Menée à partir des données d'un essai incluant 1 050 femmes enceintes, cette étude évalue l'association entre leur adhésion à un traitement substitutif nicotinique par patch et leur arrêt du tabagisme

The Association Between Treatment Adherence to Nicotine Patches and Smoking Cessation in Pregnancy : A Secondary Analysis of a Randomized Controlled Trial

Vaz, Luis R. ; Aveyard, Paul ; Cooper, Sue ; Leonardi-Bee, Jo ; Coleman, Tim ; on behalf of the SNAP trial team

Introduction : In nonpregnant “quitters,” adherence to nicotine replacement therapy (NRT) increases smoking cessation. We investigated relationships between adherence to placebo or NRT patches and cessation in pregnancy, including an assessment of reverse causation and whether any adherence: cessation relationship is moderated when using nicotine or placebo patches. Methods : Using data from 1050 pregnant trial participants, regression models investigated associations between maternal [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juillet 2014 (29 méta-analyses), cette étude, réalisée par un groupe d'experts néerlandais, présente des recommandations en matière d'alimentation pour prévenir la survenue des 10 principales maladies chroniques dont le cancer

The 2015 Dutch food-based dietary guidelines

Kromhout, D. ; Spaaij, C. J. K. ; de Goede, J. ; Weggemans, R. M.

The objective of this study was to derive food-based dietary guidelines for the Dutch population. The dietary guidelines are based on 29 systematic reviews of English language meta-analyses in PubMed summarizing randomized controlled trials and prospective cohort studies on nutrients, foods and food patterns and the risk of 10 major chronic diseases: coronary heart disease, stroke, heart failure, diabetes, breast cancer, colorectal cancer, lung cancer, chronic obstructive pulmonary disease, [...]

Menée auprès de 3 313 participants de la cohorte "SUpplémentation en VItamines et Minéraux AntioXydants" (âge: 45 à 60 ans ; durée médiane de suivi : 12,6 ans), cette étude française évalue l'association entre la consommation de fruits, de légumes ou de légumineuses et le risque de cancer de la prostate (139 cas)

Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort

Diallo,Abou ; Deschasaux,Mélanie ; Galan,Pilar ; Hercberg,Serge ; Zelek,Laurent ; Latino-Martel,Paule ; Touvier,Mathilde

Although experimental studies suggest that fruits, vegetables and legumes may exert protective effects against prostate carcinogenesis through various bioactive compounds such as dietary fibre and antioxidants, epidemiological evidence is lacking. Notably, very few prospective studies have investigated the relationship between legume intake and prostate cancer risk. Our objective was to prospectively investigate the association between fruit, vegetable, tomato products, potatoes and legume [...]

Menée auprès de 1 966 patientes porteuses d'une mutation d'un gène MMR (MLH1, MSH2, MSH6 et PMS2), cette étude évalue l'association entre une supplémentation en vitamines, calcium ou acide folique et le risque de cancer colorectal

Multivitamin, calcium and folic acid supplements and the risk of colorectal cancer in Lynch syndrome

Chau, Rowena ; Dashti, Seyedeh Ghazaleh ; Ait Ouakrim, Driss ; Buchanan, Daniel D. ; Clendenning, Mark ; Rosty, Christophe ; Winship, Ingrid M. ; Young, Joanne P. ; Giles, Graham G. ; Macrae, Finlay A. ; Boussioutas, Alex ; Parry, Susan ; Figueiredo, Jane C. ; Levine, A.Joan ; Ahnen, Dennis J. ; Casey, Graham ; Haile, Robert W. ; Gallinger, steven ; Le Marchand, Loic ; Thibodeau, Stephen N. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Potter, John D. ; Baron, John A. ; Hopper, John L. ; Jenkins, Mark A. ; Win, Aung Ko

Background : People with a DNA mismatch repair (MMR) gene mutation have a substantially elevated risk of colorectal cancer (CRC) but the modifiers of this risk are not well established. We investigated the association between dietary supplement intake and CRC risk for carriers. Methods : This study included 1966 (56% female) carriers of an MMR gene mutation (719 MLH1, 931 MSH2, 211 MSH6 and 105 PMS2) who were recruited from the USA, Canada, Australia and New Zealand into the Colon Cancer Family [...]

Menée aux Etats-Unis à partir de questionnaires auprès de 50 404 participantes présentant un risque faible de cancer du sein, cette étude évalue l'association entre différents types de régimes alimentaires végétariens (végétalien, lacto-ovo-végétalien, pesco-végétarien, ...) et le risque de développer la maladie

Vegetarian dietary patterns and the risk of breast cancer in a low-risk population

Penniecook-Sawyers,Jason A. ; Jaceldo-Siegl,Karen ; Fan,Jing ; Beeson,Larry ; Knutsen,Synnove ; Herring,Patti ; Fraser,Gary E.

Among cancers in American women, breast cancer (BC) has the second highest incidence and mortality. The association of BC with diet has been inconsistent. Studies that evaluate associations with dietary patterns are less common and reflect an individual’s whole diet. We associated dietary patterns with the risk of BC in American women of the Adventist Health Study-2 (AHS-2), a prospective cohort of 96 001 subjects recruited between 2002 and 2007. Answers to a previously validated FFQ were used [...]

Menée sur une cohorte japonaise incluant 49 552 participantes (durée de suivi : 725 534 personnes-années), cette étude évalue l'association entre trois types de régime alimentaire (régime de type occidental, japonais ou riche en fruits et légumes et pauvre en viande) et le risque de cancer du sein

Dietary pattern and breast cancer risk in Japanese women: the Japan Public Health Center-based Prospective Study (JPHC Study)

Shin,Sangah ; Saito,Eiko ; Inoue,Manami ; Sawada,Norie ; Ishihara,Junko ; Takachi,Ribeka ; Nanri,Akiko ; Shimazu,Taichi ; Yamaji,Taiki ; Iwasaki,Motoki ; Sasazuki,Shizuka ; Tsugane,Shoichiro

Evidence that diet is associated with breast cancer risk is inconsistent. Most of the studies have focused on risks associated with specific foods and nutrients, rather than overall diet. In this study, we aimed to evaluate the association between dietary patterns and breast cancer risk in Japanese women. A total of 49 552 Japanese women were followed-up from 1995 to 1998 (5-year follow-up survey) until the end of 2012 for an average of 14·6 years. During 725 534 person-years of follow-up, 718 [...]

Cet article passe en revue les études concernant la régulation des facteurs de transcription par des composés bioactifs naturels dans le traitement et la prévention des cancers

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

Shanmugam, Muthu K. ; Lee, Jong Hyun ; Chai, Edna Zhi Pei ; Kanchi, Madhu Mathi ; Kar, Shreya ; Arfuso, Frank ; Dharmarajan, Arunasalam ; Kumar, Alan Prem ; Ramar, Perumal Samy ; Looi, Chung Yeng ; Mustafa, Mohammad Rais ; Tergaonkar, Vinay ; Bishayee, Anupam ; Ahn, Kwang Seok ; Sethi, Gautam

The association between chronic inflammation and cancer development has been well documented. One of the major obstacles in cancer treatment is the persistent autocrine and paracrine activation of pro-inflammatory transcription factors such as nuclear factor-

Cet article passe en revue les données actuelles concernant l'efficacité et la sécurité des vaccins contre le papillomavirus humain (HPV), présente les résultats des principaux programmes de vaccination anti-HPV dans le monde, analyse les obstacles associés à cette vaccination et présente les recommandations de l'ASCO dans le cadre de la prévention des cancers liés au papillomavirus humain

American Society of Clinical Oncology Statement : Human Papillomavirus Vaccination for Cancer Prevention

Bailey, Howard H. ; Chuang, Linus T. ; duPont, Nefertiti C. ; Eng, Cathy ; Foxhall, Lewis E. ; Merrill, Janette K. ; Wollins, Dana S. ; Blanke, Charles D.

American Society of Clinical Oncology (ASCO), the leading medical professional oncology society, is committed to lessening the burden of cancer and as such will promote underused interventions that have the potential to save millions of lives through cancer prevention. As the main providers of cancer care worldwide, our patients, their families, and our communities look to us for guidance regarding all things cancer related, including cancer prevention. Through this statement and accompanying [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015 (17 essais incluant au total 69 445 patientes), cet article analyse l'efficacité et la sécurité des différents vaccins contre le papillomavirus humain (HPV) mis sur le marché au cours de ces 10 dernières années, puis présente les controverses associées à la vaccination contre le HPV

Ten years of HPV vaccines : state of art and controversies

Angioli, Roberto ; Lopez, Salvatore ; Aloisi, Alessia ; Terranova, Corrado ; De Cicco, Carlo ; Scaletta, Giuseppe ; Capriglione, Stella ; Miranda, Andrea ; Luvero, Daniela ; Ricciardi, Roberto ; Montera, Roberto ; Plotti, Francesco

The human papillomavirus (HPV) represents one of the most common sexually transmitted infections and it has been related to cervical cancer. The HPV vaccines prevent infection with certain species of HPV associated with the development of cervical cancer or genital warts. We carried out a PubMed search up to 2015 evaluating all randomized studies published in literature. This review discusses the current status of HPVs vaccines on the global market, efficacy, safety profiles, controversies and [...]