A partir des données de la cohorte "National Institutes of Health-AARP Diet and Health Study" incluant 492 902 participants, cette étude prospective évalue l'association entre une consommation d'alcool et le risque de cancer du poumon, par sous-type histologique (10 227 cas, dont 4 036 adénocarcinomes, 1 998 carcinomes épidermöides, 1 524 carcinomes à petites cellules, 559 carcinomes indifférenciés, 2 110 autres types)

The Association Between Alcohol Consumption and Lung Carcinoma by Histological Subtype

Troche, Jose Ramon ; Mayne, Susan T. ; Freedman, Neal D. ; Shebl, Fatma M. ; Abnet, Christian C.

Alcohol is a carcinogen suspected of increasing lung cancer risk. Therefore, we prospectively evaluated the relationship between alcohol consumption and lung carcinoma in 492,902 persons from the National Institutes of Health-AARP Diet and Health Study. We used Cox models to calculate hazard ratios and 95% confidence intervals, adjusting for tobacco smoking and other potential confounders. Between 1995/1996 and December 31, 2006, there were 10,227 incident cases of lung carcinoma, classified as [...]

Couplée à une cohorte d'employés d'une mine de taconite et incluant 80 cas et 315 témoins, cette étude américaine évalue l'association entre une exposition professionnelle aux minerais et le risque de mésothéliome

A case–control study of mesothelioma in Minnesota iron ore (taconite) miners

Lambert, Christine S ; Alexander, Bruce H ; Ramachandran, Gurumurthy ; MacLehose, Richard F ; Nelson, Heather H ; Ryan, Andrew D ; Mandel, Jeffrey H

Objectives : An excess of mesothelioma has been observed in iron ore miners in Northeastern Minnesota. Mining and processing of taconite iron ore generate exposures that include elongate mineral particles (EMPs) of amphibole and non-amphibole origin. We conducted a nested case–control study of mesothelioma in a cohort of 68 737 iron ore miners (haematite and taconite ore miners) to evaluate the association between mesothelioma, employment and EMP exposures from taconite mining. Methods [...]

Menée en Australie auprès de 1 236 cas et 862 témoins, cette étude évalue l'association entre l'utilisation d'un traitement hormonal substitutif de la ménopause et le risque de cancer du sein

Menopausal hormone therapy use and breast cancer risk in Australia: Findings from the New South Wales Cancer, Lifestyle and Evaluation of Risk study

Salagame, Usha ; Banks, Emily ; Sitas, Freddy ; Canfell, Karen

Randomised controlled trials and large-scale observational studies have found that current use of menopausal hormone therapy (MHT) is associated with an increased risk of breast cancer; this risk is higher for oestrogen–progestagen combination therapy than for oestrogen-only therapy. Our study was designed to estimate MHT-associated breast cancer risk in a population of Australian women. Data were analysed for postmenopausal women with self-reported incident invasive breast cancer (n = 1,236) [...]

Menée en Finlande auprès de 7 000 patientes et 20 000 témoins en population, cette étude évalue l'association entre l'utilisation d'hormones exogènes (dispositif intra-utérin hormonal, contraceptifs hormonaux) et le risque de cancer du sein

Use of exogenous hormones and the risk of breast cancer: results from self-reported survey data with validity assessment

Heikkinen, Sanna ; Koskenvuo, Markku ; Malila, Nea ; Sarkeala, Tytti ; Pukkala, Eero ; Pitkäniemi, Janne

Purpose : Main aim was to estimate the association between use of exogenous hormones and breast cancer (BC) risk in a large population-based survey, and to assess the representativeness and overall validity of the data. Methods : The survey ‘Women’s Health and Use of Hormones’ was conducted in Finland in 2009, including 7,000 BC cases and 20,000 matched population controls. Conditional logistic regression was used to estimate odds ratios and their 95 % confidence interval. For validation, [...]

A partir des données de la cohorte "Health Professionals Follow-Up Study" incluant 32 141 participants, cette étude prospective évalue l'association entre la durée et les troubles du sommeil et le risque de cancer de la prostate (4 261 cas)

Sleep duration and disruption and prostate cancer risk: a 23-year prospective study

Markt, Sarah C. ; Flynn-Evans, Erin E. ; Valdimarsdóttir, Unnur ; Sigurdardottir, Lara G. ; Tamimi, Rulla M. ; Batista, Julie L. ; Haneuse, Sebastien ; Lockley, Steven W. ; Stampfer, Meir ; Wilson, Kathryn M. ; Czeisler, Charles A. ; Rider, Jennifer R. ; Mucci, Lorelei A.

Background: Sleep deficiency is a major public health problem. There are limited human data on whether sleep duration or disruption are risk factors for prostate cancer. Methods: We prospectively followed 32,141 men in the Health Professionals Follow-Up Study (HPFS) who reported their typical sleep duration in 1987, 2000 and 2008. We identified 4,261 incident prostate cancer cases, including 563 lethal cases through 2010. Sleep disruption was assessed in 2004 among 19,639 men, with 930 prostate [...]

Menée en Chine, cette étude évalue l'association entre 74 polymorphismes du gène ADAMTS5 et le risque de carcinome hépatocellulaire lié à l'aflatoxine B1, ainsi que la survie des patients (1 706 cas et 2 270 témoins)

Polymorphisms of a disintegrin and metalloproteinase with thrombospondin motifs 5 and Aflatoxin B1 related-hepatocellular carcinoma

Huang, Xiao-Ying ; Yao, Jin-Guang ; Huang, Bing-Chen ; Ma, Yun ; Xia, Qiang ; Long, Xi-Dai

Background:Altered expression of a disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is observed in hepatocellular carcinoma (HCC). The genetic polymorphisms of this gene in aflatoxin B1 (AFB1)-related HCC have not yet been elucidated. Methods:We conducted a hospital-based case-controlled study, including 1706 HCC cases and 2270 controls without any liver diseases or tumors, to assess the association between 74 polymorphisms in ADAMTS5 and AFB1-related HCC risk and [...]

Menée en France à partir de données portant sur 106 patients atteints d'une papulose lymphomatoïde, cette étude rétrospective analyse les facteurs associés au risque de lymphome (52 cas, période de suivi : 11 ans)

Frequency and Risk Factors for Associated Lymphomas in Patients With Lymphomatoid Papulosis

Cordel, Nadège ; Tressières, Benoît ; D’Incan, Michel ; Machet, Laurent ; Grange, Florent ; Estève, Éric ; Dalac, Sophie ; Ingen-Housz-Oro, Saskia ; Bagot, Martine ; Beylot-Barry, Marie ; Joly, Pascal ; for the French Study Group on Cutaneous Lymphoma

Background : Lymphomatoid papulosis (LyP) is classified as an indolent cutaneous lymphoma, but outcome dramatically worsens if LyP is associated with lymphoma. The frequency of this association remains unclear in the literature. Here, we assess the frequency and risk factors of association between LyP and another lymphoma in an 11-year retrospective study conducted in 8 dermatology departments belonging to the French Study Group on Cutaneous Lymphoma (FSGCL). Patients and Methods : Patients [...]

Menée à l'aide de modélisations mathématiques, cette étude suggère que les facteurs intrinsèques, liés au nombre de divisions des cellules souches dans les tissus, ne contribuent que faiblement au risque de développer un cancer au cours d'une vie

Substantial contribution of extrinsic risk factors to cancer development

Wu, Song ; Powers, Scott ; Zhu, Wei ; Hannun, Yusuf A.

Recent research has highlighted a strong correlation between tissue-specific cancer risk and the lifetime number of tissue-specific stem-cell divisions. Whether such correlation implies a high unavoidable intrinsic cancer risk has become a key public health debate with the dissemination of the ‘bad luck’ hypothesis. Here we provide evidence that intrinsic risk factors contribute only modestly (less than ~10–30% of lifetime risk) to cancer development. First, we demonstrate that the correlation [...]