

Nobuyuki Katakami ; Koji Oda ; Katsunori Tauchi ; Ken Nakata ; Katsunori Shinozaki ; Takaaki Yokota ; Yura Suzuki ; Masaru Narabayashi ; Narikazu Boku

Purpose : This randomized, double-blind, multicenter study aimed to determine the dose of naldemedine, a peripherally-acting μ-opioid receptor antagonist, for future trials by comparing the efficacy and safety of three doses of naldemedine versus placebo in patients with cancer and opioid-induced constipation. Methods : Patients ≥ 18 years old with cancer, an Eastern Cooperative Oncology Group performance status ≤ 2, who had been receiving a stable regimen of opioid analgesics for ≥ 2 weeks, [...]

Menée aux Pays-Bas par questionnaire auprès de 123 patients atteints de cancer, cette étude analyse la faisabilité et l'efficacité d'une intervention pluridisciplinaire à base de conseils professionnels et d'activité physique afin de les aider dans leur retour au travail

Feasibility of a multidisciplinary intervention to help cancer patients return to work

Leensen, M. C. J. ; Groeneveld, I. F. ; Rejda, T. ; Groenenboom, P. ; van Berkel, S. ; Brandon, T. ; de Boer, A. G. E. M. ; Frings-Dresen, M. H. W.

This study evaluates feasibility of a multidisciplinary intervention combining occupational counselling with physical exercise to enhance cancer patients’ return to work, assesses whether care providers and patients were satisfied with the intervention, and describes barriers to and facilitators of execution. Newly diagnosed cancer patients, treated with chemotherapy and on sick leave from (self-)employment participated. Patients received counselling from an oncological occupational physician [...]

Cette étude met à jour les recommandations pour la prise en charge d'une fièvre et d'une neutropénie chez des patients pédiatriques atteints de cancer et chez des patients recevant une greffe de cellules souches hématopoïétiques

Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update

Thomas Lehrnbecher ; Paula Robinson ; Brian Fisher ; Sarah Alexander ; Roland A. Ammann ; Melissa Beauchemin ; Fabianne Carlesse ; Andreas H. Groll ; Gabrielle M. Haeusler ; Maria Santolaya ; William J. Steinbach ; Elio Castagnola ; Bonnie L. Davis ; L. Lee Dupuis ; Aditya H. Gaur ; Wim J.E. Tissing ; Theo Zaoutis ; Robert Phillips ; Lillian Sung

Purpose : To update a clinical practice guideline (CPG) for the empirical management of fever and neutropenia (FN) in children with cancer and hematopoietic stem-cell transplantation recipients. Methods : The International Pediatric Fever and Neutropenia Guideline Panel is a multidisciplinary and multinational group of experts in pediatric oncology and infectious diseases that includes a patient advocate. For questions of risk stratification and evaluation, we updated systematic reviews of [...]

Menée aux Etats-Unis à partir de données portant sur 70 patients ayant survécu à une leucémie lymphoblastique aiguë pendant l'enfance, cette étude analyse l'association entre des déficiences neurocognitives liées à une chimiothérapie, des symptômes de fatigue, des troubles du sommeil, une inflammation systémique et un stress oxydant (âge moyen : 14,3 ans)

Impact of sleep, fatigue, and systemic inflammation on neurocognitive and behavioral outcomes in long-term survivors of childhood acute lymphoblastic leukemia

Cheung, Yin Ting ; Brinkman, Tara M. ; Mulrooney, Daniel A. ; Mzayek, Yasmin ; Liu, Wei ; Banerjee, Pia ; Panoskaltsis-Mortari, Angela ; Srivastava, Deokumar ; Pui, Ching-Hon ; Robison, Leslie L. ; Hudson, Melissa M. ; Krull, Kevin R.

BACKGROUND: Long-term survivors of childhood acute lymphoblastic leukemia (ALL) are at risk for neurocognitive impairment, which may be associated with fatigue, sleep problems, systemic inflammation, and oxidative stress. We examined these associations among survivors of childhood ALL treated with chemotherapy only. METHODS: Survivors of childhood ALL (male, n = 35 and female, n = 35; mean age, 14.3 years [standard deviation, 4.7 years] and mean years from diagnosis, 7.4 years [standard [...]

A partir d'une revue systématique de la littérature publiée entre 1994 et 2017 (20 études, 2 288 participantes), cette étude analyse les attentes et la satisfaction de patientes concernant une reconstruction mammaire après une mastectomie pour traiter un cancer du sein

Women’s expectations of breast reconstruction following mastectomy for breast cancer: a systematic review

Flitcroft, Kathy ; Brennan, Meagan ; Spillane, Andrew

Purpose : Breast reconstruction (BR) makes an important positive contribution to the quality of life of many women who have undergone mastectomy for breast cancer. The purpose of this article is to evaluate the evidence for possible relationships between women’s expectations of BR and their satisfaction with outcomes to inform and facilitate improved communication about BR options prior to initial surgery. Methods : A systematic review of the literature reporting expectations of BR published [...]

Menée au Royaume-Uni à partir de données portant sur 192 081 patients adultes atteints d'un zona et sur 732 035 témoins, cette étude évalue l'association entre 21 types de cancer et le risque de développer ultérieurement un zona

Herpes zoster risk after 21 specific cancers: population-based case-control study

Hansson, Erik ; Forbes, Harriet J. ; Langan, Sinead M. ; Smeeth, Liam ; Bhaskaran, Krishnan

Background:Some malignancies are known to be associated with increased risk of herpes zoster, but little is known about how associations between cancer and subsequent zoster risk vary by cancer site, by time since cancer diagnosis, and by age. Methods:An age-, sex-, calendar time-, and practice-matched case–control study, nested in the broadly UK representative Clinical Practice Research Datalink (CPRD) primary care database, was analysed using conditional logistic regression to estimate the [...]

Menée aux Etats-Unis à partir de données portant sur 179 patients atteints d'un cancer colorectal récemment diagnostiqué, cette étude évalue l'association entre l'indice de masse corporelle, des difficultés financières ou cognitives et le délai avant une consultation médicale permettant d'établir un diagnostic de cancer colorectal

The contribution of body mass index to appraisal delay in colorectal cancer diagnosis: a structural equation modelling study

Dyer, Karen E. ; Dumenci, Levent ; Siminoff, Laura A. ; Thomson, Maria D. ; Lafata, Jennifer Elston

Background: Appraisal delay (AD) refers to the time interval between onset of symptoms and the date a patient first seeks healthcare. Because studies have shown that individuals who are overweight or obese may delay or avoid seeking healthcare due to stigma, this study aims to investigate the role that weight plays in AD among symptomatic individuals subsequently diagnosed with colorectal cancer (CRC). Methods: Structural equation modelling tested the relationship between AD, body mass index [...]

Menée aux Etats-Unis à partir de données portant sur 14 886 patients âgés de plus de 70 ans et atteints d'un glioblastome diagnostiqué entre 2004 et 2012, cette étude analyse les facteurs associés au choix d'une thérapie adjuvante

Patterns of care and predictors of adjuvant therapies in elderly patients with glioblastoma: An analysis of the National Cancer Database

Amsbaugh, Mark J. ; Yusuf, Mehran B. ; Gaskins, Jeremy ; Burton, Eric C. ; Woo, Shiao Y.

BACKGROUND: The objectives of this study were to characterize patterns of care and to identify predictors for adjuvant therapy in elderly patients with glioblastoma in the modern era. METHODS. The National Cancer Database was queried for patients aged 70 years and older with glioblastoma diagnosed from January 1, 2004 through December 31, 2012. Multinomial logistic regression was used to identify predictors for receiving adjuvant therapy. Survival outcomes were estimated using the Kaplan-Meier [...]

Menée au Canada auprès de 188 patients ayant survécu à un cancer du testicule, cette étude rétrospective évalue l'association entre des variants du gène SLC16A5 et la survenue d'effets ototoxiques induits par une chimiothérapie à base de cisplatine

Association Between SLC16A5 Genetic Variation and Cisplatin-Induced Ototoxic Effects in Adult Patients With Testicular Cancer

Drögemöller, B. I. ; Monzon, J. G. ; Bhavsar, A. P. ; et al.,

Importance : Cisplatin-induced ototoxic effects are an important complication that affects testicular cancer survivors as a consequence of treatment. The identification of genetic variants associated with this adverse drug reaction will further our mechanistic understanding of its development and potentially lead to strategies to prevent ototoxic effects. Objective : To identify the genetic variants associated with cisplatin-induced ototoxic effects in adult testicular cancer patients. Design, [...]

Mené aux Pays-Bas sur 88 patients ayant survécu à un cancer du sein, de la prostate ou du côlon-rectum, cet essai randomisé évalue l'efficacité d'une thérapie cognitive et comportementale pour diminuer la sévérité de leur peur de la récidive

Efficacy of Blended Cognitive Behavior Therapy for High Fear of Recurrence in Breast, Prostate, and Colorectal Cancer Survivors: The SWORD Study, a Randomized Controlled Trial

Marieke van de Wal ; Belinda Thewes ; Marieke Gielissen ; Anne Speckens ; Judith Prins

Purpose : Fear of cancer recurrence (FCR) is a common problem experienced by cancer survivors. Approximately one third of survivors report high FCR. This study aimed to evaluate whether blended cognitive behavior therapy (bCBT) can reduce the severity of FCR in cancer survivors curatively treated for breast, prostate, or colorectal cancer. Patients and Methods : This randomized controlled trial included 88 cancer survivors with high FCR (Cancer Worry Scale score ≥ 14) from 6 months to 5 years [...]

Menée au Royaume-Uni, cette étude évalue l'intérêt d'un programme gouvernemental de financement des anticancéreux innovants ("NHS Cancer Drugs Fund") en analysant le rapport coût-efficacité de 29 médicaments anticancéreux prescrits depuis janvier 2015 pour traiter 47 types de cancers

Do patient access schemes for high-cost cancer drugs deliver value to society?—lessons from the NHS Cancer Drugs Fund

A. Aggarwal; ; T. Fojo; ; C. Chamberlain; ; C. Davis; ; R. Sullivan

Background : The NHS Cancer Drugs Fund (CDF) was established in 2010 to reduce delays and improve access to cancer drugs, including those that had been previously appraised but not approved by NICE (National Institute for Health and Care Excellence). After 1.3 billion GBP expenditure, a UK parliamentary review in 2016 rationalized the CDF back into NICE. Methods : This paper analyses the potential value delivered by the CDF according to six value criteria. This includes validated clinical [...]

Menée aux Etats-Unis à partir de données d'enquête portant sur la période 2008-2013, cette étude analyse les effets, en termes de dépenses de santé et de perte de productivité, des maladies chroniques chez des patients ayant survécu à un cancer

Economic Burden of Chronic Conditions Among Survivors of Cancer in the United States

Gery P. Guy Jr ; K. Robin Yabroff ; Donatus U. Ekwueme ; Sun Hee Rim ; Rui Li ; Lisa C. Richardson

Purpose : The prevalence of cancer survivorship and chronic health conditions is increasing. Limited information exists on the economic burden of chronic conditions among survivors of cancer. This study examines the prevalence and economic effect of chronic conditions among survivors of cancer. Methods : Using the 2008 to 2013 Medical Expenditure Panel Survey, we present nationally representative estimates of the prevalence of chronic conditions (heart disease, high blood pressure, stroke, [...]

A partir des données de la base Medicare et des registres américains des cancers portant sur la période 2007-2012 (42 111 patients atteints de cancer), cette étude de cohorte analyse l'évolution du coût des thérapies ciblées dispensées par voie orale et son effet sur les coûts restant à charge des patients

Rising Prices of Targeted Oral Anticancer Medications and Associated Financial Burden on Medicare Beneficiaries

Ya-Chen Tina Shih ; Ying Xu ; Lei Liu ; Fabrice Smieliauskas

Purpose : The high cost of oncology drugs threatens the affordability of cancer care. Previous research identified drivers of price growth of targeted oral anticancer medications (TOAMs) in private insurance plans and projected the impact of closing the coverage gap in Medicare Part D in 2020. This study examined trends in TOAM prices and patient out-of-pocket (OOP) payments in Medicare Part D and estimated the actual effects on patient OOP payments of partial filling of the coverage gap by [...]

Menée aux Etats-Unis, cette étude analyse le rapport coût-efficacité du palbociclib en complément d'un traitement de référence chez les patientes atteintes d'un cancer du sein de stade avancé hormono-sensible

Cost-Effectiveness of Palbociclib in Hormone Receptor-Positive Advanced Breast Cancer

H. Mamiya; ; R. K. Tahara; ; S. M. Tolaney; ; N. Choudhry; ; M. Najafzadeh

Background: Palbociclib, a novel small-molecule inhibitor of cyclin-dependent kinases 4 and 6 for the treatment of advanced breast cancer, has demonstrated significant efficacy in prolonging progression-free survival when added to existing therapies. Considering the high cost of palbociclib, we assessed cost-effectiveness of adding palbociclib to usual care in treatment of advanced breast cancer. Methods: We developed a discrete event simulation model to simulate time to cancer progression and [...]

A partir des données des registres américains des cancers et de la base Medicare, cette étude analyse l'impact, sur l'utilisation de ces médicaments et sur la survenue d'événements indésirables, des avertissements imposés par la "Food and Drug Administration" sur les boîtes d'agents stimulant l'érythropoïétine utilisés pour traiter une anémie induite par une chimiothérapie

Effects of the US Food and Drug Administration Boxed Warning of Erythropoietin-Stimulating Agents on Utilization and Adverse Outcome

John Bian ; Brian Chen ; Dawn L. Hershman ; Norman Marks ; LeAnn Norris ; Richard Schulz ; Charles Bennett

Purpose : In March 2007, a US Food and Drug Administration boxed warning was issued for erythropoietin-stimulating agents (ESAs) regarding serious adverse events, such as venous thromboembolism (VTE). We evaluated the US Food and Drug Administration’s boxed warning of ESAs used to treat chemotherapy-induced anemia because evidence on the effectiveness of boxed warnings remains inconclusive. Patients and Methods : Using 2004 to 2009 SEER-Medicare data, we exploited a natural experiment to [...]

A partir d'une revue systématique de la littérature, cette étude analyse le recours, par des patients ayant survécu à un cancer, à des médecines parallèles pour améliorer leur bien-être physique et psychique

Integrative medicine in cancer survivors

Viscuse, Paul V. ; Price, Katharine ; Millstine, Denise ; Bhagra, Anjali ; Bauer, Brent ; Ruddy, Kathryn J.

Purpose of review: Due to medical advances and an aging population, the number of cancer survivors continues to rise. Survivors often experience late and long-term sequelae of cancer and its treatment (e.g., fatigue, pain, fear of recurrence, and stress). As a result, some patients have utilized or expressed interest in integrative medicine (IM) modalities for prevention of recurrence, optimizing health, enhancing quality of life, and managing symptoms. The purpose of this review is to focus on [...]