A partir d'une revue systématique de la littérature (5 études), cette étude analyse les outils permettant de mesurer une neuropathie périphérique chez les enfants et adolescents atteints de cancer

A systematic review of patient-reported outcome measures of neuropathy in children, adolescents and young adults

Johnston, Donna L. ; Sung, Lillian ; Stark, Daniel ; Frazier, A. Lindsay ; Rosenberg, Abby R.

Purpose : Peripheral neuropathy is an important, yet poorly studied, side effect of pediatric cancer treatment. There are many measures of patient-reported peripheral neuropathy in adults but very few in children. We aimed to systematically review and summarize reliable and valid patient-reported peripheral neuropathy scales used in pediatrics. Methods : Four major electronic databases (Medline, Embase, EBSCO Host in Cumulative Index to Nursing and Allied Health Literature, and PsycINFO) were [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015 (20 études), cette étude évalue l'efficacité d'une technique non invasive de stimulation électrique transcutanée pour traiter la douleur chronique chez les patients atteints de cancer

Scrambler Therapy for the management of chronic pain

Majithia, Neil ; Smith, Thomas J. ; Coyne, Patrick J. ; Abdi, Salahadin ; Pachman, Deirdre R. ; Lachance, Daniel ; Shelerud, Randy ; Cheville, Andrea ; Basford, Jeffrey R. ; Farley, David ; O’Neill, Carrie ; Ruddy, Kathryn J. ; Sparadeo, Frank ; Beutler, Andreas ; Loprinzi, Charles L.

Purpose : Chronic pain is a widespread and debilitating condition, encountered by physicians in a variety of practice settings. Although many pharmacologic and behavioral strategies exist for the management of this condition, treatment is often unsatisfactory. Scrambler Therapy is a novel, non-invasive pain modifying technique that utilizes trans-cutaneous electrical stimulation of pain fibers with the intent of re-organizing maladaptive signaling pathways. This review was conducted to further [...]

Menée en Allemagne auprès de 150 patients pédiatriques atteints de leucémie ou de lymphome, cette étude évalue l'efficacité d'un programme de réadapation sur 4 semaines pour promouvoir l'activité physique et améliorer leur qualité de vie

Physical activity and health-related quality of life in pediatric cancer patients following a 4-week inpatient rehabilitation program

Müller, Carsten ; Krauth, Konstantin A. ; Gerß, Joachim ; Rosenbaum, Dieter

Purpose : Chronic health conditions and impaired quality of life are commonly experienced in childhood cancer survivors. While rehabilitation clinics support patients in coping with the disease, studies evaluating an inpatient rehabilitation program on promoting physical activity (PA) and health-related quality of life (HRQoL) are missing. Methods : A 4-week inpatient rehabilitation program was prospectively evaluated. One hundred fifty patients with leukemia or lymphoma (N = 86), brain tumors [...]

Cette étude passe en revue les divers traitements prophylactiques pour prendre en charge les nausées et vomissements induits par la chimiothérapie et fait le point sur leur efficacité

Antiemetic Prophylaxis for Chemotherapy-Induced Nausea and Vomiting

Navari, Rudolph M. ; Aapro, Matti

One of the most important changes in cancer treatment in recent decades has been the development of treatment regimens that greatly reduce the incidence and intensity of nausea and vomiting. The most effective regimens and how they work are reviewed.

Mené au Canada et en Australie entre 2009 et 2014 auprès de 273 patients ayant survécu à un cancer du côlon de stade II ou III à haut risque de récidive, cet essai évalue l'efficacité d'un programme destiné à améliorer leur activité et leur forme physique

Effects of a structured exercise program on physical activity and fitness in colon cancer survivors: One year feasibility results from the CHALLENGE Trial

Courneya, Kerry S. ; Vardy, Janette L. ; O'Callaghan, Christopher J ; Friedenreich, Christine M. ; Campbell, Kristin L. ; Prapavessis, Harry ; Crawford, Jennifer J. ; O'Brien, Patti ; Dhillon, Haryana M. ; Jonker, Derek J ; Chua, Neil S. ; Lupichuk, Sasha ; Sanatani, Michael S. ; Gill, Sharlene ; Meyer, Ralph M ; Begbie, Stephen ; Bonaventura, Tony ; Burge, Matthew E. ; Turner, Jane ; Tu, Dongsheng ; Booth, Christopher M

Background: There is strong interest in testing lifestyle interventions to improve cancer outcomes, however, the optimal methods for achieving behavior change in large scale pragmatic trials is unknown. Here, we report the 1 year feasibility results for exercise behavior change in the Canadian Cancer Trials Group CO.21 (CHALLENGE) Trial. Methods: Between 2009 and 2014, 273 high risk stage II and III colon cancer survivors from 42 centers in Canada and Australia were randomized to a structured [...]

Menée en Australie à partir de données portant sur 505 patientes ayant survécu à un cancer du sein, cette étude évalue les disparités en termes de qualité de vie à long terme en fonction de leur statut marital et du soutien social

Inequalities in long term health-related quality of life between partnered and not partnered breast cancer survivors through the mediation effect of social support

Leung, Janni ; Smith, Michelle D. ; McLaughlin, Deirdre

Objective : To compare long-term quality of life outcomes by marital status among women living with breast cancer, and to test the mediation effects of social support as an underlying factor. Methods : Data are drawn from 1996 to 2010 of the Australian Longitudinal Study on Women's Health. The sample included 505 women with breast cancer with six years of follow-up data. Social support was measured by the Medical Outcomes Study Social Support Survey (MOS-SSS). Physical and mental health-related [...]

Menée en Australie auprès de 17 patientes atteintes d'un cancer du sein, cette étude qualitative analyse leurs expériences relatives à un dispositif de refroidissement du cuir chevelu pour prévenir et réduire une alopécie induite par la chimiothérapie

Scalp cooling: a qualitative study to assess the perceptions and experiences of Australian patients with breast cancer

Shaw, Joanne ; Baylock, Brandi ; O’Reilly, Amanda ; Winstanley, Julie ; Pugliano, Lina ; Andrews, Kerrie ; Boyle, Frances

Purpose : Chemotherapy-induced hair loss is a common and distressing side effect. Scalp cooling is increasingly being used to reduce this hair loss. The purpose of this study was to explore patients’ perceptions and experience of scalp cooling. Methods : Seventeen Australian women with a diagnosis of breast cancer participated in a focus group (n = 4) or a semi-structured interview (n = 3). Both scalp-cooled and non-scalp-cooled participant views were sought. Participant perceptions and [...]

A partir des données des registres américains des cancers portant sur la période 2000-2012 et incluant des participants âgés de 35 à 84 ans, cette étude analyse les projections d'incidence du carcinome hépatocellulaire jusqu'en 2030

Future of Hepatocellular Carcinoma Incidence in the United States Forecast Through 2030

Petrick, Jessica L. ; Kelly, Scott P. ; Altekruse, Sean F. ; McGlynn, Katherine A. ; Rosenberg, Philip S.

Purpose : Hepatocellular carcinoma (HCC) incidence rates have been increasing in the United States for the past 35 years. Because HCC has a poor prognosis, quantitative forecasts could help to inform prevention and treatment strategies to reduce the incidence and burden of HCC. Methods : Single-year HCC incident case and population data for the years 2000 to 2012 and ages 35 to 84 years were obtained from the SEER 18 Registry Database. We forecast incident HCC cases through 2030, using novel [...]

Menée aux Etats-Unis sur la période 2005-2009, cette étude analyse l'association entre des critères socio-économiques (habitat dans des zones géographiques défavorisées, statut socio-économique) le risque de cancer et le stade de la maladie au diagnostic (2,9 millions de cas)

The relationship between cancer incidence, stage and poverty in the United States

Boscoe, Francis P. ; Henry, Kevin A. ; Sherman, Recinda L. ; Johnson, Christopher J.

We extend a prior analysis on the relation between poverty and cancer incidence in a sample of 2.90 million cancers diagnosed in 16 US states plus Los Angeles over the 2005–2009 period by additionally considering stage at diagnosis. Recognizing that higher relative disparities are often found among less-common cancer sites, our analysis incorporated both relative and absolute measures of disparities. Fourteen of the 21 cancer sites analyzed were found to have significant variation by stage; in [...]

Menée dans plusieurs pays européens auprès de 1 689 patients atteints d'un cancer de stade avancé (âge moyen : 65,7 ans), cette étude prospective longitudinale analyse les facteurs associés au risque d'essouflemment et à son évolution

Who experiences higher and increasing breathlessness in advanced cancer? The longitudinal EPCCS Study

Ekström, M. ; Johnson, M. J. ; Schiöler, L. ; Kaasa, S. ; Hjermstad, M. J. ; Currow, D. C.

Purpose : Breathlessness is a major cause of suffering in advanced cancer. We aimed to determine the symptom trajectory in people with advanced cancer and to identify those at increased risk of experiencing higher or increasing breathlessness over time in advanced cancer. Patients and methods : This was an analysis of the multinational, prospective, longitudinal European Palliative Care Cancer Symptom (EPCCS) study. We included adults with confirmed incurable cancer enrolled in palliative care, [...]

Menée au Danemark à partir de données portant sur 3 530 participants présentant une trisomie 21, cette étude évalue le risque de cancers

Low risk of solid tumors in persons with Down syndrome

Hasle, Henrik ; Friedman, Jan M. ; Olsen, Jorgen H. ; Rasmussen, Sonja A.

Purpose: The aim of this study was to investigate cancer incidence in a large cohort of persons with Down syndrome. Methods: Down syndrome was identified from the Danish Cytogenetic Register. Cancer occurrence was identified by linkage to the Danish Cancer Registry. Standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) were calculated based on observed and expected numbers from rates for all Danish residents. The cohort consisted of 3,530 persons with Down syndrome [...]

A partir des données des registres canadiens des cancers, cette étude évalue les effets à long terme de la maladie sur la situation professionnelle et financière des patients ayant survécu à un cancer diagnostiqué entre 25 et 61 ans

The Long-Term Effects of Cancer on Employment and Earnings

Jeon, Sung-Hee

The study examines long-term effects of cancer on the work status and annual earnings of cancer survivors who had a strong attachment to the labor market prior to their cancer diagnosis. We use linkage data combining Canadian 1991 Census microdata with administrative records from the Canadian Cancer Registry, the Vital Statistics Registry and longitudinal personal income tax records. We estimate changes in the magnitude of cancer effects during the first 3 years following the year of the [...]

A partir des données d'un registre néerlandais des cancers incluant 560 patients atteints d'un cancer de l'œsophage sur la période 1998-2010, cette étude évalue les effets d'une utilisation, après le diagnostic, d'aspirine et d'anti-inflammatoires non stéroïdiens sur la survie des patients

The effect of aspirin and nonsteroidal anti-inflammatory drug use after diagnosis on survival of oesophageal cancer patients

van Staalduinen, Jente ; Frouws, Martine ; Reimers, Marlies ; Bastiaannet, Esther ; van Herk-Sukel, Myrthe P. P. ; Lemmens, Valery ; de Steur, Wobbe O. ; Hartgrink, Henk H. ; van de Velde, Cornelis J. H. ; Liefers, Gerrit-Jan

Background: Aspirin use has been shown to lower incidence and mortality in cancer patients. The aim of this population-based study was to determine the effect of postdiagnosis low-dose aspirin use on survival of patients with oesophageal cancer. Methods: Patients with oesophageal cancer (1998–2010) were selected from the Eindhoven Cancer Registry and linked with outpatient pharmacy data regarding aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). Users were subdivided into both [...]

Menée aux Etats-Unis auprès de 980 patients atteints d'un diabète et d'un adénocarcinome canalaire pancréatique, cette étude rétrospective évalue l'association entre une utilisation de metformine et la survie

Metformin Use and Survival of Patients With Pancreatic Cancer: A Cautionary Lesson

Chaiteerakij, Roongruedee ; Petersen, Gloria M. ; Bamlet, William R. ; Chaffee, Kari G. ; Zhen, David B. ; Burch, Patrick A. ; Leof, Emma R. ; Roberts, Lewis R. ; Oberg, Ann L.

Purpose : The inclusion of metformin in the treatment arms of cancer clinical trials is based on improved survival that has been demonstrated in retrospective epidemiologic studies; however, unintended biases may exist when analysis is performed by using a conventional Cox proportional hazards regression model with dichotomous ever/never categorization. We examined the impact of metformin exposure definitions, analytical methods, and patient selection on the estimated effect size of metformin [...]

A partir des données des registres américains des cancers portant sur la période 1973-2011, cette étude évalue les facteurs associés au risque de métastases cérébrales chez les patients atteints d'un cancer du poumon non métastatique et analyse les différences de survie selon le sous-type de cancer (non à petites cellules ou à petites cellules)

Risk of brain metastases in patients with nonmetastatic lung cancer: Analysis of the Metropolitan Detroit Surveillance, Epidemiology, and End Results (SEER) data

Goncalves, Priscila H. ; Peterson, Stephanie L. ; Vigneau, Fawn D. ; Shore, Ronald D. ; Quarshie, William O. ; Islam, Khairul ; Schwartz, Ann G. ; Wozniak, Antoinette J. ; Gadgeel, Shirish M.

BACKGROUND Brain metastases (BM) remain an important cause of morbidity and mortality in patients with lung cancer. The current study evaluated population-based incidence and outcomes of BM in patients with nonmetastatic lung cancer. METHODS Patients diagnosed with nonmetastatic first primary lung cancer between 1973 and 2011 in the Metropolitan Detroit Surveillance, Epidemiology, and End Results (SEER) registry were used for the current analysis. Age-adjusted odds ratios of developing BM based [...]

A partir des données des registres américains des cancers incluant 77 233 patientes atteintes d'un cancer du sein et âgées de plus de 65 ans (durée de suivi : 19 ans), cette étude de cohorte évalue l'association entre un traitement à base de facteurs de stimulation de colonies et/ou d'agents stimulant l'érythropoïèse et le risque de thromboembolie veineuse, d'accident vasculaire cérébral, de cardiopathie ischémique ou de syndrome myélodysplasique

Associations between hematopoietic growth factors and risks of venous thromboembolism, stroke, ischemic heart disease and myelodysplastic syndrome: findings from a large population-based cohort of women with breast cancer

Du, Xianglin L. ; Zhang, Yefei ; Hardy, Dale

Purpose : To determine the risk of venous thromboembolism (VTE), stroke, ischemic heart disease, and myelodysplastic syndrome (MDS) in association with the receipt of colony-stimulating factors (CSFs) and/or erythropoiesis-stimulating agents (ESAs) in women with breast cancer. Methods : We studied 77,233 women with breast cancer aged ≥65 in 1992–2009 from the Surveillance, Epidemiology, and End Results-Medicare linked data with up to 19 years of follow-up. Results : Incidence of VTE increased [...]

Mené aux Etats-Unis auprès de 1 488 participants, cet essai randomisé évalue l'efficacité d'une psychothérapie familiale destinée aux proches de patients atteints d'un cancer de stade avancé pour améliorer leurs relations pendant les soins palliatifs et pendant la période de deuil

Randomized Controlled Trial of Family Therapy in Advanced Cancer Continued Into Bereavement

Kissane, David W. ; Zaider, Talia I. ; Li, Yuelin ; Hichenberg, Shira ; Schuler, Tammy ; Lederberg, Marguerite ; Lavelle, Lisa ; Loeb, Rebecca ; Del Gaudio, Francesca

Purpose : Systematic family-centered cancer care is needed. We conducted a randomized controlled trial of family therapy, delivered to families identified by screening to be at risk from dysfunctional relationships when one of their relatives has advanced cancer. Patients and Methods : Eligible patients with advanced cancer and their family members screened above the cut-off on the Family Relationships Index. After screening 1,488 patients or relatives at Memorial Sloan Kettering Cancer Center [...]

A partir des données des registres américains des cancers et de la base Medicare portant sur 78 552 patients âgés de plus de 65 ans et atteints d'un cancer localisé de la prostate de stade I à III, cette étude évalue les effets d'une thérapie anti-androgénique, en fonction de sa durée, sur le risque de dépression

Association of Androgen Deprivation Therapy With Depression in Localized Prostate Cancer

Dinh, Kathryn T. ; Reznor, Gally ; Muralidhar, Vinayak ; Mahal, Brandon A. ; Nezolosky, Michelle D. ; Choueiri, Toni K. ; Hoffman, Karen E. ; Hu, Jim C. ; Sweeney, Christopher J. ; Trinh, Quoc-Dien ; Nguyen, Paul L.

Purpose : Androgen deprivation therapy (ADT) may contribute to depression, yet several studies have not demonstrated a link. We aimed to determine whether receipt of any ADT or longer duration of ADT for prostate cancer (PCa) is associated with an increased risk of depression. Methods : We identified 78,552 men older than age 65 years with stage I to III PCa using the SEER-Medicare–linked database from 1992 to 2006, excluding patients with psychiatric diagnoses within the prior year. Our [...]

Menée en Turquie par questionnaire auprès de 614 patientes ayant survécu à un cancer du sein, cette étude évalue les facteurs prédictifs du syndrome de douleur persistante après une mastectomie et de stress post-traumatique

Breast cancer survivors suffer from persistent postmastectomy pain syndrome and posttraumatic stress disorder (ORTHUS study): a study of the palliative care working committee of the Turkish Oncology Group (TOG)

Alkan, Ali ; Guc, Zeynep Gulsum ; Senler, Filiz Cay ; Yavuzsen, Tugba ; Onur, Handan ; Dogan, Mutlu ; Karci, Ebru ; Yasar, Arzu ; Koksoy, Elif Berna ; Tanriverdi, Ozgur ; Turhal, Serdar ; Urun, Yuksel ; Ozkan, Asiye ; Mizrak, Dilsa ; Akbulut, Hakan

Purpose : Persistent postmastectomy pain syndrome (PMPS) is one of the most important disturbing symptoms. Posttraumatic stress disorder (PTSD) is an anxiety disorder which is characterized by reactions to reminders of the trauma that has been experienced. The purpose of this study is to evaluate the predictors of PMPS and PTSD in Turkish breast cancer survivors and the correlation between PMPS and PTSD. Method : The study is designed as a multicenter survey study. Breast cancer patients in [...]

Menée aux Etats-Unis par enquête auprès de 305 patients ayant survécu à un cancer du sein ou de la prostate, cette étude analyse leurs expériences relatives à l'organisation de leur prise en charge par le médecin généraliste et par les professionnels de l'oncologie après la fin des traitements

Breast and prostate cancer survivors’ experiences of patient-centered cancer follow-up care from primary care physicians and oncologists

Hudson, Shawna V. ; Ohman-Strickland, Pamela A. ; Bator, Alicja ; O’Malley, Denalee ; Gundersen, Daniel ; Lee, Heather S. ; Crabtree, Benjamin F. ; Miller, Suzanne M.

Purpose : Patient-physician relationships impact health care seeking and preventive screening behaviors among patients. At the end of active treatment some cancer survivors report feeling disconnected from their care team. This study explores cancer survivors’ experiences of patient-centered cancer follow-up care provided by primary care physicians (PCP) and oncologists (ONC). Methods : Three hundred five early stage, breast and prostate cancer survivors at least 2 years post treatment were [...]

Menée aux Etats-Unis par enquête auprès de deux cohortes constituées de 421 et 440 patients atteints de cancer, cette étude rétrospective analyse leur satisfaction vis-à-vis de l'information reçue dans le cadre d'un programme de conseils sur la fertilité (risques liés aux traitements, options de préservation de la fertilité, consultations chez des infimières spécialisées, etc)

Cancer and Fertility Program Improves Patient Satisfaction With Information Received

Kelvin, Joanne F. ; Thom, Bridgette ; Benedict, Catherine ; Carter, Jeanne ; Corcoran, Stacie ; Dickler, Maura N. ; Goodman, Karyn A. ; Margolies, Allison ; Matasar, Matthew J. ; Noy, Ariela ; Goldfarb, Shari B.

Purpose : A cancer and fertility program was established at a large cancer center to support clinicians in discussing treatment-related fertility risks and fertility preservation (FP) options with patients and in referring patients to reproductive specialists. The program provides resources, clinician education, and fertility clinical nurse specialist consultation. This study evaluated the program’s impact on patient satisfaction with information received. Patients and Methods : Retrospective [...]

A partir d'une revue systématique des essais randomisés contrôlés (11 essais) incluant 831 participants, cette étude analyse l'efficacité d'une thérapie par le Qigong dans les soins de support dédiés aux patients atteints de cancer

Qigong in cancer care: a systematic review and construct analysis of effective Qigong therapy

Klein, P. J. ; Schneider, Roger ; Rhoads, C. J.

Purpose :This review (a) assesses the strength of evidence addressing Qigong therapy in supportive cancer care and (b) provides insights for definition of effective Qigong therapy in supportive cancer care. Methods : This mixed-methods study includes (a) a systematic review of randomized clinical trials (RCTs) following PRISMA guidelines and (b) a constant-comparative qualitative analysis of effective intervention protocols. Results : Eleven published randomized clinical trials were reviewed. A [...]