Menée au Canada par questionnaire auprès de 615 patients atteints de divers types de cancers, cette étude analyse l'efficacité de deux outils pour détecter l'insomnie

Capacity of the Edmonton Symptom Assessment System and the Canadian Problem Checklist to screen clinical insomnia in cancer patients

Savard, Josée ; Ivers, Hans ; Savard, Marie-Hélène

Purpose : Insomnia is highly prevalent in cancer patients. Efficacious treatments exist for this condition but, for these interventions to be offered, an effective screening needs to be carried out beforehand. The pan-Canadian practice guidelines on sleep disturbances provide recommendations on how to use the Edmonton Symptom Assessment System (ESAS) and the Canadian Problem Checklist (CPC) to screen for sleep difficulties in cancer. However, empirical evidence to support these recommendations [...]

Menée au Canada auprès de 59 couples constitués de patients atteints d'un cancer de la prostate et de leur partenaire de vie, cette étude évalue l'efficacité d'une intervention pour améliorer leur vie sexuelle après les traitements

Intimacy after prostate cancer: A brief couples' workshop is associated with improvements in relationship satisfaction

Walker, Lauren M. ; King, Ngaire ; Kwasny, Zoe ; Robinson, John W.

Objective : Prostate cancer (PCa) treatments often leave men with erectile dysfunction (ED). Even when ED treatments are effective in restoring men's ability to have an erection sufficient for intercourse, couples continue to struggle sexually. Effective treatments to help couples recover sexually are needed. Method : PCa patients and partners (N = 59 couples) attending a one-time couples' intimacy workshop, participated in an evaluation. The workshop, offered eight times over a 2-year period, [...]

A partir dune revue systématique de la littérature, cette étude compare 3 outils sous forme de questionnaire permettant d'évaluer la qualité de vie des patients atteints d'un cancer colorectal

Comparison of the FACT-C, EORTC QLQ-CR38, and QLQ-CR29 quality of life questionnaires for patients with colorectal cancer: a literature review

Ganesh, Vithusha ; Agarwal, Arnav ; Popovic, Marko ; Cella, David ; McDonald, Rachel ; Vuong, Sherlyn ; Lam, Henry ; Rowbottom, Leigha ; Chan, Stephanie ; Barakat, Tasneem ; DeAngelis, Carlo ; Borean, Michael ; Chow, Edward ; Bottomley, Andrew

Purpose : The purpose of this review was to compare the development, characteristics, validity, and reliability of three widely used quality of life (QOL) assessment tools used in colorectal cancer (CRC) patients: the Functional Assessment of Cancer Therapy-Colorectal (FACT-C), the European Organization for Research and Treatment of Cancer Quality of Life (EORTC) Quality of Life Questionnaire Colorectal Cancer Module (QLQ-CR38) and its successor, the QLQ-CR29. Methods : A literature search was [...]

Menée aux Etats-Unis auprès de 2 973 patientes atteintes d'un cancer du sein non métastatique (âge moyen : 57 ans), cette étude évalue l'association entre la pratique d'une activité physique de loisir et le risque d'événements cardiovasculaires

Exercise and Risk of Cardiovascular Events in Women With Nonmetastatic Breast Cancer

Jones, Lee W. ; Habel, Laurel A. ; Weltzien, Erin ; Castillo, Adrienne ; Gupta, Dipti ; Kroenke, Candyce H. ; Kwan, Marilyn L. ; Quesenberry, Charles P. ; Scott, Jessica ; Sternfeld, Barbara ; Yu, Anthony ; Kushi, Lawrence H. ; Caan, Bette J.

Purpose : Cardiovascular disease (CVD) is a leading cause of death among women with nonmetastatic breast cancer. Whether exercise is associated with reductions in CVD risk in patients with breast cancer with an elevated CVD risk phenotype is not known. Methods : Using a prospective design, women (n = 2,973; mean age, 57 years) diagnosed with nonmetastatic breast cancer participating in two registry-based, regional cohort studies, completed a questionnaire that assessed leisure-time recreational [...]

A partir des données des registres américains des cancers portant sur 1 653 participants, cette étude analyse l'évolution de la qualité de vie de patients atteints d'un carcinome épidermoïde de la tête et du cou, entre 5 ans avant le diagnostic et 10 ans après

Health-related quality of life before and after head and neck squamous cell carcinoma: Analysis of the Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey linkage

Rettig, Eleni M. ; D'Souza, Gypsyamber ; Thompson, Carol B. ; Koch, Wayne M. ; Eisele, David W. ; Fakhry, Carole

BACKGROUND Understanding health-related quality of life (HRQOL) is crucial to providing high-quality survivorship care for patients with head and neck squamous cell carcinoma (HNSCC). Trends in and prognostic significance of HRQOL before and after HNSCC have not been well described. METHODS HRQOL for older individuals with HNSCC was examined using the linked Surveillance, Epidemiology, and End Results-Medicare Health Outcomes Survey database. Surveys assessing HRQOL from 5 years prediagnosis to [...]

A partir des données des registres américains des cancers sur la période 2003-2011, cette étude analyse les disparités ethniques dans l'évolution de l'incidence du carcinome hépatocellulaire et de la survie globale

Race/ethnicity-specific disparities in cancer incidence, burden of disease, and overall survival among patients with hepatocellular carcinoma in the United States

Ha, John ; Yan, Melissa ; Aguilar, Maria ; Bhuket, Taft ; Tana, Michele M. ; Liu, Benny ; Gish, Robert G. ; Wong, Robert J.

BACKGROUND Hepatocellular carcinoma (HCC) is one of the fastest rising causes of cancer-related deaths in the United States, with disparities observed in cancer incidence and survival between ethnic groups. This report provides updated analyses on race-specific disparities in US HCC trends. METHODS This large, population-based cohort study was conducted using Surveillance, Epidemiology, and End Results cancer registry data from 2003 to 2011 to investigate race-specific disparities in HCC [...]

Menée en France par questionnaire auprès de 845 jeunes patients ayant survécu à une leucémie pendant l'enfance (âge moyen : 22,3 ans), cette étude analyse leur situation professionnelle et les facteurs associés à leur stabilité dans l'emploi

Employment in French young adult survivors of childhood leukemia: an LEA study (for Leucemies de l’Enfant et de l’Adolescent—childhood and adolescent leukemia)

Berbis, Julie ; Reggio, Céline ; Michel, Gérard ; Chastagner, Pascal ; Bertrand, Yves ; Kanold, Justyna ; Sirvent, Nicolas ; Plantaz, Dominique ; Baruchel, André ; Tabone, Marie-Dominique ; Garnier, Floriane ; Lehucher-Michel, Marie-Pascale ; Auquier, Pascal

Purpose : Our principal aim was to assess the occupational outcomes of French survivors of childhood leukemia, compared to national population. The secondary objective was to identify determinants linked with employment stability after childhood leukemia. Methods : All survivors aged 15 and over enrolled in the French LEA Cohort (Childhood and Adolescent Leukemia) were included. Occupational data were self-reported. The occupational distributions expected in the cohort for each age range were [...]

Menée auprès de 421 patients atteints d'un cancer du poumon non à petites cellules cellules de stade avancé, cette étude rétrospective évalue l'association entre une prise de poids pendant les traitements et l'amélioration de la survie

Relationship between Efficacy Outcomes and Weight Gain during Treatment of Advanced, Nonsquamous, Non-small Cell Lung Cancer Patients

Patel, J.D. ; Pereira, J.R. ; Chen, J. ; Liu, J. ; Guba, S.C. ; John, W.J. ; Orlando, M. ; Scagliotti, G. ; Bonomi, P.D.

Background : Unintentional weight loss occurs among advanced non-small cell lung cancer (NSCLC) patients and is associated with worse survival. Small studies have suggested that weight gain during treatment is associated with superior survival. Patients and Methods : A retrospective analysis analyzed data from three international phase III studies comprising 2301 advanced, nonsquamous NSCLC patients who received a platinum-based, first-line doublet, with or without bevacizumab and maintenance [...]

A partir de données de 13 registres américains et 12 registres allemands des cancers, cette étude évalue l'impact de l'utilisation du test du dosage du PSA sur l'incidence du cancer de la prostate, le stade au diagnostic, la survie relative et la mortalité, en comparant les données de ces deux pays sur la période 1999-2010

Comparison of prostate cancer survival in Germany and the United States: Can differences be attributed to differences in stage distributions?

Winter, Alexander ; Sirri, Eunice ; Jansen, Lina ; Wawroschek, Friedhelm ; Kieschke, Joachim ; Castro, Felipe A. ; Krilaviciute, Agne ; Holleczek, Bernd ; Emrich, Katharina ; Waldmann, Annika ; Brenner, Hermann ; the, Gekid Cancer Survival Working Group

Objectives : To better understand influence of prostate-specific antigen (PSA) screening and other health system determinants on prognosis of prostate cancer (PCa), up-to-date relative survival (RS), stage distributions, and trends in survival and incidence in Germany were evaluated and compared with the United States (US). Patients and Methods : Incidence and mortality rates for Germany and the US for the period 1999 to 2010 were obtained from the Center for Cancer Registry Data at the Robert [...]

A partir des données de 6 études prospectives américaines incluant 2 249 cas de cancer colorectal (durée de suivi : 4,5 ans), cette étude analyse l'association entre l'indice de masse corporelle mesuré avant le diagnostic et la survie

Relationship of prediagnostic body mass index with survival after colorectal cancer: Stage-specific associations

Kocarnik, Jonathan M. ; Chan, Andrew T. ; Slattery, Martha L. ; Potter, John D. ; Meyerhardt, Jeffrey ; Phipps, Amanda ; Nan, Hongmei ; Harrison, Tabitha ; Rohan, Thomas E. ; Qi, Lihong ; Hou, Lifang ; Caan, Bette ; Kroenke, Candyce H. ; Strickler, Howard ; Hayes, Richard B. ; Schoen, Robert E. ; Chong, Dawn Q. ; White, Emily ; Berndt, Sonja I. ; Peters, Ulrike ; Newcomb, Polly A.

Higher body mass index (BMI) is a well-established risk factor for colorectal cancer (CRC), but is inconsistently associated with CRC survival. In 6 prospective studies participating in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), 2,249 non-Hispanic white CRC cases were followed for a median 4.5 years after diagnosis, during which 777 died, 554 from CRC-related causes. Associations between prediagnosis BMI and survival (overall and CRC-specific) were evaluated using [...]

Mené auprès de 6 193 patientes atteintes d'un cancer du sein traité par tamoxifène ou par létrozole ou par les deux agents de façon séquentielle, cet essai évalue l'impact de l'adhésion au traitement sur l'amélioration de la survie sans maladie

Treatment Adherence and Its Impact on Disease-Free Survival in the Breast International Group 1-98 Trial of Tamoxifen and Letrozole, Alone and in Sequence

Chirgwin, Jacquie H. ; Giobbie-Hurder, Anita ; Coates, Alan S. ; Price, Karen N. ; Ejlertsen, Bent ; Debled, Marc ; Gelber, Richard D. ; Goldhirsch, Aron ; Smith, Ian ; Rabaglio, Manuela ; Forbes, John F. ; Neven, Patrick ; Lang, István ; Colleoni, Marco ; Thürlimann, Beat

Purpose : To investigate adherence to endocrine treatment and its relationship with disease-free survival (DFS) in the Breast International Group (BIG) 1-98 clinical trial. Methods : The BIG 1-98 trial is a double-blind trial that randomly assigned 6,193 postmenopausal women with hormone receptor–positive early breast cancer in the four-arm option to 5 years of tamoxifen (Tam), letrozole (Let), or the agents in sequence (Let-Tam, Tam-Let). This analysis included 6,144 women who received at [...]

Menée en France à partir des données de la cohorte "E3N" incluant 3 006 patientes atteintes d'un cancer invasif du sein diagnostiqué entre 1995 et 2008, cette étude de cohorte prospective évalue l'association entre diverses mesures de l'adiposité avant le diagnostic et la survie

Prediagnostic body size and breast cancer survival in the E3N cohort study

His, Mathilde ; Fagherazzi, Guy ; Mesrine, Sylvie ; Boutron-Ruault, Marie-Christine ; Clavel-Chapelon, Françoise ; Dossus, Laure

Obesity has been associated with poor breast cancer prognosis, however most studies have focused on body mass index (BMI) and few have considered the distribution of adipose tissue. We investigated associations between prediagnostic adiposity and breast cancer survival, considering BMI, waist and hip circumferences (WC and HC), and waist-to-hip ratio (WHR). Analyses included 3,006 women from the French E3N prospective cohort study diagnosed with primary invasive breast cancer between 1995 and [...]

A partir des données d'un registre anglais des cancers portant sur 36 793 patientes atteintes d'un cancer du sein diagnostiqué entre 2000 et 2007, cette étude analyse l'association entre le stade de la tumeur au diagnostic, les traitements reçus et les disparités socioéconomiques dans la survie

How much do tumor stage and treatment explain socioeconomic inequalities in breast cancer survival? Applying causal mediation analysis to population-based data

Li, Ruoran ; Daniel, Rhian ; Rachet, Bernard

Substantial socioeconomic inequalities in breast cancer survival persist in England, possibly due to more advanced cancer at diagnosis and differential access to treatment. We aim to disentangle the contributions of differential stage at diagnosis and differential treatment to the socioeconomic inequalities in cancer survival. Information on 36,793 women diagnosed with breast cancer during 2000–2007 was routinely collected by an English population-based cancer registry. Deprivation was [...]

A partir des données de la cohorte "Women's Health Initiative" et d'un essai ayant inclus 7 835 patientes atteintes d'un cancer du sein, cette étude évalue l'association entre une consommation d'alcool, avant et après le diagnostic, et la mortalité spécifique ou toutes causes confondues

Alcohol use and breast cancer survival among participants in the Women's Health Initiative

Lowry, Sarah J ; Kapphahn, Kristopher ; Chlebowski, Rowan T ; Li, Christopher I.

Background: Alcohol increases the risk of breast cancer even at moderate levels of intake. However, the relationship between alcohol consumption and mortality among breast cancer patients is less clear. Methods: This study included women from the WHI observational study and randomized trial diagnosed with breast cancer (n=7,835). Cox proportional hazards regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for overall and breast-cancer-specific [...]

Menée à partir des données d'un registre canadien des cancers sur la période 1994-2012, cette étude analyse l'évolution de l'incidence des cancers des voies biliaires et de la survie (9 039 cas)

Increased incidence but improved median overall survival for biliary tract cancers diagnosed in Ontario from 1994 through 2012: A population-based study

Flemming, Jennifer A. ; Zhang-Salomons, Jina ; Nanji, Sulaiman ; Booth, Christopher M.

BACKGROUND To the authors’ knowledge, the incidence of biliary tract cancer (BTC) in Canada is unknown. In the current study, the authors sought to describe the epidemiology of BTC using a large population-based cancer database from Ontario, Canada. METHODS The current study was a population-based cohort study using the Ontario Cancer Registry. Patients with intrahepatic cholangiocarcinoma (IHCC), extrahepatic cholangiocarcinoma (EHCC), and gallbladder cancer (GBC) diagnosed between 1994 and [...]

Menée aux Etats-Unis auprès de 275 aidants familiaux de patients atteints d'un cancer incurable, cette étude analyse les facteurs associés à un risque de dépression et de symptômes d'anxiété

Factors associated with depression and anxiety symptoms in family caregivers of patients with incurable cancer

Nipp, R. D. ; El-Jawahri, A. ; Fishbein, J. N. ; Gallagher, E. R. ; Stagl, J. M. ; Park, E. R. ; Jackson, V. A. ; Pirl, W. F. ; Greer, J. A. ; Temel, J. S.

Background : Family caregivers (FCs) are critically important for patients with cancer, yet they may experience psychological distress related to caregiving demands. We sought to describe rates of depression and anxiety in FCs of patients with incurable cancer and identify factors associated with these symptoms to determine those at greatest risk for psychological distress. Patients and Methods : We performed a cross-sectional analysis of baseline data from a randomized trial of early [...]

Menée aux Etats-Unis par entretiens auprès de 201 patients atteints de cancer et âgés de plus de 70 ans, cette étude analyse l'efficacité de trois outils d'auto-déclaration pour évaluer la dépression chez une population gériatrique

Assessing depression in a geriatric cancer population

Saracino, Rebecca M. ; Weinberger, Mark I. ; Roth, Andrew J. ; Hurria, Arti ; Nelson, Christian J.

Objective : To examine the ability of three popular self-report measures of depression to assess depression in a geriatric cancer setting. Method : Cancer patients 70 years or older and on active treatment completed the Geriatric Depression Scale-Short Form, the Hospital Anxiety and Depression Scale, and the Center for Epidemiological Studies Depression Scale—Revised, and were interviewed using the depression module of the Structured Clinical Interview for DSM disorders (SCID) as the ‘gold [...]

Menée en Australie par questionnaire auprès de 75 patientes atteintes d'un cancer du sein, cette étude analyse les perturbations liées à leur image corporelle après avoir subi une mastectomie avec conservation de la plaque aréolo-mamelonnaire suivie d'une reconstruction mammaire

Body image and psychological distress in nipple-sparing mastectomy: the roles of self-compassion and appearance investment

Sherman, K. A. ; Woon, S. ; French, J. ; Elder, E.

Objective : Women with breast cancer face threats to body image following surgery. Nipple-sparing mastectomy with immediate breast reconstruction (NSM + IBR) may minimise body image disturbance as this preserves the woman's skin and areola complex. We assessed levels of body image disturbance and psychological distress in women undergoing NSM + IBR. To further understand the body image–distress relationship, we investigated the potential moderating effect of self-compassion and appearance [...]

Cet article présente les enjeux éthiques et pratiques liés à l'utilisation de traitements innovants et onéreux pour la prise en charge des patients atteints de cancer

The ethical and practical challenges of value-based cancer care at the patient’s bedside

Goldstein, D. A.

Value-based cancer care has now taken center stage in both the mainstream media and academic arena. Professional societies have developed frameworks for evaluating the value of particular treatments, and I commend them for addressing a subject that was considered taboo only a few years ago. But how should these guidelines and other economic literature be used by practicing physicians? How do concepts of value intersect with the ethics of serving an individual patient as a physician? How does a [...]

Menée aux Etats-Unis auprès de 178 patients atteints d'un cancer de stade avancé, cette étude analyse l'association entre les discussions médecin/patient, relatives au pronostic et à l'espérance de vie, et l'amélioration de la compréhension de la maladie par les patients

Discussions of Life Expectancy and Changes in Illness Understanding in Patients With Advanced Cancer

Epstein, Andrew S. ; Prigerson, Holly G. ; O’Reilly, Eileen M. ; Maciejewski, Paul K.

Purpose Accurate illness understanding enables patients to make informed decisions. Evidence of the influence of prognostic discussions on the accuracy of illness understanding by patients would demonstrate the value of discussions. Methods Recent and past oncology provider-patient discussions about prognosis/life expectancy were examined for their association with changes in illness understanding by patients. Patients (N = 178) with advanced cancers refractory to prior chemotherapy whom [...]

A partir d'une revue systématique de la littérature publiée entre 1948 et 2015 (21 études), cette étude fait le point sur les critères permettant de définir le moment adéquat pour orienter les patients atteints de cancer vers des soins palliatifs à l'extérieur de l'hôpital

Referral Criteria for Outpatient Palliative Cancer Care: A Systematic Review

Hui, David ; Meng, Yee-Choon ; Bruera, Sebastian ; Geng, Yimin ; Hutchins, Ron ; Mori, Masanori ; Strasser, Florian ; Bruera, Eduardo

Outpatient palliative care clinics facilitate early referral and are associated with improved outcomes in cancer patients. However, appropriate candidates for outpatient palliative care referral and optimal timing remain unclear. We conducted a systematic review of the literature to identify criteria that are considered when an outpatient palliative cancer care referral is initiated.We searched Ovid MEDLINE and Ovid Embase between 1948 and 2015 for articles related to outpatient palliative [...]

Menée en Norvège à partir de données portant sur 286 patients atteints d'un cancer du poumon non à petites cellules en phase terminale, cette étude analyse les effets d'un recours précoce à des soins palliatifs sur la qualité de la fin de vie

Impact of early palliative interventions on the outcomes of care for patients with non-small cell lung cancer

Nieder, Carsten ; Tollåli, Terje ; Haukland, Ellinor ; Reigstad, Anne ; Flatøy, Liv Randi ; Engljähringer, Kirsten

Purpose : The aim of this study is to address the question “does early palliative care in addition to standard oncology care or late additional palliative care improve patterns of terminal care in patients who died from non-small cell lung cancer (NSCLC)?” Methods : We performed retrospective single-institution study of 286 patients. Palliative care was provided by a dedicated multidisciplinary palliative care team (PCT). An arbitrarily defined cutoff of 3 months before death was chosen to [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2014 (25 articles), cette étude analyse les différences dans les recommandations de pratique clinique relatives à la préservation de la fertilité pour les enfants, adolescents et jeunes adultes atteints d'un cancer, puis évalue leur qualité

Fertility preservation in children, adolescents, and young adults with cancer: Quality of clinical practice guidelines and variations in recommendations

Font-Gonzalez, Anna ; Mulder, Renée L. ; Loeffen, Erik A. H. ; Byrne, Julianne ; van Dulmen-den Broeder, Eline ; van den Heuvel-Eibrink, Marry M. ; Hudson, Melissa M. ; Kenney, Lisa B. ; Levine, Jennifer M. ; Tissing, Wim J. E. ; van de Wetering, Marianne D. ; Kremer, Leontien C. M. ; on behalf of the PanCare, Life Consortium

BACKGROUND Fertility preservation care for children, adolescents, and young adults (CAYAs) with cancer is not uniform among practitioners. To ensure high-quality care, evidence-based clinical practice guidelines (CPGs) are essential. The authors identified existing CPGs for fertility preservation in CAYAs with cancer, evaluated their quality, and explored differences in recommendations. METHODS A systematic search in PubMed (January 2000-October 2014); guideline databases; and Web sites of [...]