Mené aux Etats-Unis auprès de 65 patients âgés de 7 à 17 ans et ayant survécu à un cancer pédiatrique, cet essai randomisé évalue l'efficacité d'une intervention de stimulation mécanique de basse amplitude et haute fréquence pour améliorer leur densité minérale osseuse

Effect of low-magnitude, high-frequency mechanical stimulation on BMD among young childhood cancer survivors: A randomized clinical trial

Mogil, R. J. ; Kaste, S. C. ; Ferry, R. J.

Importance : Bone accrual during youth is critical to establish sufficient strength for lifelong skeletal health. Children with cancer may develop low bone mineral density (BMD) any time before or after diagnosis. Objective : To evaluate the ability of low-magnitude, high-frequency mechanical stimulation to enhance BMD among childhood cancer survivors. Design, Setting, and Participants : Double-blind randomized clinical trial conducted at St Jude Children’s Research Hospital from June 1, 2010, [...]

Menée aux Etats-Unis par enquête auprès de 7 619 patientes atteintes d'un cancer du sein, cette étude analyse l'association entre une mastectomie prophylactique controlatérale, leur bien-être psychique et leur qualité de vie

Patient-Reported Outcomes After Choice for Contralateral Prophylactic Mastectomy

Hwang, E. Shelley ; Locklear, Tracie D. ; Rushing, Christel N. ; Samsa, Greg ; Abernethy, Amy P. ; Hyslop, Terry ; Atisha, Dunya M.

Purpose : The rate of contralateral prophylactic mastectomies (CPMs) continues to rise, although there is little evidence to support improvement in quality of life (QOL) with CPM. We sought to ascertain whether patient-reported outcomes and, more specifically, QOL differed according to receipt of CPM. Methods : Volunteers recruited from the Army of Women with a history of breast cancer surgery took an electronically administered survey, which included the BREAST-Q, a well-validated breast [...]

Mené aux Etats-Unis auprès de 692 patientes en surpoids ou obèses ayant survécu à un cancer du sein, cet essai de phase III analyse les effets d'une intervention, destinée à la perte de poids, sur la diminution de leurs comorbidités à 12 et 24 mois

Impact of a behavioral weight loss intervention on comorbidities in overweight and obese breast cancer survivors

Sedjo, Rebecca L. ; Flatt, Shirley W. ; Byers, Tim ; Colditz, Graham A. ; Demark-Wahnefried, Wendy ; Ganz, Patricia A. ; Wolin, Kathleen Y. ; Elias, Anthony ; Krontiras, Helen ; Liu, Jingxia ; Naughton, Michael ; Pakiz, Bilgé ; Parker, Barbara A. ; Wyatt, Holly ; Rock, Cheryl L.

Purpose : Comorbid medical conditions are common among breast cancer survivors, contribute to poorer long-term survival and increased overall mortality, and may be ameliorated by weight loss. This secondary analysis evaluated the impact of a weight loss intervention on comorbid medical conditions immediately following an intervention (12 months) and 1-year postintervention (24 months) using data from the Exercise and Nutrition to Enhance Recovery and Good health for You (ENERGY) trial—a phase [...]

Menée aux Etats-Unis auprès de 5 673 cas et 57 617 témoins, cette étude rétrospective analyse les facteurs associés au risque de maladies cardiovasculaires chez des patients ayant survécu à un cancer diagnostiqué entre 15 et 39 ans

Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer: The Kaiser Permanente AYA Cancer Survivors Study

Chao, Chun ; Xu, Lanfang ; Bhatia, Smita ; Cooper, Robert ; Brar, Somjot ; Wong, F. Lennie ; Armenian, Saro H.

Purpose : To describe the epidemiology and risk factors for cardiovascular disease (CVD) in survivors of adolescent and young adult (AYA) cancer. Methods : We identified a retrospective cohort of 2-year survivors of AYA cancer who were diagnosed between the ages of 15 to 39 years (1998 to 2009) at Kaiser Permanente Southern California. A comparison group without cancer was selected and matched 10:1 to cancer survivors on the basis of age, sex, Kaiser Permanente Southern California membership, [...]

Menée dans 15 pays à partir de données portant sur 3 504 participants et à partir de données issues de 7 études incluant 616 participants, cette méta-analyse évalue l'efficacité d'un modèle de prédiction du risque d'infection liée à une neutropénie fébrile chez des enfants et jeunes adultes atteints de cancer

Predicting microbiologically defined infection in febrile neutropenic episodes in children: global individual participant data multivariable meta-analysis

Phillips, Robert S. ; Sung, Lillian ; Amman, Roland A. ; Riley, Richard D. ; Castagnola, Elio ; Haeusler, Gabrielle M. ; Klaassen, Robert ; Tissing, Wim J. E. ; Lehrnbecher, Thomas ; Chisholm, Julia ; Hakim, Hana ; Ranasinghe, Neil ; Paesmans, Marianne ; Hann, Ian M. ; Stewart, Lesley A.

Background: Risk-stratified management of fever with neutropenia (FN), allows intensive management of high-risk cases and early discharge of low-risk cases. No single, internationally validated, prediction model of the risk of adverse outcomes exists for children and young people. An individual patient data (IPD) meta-analysis was undertaken to devise one. Methods: The ‘Predicting Infectious Complications in Children with Cancer’ (PICNICC) collaboration was formed by parent representatives, [...]

Menée dans plusieurs pays européens auprès de 183 participants (âge médian : 45 ans), cette étude de cohorte rétrospective analyse l'efficacité d'une greffe allogénique de cellules souches hématopoïétiques à intensité réduite pour traiter des patients atteints d'un lymphome folliculaire récidivant après une première greffe autologue

Reduced intensity allogeneic stem cell transplantation for follicular lymphoma relapsing after an autologous transplant achieves durable long term disease control. An analysis from the Lymphoma Working Party Of the EBMT

Robinson, S.P. ; Boumendil, A. ; Finel, H. ; Schouten, H. ; Ehninger, G. ; Maertens, J. ; Crawley, C. ; Rambaldi, A. ; Russell, N. ; Anders, W. ; Blaise, D. ; Yakoub-Agha, I. ; Ganser, A. ; Castagna, L. ; Volin, L. ; Cahn, J-Y ; Montoto, S. ; Dreger, P.

Background : Patients with follicular lymphoma (FL) relapsing after an autologous transplant (autoSCT) may be treated with a variety of therapies including a reduced intensity allogeneic transplant (RICalloSCT). We conducted a retrospective analysis of a large cohort of patients undergoing RICalloSCT for FL in this setting. Patients and Methods : 183 patients, median age 45 years (range 21-69), had undergone an autoSCT at a median of 30 months prior to the RICalloSCT. Before the RICalloSCT they [...]

Menée au Japon, cette étude évalue le risque d'infarctus cérébral chez 515 patients atteints d'un cancer du poumon non à petites cellules de stade avancé ou récidivant, après un traitement chirurgical

Cerebral infarction in advanced non-small cell lung cancer: a case control study

Kato, Motoyasu ; Shukuya, Takehito ; Mori, Keita ; Kanemaru, Ryota ; Honma, Yuichiro ; Nanjo, Yuta ; Muraki, Keiko ; Shibayama, Rina ; Koyama, Ryo ; Shimada, Naoko ; Takahashi, Fumiyuki ; Takahashi, Kazuhisa

Background : Advanced non-small cell lung cancer (NSCLC) patients often develop thromboembolic events, including cerebral infarction (CI). However, the relationship between advanced NSCLC and CI has not been thoroughly investigated. We examined the association between advanced NSCLC and CI and risk factors for CI in advanced or post-operative recurrent NSCLC patients. Methods : We retrospectively investigated 515 patients diagnosed with advanced or post-operative recurrent NSCLC at Juntendo [...]

A partir de données portant sur 8 820 patients atteints d'un cancer de la prostate résistant à la castration traité par docétaxel et inclus dans 9 essais de phase III, cette méta-analyse évalue l'association entre la localisation des métastases (ganglions lymphatiques, os, poumon, foie) et la survie globale

Meta-Analysis Evaluating the Impact of Site of Metastasis on Overall Survival in Men With Castration-Resistant Prostate Cancer

Halabi, Susan ; Kelly, William Kevin ; Ma, Hua ; Zhou, Haojin ; Solomon, Nicole C. ; Fizazi, Karim ; Tangen, Catherine M. ; Rosenthal, Mark ; Petrylak, Daniel P. ; Hussain, Maha ; Vogelzang, Nicholas J. ; Thompson, Ian M. ; Chi, Kim N. ; de Bono, Johann ; Armstrong, Andrew J. ; Eisenberger, Mario A. ; Fandi, Abderrahim ; Li, Shaoyi ; Araujo, John C. ; Logothetis, Christopher J. ; Quinn, David I. ; Morris, Michael J. ; Higano, Celestia S. ; Tannock, Ian F. ; Small, Eric J.

Purpose : Reports have suggested that metastatic site is an important predictor of overall survival (OS) in men with metastatic castration-resistant prostate cancer (mCRPC), but these were based on a limited number of patients. We investigate the impact of site of metastases on OS of a substantial sample of men with mCRPC who received docetaxel chemotherapy in nine phase III trials. Patients and Methods : Individual patient data from 8,820 men with mCRPC enrolled onto nine phase III trials were [...]

A partir d'une revue systématique de la littérature publiée entre 1996 et 2015 (22 études), cette étude analyse les facteurs associés aux délais entre l'apparition de symptômes et une première consultation médicale, puis entre la consultation et le diagnostic de cancer du sein

Identifying predictors of delayed diagnoses in symptomatic breast cancer: a scoping review

Webber, Colleen ; Jiang, Li ; Grunfeld, Eva ; Groome, Patti A.

Delayed diagnosis of breast cancer can adversely impact patient outcomes. To better understand this issue, we conducted a scoping review of literature from 1996 to 2015 that examined predictors of delayed presentation and diagnosis among women with breast cancer symptoms. We performed searches to identify studies of predictors of the time from symptom onset to first presentation (the patient interval), first presentation to diagnosis (the diagnostic interval) and symptom onset to diagnosis (the [...]

A partir des données des registres américains des cancers incluant 496 488 patientes atteintes d'un cancer du sein invasif unilatéral diagnostiqué entre 1998 et 2012, cette étude identifie une augmentation du nombre de mastectomies prophylactiques controlatérales et met en évidence une absence d'amélioration de la survie à long terme

Growing Use of Contralateral Prophylactic Mastectomy Despite no Improvement in Long-term Survival for Invasive Breast Cancer

Wong, Stephanie ; Freedman, Rachel ; Sagara, Yasuaki ; Aydogan Fatih ; Barry, William ; Golshan, Mehra

bjective: To update and examine national temporal trends in contralateral prophylactic mastectomy (CPM) and determine whether survival differed for invasive breast cancer patients based on hormone receptor (HR) status and age. Methods: We identified women diagnosed with unilateral stage I to III breast cancer between 1998 and 2012 within the Surveillance, Epidemiology, and End Results registry. We compared characteristics and temporal trends between patients undergoing breast-conserving [...]

Menée au Canada à partir de données portant sur 1 202 patients adultes ayant survécu à un gliome de bas grade pendant l'enfance, cette étude de cohorte analyse les facteurs cliniques et thérapeutiques associés à la survie à long terme (durée médiane de suivie : 12,7 ans)

Clinical and treatment factors determining long-term outcomes for adult survivors of childhood low-grade glioma: A population-based study

Krishnatry, Rahul ; Zhukova, Nataliya ; Guerreiro Stucklin, Ana S. ; Pole, Jason D. ; Mistry, Matthew ; Fried, Iris ; Ramaswamy, Vijay ; Bartels, Ute ; Huang, Annie ; Laperriere, Normand ; Dirks, Peter ; Nathan, Paul C. ; Greenberg, Mark ; Malkin, David ; Hawkins, Cynthia ; Bandopadhayay, Pratiti ; Kieran, Mark W. ; Manley, Peter E. ; Bouffet, Eric ; Tabori, Uri

BACKGROUND The determinants of outcomes for adult survivors of pediatric low-grade glioma (PLGG) are largely unknown. METHODS This study collected population-based follow-up information for all PLGG patients diagnosed in Ontario, Canada from 1985 to 2012 (n = 1202) and determined factors affecting survival. The impact of upfront radiation treatment on overall survival (OS) was determined for a cohort of Ontario patients and an independent reference cohort from the Surveillance, Epidemiology, [...]

A partir des données des registres américains des cancers portant sur la période 1975-2002, cette étude analyse l'évolution du nombre de patients ayant survécu à un cancer de l'oropharynx ou de la cavité buccale

Rising population of survivors of oral squamous cell cancer in the United States

Patel, Mira A. ; Blackford, Amanda L. ; Rettig, Eleni M. ; Richmon, Jeremy D. ; Eisele, David W. ; Fakhry, Carole

BACKGROUND : The incidence of oropharyngeal cancer (OPC) and a subset of oral cavity cancer (OCC) is increasing in the United States. To the authors' knowledge, the presumed growing prevalence of survivors of OPC and OCC has not been investigated to date. METHODS : Retrospective analysis of Surveillance, Epidemiology, and End Results data (1975-2012) estimated changes in incidence, 5-year cause-specific survival, and prevalence for OPC and OCC. Changes in incidence, cause-specific survival and [...]

Menée en Irlande auprès de patients atteints de tumeurs solides en dehors de la tête et du cou, cette étude prospective observationnelle analyse la prévalence et la sévérité des changements dans leur goût et leur odorat, avant une chimiothérapie ou une radiothérapie

Subjective taste and smell changes in treatment-naive people with solid tumours

Spotten, L. ; Corish, C. ; Lorton, C. ; Dhuibhir, P. Ui ; O’Donoghue, N. ; O’Connor, B. ; Cunningham, M. ; Beltagi, N. ; Gillham, C. ; Walsh, D.

Purpose : Taste and smell changes (TSCs) are common in head and neck (H&N) cancer and during and after chemotherapy (CT) and radiotherapy (RT). It is an area that has been under-investigated, particularly in the treatment-naive, but can negatively impact nutritional status. This study examined the prevalence, severity and characteristics of TSCs in people with non-H&N solid tumours, before CT and RT, and their relationship with co-occurring symptoms. Methods : A prospective, observational study [...]

Menée en Belgique auprès de 166 patients âgés de plus de 65 ans et atteints de tumeurs hématologiques, cette étude analyse leur auto-évaluation de la charge matérielle et affective pesant sur l'aidant principal, au début de la chimiothérapie

Factors associated with self-perceived burden to the primary caregiver in older patients with hematologic malignancies: an exploratory study

Libert, Yves ; Borghgraef, Cindy ; Beguin, Yves ; Delvaux, Nicole ; Devos, Martine ; Doyen, Chantal ; Dubruille, Stéphanie ; Etienne, Anne-Marie ; Liénard, Aurore ; Merckaert, Isabelle ; Reynaert, Christine ; Slachmuylder, Jean-Louis ; Straetmans, Nicole ; Neste, Eric Van Den ; Bron, Dominique ; Razavi, Darius

Objective : Although cancer patients frequently experience self-perceived burden to others, this perception has not been enough studied. The aim of this study was to investigate the prevalence of self-perceived burden to the primary caregiver (SPB-PC) and associated factors in an older patient population with hematologic malignancies at the time of chemotherapy initiation. Methods : In total, 166 consecutive patients with hematologic malignancies aged ≥65 years were recruited at the time of [...]

Menée en Australie, cette étude pilote analyse l'efficacité d'une intervention destinée à réduire le stress et la détresse pshychologique chez des patients atteints d'un cancer de la tête et du cou traité par radiothérapie

Individualised mindfulness-based stress reduction for head and neck cancer patients undergoing radiotherapy of curative intent: a descriptive pilot study

Pollard, A. ; Burchell, J. L. ; Castle, D. ; Neilson, K. ; Ftanou, M. ; Corry, J. ; Rischin, D. ; Kissane, D. W. ; Krishnasamy, M. ; Carlson, L. E. ; Couper, J.

People with head and neck cancer (HNC) experience elevated symptom toxicity and co-morbidity as a result of treatment, which is associated with poorer psychosocial and quality-of-life (QoL) outcomes. This Phase I study examined whether an individualised mindfulness-based stress reduction (IMBSR) programme could be successfully used with HNC patients undergoing curative treatment. Primary aims were to explore feasibility, compliance, acceptability and fidelity. Secondary aims were to determine [...]

Menée aux Etats-Unis, cette étude analyse le rapport coût-efficacité d'une stratégie thérapeutique utilisant tout d'abord un médicament générique de l'imatinib, puis un autre inhibiteur de tyrosine kinase (dasatinib ou nilotinib), pour les patients atteints d'une leucémie myéloïde chronique en phase chronique

Cost-effectiveness of Tyrosine Kinase Inhibitor Treatment Strategies for Chronic Myeloid Leukemia in Chronic Phase After Generic Entry of Imatinib in the United States

Padula, William V. ; Larson, Richard A. ; Dusetzina, Stacie B. ; Apperley, Jane F. ; Hehlmann, Rüdiger ; Baccarani, Michele ; Eigendorff, Ekkehard ; Guilhot, Joëlle ; Guilhot, François ; Mahon, François-Xavier ; Martinelli, Giovanni ; Mayer, Jiri ; Müller, Martin C. ; Niederwieser, Dietger ; Saussele, Susanne ; Schiffer, Charles A. ; Silver, Richard T. ; Simonsson, Bengt ; Conti, Rena M.

Background: We analyzed the cost-effectiveness of treating incident chronic myeloid leukemia in chronic phase (CML-CP) with generic imatinib when it becomes available in United States in 2016. In the year following generic entry, imatinib’s price is expected to drop 70% to 90%. We hypothesized that initiating treatment with generic imatinib in these patients and then switching to the other tyrosine-kinase inhibitors (TKIs), dasatinib or nilotinib, because of intolerance or lack of effectiveness [...]

Mené aux Etats-Unis auprès de 32 couples dont un des partenaires est atteint d'un cancer gastro-intestinal de stade avancé, cet essai randomisé évalue l'efficacité d'une intervention psychosociale par visioconférence destinée à améliorer la communication au sein du couple

A randomized pilot trial of a videoconference couples communication intervention for advanced GI cancer

Porter, Laura S. ; Keefe, Francis J. ; Baucom, Donald H. ; Olsen, Maren ; Zafar, S. Yousuf ; Uronis, Hope

Objective : This study aims to test the feasibility and preliminary efficacy of a couple-based communication intervention for advanced GI cancer delivered via videoconference. Methods : Thirty-two couples were randomly assigned to either couples communication skills training (CCST) or an education comparison intervention, both delivered via videoconference. Participation was limited to couples who reported communication difficulties at screening. Patients and partners completed measures of [...]

Menée à Taïwan auprès de 325 patients atteints d'un cancer en phase terminale, cette étude de cohorte prospective analyse les déterminants psychosociaux associés à leurs préférences relatives aux soins de fin de vie (sentiment d'être un poids pour leur entourage, faibles ressources financières, symptômes sévères de détresse, soutien social, etc)

Impact of high self-perceived burden to others with preferences for end-of-life care and its determinants for terminally ill cancer patients: a prospective cohort study

Tang, Siew Tzuh ; Hsieh, Chia-Hsun ; Chiang, Ming-Chu ; Chen, Jen-Shi ; Chang, Wen-Cheng ; Chou, Wen-Chi ; Hou, Ming-Mo

Background/Objective : Self-perceived burden to others (SPB) is a major concern of terminally ill cancer patients and is frequently factored into end-of-life (EOL) care decision-making. However, changes in and determinants of SPB and its longitudinal impact on preferences for EOL care over the dying process have not been investigated. Our study was aimed at filling this gap in knowledge. Methods : A convenience sample of 325 cancer patients was followed until death. High SPB was identified as [...]