Menée en Afrique du sud auprès de 49 patients et de 21 témoins, cette étude analyse les effets des traitements anti-cancéreux sur la prévalence d'une infection buccale par "Candida albicans"

Influence of cancer treatment on the Candida albicans isolated from the oral cavities of cancer patients

Ramla, Shilpa ; Sharma, Vinay ; Patel, Mrudula

Purpose : Cancer treatment causes mucositis and the manifestation of oral candidiasis. This study investigated the virulence properties and antifungal susceptibilities of Candida albicans isolated from cancer patients undergoing therapy. Methods : C. albicans were isolated from 49 patients on cancer treatment and 21 healthy individuals and their virulence attributes measured. A correlation was determined between the length of treatment and the fungal counts and their virulence factors. Results [...]

Mené au Royaume-Uni auprès de 163 patients atteints de cancer, cet essai randomisé analyse l'efficacité d'une intervention en ligne pour améliorer leurs capacités à prendre en charge leurs symptômes de fatigue après un traitement curatif

A web-based intervention (RESTORE) to support self-management of cancer-related fatigue following primary cancer treatment: a multi-centre proof of concept randomised controlled trial

Foster, Claire ; Grimmett, Chloe ; May, ChristineM ; Ewings, Sean ; Myall, Michelle ; Hulme, Claire ; Smith, PeterW ; Powers, Cassandra ; Calman, Lynn ; Armes, Jo ; Breckons, Matthew ; Corner, Jessica ; Fenlon, Deborah ; Batehup, Lynn ; Lennan, Elaine ; R. May, Carl ; Morris, Carolyn ; Neylon, Amanda ; Ream, Emma ; Turner, Lesley ; Yardley, Lucy ; Richardson, Alison

Purpose : Cancer-related fatigue (CRF) is a frequent and distressing symptom experienced after cancer treatment. RESTORE is the first web-based resource designed to enhance self-efficacy to manage CRF following curative-intent treatment. The aim of this study is to test the proof of concept and inform the design of an effectiveness trial. Methods : A multi-centre parallel-group two-armed (1:1) exploratory randomised controlled trial (RCT) with qualitative process evaluation was employed in the [...]

Menée aux Etats-Unis auprès de 90 patients ayant reçu une greffe de cellules souches hématopoïétiques, cette étude prospective longitudinale analyse l'association entre la détérioration de leur qualité de vie, mesurée six mois après la greffe, et des symptômes de stress post-traumatique

Quality of life and mood predict posttraumatic stress disorder after hematopoietic stem cell transplantation

El-Jawahri, Areej R. ; Vandusen, Harry B. ; Traeger, Lara N. ; Fishbein, Joel N. ; Keenan, Tanya ; Gallagher, Emily R. ; Greer, Joseph A. ; Pirl, William F. ; Jackson, Vicki A. ; Spitzer, Thomas R. ; Chen, Yi-Bin A. ; Temel, Jennifer S.

BACKGROUND During hospitalization for hematopoietic stem cell transplantation (HCT), patients experience a steep deterioration in quality of life (QOL) and mood. To our knowledge, the impact of this deterioration on patients' QOL and posttraumatic stress disorder (PTSD) symptoms after HCT is unknown. METHODS We conducted a prospective longitudinal study of patients hospitalized for HCT. They assessed QOL using the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation (FACT-BMT) [...]

Menée aux Pays-Bas auprès de 156 patients atteints d'un myélome multiple diagnostiqué entre 2000 et 2014, cette étude analyse l'efficacité d'un outil permettant d'évaluer une neuropathie induite par la chimiothérapie ainsi que son association avec la qualité de vie des patients

Chemotherapy-induced neuropathy in multiple myeloma: influence on quality of life and development of a questionnaire to compose common toxicity criteria grading for use in daily clinical practice

Beijers, A. J. M. ; Vreugdenhil, G. ; Oerlemans, S. ; Eurelings, M. ; Minnema, M. C. ; Eeltink, C. M. ; van de Poll-Franse, L. V. ; Mols, F.

Purpose : Chemotherapy-induced peripheral neuropathy (CIPN) may negatively influence multiple myeloma (MM) patients’ health-related quality of life (HRQOL). Dose modification is the only way to minimize CIPN. To measure CIPN in daily practice, the Indication for Common Toxicity Criteria (CTC) Grading of Peripheral Neuropathy Questionnaire (ICPNQ) was developed which can be completed within five minutes by the patient. The aims of this study were to (1) perform a psychometric evaluation of the [...]

Menée en Suède auprès de 692 patientes ayant survécu à un cancer du sein et âgées de 20 à 63 ans, cette étude évalue les facteurs associés à leur qualité de vie au travail et à leur satisfaction professionnelle, dans les deux années suivant un traitement chirurgical mammaire

Changes in importance of work and vocational satisfaction during the 2 years after breast cancer surgery and factors associated with this

Nilsson, MarieI ; Saboonchi, Fredrik ; Alexanderson, Kristina ; Olsson, Mariann ; Wennman-Larsen, Agneta ; Petersson, Lena-Marie

Purpose : The purpose of this study is to investigate how women, during the 2 years following breast cancer surgery, rate importance of work and vocational satisfaction, and baseline factors associated with rating over time. Methods : A prospective cohort study of 692 women aged 20–63 included about 4 weeks after a first breast cancer surgery. Register data on treatment and data from six repeated questionnaires during a 2-year follow-up (at baseline, 4, 8, 12, 18, 24 months) were used in [...]

A partir d'une revue systématique de la littérature (25 études), cette étude analyse les effets indésirables sur le squelette d'une hormonothérapie de type lévothyroxine chez des patients atteints d'un cancer de la thyroïde

Effect of Thyrotropin Suppression Therapy on Bone in Thyroid Cancer Patients

Papaleontiou, Maria ; Hawley, Sarah T. ; Haymart, Megan R.

The thyroid cancer incidence is rising. Despite current guidelines, controversy exists regarding the degree and duration of thyrotropin suppression therapy. Also, its potential skeletal effects remain a concern to physicians caring for thyroid cancer patients. We conducted a review of published data to evaluate existing studies focusing on the skeletal effects of thyrotropin suppression therapy in thyroid cancer patients.A systematic search of the PubMed, Ovid/Medline, and Cochrane Central [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2014 (6 études, 114 105 participants), cette méta-analyse évalue l'association entre un syndrome d'apnées obstructives du sommeil, le risque de cancer et la mortalité par cancer

Obstructive sleep apnoea and the incidence and mortality of cancer: a meta-analysis

Zhang, Xiao-Bin ; Peng, Li-Hong ; Lyu, Zhi ; Jiang, Xing-Tang ; Du, Yan-Ping

As there are conflicting reports regarding the association between obstructive sleep apnoea (OSA) and cancer incidence and mortality, a meta-analysis was performed to evaluate whether OSA is independently associated with cancer incidence and mortality. Pubmed, EMBASE and Web of Science were searched up until November 2014. Studies that assessed OSA and the future risk of cancer incidence or mortality were included. Pooled hazard ratios (HR) and corresponding 95% confidence intervals (CI) were [...]

Menée aux Etats-Unis auprès de 1 337 participantes, cette étude de cohorte évalue l'association entre la sévérité d'une maladie parodontale et le risque de cancer après la ménopause (203 cas, durée moyenne de suivi : 12, 2 ans)

Periodontal disease severity and cancer risk in postmenopausal women: the Buffalo OsteoPerio Study

Mai, Xiaodan ; LaMonte, MichaelJ ; Hovey, KathleenM ; Freudenheim, JoL ; Andrews, ChristopherA ; Genco, RobertJ ; Wactawski-Wende, Jean

Purpose : Few prospective studies have reported on relationships between objective periodontal disease (PD) measures and cancer risk. This association was examined in 1,337 postmenopausal women participating in the Buffalo OsteoPerio Study. Methods : Oral alveolar crestal height (ACH) was measured using oral radiographs. Incident cancers were adjudicated with medical records. Hazard ratios (HRs) and 95 % confidence intervals (CIs) for associations between ACH and incident cancer outcomes were [...]

Menée aux Etats-Unis à partir de données portant sur 16 888 patients atteints d'un cancer de la prostate, cette étude de cohorte rétrospective évalue l'association entre une thérapie anti-androgénique (2 397 patients) et le risque ultérieur de maladie d'Alzheimer

Androgen Deprivation Therapy and Future Alzheimer’s Disease Risk

Nead, Kevin T. ; Gaskin, Greg ; Chester, Cariad ; Swisher-McClure, Samuel ; Leeper, Nicholas J. ; Shah, Nigam H.

Purpose : To test the association of androgen deprivation therapy (ADT) in the treatment of prostate cancer with subsequent Alzheimer’s disease risk. Methods : We used a previously validated and implemented text-processing pipeline to analyze electronic medical record data in a retrospective cohort of patients at Stanford University and Mt. Sinai hospitals. Specifically, we extracted International Classification of Diseases-9th revision diagnosis and Current Procedural Terminology codes, [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution de l'incidence du cancer de la prostate, en fonction de l'âge du patient (50-69 ans, ou 70 ans et plus) et du stade de la maladie, sur la période 1995-2012

Trends in United States prostate cancer incidence rates by age and stage, 1995-2012

Hoffman, Richard M. ; Meisner, Angela ; Arap, Wadih ; Barry, Marc ; Shah, Satyan ; Zeliadt, Steven ; Wiggins, Charles L.

Background: The advent of PSA testing in the late 1980s substantially increased prostate cancer incidence rates. Concerns about overscreening and overdiagnosis subsequently led professional guidelines (circa 2000 and later) to recommend against routine PSA testing. We evaluated trends in prostate cancer incidence, including late-stage diagnoses, from 1995 through 2012. Methods: We used joinpoint regression analyses to evaluate all-, localized/regional-, and distant-stage prostate cancer [...]

Menée aux Etats-Unis à partir de données portant sur 16 887 patientes ayant survécu à un cancer du sein diagnostiqué entre 1996 et 2007, cette étude évalue l'association entre l'utilisation concomitante du tamoxifène et de médicaments antidépresseurs et le risque de récidive de la maladie ou de cancer du sein controlatéral (durée de suivi : 14 ans)

Tamoxifen and Antidepressant Drug Interaction in a Cohort of 16 887 Breast Cancer Survivors

Haque, Reina ; Shi, Jiaxiao ; Schottinger, Joanne E. ; Ahmed, Syed A. ; Cheetham, T. Craig ; Chung, Joanie ; Avila, Chantal ; Kleinman, Ken ; Habel, Laurel A. ; Fletcher, Suzanne W. ; Kwan, Marilyn L.

Background: Controversy persists about whether certain antidepressants reduce tamoxifen’s effectiveness on lowering breast cancer recurrence. We investigated whether taking tamoxifen and antidepressants (in particular, paroxetine) concomitantly is associated with an increased risk of recurrence or contralateral breast cancer. Methods: We examined 16 887 breast cancer survivors (TNM stages 0–II) diagnosed between 1996 and 2007 and treated with tamoxifen in two California health plans. Women were [...]

Menée aux Etats-Unis auprès de patientes traitées pour un cancer du sein, cette étude de cohorte évalue l'association entre divers facteurs, notamment des prélévements sanguins, des injections, des prises de tension artérielle, de la cellulite dans le bras, des voyages en avion, et le risque de lymphœdème

Impact of Ipsilateral Blood Draws, Injections, Blood Pressure Measurements, and Air Travel on the Risk of Lymphedema for Patients Treated for Breast Cancer

Ferguson, Chantal M. ; Swaroop, Meyha N. ; Horick, Nora ; Skolny, Melissa N. ; Miller, Cynthia L. ; Jammallo, Lauren S. ; Brunelle, Cheryl ; O’Toole, Jean A. ; Salama, Laura ; Specht, Michelle C. ; Taghian, Alphonse G.

Purpose : The goal of this study was to investigate the association between blood draws, injections, blood pressure readings, trauma, cellulitis in the at-risk arm, and air travel and increases in arm volume in a cohort of patients treated for breast cancer and screened for lymphedema. Patients and Methods : Between 2005 and 2014, patients undergoing treatment of breast cancer at our institution were screened prospectively for lymphedema. Bilateral arm volume measurements were performed [...]

Menée en Allemagne auprès de 361 patients atteints de mélanome, cette étude analyse les disparités entre les besoins en soins de support auto-rapportés par les patients et ceux déclarés par les médecins

Comparison of patient-reported need of psycho-oncologic support and the doctor's perspective: how do they relate to disease severity in melanoma patients?

Nolte, Sandra ; van der Mei, Sicco H. ; Strehl-Schwarz, Kerstin ; Köster, Johanna ; Bender, Armin ; Rose, Matthias ; Kruse, Johannes ; Peters, Eva M. J.

Objective : Psycho-neuro-immune research suggests an association between cancer outcomes and psychosocial distress. Objective criteria to determine patients' levels of distress are important to establish potential links to disease outcomes. Methods : We compared three patient-reported with one doctor-reported measures of psycho-oncologic distress frequently used in routine cancer care and investigated associations with standard disease severity parameters in melanoma patients. We enrolled [...]

A partir d'une revue systématique de la littérature (24 études, 3 623 patients), cette méta-analyse évalue la prévalence d'une dépression et de symptômes d'anxiété chez des patientes atteintes d'un cancer de l'ovaire, avant, pendant et après les traitements

Depression and anxiety in ovarian cancer: a systematic review and meta-analysis of prevalence rates

Watts, Sam ; Prescott, Philip ; Mason, Jessica ; McLeod, Natalie ; Lewith, George

Objectives : To systematically review the literature pertaining to the prevalence of depression and anxiety in patients with ovarian cancer as a function of treatment stage. Design : Systematic review and meta-analysis. Participants : 3623 patients with ovarian cancer from primary research investigations.Primary outcome measure The prevalence of depression and anxiety in patients with ovarian cancer as a function of treatment stage. Results : We identified 24 full journal articles that met the [...]

Menée aux Pays-Bas par questionnaire auprès de 152 participants, cette étude prospective analyse les effets psychologiques (anxiété, dépression) d'examens annuels d'imagerie chez des individus à risque élevé de développer un cancer du pancréas

Repeated participation in pancreatic cancer surveillance by high-risk individuals imposes low psychological burden

Konings, Ingrid C.   A.   W. ; Sidharta, Grace N. ; Harinck, Femme ; Aalfs, Cora M. ; Poley, Jan-Werner ; Kieffer, Jacobien M. ; Kuenen, Marianne A. ; Smets, Ellen M.   A. ; Wagner, Anja ; van Hooft, Jeanin E. ; van Rens, Anja ; Fockens, Paul ; Bruno, Marco J. ; Bleiker, Eveline M.   A.

Background : When assessing the feasibility of surveillance for pancreatic cancer (PC), it is important to address its psychological burden. The aim of this ongoing study is to evaluate the psychological burden of annual pancreatic surveillance for individuals at high risk to develop PC. Methods : This is a multicenter prospective study. High-risk individuals who undergo annual pancreatic surveillance with magnetic resonance imaging (MRI) and endoscopic ultrasound (EUS) were invited to complete [...]

Menée en Allemagne à partir de l'analyse de 30 consultations enregistrées sur vidéo, cette étude qualitative analyse le rôle de l'épouse dans le choix d'une prostatectomie radicale pour son mari atteint d'un cancer de la prostate

The complex interplay of physician, patient, and spouse in preoperative counseling for radical prostatectomy: a comparative mixed-method analysis of 30 videotaped consultations

Huber, Johannes ; Streuli, Jürg C. ; Lozankovski, Novica ; Stredele, Regina J. F. ; Moll, Peter ; Hohenfellner, Markus ; Huber, Christian G. ; Ihrig, Andreas ; Peters, Tim

Objectives: Spouses of cancer patients play a crucial role in deciding on therapeutic choices. The aim of our study was to assess their role in counseling for radical prostatectomy. Methods : We analyzed 30 videotaped preoperative consultations prior to radical prostatectomy. Thereof, 14 included the patients' female partner and 16 took place without partner attendance. We performed quantitative and qualitative conversation analysis to compare both settings. Results : Mean age of patients was [...]

Menée aux Etats-Unis par questionnaires auprès de 1 202 patients adultes ayant survécu à un cancer, cette étude analyse les facteurs associés à leurs difficultés financières en lien avec la maladie, les traitements ou leurs effets indésirables

Financial Hardship Associated With Cancer in the United States: Findings From a Population-Based Sample of Adult Cancer Survivors

Yabroff, K. Robin ; Dowling, Emily C. ; Guy, Gery P. ; Banegas, Matthew P. ; Davidoff, Amy ; Han, Xuesong ; Virgo, Katherine S. ; McNeel, Timothy S. ; Chawla, Neetu ; Blanch-Hartigan, Danielle ; Kent, Erin E. ; Li, Chunyu ; Rodriguez, Juan L. ; de Moor, Janet S. ; Zheng, Zhiyuan ; Jemal, Ahmedin ; Ekwueme, Donatus U.

Purpose : To estimate the prevalence of financial hardship associated with cancer in the United States and identify characteristics of cancer survivors associated with financial hardship. Methods : We identified 1,202 adult cancer survivors diagnosed or treated at ≥ 18 years of age from the 2011 Medical Expenditure Panel Survey Experiences With Cancer questionnaire. Material financial hardship was measured by ever (1) borrowing money or going into debt, (2) filing for bankruptcy, (3) being [...]

A partir d'une revue de la littérature publiée entre 1991 et 2012, cette étude analyse l'association entre des financements d'études par l'industrie pharmaceutique et leurs résultats en matière de rapport coût-efficacité de divers traitements du cancer du sein

Associations between industry sponsorship and results of cost-effectiveness analyses of drugs used in breast cancer treatment

Lane, J. D. ; Friedberg, M. W. ; Bennett, C. L.

This study describes the association between pharmaceutical industry–sponsored studies and findings from cost-effectiveness analyses of drugs used in breast cancer treatment. A 1999 investigation found that industry sponsorship of cost-effectiveness analyses (CEAs) for oncology drugs was associated with lower likelihood of reporting unfavorable conclusions relative to CEAs with other sponsorship. Over the past 15 years, the CEA literature for oncology drugs has expanded dramatically, and [...]

Menée en France par questionnaire auprès de 60 patients atteints de cancer et auprès de leurs aidants familiaux, cette étude analyse les facteurs associés à la détresse psychologique de chacun des membres de la dyade pendant les soins palliatifs

Crossed views of burden and emotional distress of cancer patients and family caregivers during palliative care

Leroy, Tanguy ; Fournier, Emmanuelle ; Penel, Nicolas ; Christophe, Véronique

Objective : Studies regarding natural caregivers' burden (CB) in palliative situations, as well as its determinants and consequences, have been numerous during the last 20 years. Yet, studies regarding how terminally ill cancer patients perceive their CB (self-perceived burden, SPB) are less common. This study aims to assess the links between CB and SPB evaluated by means of the very same items. It also aims at identifying the determinants of potential differences between CB and SPB and their [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2015 (237 études), cette étude présente les recommandations de l'"American Cancer Society" et de l'"American Society of Clinical Oncology" en matière de prise en charge et de suivi des patientes ayant survécu à un cancer du sein

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline

Runowicz, Carolyn D. ; Leach, Corinne R. ; Henry, N. Lynn ; Henry, Karen S. ; Mackey, Heather T. ; Cowens-Alvarado, Rebecca L. ; Cannady, Rachel S. ; Pratt-Chapman, Mandi L. ; Edge, Stephen B. ; Jacobs, Linda A. ; Hurria, Arti ; Marks, Lawrence B. ; LaMonte, Samuel J. ; Warner, Ellen ; Lyman, Gary H. ; Ganz, Patricia A.

The purpose of the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline is to provide recommendations to assist primary care and other clinicians in the care of female adult survivors of breast cancer. A systematic review of the literature was conducted using PubMed through April 2015. A multidisciplinary expert workgroup with expertise in primary care, gynecology, surgical oncology, medical oncology, radiation oncology, and nursing was formed [...]