Menée au Danemark à partir de données portant sur 41 participantes, cette étude de cohorte rétrospective analyse l'efficacité d'une greffe de tissu ovarien cryopréservé pour préserver la fonction ovarienne et la fertilité de patientes ayant survécu à un cancer

Outcomes of transplantations of cryopreserved ovarian tissue to 41 women in Denmark

Jensen, A.K. ; Kristensen, S.G. ; Macklon, K.T. ; Jeppesen, J.V. ; Fedder, J. ; Ernst, E. ; Andersen, C.Y.

STUDY QUESTION What are the results of transplanting cryopreserved ovarian tissue? SUMMARY ANSWER The transplanted ovarian tissue can last up to 10 years, with no relapses following the 53 transplantations, and the chance of a successful pregnancy is currently around one in three for those with a pregnancy-wish. WHAT IS KNOWN ALREADY Cryopreservation of ovarian tissue is now gaining ground as a valid method for fertility preservation. More than 36 children worldwide have now been born following [...]

Mené en Corée auprès de 60 patientes atteintes d'un cancer du sein, cet essai randomisé de phase II/III détermine la dose adéquate et évalue l'efficacité du pegteograstim pour prévenir une neutropénie induite par la chimiothérapie

A randomized, multicenter, phase II/III study to determine the optimal dose and to evaluate the efficacy and safety of pegteograstim (GCPGC) on chemotherapy-induced neutropenia compared to pegfilgrastim in breast cancer patients: KCSG PC10-09

Lee, KiHyeong ; Kim, Ji-Yeon ; Lee, MoonHee ; Han, HyeSook ; Lim, JooHan ; Park, KeonUk ; Park, InHae ; Cho, EunKyung ; Yoon, SoYoung ; Kim, JeeHyun ; Choi, InSil ; Park, JaeHoo ; Choi, YoungJin ; Kim, Hee-Jun ; Jung, KyungHae ; Kim, Si-Young ; Oh, Do-Youn ; Im, Seock-Ah

Purpose : Pegylated granulocyte-colony-stimulating factor (G-CSF) is frequently used to prevent febrile neutropenia (FN) in patients undergoing chemotherapy with a high risk of myelosuppression. This phase II/III study was conducted to determine the adequate dose of pegteograstim, a new formulation of pegylated G-CSF, and to evaluate the efficacy and safety of pegteograstim compared to pegfilgrastim. Methods : In the phase II part, 60 breast cancer patients who were undergoing DA (docetaxel and [...]

A partir des données du registre finlandais des cancers et menée par entretiens qualitatifs auprès de 21 patients ayant survécu plus de 5 ans à des tumeurs cérébrales pédiatriques, cette étude analyse leur qualité de vie, en prenant en compte leurs difficultés dans la vie quotidienne, leur état psychologique, leurs déficiences d'apprentissage, leurs relations sociales

Quality of life and late-effects among childhood brain tumor survivors: a mixed method analysis

Gunn, Mirja Erika ; Mört, Susanna ; Arola, Mikko ; Taskinen, Mervi ; Riikonen, Pekka ; Möttönen, Merja ; Lähteenmäki, Päivi Maria

Background : Reports on the quality of life (QOL) of childhood brain tumor (BT) survivors have been inconsistent. As cognitive limitations may restrict their participation in questionnaire-based studies, our aim was to evaluate in depth the QOL with a mixed-method analysis. Methods : The 5-year survivors of childhood BTs born in 1975–2000 and alive in 2010 were identified via the Finnish Cancer Registry and treating clinics. Twenty-one survivors (32%) participated in a mixed-method analysis [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2015 (10 études), cette étude analyse les effets d'un diabète sur la qualité de vie des patients atteints de cancer

The impact of having both cancer and diabetes on patient-reported outcomes: a systematic review and directions for future research

Vissers, PaulineA J. ; Falzon, Louise ; van de Poll-Franse, LonnekeV ; Pouwer, Frans ; Thong, MelissaS Y.

Purpose : This systematic review aims to summarize the current literature regarding potential effects of having both cancer and diabetes on patient-reported outcomes (PROs) and to provide directions for future research. Methods : MEDLINE, The Cochrane Library, CINAHL, and PsycINFO were searched from inception to January 2015. All English peer-reviewed studies that included patients with both cancer and diabetes and assessed PROs were included. All included studies were independently assessed on [...]

A partir des données de l'Organisation mondiale de la santé, cette étude analyse l'évolution de la mortalité par cancer colorectal dans 34 pays européens, sur la période 1970-2011

Trends in colorectal cancer mortality in Europe: retrospective analysis of the WHO mortality database

Ait Ouakrim, Driss ; Pizot, Cécile ; Boniol, Magali ; Malvezzi, Matteo ; Boniol, Mathieu ; Negri, Eva ; Bota, Maria ; Jenkins, Mark A ; Bleiberg, Harry ; Autier, Philippe

Objective : To examine changes in colorectal cancer mortality in 34 European countries between 1970 and 2011. Design : Retrospective trend analysis.Data source World Health Organization mortality database.Population Deaths from colorectal cancer between 1970 and 2011. Profound changes in screening and treatment efficiency took place after 1988; therefore, particular attention was paid to the evolution of colorectal cancer mortality in the subsequent period. Main outcomes measures : Time trends [...]

A partir des données des registres américains des cancers, cette étude présente les projections d'incidence de cancer du sein in situ pour l'année 2015, et fait le point sur ses facteurs de risque, sa prévention, sa détection et ses traitements

Cancer statistics: Breast cancer in situ

Ward, Elizabeth M. ; DeSantis, Carol E. ; Lin, Chun Chieh ; Kramer, Joan L. ; Jemal, Ahmedin ; Kohler, Betsy ; Brawley, Otis W. ; Gansler, Ted

An estimated 60,290 new cases of breast carcinoma in situ are expected to be diagnosed in 2015, and approximately 1 in 33 women is likely to receive an in situ breast cancer diagnosis in her lifetime. Although in situ breast cancers are relatively common, their clinical significance and optimal treatment are topics of uncertainty and concern for both patients and clinicians. In this article, the American Cancer Society provides information about occurrence and treatment patterns for the 2 major [...]

Menée aux Etats-Unis à partir de données portant sur 1 109 patientes atteintes d'un cancer du sein, cette étude de cohorte évalue les effets d'une adiposité mesurée après le diagnostic sur la survie, en fonction du sous-type de cancer

Post-diagnosis adiposity and survival among breast cancer patients: influence of breast cancer subtype

Sun, Xuezheng ; Nichols, HazelB ; Robinson, Whitney ; Sherman, MarkE ; Olshan, AndrewF ; Troester, MelissaA

Purpose : adiposity has been linked with increased breast cancer risk and mortality. It is established that etiologic associations for adiposity vary by tumor subtype, but the influence of adiposity on subtype-specific survival is unknown. Methods : Study participants were 1,109 invasive breast cancer participants in the population-based Carolina Breast Cancer Study, diagnosed between 1993 and 2001, and with tissue blocks available for immunohistochemical subtyping. General and central [...]

A partir des données des registres néerlandais des cancers incluant 173 797 patientes atteintes d'un cancer du sein diagnostiqué entre 1999 et 2012, cette étude prospective évalue les effets du stade et des caractéristiques de la tumeur au diagnostic, et ceux des traitements reçus sur l'amélioration de la survie

Influence of tumour stage at breast cancer detection on survival in modern times: population based study in 173 797 patients

Saadatmand, Sepideh ; Bretveld, Reini ; Siesling, Sabine ; Tilanus-Linthorst, Madeleine M A

Objectives : To assess the influence of stage at breast cancer diagnosis, tumour biology, and treatment on survival in contemporary times of better (neo-)adjuvant systemic therapy. Design : Prospective nationwide population based study. Setting : Nationwide Netherlands Cancer Registry. Participants : Female patients with primary breast cancer diagnosed between 1999 and 2012 (n=173 797), subdivided into two time cohorts on the basis of breast cancer diagnosis: 1999-2005 (n=80 228) and 2006-12 [...]

Menée aux Etats-Unis auprès de 590 patients atteints d'un cancer de stade avancé, cette étude multicentrique observationnelle analyse l'association entre l'annonce d'un pronostic par le médecin, les perceptions du patient relatives à son espérance de vie, et sa détresse psychologique

Outcomes of Prognostic Disclosure: Associations With Prognostic Understanding, Distress, and Relationship With Physician Among Patients With Advanced Cancer

Enzinger, Andrea C. ; Zhang, Baohui ; Schrag, Deborah ; Prigerson, Holly G.

Purpose : To determine how prognostic conversations influence perceptions of life expectancy (LE), distress, and the patient-physician relationship among patients with advanced cancer. Patients and Methods : This was a multicenter observational study of 590 patients with metastatic solid malignancies with progressive disease after ≥ one line of palliative chemotherapy, undergoing follow-up to death. At baseline, patients were asked whether their oncologist had disclosed an estimate of [...]

Menée en Australie par questionnaires auprès de 138 patients atteints d'un cancer de la prostate, cette étude analyse l'efficacité de 3 outils pour évaluer leurs symptômes de dépression

Measuring depression in prostate cancer patients: does the scale used make a difference?

Sharpley, C. F. ; Bitsika, V. ; Christie, D. R. H. ; Hunter, M. S.

This study investigated differences in the scores, relative severity and major depressive disorder (MDD) and subsyndromal depression status from three standardised self-report scales for depression in prostate cancer (PCa) patients. The Hospital Anxiety and Depression Scale Depression subscale (HADS-D), the Self-rating Depression Scale (SDS) and the Patient Health Questionnaire (PHQ-9) for depression were administered to a sample of 138 PCa patients via mail-out self-reports in Queensland, [...]

Menée en Suède par questionnaire auprès de 209 patients atteints d'une polypose adénomateuse familiale, cette étude analyse l'association entre leurs perceptions de la maladie et leur adhésion à un suivi médical régulier par endoscopie

The role of illness perceptions in adherence to surveillance in patients with familial adenomatous polyposis (FAP)

Eriksson, Lars E. ; Fritzell, Kaisa ; Rixon, Lorna ; Björk, Jan ; Wettergren, Lena

Objective : The aim of the study was to examine patients' beliefs about having familial adenomatous polyposis (FAP), a hereditary colorectal cancer syndrome, and how these beliefs are associated with adherence to endoscopic surveillance. Methods : Adult patients diagnosed with FAP on the national Swedish polyposis register who had undergone prophylactic colorectal surgery (n 209, response rate 76%) completed the Illness Perception Questionnaire (IPQ). Logistic regression analysis was used to [...]

Menée en Ecosse par enquête auprès de 12 255 participantes, cette étude analyse l'association entre le degré d'optimisme et la détresse psychologique, en fonction de l'état de santé général, chez des patientes ayant survécu à un cancer du sein (295 cas et 11 960 témoins)

Psychological distress, optimism and general health in breast cancer survivors: a data linkage study using the Scottish Health Survey

Leung, Janni ; Atherton, Iain ; Kyle, RichardG ; Hubbard, Gill ; McLaughlin, Deirdre

Purpose : The aim of this study is to examine the association between optimism and psychological distress in women with breast cancer after taking into account their self-rated general health. Methods : Data were aggregated from the Scottish Health Survey (2008 to 2011) to derive a nationally representative sample of 12,255 women (11,960 cancer-free controls, and 295 breast cancer cases identified from linked cancer registry data). The explanatory variables were optimism and general health, and [...]

Menée en Corée par questionnaire auprès de 82 soignants de patients pédiatriques atteints de tumeurs cérébrales, cette étude analyse les facteurs associés à leurs symptômes de dépression et de détresse psychologique

Depression and distress in caregivers of children with brain tumors undergoing treatment: psychosocial factors as moderators

Choi, Eun Kyung ; Yoon, Soo Jin ; Kim, Jong-Heun ; Park, Hyeon Jin ; Kim, Joo Young ; Yu, Eun-Seung

Objective This study's objectives were to examine the effects of depression on the distress of caregivers of children with brain tumors and to identify the factors moderating depression and caregiver distress. Methods Participants were 82 caregivers of children with brain tumors undergoing treatment in the National Cancer Center of South Korea. The depression subscale of the Symptom Checklist 90-Revised (SCL-90-R) and the Burden of a Primary Caregiver (BPC) Scale were used to measure [...]

Menée aux Etats-Unis, cette étude analyse le rapport coût-efficacité d'un programme de vaccination utilisant un vaccin nonavalent contre le papillomavirus humain en remplacement du vaccin tétravalent

Health and Economic Impact of Switching from a 4-Valent to a 9-Valent HPV Vaccination Program in the United States

Brisson, Marc ; Laprise, Jean-François ; Chesson, Harrell W. ; Drolet, Mélanie ; Malagón, Talía ; Boily, Marie-Claude ; Markowitz, Lauri E.

Background: Randomized clinical trials have shown the 9-valent human papillomavirus (HPV) vaccine to be highly effective against types 31/33/45/52/58 compared with the 4-valent. Evidence on the added health and economic benefit of the 9-valent is required for policy decisions. We compare population-level effectiveness and cost-effectiveness of 9- and 4-valent HPV vaccination in the United States. Methods: We used a multitype individual-based transmission-dynamic model of HPV infection and [...]

A partir des données des registres américains des cancers incluant 18 777 patients atteints de lymphome et âgés de plus de 65 ans, cette étude de cohorte analyse l'association entre des caractéristiques liées à la maladie (agressivité, curabilité, etc) et le recours à une unité de soins palliatifs

Hospice Use Among Patients With Lymphoma: Impact of Disease Aggressiveness and Curability

Odejide, Oreofe O. ; Cronin, Angel M. ; Earle, Craig C. ; LaCasce, Ann S. ; Abel, Gregory A.

Background: Little is known about factors that influence hospice use for patients with blood cancers. We aimed to characterize hospice enrollment in a large population of patients with B-cell non-Hodgkin lymphoma (NHL) and assess the impact of disease characteristics such as aggressiveness and curability. Methods: Using the Surveillance, Epidemiology, and End Results-Medicare database, we identified patients age 65 years and older who were diagnosed with indolent NHL, aggressive NHL, or mantle [...]

Cette étude passe en revue les facteurs génétiques et cliniques impliqués dans le développement des cancers gastriques familiaux, ainsi que les recommandations en matière de prévention et de prise en charge

Familial Gastric Cancers

Setia, Namrata ; Clark, Jeffrey W. ; Duda, Dan G. ; Hong, Theodore S. ; Kwak, Eunice L. ; Mullen, John T. ; Lauwers, Gregory Y.

Although the majority of gastric carcinomas are sporadic, approximately 10% show familial aggregation, and a hereditary cause is determined in 1%–3% cases. Of these, hereditary diffuse gastric cancer is the most recognized predisposition syndrome. Although rare, the less commonly known syndromes also confer a markedly increased risk for development of gastric cancer. Identification and characterization of these syndromes require a multidisciplinary effort involving oncologists, surgeons, [...]

Cette étude passe en revue les enjeux liés au suivi à long terme des patients atteints de cancer et ayant été inclus dans des essais cliniques

Statistical Controversies in Clinical Research: Long Term Follow up of Clinical Trials in Cancer

Cuzick, Jack

Long term follow up is an important unmet need for the full analysis of new treatments for cancer. Earlier detection of cancer and more effective treatment has led to many more patients surviving for more than 5 and even 10 years, so that evaluating late recurrences and side effects is an increasingly important issue. This is particularly relevant for oestrogen receptor positive breast cancer, where the existence of late recurrences is well documented. However survival for other cancers, [...]