Menée aux Etats-Unis à partir de données portant sur 1 217 patients atteints d'un cancer du rein et sur 1 235 témoins, cette étude évalue l'association entre diverses expositions professionnelles à des solvants chlorés et le risque de la maladie

Occupational exposure to chlorinated solvents and kidney cancer: a case–control study

Purdue, Mark P ; Stewart, Patricia A ; Friesen, Melissa C ; Colt, Joanne S ; Locke, Sarah J ; Hein, Misty J ; Waters, Martha A ; Graubard, Barry I ; Davis, Faith ; Ruterbusch, Julie ; Schwartz, Kendra ; Chow, Wong-Ho ; Rothman, Nathaniel ; Hofmann, Jonathan N

Objectives : Trichloroethylene, a chlorinated solvent widely used for metal degreasing, is classified by the International Agency for Research on Cancer as a kidney carcinogen. Other chlorinated solvents are suspected carcinogens, most notably the cleaning solvent perchloroethylene, although it is unclear whether they are associated with kidney cancer. We investigated kidney cancer associations with occupational exposure to 6 chlorinated solvents (trichloroethylene, perchloroethylene, [...]

Menée à partir de données portant sur 792 patients atteints d'un gliome diagnostiqué entre 2000 et 2004, cette étude internationale évalue l'association entre l'utilisation d'un téléphone mobile et le risque de la maladie, en fonction de la localisation intracrânienne

The Intracranial Distribution of Gliomas in Relation to Exposure From Mobile Phones: Analyses From the INTERPHONE Study

Grell, Kathrine ; Frederiksen, Kirsten ; Schüz, Joachim ; Cardis, Elisabeth ; Armstrong, Bruce ; Siemiatycki, Jack ; Krewski, Daniel R. ; McBride, Mary L. ; Johansen, Christoffer ; Auvinen, Anssi ; Hours, Martine ; Blettner, Maria ; Sadetzki, Siegal ; Lagorio, Susanna ; Yamaguchi, Naohito ; Woodward, Alistair ; Tynes, Tore ; Feychting, Maria ; Fleming, Sarah J. ; Swerdlow, Anthony J. ; Andersen, Per K.

When investigating the association between brain tumors and use of mobile telephones, accurate data on tumor position are essential, due to the highly localized absorption of energy in the human brain from the radio-frequency fields emitted. We used a point process model to investigate this association using information that included tumor localization data from the INTERPHONE Study (Australia, Canada, Denmark, Finland, France, Germany, Israel, Italy, Japan, New Zealand, Norway, Sweden, and the [...]

Menée au Canada auprès de 326 607 participants âgés de 20 à 65 ans sur la période 1994-2012, cette étude de cohorte évalue l'association entre une vasectomie et le risque de cancer de la prostate (3 462 cas)

Vasectomy and risk of prostate cancer: population based matched cohort study

Madhur Nayan, ; Robert J Hamilton, ; Erin M Macdonald, ; Qing Li, ; Muhammad M Mamdani, ; Craig C Earle, ; Girish S Kulkarni, ; Keith A Jarvi, ; David N Juurlink

Objective : To determine the association between vasectomy and prostate cancer, adjusting for measures of health seeking behaviour. Design : Population based matched cohort study. Setting : Multiple validated healthcare databases in Ontario, Canada, 1994-2012. Participants : 326 607 men aged 20 to 65 who had undergone vasectomy were identified through physician billing codes and matched 1:1 on age (within two years), year of cohort entry, comorbidity score, and geographical region to men who [...]

A partir des données des registres américains, canadiens et australiens des cancers portant sur les familles de 5 744 patients atteints d'un cancer colorectal, cette étude évalue la prévalence des mutations des gènes MUTYH, des gènes de réparation des mésappariements de l'ADN (gènes MLH1, MSH2, MSH6, PMS2) et estime la prévalence de gènes mutés non encore identifiés

Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer

Win, Aung Ko ; Jenkins, Mark A. ; Dowty, James G ; Antoniou, Antonis C. ; Lee, Andrew ; Giles, Graham G ; Buchanan, Daniel D. ; Clendenning, Mark ; Rosty, Christophe ; Ahnen, Dennis J. ; Thibodeau, Stephen N. ; Casey, Graham ; Gallinger, steven ; Le Marchand, Loic ; Haile, Robert W. ; Potter, John D. ; Zheng, Yingye ; Lindor, Noralane M. ; Newcomb, Polly A. ; Hopper, John L. ; MacInnis, Robert J

Background: While high-risk mutations in identified major susceptibility genes (DNA mismatch repair genes and MUTYH) account for some familial aggregation of colorectal cancer, their population prevalence and the causes of the remaining familial aggregation are not known. Methods: We studied the families of 5,744 colorectal cancer cases (probands) recruited from population cancer registries in the USA, Canada and Australia and screened probands for mutations in mismatch repair genes and MUTYH. [...]

A partir des données des registres danois des cancers portant sur la période 1992-2011, cette étude évalue l'association entre des facteurs liés à la reproduction (âge à la première grossesse, nombre de naissances, ...) et le risque de cancer du sein en fonction de l'expression des récepteurs ER et HER2 (45 786 patientes âgées de 20 à 84 ans)

Associations of parity-related reproductive histories with ER± and HER2± receptor-specific breast cancer aetiology

Anderson, William F ; Pfeiffer, Ruth M ; Wohlfahrt, Jan ; Ejlertsen, Bent ; Jensen, Maj-Britt ; Kroman, Niels

Background: Associations of reproductive history with breast cancer risk differ by oestrogen receptor (ER±) status and possibly by the joint expression of ER and the human epidermal growth factor receptor-2 (ER±/HER2±). However, large sample sizes are needed to establish ER-specific risks by HER2± expression. Methods: We linked a cancer registry covering nearly 95% of the primary breast cancer diagnoses in Denmark with a research parity database to assess associations for parity, number of live [...]

Menée en Australie à partir des données du registre des cancers familiaux du côlon incluant 1 925 individus porteurs d'une mutation d'un des gènes MMR, cette étude évalue l'association entre une consommation d'alcool et le risque de cancer colorectal (769 cas)

Alcohol Consumption and the Risk of Colorectal Cancer in Mismatch Repair Gene Mutation Carriers

Dashti, S. Ghazaleh ; Buchanan, Daniel D. ; Jayasekara, Harindra ; Ait Ouakrim, Driss ; Clendenning, Mark ; Rosty, Christophe ; Winship, Ingrid M. ; Macrae, Finlay A. ; Giles, Graham G ; Parry, Susan ; Casey, Graham ; Haile, Robert W. ; Gallinger, steven ; Le Marchand, Loic ; Thibodeau, Stephen N. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Potter, John D. ; Baron, John A. ; Hopper, John L. ; Jenkins, Mark A. ; Win, Aung Ko

Background : People with germline mutation in one of the DNA mismatch repair (MMR) genes have increased colorectal cancer risk. For these high-risk people, study findings of the relationship between alcohol consumption and colorectal cancer risk have been inconclusive. Methods : 1,925 MMR gene mutations carriers recruited into the Colon Cancer Family Registry who had completed a questionnaire on lifestyle factors were included. Weighted Cox proportional hazard regression models were used to [...]