Menée aux Etats-Unis, cette étude rétrospective analyse l'association entre l'interruption précoce d'un traitement prophylactique par pegfilgrastim (premier cycle reçu) et le risque de neutropénie fébrile induite par la chimiothérapie

Risk of chemotherapy-induced febrile neutropenia with early discontinuation of pegfilgrastim prophylaxis in US clinical practice

Weycker, Derek ; Li, Xiaoyan ; Barron, Rich ; Li, Yanli ; Reiner, Maureen ; Kartashov, Alex ; Figueredo, Jacqueline ; Tzivelekis, Spiros ; Garcia, Jacob

Purpose : Accumulating evidence suggests that not all cancer chemotherapy patients who receive first-cycle pegfilgrastim prophylaxis continue to receive it in subsequent cycles and that these patients may be subsequently at higher risk of febrile neutropenia (FN). Additional evidence from US clinical practice is warranted. Methods : Data from two US private healthcare claims repositories were employed. The source population comprised adults who received “intermediate-risk” or “high-risk” [...]

A partir d'une revue systématique de la littérature, cette étude analyse l'efficacité de diverses interventions pour la prise en charge des douleurs persistantes réfractaires chez les patients atteints de cancer

Interventional options for the management of refractory cancer pain—what is the evidence?

Vayne-Bossert, Petra ; Afsharimani, Banafsheh ; Good, Phillip ; Gray, Paul ; Hardy, Janet

Purpose : Pain is the most common symptom in cancer patients. Standard pain treatment according to the WHO three-step analgesic ladder provides effective pain management in approximately 70–90 % of cancer patients. Refractory pain is defined as not responding to “standard” treatments. Interventional analgesic techniques can be used in an attempt to control refractory pain in patients in whom conventional analgesic strategies fail to provide effective pain relief or are intolerable due to severe [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2015 (37 études), cette méta-synthèse fait le point sur les facteurs entravant ou facilitant le recours à des techniques de préservation de la fertilité chez des patients atteints de cancer

Barriers and facilitators towards fertility preservation care for cancer patients: a meta-synthesis

Panagiotopoulou, N. ; Ghuman, N. ; Sandher, R. ; Herbert, M. ; Stewart, J. A.

Infertility is a potential late-effect of cancer treatment, which negatively impact on young cancer survivors' quality of life. This paper aims to synthesise factors that influence patients', carers’ and healthcare professionals’ decision to engage in fertility preservation programmes at the time of cancer diagnosis. Four databases and grey literature were systematically searched to identify qualitative and mixed-method studies published between 2000 and 2015. Thematic framework and synthesis [...]

Menée aux Etats-Unis par enquête en ligne auprès de 1 788 participants, cette étude analyse les facteurs associés à la prévalence, la persistance et la sévérité de la fatigue chez des patients atteints de néoplasies myéloprolifératives

Comprehensively understanding fatigue in patients with myeloproliferative neoplasms

Scherber, Robyn M. ; Kosiorek, Heidi E. ; Senyak, Zhenya ; Dueck, Amylou C. ; Clark, Matthew M. ; Boxer, Michael A. ; Geyer, Holly L. ; McCallister, Archie ; Cotter, Mary ; Van Husen, Barbara ; Harrison, Claire N. ; Mesa, Ruben A.

BACKGROUND :Patients with myeloproliferative neoplasms (MPNs) experience a high persistence, prevalence, and severity of fatigue. There is currently only limited information regarding factors that contribute to fatigue in patients with MPNs. METHODS : A 70-item, Internet-based survey regarding fatigue was developed by MPN investigators and patients/advocates and hosted by the Mayo Clinic Survey Research Center. RESULTS : Fatigue was found to be prevalent and severe among international survey [...]

Mené aux Etats-Unis aurès de 70 patientes ayant survécu à un cancer du rectum ou de l'anus, cet essai randomisé analyse l'efficacité d'une intervention pédagogique dispensée par téléphone pour améliorer leur qualité de vie psychique et sexuelle

The sexual health of female rectal and anal cancer survivors: results of a pilot randomized psycho-educational intervention trial

DuHamel, Katherine ; Schuler, Tammy ; Nelson, Christian ; Philip, Errol ; Temple, Larissa ; Schover, Leslie ; Baser, RaymondE ; Starr, TatianaD ; Cannon, Kathleen ; Jennings, Sabrina ; Jandorf, Lina ; Carter, Jeanne

Background : Sexual dysfunction is a frequently reported consequence of rectal/anal cancer treatment for female patients. Purpose : The purpose of this study was to conduct a small randomized controlled trial to assess the efficacy of a telephone-based, four-session Cancer Survivorship Intervention-Sexual Health (CSI-SH). Methods : Participants (N = 70) were stratified by chemotherapy, stoma, and menopause statuses before randomization to CSI-SH or assessment only (AO). Participants were [...]

Mené au Canada auprès de 95 patientes atteintes d'un cancer du sein, cet essai randomisé analyse l'efficacité d'une intervention destinée à promouvoir l'activité physique et à inciter les patientes à modifier leurs comportements de santé durant leur chimiothérapie

Exploring the feasibility of a broad-reach physical activity behavior change intervention for women receiving chemotherapy for breast cancer: A randomized trial

Vallance, Jeff K. ; Friedenreich, Christine M. ; Lavallee, Celeste M ; Culos-Reed, Nicole ; Mackey, John R. ; Walley, Barbara ; Courneya, Kerry S.

Background: Facilitating healthy levels of physical activity (PA) during chemotherapy are important for the psychosocial and physical health of breast cancer survivors. The primary objective of this feasibility study was to examine the effects of a broad-reach PA behavior change intervention among women with breast cancer receiving adjuvant chemotherapy. Methods: Breast cancer patients receiving adjuvant chemotherapy (N=95) were randomly assigned to receive a PA resource kit consisting of [...]

A partir d'une revue systématique de la littérature, cette étude analyse les recommandations d'un groupe de travail européen relatives à l'utilisation de bisphosphonates en traitement adjuvant pour prévenir les complications osseuses chez des patientes atteintes d'un cancer du sein de stade précoce

Adjuvant bisphosphonates in early breast cancer: Consensus guidance for clinical practice from a European Panel

Hadji, P. ; Coleman, R.E. ; Wilson, C. ; Powles, T. J. ; Clézardin, P. ; Aapro, M. ; Costa, L. ; Body, J-J. ; Markopoulos, C. ; Santini, D. ; Diel, I. ; Di Leo, A. ; Cameron, D. ; Dodwell, D. ; Smith, I. ; Gnant, M. ; Gray, R. ; Harbeck, N. ; Thürlimann, B. ; Untch, M. ; Cortés, J. ; Martín, M. ; Albert, U-S. ; Conte, P-F. ; Ejlertsen, B. ; Bergh, J. ; Kaufmann, M. ; Holen, I.

Bisphosphonates have been studied in randomised trials in early breast cancer to investigate their ability to prevent cancer treatment induced bone loss and reduce the risk of disease recurrence and metastasis. Treatment benefits have been reported but bisphosphonates do not currently have regulatory approval for either of these potential indications. This consensus paper provides a review of the evidence and offers guidance to breast cancer clinicians on the use of bisphosphonates in early [...]

Menée au Royaume-Uni par enquête auprès de 280 patients ayant survécu à un cancer de la tête et du cou, cette étude transversale analyse les facteurs démographiques, socio-économiques et médicaux associés à leur qualité de vie dans les 5 années suivant la fin des traitements

Predictors of quality of life in head and neck cancer survivors up to 5 years after end of treatment: a cross-sectional survey

Wells, Mary ; Swartzman, Samantha ; Lang, Heidi ; Cunningham, Margaret ; Taylor, Lesley ; Thomson, Jane ; Philp, Julie ; McCowan, Colin

Purpose : This study aimed to assess quality of life (QoL) in head and neck cancer (HNC) survivors and determine factors predictive of poor QoL in the first 5 years after the end of treatment. Methods : A cross-sectional survey, including the Quality of Life in Adult Cancer Survivors (QLACS) measure, was sent to HNC survivors in three Scottish health regions, with responses linked to routinely collected clinical data. Independent sample t tests, ANOVAs, Pearson correlations and multiple [...]

A partir des données du registre californien des cancers sur la période 1988-2010, cette étude analyse l'évolution de l'incidence du carcinome hépatocellulaire de stade précoce, ainsi que la survie des patients (13 855 cas)

Trends in early-stage hepatocellular carcinoma, California 1988–2010

Rodriguez, DanielleN ; Torruellas, Cara ; Cress, RosemaryD

Purpose : California Cancer Registry data were used to explore the impact of hepatocellular carcinoma (HCC) surveillance on patient outcomes. The purpose of this analysis was to determine the trend in diagnosis of early-stage HCC in California from 1988 to 2010. Methods : Patients 20+ years old, diagnosed with early HCC during 1988–2010 in California, were included. Stratified proportions of early HCC were evaluated to estimate any trends and significant disparities. The primary endpoint was [...]

Menée en France à partir de données portant sur 4 688 individus travaillant dans le secteur de l'enrichissement de l'uranium entre 1964 et 2006 et exposés à des composés d'uranium rapidement solubles, cette étude de cohorte évalue l'évolution de la mortalité par cancer sur la période 1968-2008

Mortality (1968–2008) in a French cohort of uranium enrichment workers potentially exposed to rapidly soluble uranium compounds

Zhivin, Sergey ; Guseva Canu, Irina ; Samson, Eric ; Laurent, Olivier ; Grellier, James ; Collomb, Philippe ; Zablotska, Lydia B ; Laurier, Dominique

Objectives : Until recently, enrichment of uranium for civil and military purposes in France was carried out by gaseous diffusion using rapidly soluble uranium compounds. We analysed the relationship between exposure to soluble uranium compounds and exposure to external γ-radiation and mortality in a cohort of 4688 French uranium enrichment workers who were employed between 1964 and 2006. Methods : Data on individual annual exposure to radiological and non-radiological hazards were collected [...]

A partir de données de consommation médicamenteuse et de données du registre finandais des cancers portant sur 8 197 patients ayant survécu à un cancer diagnostiqué avant l'âge de 35 ans et auprès de 29 974 témoins, cette étude analyse la prévalence de morbidités cardiovasculaires

Cardiovascular medication after cancer at a young age in Finland: A nationwide registry linkage study

Kero, A. E. ; Madanat-Harjuoja, L. M. ; Järvelä, L. S. ; Malila, N. ; Matomäki, J. ; Lähteenmäki, P. M.

Despite improved survival rates, childhood and young adult (YA) cancer survivors face elevated risks for life-threatening morbidities, especially cardiovascular complications. Our nationwide Finnish registry study investigated the purchases of cardiovascular medication from 1993 to 2011 in patients diagnosed with cancer aged below 35 years (N = 8,197) between 1993 and 2004 compared to siblings (N = 29,974) via linkage to the drug purchase registry. The cumulative incidence for purchasing [...]

A partir des données de la cohorte "Women's Health Initiative", cette étude évalue l'association entre un diabète, une utilisation de metformine et le risque de cancer chez les femmes après la ménopause, ainsi que la mortalité par cancer, en fonction de la durée du traitement antidiabétique

Diabetes, metformin and incidence of and death from invasive cancer in postmenopausal women: Results from the Women's Health Initiative

Gong, Zhihong ; Aragaki, Aaron K. ; Chlebowski, Rowan T. ; Manson, JoAnn E. ; Rohan, Thomas E. ; Chen, Chu ; Vitolins, Mara Z. ; Tinker, Lesley F. ; LeBlanc, Erin S. ; Kuller, Lewis H. ; Hou, Lifang ; LaMonte, Michael J. ; Luo, Juhua ; Wactawski-Wende, Jean

Findings from studies of metformin use with risk of cancer incidence and outcome provide mixed results; with few studies examined associations by recency of diabetes diagnosis or duration of medication use. Thus, in the Women's Health Initiative, we examined these associations and further explored whether associations differ by recency of diabetes and duration of metformin use. Cox regression models were used to estimate hazard ratios (HR) and their 95% confidence intervals. Diabetes was [...]

Menée en Suède à partir de données portant sur 449 patientes atteintes d'un lymphome hodgkinien diagnostiqué entre 1992 et 2009, cette étude évalue l'association entre une grossesse survenue après le diagnostic et le risque de récidive de la maladie dans les 5 années suivant la naissance de l'enfant

Pregnancy and the Risk of Relapse in Patients Diagnosed With Hodgkin Lymphoma

Weibull, Caroline E. ; Eloranta, Sandra ; Smedby, Karin E. ; Björkholm, Magnus ; Kristinsson, Sigurdur Y. ; Johansson, Anna L.V. ; Dickman, Paul W. ; Glimelius, Ingrid

Purpose : Many patients and clinicians are worried that pregnancy after the diagnosis of Hodgkin lymphoma (HL) may increase the risk of relapse despite a lack of empirical evidence to support such concerns. We investigated if an association exists between pregnancy and relapse in women with a diagnosis of HL. Materials and Methods : Using Swedish healthcare registers combined with medical records, we included 449 women who received a diagnosis of HL between 1992 and 2009 and who were age 18 to [...]

Menée aux Etats-Unis à partir de données portant sur 16 888 patients atteints d'un cancer de la prostate, cette étude évalue l'association entre une hormonothérapie anti-androgénique et le risque ultérieur de maladie d'Alzheimer

Androgen Deprivation Therapy and Future Alzheimer’s Disease Risk

Nead, Kevin T. ; Gaskin, Greg ; Chester, Cariad ; Swisher-McClure, Samuel ; Dudley, Joel T. ; Leeper, Nicholas J. ; Shah, Nigam H.

Purpose : To test the association of androgen deprivation therapy (ADT) in the treatment of prostate cancer with subsequent Alzheimer’s disease risk. Methods : We used a previously validated and implemented text-processing pipeline to analyze electronic medical record data in a retrospective cohort of patients at Stanford University and Mt. Sinai hospitals. Specifically, we extracted International Classification of Diseases-9th revision diagnosis and Current Procedural Terminology codes, [...]

Menée aux Etats-Unis auprès de 634 patients atteints d'un cancer colorectal, cette étude de cohorte évalue l'association entre une obésité sévère, pré-existante au diagnostic, le risque de récidive et la survie des patients

Severe obesity prior to diagnosis limits survival in colorectal cancer patients evaluated at a large cancer centre

Daniel, C. R. ; Shu, X. ; Ye, Y. ; Gu, J. ; Raju, G. S. ; Kopetz, S. ; Wu, X.

Background: In contrast to the consistent evidence for obesity and colorectal cancer (CRC) risk, the impact of obesity in CRC patients is less clear. In a well-characterised cohort of CRC patients, we prospectively evaluated class I and class II obesity with survival outcomes. Methods: The CRC patients (N=634) were followed from the date of diagnosis until disease progression/first recurrence (progression-free survival (PFS)) or death (overall survival (OS)). Body mass index (BMI) was [...]

Menée au Royaume-Uni à partir de données portant sur 317 patients atteints de glioblastome, cette étude de cohorte rétrospective analyse l'évolution de la survie des patients sur la période 1999-2010

Has the survival of patients with glioblastoma changed over the years?

deSouza, R. M. ; Shaweis, H. ; Han, C. ; Sivasubramiam, V. ; Brazil, L. ; Beaney, R. ; Sadler, G. ; Al-Sarraj, S. ; Hampton, T. ; Logan, J. ; Hurwitz, V. ; Bhangoo, R. ; Gullan, R. ; Ashkan, K.

Background : Over the last decade, the approach to the management of brain tumours and the understanding of glioblastoma tumour biology has advanced and a number of therapeutic interventions have evolved, some of which have shown statistically significant effects on overall survival (OS) and progression-free survival in glioblastoma. The aim of this study is to compare survival in glioblastoma patients over a 10-year period (1999–2000 and 2009–2010). Methods: A retrospective cohort study was [...]

Menée aux Etats-Unis, cette étude cas-témoins analyse les capacités d'apprentissage et de mémorisation chez des patientes ayant survécu à un cancer du sein, 2 à 6 ans après la fin des traitements

Learning and memory performance in breast cancer survivors 2 to 6 years post-treatment: the role of encoding versus forgetting

Root, JamesC ; Andreotti, Charissa ; Tsu, Loretta ; Ellmore, TimothyM ; Ahles, TimA

Purpose : Our previous retrospective analysis of clinically referred breast cancer survivors’ performance on learning and memory measures found a primary weakness in initial encoding of information into working memory with intact retention and recall of this same information at a delay. This suggests that survivors may misinterpret cognitive lapses as being due to forgetting when, in actuality, they were not able to properly encode this information at the time of initial exposure. Our objective [...]

Menée en Italie par questionnaire auprès de 276 patients atteints d'un cancer, cette étude met en évidence l'importance d'un dialogue rassurant avec le médecin, les proches et les patients atteints de la même maladie, pour entretenir l'espoir (mesuré par l'indicateur de Herth)

Is it possible to encourage hope in non-advanced cancer patients? We must try

Ripamonti, C.I ; Miccinesi, G. ; Pessi, M.A. ; Di Pede, P. ; Ferrari, M.

Background : Data are lacking on the relationship between hope and other variables in non-advanced cancer patients. The study explored the relationship between hope, symptoms, needs and, spirituality/religiosity in patients treated in a Supportive Care Unit (SCU). Methods : From September 2013 to March 2014 the consecutive patients who accepted to complete: 1. Needs evaluation questionnaire (NEQ) 2. The Edmonton Symptom Assessment System (ESAS) 3. Hope Herth Index (HHI) 4. The System of Belief [...]

Menée aux Etats-Unis auprès de 103 patients atteints d'un gliome du lobe temporal, cette étude analyse l'association entre des troubles de l'humeur ou des symptômes dépressifs, leur fonctionnement neurocognitif (apprentissage, mémoire, langage, etc.) et leur qualité de vie

Relationships between neurocognitive functioning, mood, and quality of life in patients with temporal lobe glioma

Noll, Kyle R. ; Bradshaw, Mariana E. ; Weinberg, Jeffrey S. ; Wefel, Jeffrey S.

Objective : While neurocognitive functioning (NCF) and mood disturbance share a relationship with health-related quality of life (HRQOL), few studies have examined relationships between these constructs in glioma patients prior to treatment. Methods : Newly diagnosed patients with glioma in the left (N = 73; 49% glioblastoma) or right (N = 30; 57% glioblastoma) temporal lobe completed neuropsychological testing and self-report measures of HRQOL (Functional Assessment of Cancer Therapy [...]

Cet article évalue le rapport coût-efficacité des techniques de séquençage du génome dans le diagnostic et les traitements des patients

Assessing the Costs and Cost-Effectiveness of Genomic Sequencing

Christensen, Kurt ; Dukhovny, Dmitry ; Siebert, Uwe ; Green, Robert

Despite dramatic drops in DNA sequencing costs, concerns are great that the integration of genomic sequencing into clinical settings will drastically increase health care expenditures. This commentary presents an overview of what is known about the costs and cost-effectiveness of genomic sequencing. We discuss the cost of germline genomic sequencing, addressing factors that have facilitated the decrease in sequencing costs to date and anticipating the factors that will drive sequencing costs in [...]

Menée en Suisse par entretiens auprès de 17 patients atteints de cancer et âgés de 9 à 17 ans, cette étude analyse leurs expériences relatives aux échanges avec leur médecin lors du diagnostic de la maladie et leur éventuelle participation dans la prise de décision thérapeutique

Participation in pediatric oncology: views of child and adolescent patients

Ruhe, Katharina M. ; Badarau, Domnita O. ; Brazzola, Pierluigi ; Hengartner, Heinz ; Elger, Bernice S. ; Wangmo, Tenzin ; for the Swiss Pediatric Oncology, Group

Objective : The aim of the present study is to explore patient's perspectives in pediatric oncology on participation in discussions and decision-making surrounding their cancer diagnosis. Methods : Seventeen patients between 9 and 17 years of age receiving treatment at centers of the Swiss Pediatric Oncology Group were interviewed for this study. Their interview data was analyzed qualitatively to identify themes with regard to participation in medical communication and/or decision-making. [...]

Menée en France par questionnaire auprès de 500 médecins généralistes, cette étude prospective analyse leur rôle dans le dispositif d'annonce du cancer

Primary care physicians and oncologists are partners in cancer announcement

Rougé Bugat, Marie-Eve ; Omnes, Christelle ; Delpierre, Cyrille ; Escourrou, Emile ; Boussier, Nathalie ; Oustric, Stéphane ; Delord, Jean-Pierre ; Bauvin, Eric ; Grosclaude, Pascale

Purpose : The primary care physician (PCP) is central to cancer patients’ management. Announcement of the diagnosis is a critical time for patients, even if they wish to be fully informed. The French National Cancer Plan, developed 10 years ago, includes a diagnosis disclosure procedure (DDP) to be used by oncologists, which makes specific provision for a time of communication with PCPs. So, we asked PCPs about their role in cancer announcement since the launching of the DDP. Methods : A [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2012 (20 études), cette étude analyse les préférences des patients atteints d'un cancer du poumon concernant leur participation dans la prise de décision thérapeutique

Preferences of lung cancer patients for treatment and decision-making: a systematic literature review

Schmidt, K. ; Damm, K. ; Prenzler, A. ; Golpon, H. ; Welte, T.

The consideration of patient preferences in decision-making has become more important, especially for life-threatening diseases such as lung cancer. This paper aims to identify the preferences of lung cancer patients with regard to their treatment and involvement in the decision-making process. We conducted a systematic literature review from 12 electronic databases and included studies published between 2000 and 2012. A total of 20 studies were included in this review. These revealed that lung [...]

Menée au Brésil auprès de 48 patientes atteintes d'un cancer du sein et recevant un traitement chirurgical, cette étude analyse l'efficacité de l'acupuncture pour soulager les troubles physiques et fonctionnels (douleurs, amplitude du mouvement, fonctions du membre supérieur, symptômes dépressifs)

Effectiveness of acupuncture in rehabilitation of physical and functional disorders of women undergoing breast cancer surgery

Giron, PatriciaSantolia ; Haddad, CiniraAssadSimão ; Lopes de Almeida Rizzi, SamanthaKarlla ; Nazário, AfonsoCelsoPinto ; Facina, Gil

Purpose : The purpose of the study is to verify the effectiveness of acupuncture in rehabilitation of physical and functional disorders of women undergoing breast cancer surgery on the following parameters: pain, range of motion, upper limb function, and depressive symptoms. Methods : The following are the inclusion criteria: women aged more than 18 years with scapular girdle and upper limb pain after 3 months of surgery and with pain ≥3 in visual analog scale. Patients were divided into two [...]