A partir d'une revue systématique de la littérature (32 articles), cette étude évalue l'efficacité de 27 interventions destinées aux patientes ayant survécu à un cancer, obèses ou en surpoids, pour les aider à perdre du poids de façon durable

Toward the optimal strategy for sustained weight loss in overweight cancer survivors: a systematic review of the literature

Hoedjes, Meeke ; van Stralen, Maartje M. ; Joe, Sheena Tjon A. ; Rookus, Matti ; van Leeuwen, Flora ; Michie, Susan ; Seidell, Jacob C. ; Kampman, Ellen

Purpose : To gain more insight into the optimal strategy to achieve weight loss and weight loss maintenance in overweight and obese cancer survivors after completion of initial treatment, this systematic review aimed to provide an overview of the literature on intervention effects on weight, to describe intervention components used in effective interventions, to identify and synthesize behaviour change techniques (BCTs) and to assess the frequency with which these BCTs were used in effective [...]

Menée aux Etats-Unis par questionnaire auprès de 176 patients atteints de cancer et âgés de 15 à 39 ans, cette étude prospective multicentrique analyse l'évolution de leur qualité de vie pendant les deux années suivant le diagnostic

Health-Related Quality of Life in Adolescent and Young Adult Patients With Cancer: A Longitudinal Study

Olga Husson ; Brad J. Zebrack ; Rebecca Block ; Leanne Embry ; Christine Aguilar ; Brandon Hayes-Lattin ; Steve Cole

Purpose : To examine changes in health-related quality of life (HRQoL) and its predictors during the first 2 years after initial cancer diagnosis in adolescent and young adult (AYA) patients with cancer. Patients and Methods : A multicenter, longitudinal, prospective study was conducted among a diverse sample of AYA patients with cancer ages 15 to 39 years. One hundred seventy-six patients (75% response) completed a self-report measure of HRQoL (Short Form-36 [SF-36]) within the first 4 months [...]

Menée en Italie par questionnaire auprès de 289 patients atteints d'une tumeur solide ou hématologique, cette étude transversale analyse les troubles du goût pendant et après la chimiothérapie et évalue l'association entre une dysgueusie et leur qualité de vie

Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: A cross-sectional study

Ponticelli, E. ; Clari, M. ; Frigerio, S. ; De Clemente, A. ; Bergese, I. ; Scavino, E. ; Bernardini, A. ; Sacerdote, C.

The aim of the study was to evaluate taste disorders in patients receiving chemotherapy and to assess the impact of dysgeusia on patients’ health-related quality of life (HRQOL). A total of 289 patients with a diagnosis of malignant solid or haematological cancer undergoing chemotherapy completed a questionnaire assessing dysgeusia and HRQOL. Sixty-four per cent of patients developed dysgeusia after and during chemotherapy. A statistically significant correlation was found between type of [...]

Mené sur 114 patients atteints d'un cancer et présentant des symptômes douloureux, cet essai évalue, du point de vue de la réduction de l'intensité des douleurs 10, 20 et 30 minutes après l'administration du médicament, la non infériorité du fentanyl en comprimés sublinguaux par rapport à la morphine sous-cutanée

Fentanyl Sublingual Tablets Versus Subcutaneous Morphine for the Management of Severe Cancer Pain Episodes in Patients Receiving Opioid Treatment : A Double-Blind, Randomized, Noninferiority Trial

Zecca, Ernesto ; Brunelli, Cinzia ; Centurioni, Fabio ; Manzoni, Andrea ; Pigni, Alessandra ; Caraceni, Augusto

Purpose : Fentanyl sublingual tablets (FST) are a potentially useful alternative to parenteral opioids such as subcutaneous morphine (SCM) to treat severe cancer pain episodes. No direct comparison between FST and SCM is available. The aim of this study was to test noninferiority of FST versus SCM during the first 30 min postadministration. Methods : Patients receiving stable opioid therapy and experiencing a severe pain episode were randomly assigned to either 100 µg FST or 5 mg SCM in a [...]

A partir d'une revue systématique de la littérature (14 études, 2 002 participants), cette méta-analyse évalue l'efficacité de diverses interventions menées par téléphone pour réduire les symptômes d'anxiété et de dépression et améliorer la qualité de vie de patientes atteintes d'un cancer du sein

Effectiveness of telephone-based interventions on health-related quality of life and prognostic outcomes in breast cancer patients and survivors—A meta-analysis

Zhang, Q. ; Zhang, L. ; Yin, R. ; Fu, T. ; Chen, H. ; Shen, B.

The aim of this meta-analysis was to evaluate the effect of telephone-based interventions on prognostic outcomes and health-related quality of life (HRQoL) in breast cancer patients and survivors. A systematic search of the Cochrane Library, Web of science, Medline, EMBASE, CNKI and CBM database was carried out. Randomised, controlled trials (RCTs) examining the effects of telephone-based intervention versus a control group receiving no telephone intervention, on prognostic outcomes and HRQoL [...]

Menée au Japon à partir de données portant sur 53 patients atteints d'un cancer de l'estomac de stade avancé (âge moyen : 64,4 ans), cette étude rétrospective analyse l'effet d'une perte de poids pendant la chimiothérapie sur la survie

Weight Loss During Initial Chemotherapy Predicts Survival in Patients With Advanced Gastric Cancer

Takayoshi, Kotoe ; Uchino, Keita ; Nakano, Masahiro ; Ikejiri, Koji ; Baba, Eishi

Background: Patients with advanced gastric cancer (AGC) often suffer weight loss, which can be used to predict prognosis. Few reports have assessed the correlation between weight loss during chemotherapy and survival in patients with AGC. Methods: Fifty-three patients with histologically proven AGC, who started systemic chemotherapy from September 2010 to March 2014, were retrospectively examined for body weight, inflammatory status, and survival. Correlation analyses were performed between [...]

A partir des données des registres américains des cancers, cette étude présente une estimation du nombre de patients ayant survécu au moins 5 ans à un cancer traité par radiothérapie entre 2000 et 2030

Trends in radiation therapy among cancer survivors in the United States, 2000-2030

Bryant, Alex K ; Banegas, Matthew ; Martinez, Maria E. ; Mell, Loren K. ; Murphy, James D.

Background: Although the number of cancer survivors has increased substantially over the past several decades, the composition of survivors treated with radiotherapy is not well defined. Radiotherapy carries unique long-term toxicity risks for cancer survivors. This study describes the current estimates and future projections of the epidemiology of five-year cancer survivors who receive radiation therapy. Methods: We used cancer incidence and survival data from the Surveillance, Epidemiology, [...]

Menée aux Etats-Unis à partir des données de la troisième édition de l'enquête "National Health and Nutrition Examination Survey" portant sur 14 916 participants, cette étude évalue l'association entre un syndrome métabolique et la mortalité par cancer (687 décès par cancer)

Metabolic syndrome and total cancer mortality in the Third National Health and Nutrition Examination Survey

Gathirua-Mwangi, Wambui G. ; Monahan, Patrick O. ; Murage, Mwangi J. ; Zhang, Jianjun

Purpose : Although metabolic syndrome incidence has substantially increased during the last few decades, it largely remains unclear whether this metabolic disorder is associated with total cancer mortality. The present study was carried out to investigate this important question. Methods : A total of 687 cancer deaths were identified from 14,916 participants in the third National Health and Nutrition Examination Survey by linking them to the National Death Index database through December 31, [...]

Menée aux Etats-Unis à partir de données portant sur 821 patients âgés de moins de 18 ans et décédés d'un cancer entre 2003 et 2012, cette étude de cohorte analyse la proportion de décès liés aux traitements

Evaluation of treatment-related mortality among paediatric cancer deaths: a population based analysis

Pole, Jason D. ; Gibson, Paul ; Ethier, Marie-Chantal ; Lazor, Tanya ; Johnston, Donna L. ; Portwine, Carol ; Silva, Mariana ; Alexander, Sarah ; Sung, Lillian

Background: Objectives were to describe the proportion of deaths due to treatment-related mortality (TRM) and to identify risk factors and probable causes of TRM among paediatric cancer deaths in a population-based cohort. Methods: We included children with cancer less than or equal to18 years diagnosed and treated in Ontario who died between January 2003 and December 2012. Deaths were identified using a provincial registry, the Pediatric Oncology Group of Ontario Networked Information System. [...]

A partir des données du registre danois des lymphomes portant sur 1 621 patients atteints d'un lymphome diffus à grandes cellules B diagnostiqué entre 2003 et 2011, cette étude analyse la survie des patients en rémission complète 2 ans après la fin d'un traitement de première ligne de type R-CHOP ou analogue

Minimal Loss of Lifetime for Patients With Diffuse Large B-Cell Lymphoma in Remission and Event Free 24 Months After Treatment: A Danish Population-Based Study

Lasse Hjort Jakobsen ; Martin Bøgsted ; Peter de Nully Brown ; Bente Arboe ; Judit Jørgensen ; Thomas Stauffer Larsen ; Maja Bech Juul ; Lene Schurmann ; Linda Højberg ; Olav Jonas Bergmann ; Therese Lassen ; Pär Lars Josefsson ; Paw Jensen ; Hans Erik Johnsen ; Tarec Christoffer El-Galaly

Purpose : The general outlook for patients with diffuse large B-cell lymphoma (DLBCL) in first remission is important information for patients and for planning post-treatment follow-up. The purpose of this study was to evaluate the survival of patients with DLBCL in remission compared with a matched general population. Methods : A total of 1,621 patients from the Danish Lymphoma Registry who were newly diagnosed with DLBCL between 2003 and 2011 were included in this study. All patients were ≥ [...]

A partir des données des registres américains des cancers portant sur 34 473 patients âgés de 66 à 75 ans atteints d'un cancer de la prostate et sur une cohorte de témoins, cette étude compare l'efficacité, en termes de bénéfices sur la survie globale, d'une prostatectomie radicale et d'une radiothérapie, puis suggère l'existence d'un biais de sélection affectant les données

Discerning the survival advantage among patients with prostate cancer who undergo radical prostatectomy or radiotherapy: The limitations of cancer registry data

Williams, Stephen B. ; Huo, Jinhai ; Chamie, Karim ; Smaldone, Marc C. ; Kosarek, Christopher D. ; Fang, Justin E. ; Ynalvez, Leslie M. ; Kim, Simon P. ; Hoffman, Karen E. ; Giordano, Sharon H. ; Chapin, Brian F.

BACKGROUND: The objective of this study was to compare the overall survival of patients who undergo radical prostatectomy or radiotherapy versus noncancer controls to discern whether there is a survival advantage according to prostate cancer treatment and the impact of selection bias on these results. METHODS: A matched cohort study was performed using the Surveillance, Epidemiology, and End Results (SEER)-Medicare–linked database. In total, 34,473 patients ages 66 to 75 years were identified [...]

A partir des données des dossiers médicaux de patients atteints d'un syndrome de Li Fraumeni, issus de 58 familles brésiliennes et porteurs d'une mutation constitutionnelle TP53 p.R337H, cette étude analyse la prévalence d'un carcinome de la thyroïde

Frequency of thyroid carcinoma in Brazilian TP53 p.R337H carriers with Li Fraumeni syndrome

Formiga, M. ; de Andrade, K. ; Kowalski, L. ; Achatz, M.

Importance : Li Fraumeni syndrome (LFS) is associated with a wide variety of tumors; nevertheless, thyroid carcinoma has not been evaluated in this syndrome. Due to the Brazilian founder mutation p.R337H, some tumors that have not been described in the classic LFS have been observed in a higher-than-expected prevalence in Brazil. Objective : To determine the frequency of thyroid carcinoma in Brazilian carriers of a founder TP53 p.R337H mutation. Design, Setting, and Participants : We reviewed [...]

Menée aux Etats-Unis auprès de 1 116 patients atteints de dépression et de 6 317 témoins tous atteints de cancer et devant recevoir une greffe de cellules souches hématopoïétiques, cette étude évalue l'effet d'un état dépressif antérieur à la greffe sur la survie globale et sur le risque de complications, notamment sur le risque de réaction du greffon contre l'hôte

Impact of pre-transplant depression on outcomes of allogeneic and autologous hematopoietic stem cell transplantation

El-Jawahri, Areej ; Chen, Yi-Bin ; Brazauskas, Ruta ; He, Naya ; Lee, Stephanie J. ; Knight, Jennifer M. ; Majhail, Navneet ; Buchbinder, David ; Schears, Raquel M. ; Wirk, Baldeep M. ; Wood, William A. ; Ahmed, Ibrahim ; Aljurf, Mahmoud ; Szer, Jeff ; Beattie, Sara M. ; Battiwalla, Minoo ; Dandoy, Christopher ; Diaz, Miguel-Angel ; D'Souza, Anita ; Freytes, Cesar O. ; Gajewski, James ; Gergis, Usama ; Hashmi, Shahrukh K. ; Jakubowski, Ann ; Kamble, Rammurti T. ; Kindwall-Keller, Tamila ; Lazarus, Hilard M. ; Malone, Adriana K. ; Marks, David I. ; Meehan, Kenneth ; Savani, Bipin N. ; Olsson, Richard F. ; Rizzieri, David ; Steinberg, Amir ; Speckhart, Dawn ; Szwajcer, David ; Schoemans, Helene ; Seo, Sachiko ; Ustun, Celalettin ; Atsuta, Yoshiko ; Dalal, Jignesh ; Sales-Bonfim, Carmem ; Khera, Nandita ; Hahn, Theresa ; Saber, Wael

BACKGROUND: To evaluate the impact of depression before autologous and allogeneic hematopoietic cell transplantation (HCT) on clinical outcomes posttransplantation. METHODS: We analyzed data from the Center for International Blood and Marrow Transplant Research to compare outcomes after autologous (n = 3786) or allogeneic (n = 7433) HCT for adult patients with hematologic malignancies with an existing diagnosis of pre-HCT depression requiring treatment versus those without pre-HCT depression. [...]

Mené aux Etats-Unis auprès de 95 patients ayant survécu à un cancer, cet essai randomisé évalue l'efficacité d'une psychothérapie comportementale, avec ou sans armodafinil, pour soulager leurs symptômes d'insomnie et améliorer leur qualité de vie

Effects of cognitive behavioral therapy for insomnia and armodafinil on quality of life in cancer survivors: a randomized placebo-controlled trial

Peoples, Anita R. ; Garland, Sheila N. ; Perlis, Michael L. ; Savard, Josée ; Heckler, Charles E. ; Kamen, Charles S. ; Ryan, Julie L. ; Mustian, Karen M. ; Janelsins, Michelle C. ; Peppone, Luke J. ; Morrow, Gary R. ; Roscoe, Joseph A.

Purpose : Cancer-related insomnia is associated with diminished quality of life (QOL), suggesting that improvement in insomnia may improve QOL in cancer survivors. Cognitive behavioral therapy for insomnia (CBT-I) has been shown to improve insomnia, but less is known regarding its effect on QOL and whether improvement in insomnia corresponds to improved QOL. The present analysis examines the effects of CBT-I, with and without armodafinil, on QOL both directly and indirectly through improvements [...]

Menée aux Etats-Unis par questionnaire auprès de 3 001 patients adultes ayant survécu à un cancer pendant l'enfance (âge moyen: 32,5 ans), cette étude analyse leurs perceptions des effets de la maladie sur leur vie quotidienne, notamment sur leurs relations sociales et affectives, sur leur activité physique et sur leur situation financière

The impact of childhood cancer: Perceptions of adult survivors

Willard, Victoria W. ; Klosky, James L. ; Li, Chenghong ; Srivastava, Deo Kumar ; Brinkman, Tara M. ; Robison, Leslie L. ; Hudson, Melissa M. ; Phipps, Sean

BACKGROUND: The objective of this study was to describe perceptions and associated risk factors of the impact of cancer on functional outcomes, including social relationships, exercise, finances, and religion, among adult survivors of childhood cancer. METHODS: Evaluable participants included 3001 adult survivors (mean age, 32.5 years; range, 18.3-63.8 years; 24.1 years from diagnosis; 50.8% male; 84.9% Caucasian) who were enrolled in the St. Jude Lifetime Cohort study. Perceptions of the [...]

A partir d'une revue systématique de la littérature (7 articles), cette étude analyse, peu après l'arrêt des traitements, la détresse psychologique de patients ayant survécu à un cancer hématologique

Psychosocial distress in haematological cancer survivors: An integrative review

Raphael, D. ; Frey, R. ; Gott, M.

Haematological cancers are becoming more prevalent, however, survival is also increasing. Many survivors are faced with psychosocial issues after treatment ends, and they may not receive the support they need. This review aims to examine peer reviewed literature reporting psychosocial distress faced by haematological cancer survivors in the early post-treatment period. Database and hand searches were conducted between August and September 2015, with no year restriction. Eligible studies were [...]

Menée en Italie par enquête auprès de 150 professionnels de santé impliqués dans les soins de fin de vie pour les patients atteints de cancer, cette étude analyse leurs opinions et pratiques relatives à la sédation palliative à domicile

Attitudes of palliative home care physicians towards palliative sedation at home in Italy

Mercadante, Sebastiano ; Masedu, Francesco ; Mercadante, Alessandro ; Marinangeli, Franco ; Aielli, Federica

Background : Information about the attitudes towards palliative sedation (PS) at home is limited. Aim : The aim of this survey was to assess the attitudes of palliative care physicians in Italy regarding PS at home. Design : A questionnaire was submitted to a sample of palliative care physicians, asking information about their activity and attitudes towards PS at home. Setting : This is a survey of home care physicians in Italy who were involved in end-of-life care decisions at home. Results : [...]

Menée aux Etats-Unis à partir de données portant sur 69 patients âgés de 15 à 26 ans, atteints d'un cancer et décédés durant leur hospitalisation entre 2008 et 2014, cette étude évalue l'association entre les caractéristiques liées aux traitements reçus, qu'il s'agisse de soins intensifs, de soins palliatifs ou de soins de support, et les symptômes pendant leur dernier mois de vie

Palliative Care Involvement Is Associated with Less Intensive End-of-Life Care in Adolescent and Young Adult Oncology Patients

Snaman, Jennifer M. ; Kaye, Erica C. ; Lu, Jessie J. ; Sykes, April ; Baker, Justin N.

Background: Adolescent and young adult oncology (AYAO) patients often receive intensive medical care and experience significant symptoms at the end of life (EOL). Objective: This study aimed to describe the characteristics of AYAO patients aged 15–26 years who died as inpatients in a hospital and to compare the illness and EOL experiences of AYAO patients who did and did not receive palliative care (PC). Design and Setting: A standardized data extraction tool was used to collect information [...]